Professor Michael Olson
- Honrary Senior Lecturer (School of Cancer Sciences)
email:
Michael.Olson@glasgow.ac.uk
Beatson Institute, Glasgow G61 1BD
https://orcid.org/0000-0003-3428-3507Publications
2023
Ruscetta, V. M., Seaton, T. J., Shakeel, A., Vasconcelos, S. N. S., Viirre, R. D., Adler, M. J. and Olson, M. F. (2023) Opportunities and challenges for the development of MRCK kinases inhibitors as potential cancer chemotherapeutics. Cells, 12(4), 534. (doi: 10.3390/cells12040534) (PMID:36831201) (PMCID:PMC9954052)
Li, X., McLain, C., Samuel, M. S., Olson, M. F. and Radice, G. L. (2023) Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through α5 integrin signaling. Development, 150(2), dev201013. (doi: 10.1242/dev.201013) (PMID:36621002)
Olson, M. F. (2023) Actin-myosin cytoskeleton regulation and function. Cells, 12(1), 9. (doi: 10.3390/cells12010009) (PMID:36611802) (PMCID:PMC9818783)
2022
Naylor, G., Julian, L., Watson-Bryce, S., Mullin, M., Nibbs, R. J. and Olson, M. F. (2022) Immunogenic death of hepatocellular carcinoma cells in mice expressing caspase-resistant ROCK1 is not replicated by ROCK inhibitors. Cancers, 14(23), 5943. (doi: 10.3390/cancers14235943)
Haikazian, S. and Olson, M. F. (2022) MICAL1 monooxygenase in autosomal dominant lateral temporal epilepsy: role in cytoskeletal regulation and relation to cancer. Genes, 13(5), 715. (doi: 10.3390/genes13050715)
Tonon, F. et al. (2022) 5-azacytidine downregulates the proliferation and migration of hepatocellular carcinoma cells in vitro and in vivo by targeting miR-139-5p/ROCK2 pathway. Cancers, 14(7), 1630. (doi: 10.3390/cancers14071630) (PMID:35406401) (PMCID:PMC8996928)
2021
McGarry, D. J., Armstrong, G., Castino, G., Mason, S., Clark, W., Shaw, R., McGarry, L., Blyth, K. and Olson, M. F. (2021) MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours. Cancer Letters, 519, pp. 226-236. (doi: 10.1016/j.canlet.2021.07.039) (PMID:34314753)
Olson, M. F. and Machesky, L. M. (2021) MICAL2 fine-tunes Arp2/3 for actin branching. Journal of Cell Biology, 220(8), e202106176. (doi: 10.1083/jcb.202106176) (PMID:34264264)
2020
Masre, S. F., Rath, N., Olson, M. F. and Greenhalgh, D. A. (2020) Epidermal ROCK2-induces AKT1/GSK3β/β-catenin, NFκB and dermal tenascin-C; but enhanced differentiation and p53/p21 inhibit papilloma. Carcinogenesis, 41(10), pp. 1409-1420. (doi: 10.1093/carcin/bgz205) (PMID:31907522) (PMCID:PMC7566339)
Unbekandt, M., Lilla, S., Zanivan, S. R. and Olson, M. F. (2020) The CDC42 effector protein MRCKß autophosphorylates on Threonine 1108. Small GTPases, 11(6), pp. 451-460. (doi: 10.1080/21541248.2018.1564472) (PMID:30667325) (PMCID:PMC7549636)
Vennin, C., Rath, N., Pajic, M., Olson, M. F. and Timpson, P. (2020) Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy. Small GTPases, 11(1), pp. 45-52. (doi: 10.1080/21541248.2017.1345712) (PMID:28972449)
2019
Rudzka, D. A. et al. (2019) Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization. Journal of Cell Science, 132(11), jcs224071. (doi: 10.1242/jcs.224071) (PMID:31152052) (PMCID:PMC6589089)
2018
Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)
