Dr Ya-Ching Hsieh
- Bioinformatician (Paul O'Gorman Leukaemia Research Centre)
email:
Ya-Ching.Hsieh@glasgow.ac.uk
Publications
2021
Chantkran, W., Hsieh, Y.-C., Zheleva, D., Frame, S., Wheadon, H. and Copland, M. (2021) Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML. Cell Death Discovery, 7, 137. (doi: 10.1038/s41420-021-00496-y) (PMID:34112754) (PMCID:PMC8192769)
Wang, Y.-Y. et al. (2021) MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner. Oncogene, 40(20), pp. 3510-3532. (doi: 10.1038/s41388-021-01698-5) (PMID:33927349) (PMCID:PMC8134045)
Hsieh, Y.-C., Kirschner, K. and Copland, M. (2021) Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape. Leukemia, 35(5), pp. 1229-1242. (doi: 10.1038/s41375-021-01238-w) (PMID:33833387) (PMCID:PMC8102187)
2020
Wang, Y.-Y., Chen, H.-D., Lo, S. , Chen, Y.-K., Huang, Y.-C., Hu, S. C.-S., Hsieh, Y.-C., Hung, A. C., Hou, M.-F. and Yuan, S.-S. F. (2020) Visfatin enhances breast cancer progression through CXCL1 induction in tumor-associated macrophages. Cancers, 12(12), e3526. (doi: 10.3390/cancers12123526) (PMID:33256011) (PMCID:PMC7760195)
Yang, Y.-F., Wang, Y.-Y., Hsiao, M., Lo, S. , Chang, Y.-C., Jan, Y.-H., Lai, T.-C., Lee, Y.-C., Hsieh, Y.-C. and Yuan, S.-S. F. (2020) IMPAD1 functions as mitochondrial electron transport inhibitor that prevents ROS production and promotes lung cancer metastasis through the AMPK-Notch1-HEY1 pathway. Cancer Letters, 485, pp. 27-37. (doi: 10.1016/j.canlet.2020.04.025) (PMID:32417395)
2019
Hayatigolkhatmi, K., Padroni, G., Su, W., Fang, L., Gómez-Castañeda, E., Hsieh, Y.C., Jackson, L., Pellicano, F., Burley, G.A. and Jørgensen, H.G. (2019) An investigation of targeted inhibition of transcription factor activity with pyrrole imidazole polyamide (PA) in chronic myeloid leukemia (CML) blast crisis cells. Bioorganic and Medicinal Chemistry Letters, 29(18), pp. 2622-2625. (doi: 10.1016/j.bmcl.2019.07.049) (PMID:31378570)
2018
Yang, Y.-F., Lee, Y.-C., Lo, S. , Chung, Y.-N., Hsieh, Y.-C., Chiu, W.-C. and Yuan, S.-S. F. (2018) A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis. Cancer Letters, 422, pp. 44-55. (doi: 10.1016/j.canlet.2018.02.037) (PMID:29496538)
Hayatigolkhatmi, K. et al. (2018) Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells. Blood Cells, Molecules, and Diseases, 69, pp. 119-122. (doi: 10.1016/j.bcmd.2017.11.002) (PMID:29217295)
Wang, C.-H. et al. (2018) Resistin facilitates breast cancer progression via TLR4-mediated induction of mesenchymal phenotypes and stemness properties. Oncogene, 37, pp. 589-600. (doi: 10.1038/onc.2017.357) (PMID:28991224)
2016
Hung, A. C. et al. (2016) Extracellular visfatin-promoted malignant behavior in breast cancer is mediated through c-Abl and STAT3 activation. Clinical Cancer Research, 22(17), pp. 4478-4490. (doi: 10.1158/1078-0432.CCR-15-2704) (PMID:27036136)
Articles
Chantkran, W., Hsieh, Y.-C., Zheleva, D., Frame, S., Wheadon, H. and Copland, M. (2021) Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML. Cell Death Discovery, 7, 137. (doi: 10.1038/s41420-021-00496-y) (PMID:34112754) (PMCID:PMC8192769)
Wang, Y.-Y. et al. (2021) MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner. Oncogene, 40(20), pp. 3510-3532. (doi: 10.1038/s41388-021-01698-5) (PMID:33927349) (PMCID:PMC8134045)
Hsieh, Y.-C., Kirschner, K. and Copland, M. (2021) Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape. Leukemia, 35(5), pp. 1229-1242. (doi: 10.1038/s41375-021-01238-w) (PMID:33833387) (PMCID:PMC8102187)
Wang, Y.-Y., Chen, H.-D., Lo, S. , Chen, Y.-K., Huang, Y.-C., Hu, S. C.-S., Hsieh, Y.-C., Hung, A. C., Hou, M.-F. and Yuan, S.-S. F. (2020) Visfatin enhances breast cancer progression through CXCL1 induction in tumor-associated macrophages. Cancers, 12(12), e3526. (doi: 10.3390/cancers12123526) (PMID:33256011) (PMCID:PMC7760195)
Yang, Y.-F., Wang, Y.-Y., Hsiao, M., Lo, S. , Chang, Y.-C., Jan, Y.-H., Lai, T.-C., Lee, Y.-C., Hsieh, Y.-C. and Yuan, S.-S. F. (2020) IMPAD1 functions as mitochondrial electron transport inhibitor that prevents ROS production and promotes lung cancer metastasis through the AMPK-Notch1-HEY1 pathway. Cancer Letters, 485, pp. 27-37. (doi: 10.1016/j.canlet.2020.04.025) (PMID:32417395)
Hayatigolkhatmi, K., Padroni, G., Su, W., Fang, L., Gómez-Castañeda, E., Hsieh, Y.C., Jackson, L., Pellicano, F., Burley, G.A. and Jørgensen, H.G. (2019) An investigation of targeted inhibition of transcription factor activity with pyrrole imidazole polyamide (PA) in chronic myeloid leukemia (CML) blast crisis cells. Bioorganic and Medicinal Chemistry Letters, 29(18), pp. 2622-2625. (doi: 10.1016/j.bmcl.2019.07.049) (PMID:31378570)
Yang, Y.-F., Lee, Y.-C., Lo, S. , Chung, Y.-N., Hsieh, Y.-C., Chiu, W.-C. and Yuan, S.-S. F. (2018) A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis. Cancer Letters, 422, pp. 44-55. (doi: 10.1016/j.canlet.2018.02.037) (PMID:29496538)
Hayatigolkhatmi, K. et al. (2018) Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells. Blood Cells, Molecules, and Diseases, 69, pp. 119-122. (doi: 10.1016/j.bcmd.2017.11.002) (PMID:29217295)
Wang, C.-H. et al. (2018) Resistin facilitates breast cancer progression via TLR4-mediated induction of mesenchymal phenotypes and stemness properties. Oncogene, 37, pp. 589-600. (doi: 10.1038/onc.2017.357) (PMID:28991224)
Hung, A. C. et al. (2016) Extracellular visfatin-promoted malignant behavior in breast cancer is mediated through c-Abl and STAT3 activation. Clinical Cancer Research, 22(17), pp. 4478-4490. (doi: 10.1158/1078-0432.CCR-15-2704) (PMID:27036136)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Single cell transcriptome and protein BM niche profiling with CITE-seq in CML disease progression
NHS Greater Glasgow and Clyde Endowment Funds
2020 - 2021