Chim, Y. H., Mason, L. M., Rath, N., Olson, M. F. , Tassieri, M. and Yin, H. (2018) A one-step procedure to probe the viscoelastic properties of cells by Atomic Force Microscopy. Scientific Reports, 8, 14462. (doi: 10.1038/s41598-018-32704-8) (PMID:30262873) (PMCID:PMC6160452)
Rath, N. et al. (2018) Rho kinase inhibition by AT13148 blocks pancreatic ductal adenocarinoma invasion and tumor growth. Cancer Research, 78(12), pp. 3321-3336. (doi: 10.1158/0008-5472.CAN-17-1339) (PMID:29669760) (PMCID:PMC6005347)
Unbekandt, M. et al. (2018) Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer. Cancer Research, 78(8), pp. 2096-2114. (doi: 10.1158/0008-5472.CAN-17-2870) (PMID:29382705) (PMCID:PMC5901721)
Masre, S. F., Linkov, N., Olson, M. F. and Greenhalgh, D. A. (2018) Accelerated differentiation and p21/p53 responses to ROCK-mediated p-AKT/p-GSK3β/β-catenin overexpression prevent papillomas in transgenic mice. BSID Annual Meeting 2018, London, UK, 26-28 Mar 2018.
Olson, M. F. (2018) Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors. Small GTPases, 9(3), pp. 203-215. (doi: 10.1080/21541248.2016.1218407) (PMID:27548350) (PMCID:PMC5927519)
2017
Rudzka, D. A., Clark, W., Hedley, A., Kalna, G. and Olson, M. F. (2017) Transcriptomic profiling of human breast and melanoma cells selected by migration through narrow constraints. Scientific Data, 4, 170172. (doi: 10.1038/sdata.2017.172) (PMID:29135975) (PMCID:PMC5685158)
Masre, S.F., Rath, N., Olson, M.F. and Greenhalgh, D.A. (2017) ROCK2/rasHa cooperation induce malignant conversion via p53 loss, elevated NF-κβ and tenascin C-associated rigidity but p21 inhibits ROCK2/NF-κβ-mediated progression. Oncogene, 36, pp. 2529-2542. (doi: 10.1038/onc.2016.402) (PMID:27991921)
Rath, N. et al. (2017) ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Molecular Medicine, 9(2), pp. 198-218. (doi: 10.15252/emmm.201606743) (PMID:28031255) (PMCID:PMC5286371)
2016
Samuel, M. S., Rath, N., Masre, S. F., Boyle, S. T., Greenhalgh, D. A. , Kochetkova, M., Bryson, S., Stevenson, D. and Olson, M. F. (2016) Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein. Genesis, 54(12), pp. 636-646. (doi: 10.1002/dvg.22988) (PMID:27775859)
McGarry, D. J. and Olson, M. F. (2016) Coping with loss: cell adaptation to cytoskeleton disruption. Developmental Cell, 39(1), pp. 3-4. (doi: 10.1016/j.devcel.2016.09.020) (PMID:27728780)
McGarry, D. J., Shchepinova, M. M., Lillla, S., Hartley, R. C. and Olson, M. F. (2016) A cell-permeable biscyclooctyne as a novel probe for the identification of protein sulfenic acids. ACS Chemical Biology, 11(12), pp. 3300-3304. (doi: 10.1021/acschembio.6b00742) (PMID:27792307)
Rath, N., Kalna, G., Clark, W. and Olson, M. F. (2016) ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells. Scientific Data, 3, p. 160101. (doi: 10.1038/sdata.2016.101) (PMID:27824338) (PMCID:PMC5100681)
Rath, N. and Olson, M. (2016) Regulation of pancreatic cancer aggressiveness by stromal stiffening. Nature Medicine, 22(5), pp. 462-463. (doi: 10.1038/nm.4099) (PMID:27149218)
2015
Mardilovich, K. et al. (2015) LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget, 6(36), pp. 38469-38486. (doi: 10.18632/oncotarget.6288) (PMID:26540348) (PMCID:PMC4770715)
Charles, M. D. et al. (2015) Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties. Journal of Medicinal Chemistry, 58(20), pp. 8309-8313. (doi: 10.1021/acs.jmedchem.5b01242) (PMID:26356364)
Julian, L. and Olson, M. F. (2015) Apoptotic membrane dynamics in health and disease. Cell Health and Cytoskeleton, 2015(7), pp. 133-142. (doi: 10.2147/CHC.S57893)
Giancotti, F. G., Haynes, C. M., Machesky, L. M. , Olson, M. F. and Overholtzer, M. (2015) Alan Hall 1952–2015. Nature Cell Biology, 17(7), pp. 839-840. (doi: 10.1038/ncb3190) (PMID:26005836)
Cameron, J. M., Gabrielsen, M. , Chim, Y. H., Munro, J., McGhee, E. J., Sumpton, D., Eaton, P., Anderson, K. I., Yin, H. and Olson, M. F. (2015) Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation. Current Biology, 25(11), pp. 1520-1525. (doi: 10.1016/j.cub.2015.04.020)
Mardilovich, K., Gabrielsen, M. , McGarry, L., Orange, C., Patel, R., Shanks, E., Edwards, J. and Olson, M. F. (2015) Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation. Molecular Cancer Therapeutics, 14(1), pp. 246-258. (doi: 10.1158/1535-7163.MCT-14-0447)
Rudzka, D. A., Cameron, J. M. and Olson, M. F. (2015) Reactive oxygen species and hydrogen peroxide generation in cell migration. Communicative and Integrative Biology, 8(5), e1074360. (doi: 10.1080/19420889.2015.1074360) (PMID:27066166) (PMCID:PMC4802769)
Rudzka, D. A. and Olson, M. F. (2015) Microtrack migration: insights into 3D cell motility: focus on 'comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks'. American Journal of Physiology: Cell Physiology, 308(6), C434-C435. (doi: 10.1152/ajpcell.00016.2015) (PMID:25608531)
2014
Lourenco, F.C. et al. (2014) Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. Gut, 63(3), pp. 480-493. (doi: 10.1136/gutjnl-2012-303883)
Unbekandt, M. and Olson, M. F. (2014) The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer. Journal of Molecular Medicine, 92(3), pp. 217-225. (doi: 10.1007/s00109-014-1133-6)
Julian, L. and Olson, M. F. (2014) Rho-associated coiled-coil containing kinases (ROCK). Small GTPases, 5(2), e29846. (doi: 10.4161/sgtp.29846) (PMID:25010901) (PMCID:PMC4114931)
Prater, M. D. et al. (2014) Mammary stem cells have myoepithelial cell properties. Nature Cell Biology, 16(10), pp. 942-950. (doi: 10.1038/ncb3025) (PMID:25173976) (PMCID:PMC4183554)
Unbekandt, M. et al. (2014) A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Communication and Signaling, 12, 54. (doi: 10.1186/s12964-014-0054-x) (PMID:25288205) (PMCID:PMC4195943)
2013
Ibbetson, S. J., Pyne, N. T., Pollard, A. N., Olson, M. F. and Samuel, M. S. (2013) Mechanotransduction pathways promoting tumor progression are activated in invasive human squamous cell carcinoma. American Journal of Pathology, 183(3), pp. 930-937. (doi: 10.1016/j.ajpath.2013.05.014) (PMID:23830873)
Klejnot, M., Gabrielsen, M. , Cameron, J., Mleczak, A., Talapatra, S.K., Kozielski, F., Pannifer, A. and Olson, M.F. (2013) Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding. Acta Crystallographica. Section D: Biological Crystallography, 69(9), pp. 1780-1788. (doi: 10.1107/S0907444913014418)
Masre, S.F., Olson, M.F. and Greenhalgh, D.A. (2013) Inducible ROCK 2 activation increases primary keratinocyte differentiation but co-operates with rasHa activation in transgenic mouse skin carcinogenesis. Journal of Investigative Dermatology, 133(S1), S57-S57. (doi: 10.1038/jid.2013.96)
Gabrielsen, M. , Schuldt, M., Munro, J., Borucka, D., Cameron, J., Baugh, M., Mleczak, A., Lilla, S., Morrice, N. and Olson, M.F. (2013) Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target. Cell Communication and Signaling, 11(58), (doi: 10.1186/1478-811X-11-58)
Mleczak, A., Millar, S., Tooze, S.A., Olson, M.F. and Chan, E.Y.W. (2013) Regulation of autophagosome formation by Rho kinase. Cellular Signalling, 25(1), pp. 1-11. (doi: 10.1016/j.cellsig.2012.09.010)
Olson, M.F. (2013) Finding the shape-shifter genes. Nature Cell Biology, 15, pp. 723-725. (doi: 10.1038/ncb2792)
Wickman, G.R. et al. (2013) Blebs produced by actin–myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs. Cell Death and Differentiation, 20, pp. 1293-1305. (doi: 10.1038/cdd.2013.69)
2012
Rath, N. and Olson, M.F. (2012) Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy. EMBO Reports, 13(10), pp. 900-908. (doi: 10.1038/embor.2012.127)
Jamieson, T. et al. (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. Journal of Clinical Investigation, 122(9), pp. 3127-3144. (doi: 10.1172/JCI61067)
Mardilovich, K., Olson, M.F. and Baugh, M. (2012) Targeting Rho GTPase signaling for cancer therapy. Future Oncology, 8(2), pp. 165-177. (doi: 10.2217/fon.11.143)
Boomkamp, S.D., Riehle, M.O. , Wood, J., Olson, M.F. and Barnett, S.C. (2012) The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination. Glia, 60(3), pp. 441-456. (doi: 10.1002/glia.22278)
Mezna, M., Wong, A.C., Ainger, M., Scott, R.W., Hammonds, T. and Olson, M.F. (2012) Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption. Journal of Biomolecular Screening, 17(4), pp. 460-468. (doi: 10.1177/1087057111430529)
Wickman, G., Julian, L. and Olson, M.F. (2012) How apoptotic cells aid in the removal of their own cold dead bodies. Cell Death and Differentiation, 19(5), pp. 735-742. (doi: 10.1038/cdd.2012.25)
Wood, J.M. and Olson, M.F. (2012) Collective migration: spatial tension relief. Current Biology, 22(4), R125-R127. (doi: 10.1016/j.cub.2012.01.026)
2011
Scott, R. W., Crighton, D. and Olson, M. F. (2011) Modeling and imaging 3-dimensional collective cell invasion. Journal of Visualized Experiments(58), e3525. (doi: 10.3791/3525) (PMID:22157886) (PMCID:PMC3346048)
Samuel, M.S. and Olson, M.F. (2011) Actomyosin contractililty: force power drives tumor growth. Cell Cycle, 10(20), pp. 3409-3410. (doi: 10.4161/cc.10.20.17722)
Heikkila, T. et al. (2011) Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. PLoS ONE, 6(9), e24825. (doi: 10.1371/journal.pone.0024825)
Croft, D. R. and Olson, M. F. (2011) Transcriptional regulation of Rho GTPase signaling. Transcription, 2(5), pp. 211-215. (doi: 10.4161/trns.2.5.16904) (PMID:22231116) (PMCID:PMC3265777)
Croft, D.R. et al. (2011) p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Research, 21(4), pp. 666-682. (doi: 10.1038/cr.2010.154)
Crighton, D. and Olson, M. F. (2011) Trailblazing LIM kinases take the lead in collective tumor cell invasion. BioArchitecture, 1(1), pp. 5-8. (doi: 10.4161/bioa.1.1.14628) (PMID:21866254) (PMCID:PMC3158634)
Morin, P., Wickman, G., Munro, J., Inman, G.J. and Olson, M.F. (2011) Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion. European Journal of Cell Biology, 90(1), pp. 13-25. (doi: 10.1016/j.ejcb.2010.09.009) (PMID:21074289)
Samuel, M.S. et al. (2011) Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth. Cancer Cell, 19(6), pp. 776-791. (doi: 10.1016/j.ccr.2011.05.008)
Samuel, M.S., Lourenço, F.C. and Olson, M.F. (2011) K-Ras mediated murine epidermal tumorigenesis Is dependent upon and associated with elevated Rac1 activity. PLoS ONE, 6(2), e17143. (doi: 10.1371/journal.pone.0017143)
Sleebs, B.E., Levit, A., Street, I.P., Falk, H., Hammonds, T., Wong, A.C., Charles, M.D., Olson, M.F. and Baell, J.B. (2011) Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors. MedChemComm, 2(10), p. 977. (doi: 10.1039/C1MD00137J)
Timpson, P. et al. (2011) Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53. Cancer Research, 71(3), pp. 747-757. (doi: 10.1158/0008-5472.CAN-10-2267)
2010
Lochhead, P., Wickman, G., Mezna, M. and Olson, M. (2010) Activating ROCK1 somatic mutations in human cancer. Oncogene, 29(17), pp. 2591-2598. (doi: 10.1038/onc.2010.3)
Olson, M.F. (2010) Follow the leader: LIM kinases pave the way for collective tumor cell invasion. Cell Cycle, 9(22), pp. 4417-4418. (doi: 10.4161/cc.9.22.14049)
Samuel, M.S. and Olson, M.F. (2010) Dying Alone: A Tale of Rho. Cell Stem Cell, 7(2), pp. 135-136. (doi: 10.1016/j.stem.2010.07.002)
Scott, R.W. et al. (2010) LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. Journal of Cell Biology, 191(1), pp. 169-185. (doi: 10.1083/jcb.201002041)
Wickman, G., Samuel, M.S., Lochhead, P.A. and Olson, M.F. (2010) The Rho-Regulated ROCK Kinases in Cancer. In: van Golen, K. (ed.) The Rho GTPases in Cancer. Part 3. Springer, pp. 163-192. ISBN 9781441911117
2009
Brady, S. C., Coleman, M. L., Munro, J., Feller, S. M., Morrice, N. A. and Olson, M. F. (2009) Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation. Cancer Research, 69(17), pp. 6773-6781. (doi: 10.1158/0008-5472.CAN-08-4447)
Densham, R., O'Neill, E., Munro, J., Konig, I., Anderson, K., Kolch, W. and Olson, M. (2009) MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability. Molecular and Cellular Biology, 29(24), pp. 6380-6390. (doi: 10.1128/MCB.00116-09)
Morin, P., Flors, C. and Olson, M.F. (2009) Constitutively active RhoA inhibits proliferation by retarding G1 to S phase cell cycle progression and impairing cytokinesis. European Journal of Cell Biology, 88(9), pp. 495-507. (doi: 10.1016/j.ejcb.2009.04.005)
Olson, M.F. and Sahai, E. (2009) The actin cytoskeleton in cancer cell motility. Clinical and Experimental Metastasis, 26(4), pp. 273-287. (doi: 10.1007/s10585-008-9174-2)
Samuel, M.S., Munro, J., Bryson, S., Forrow, S., Stevenson, D. and Olson, M.F. (2009) Tissue selective expression of conditionally-regulated ROCK by gene targeting to a defined locus. Genesis, 47(7), pp. 440-446. (doi: 10.1002/dvg.20519)
2008
Croft, D. and Olson, M. (2008) Regulating the Conversion between Rounded and Elongated Modes of Cancer Cell Movement. Cancer Cell, 14(5), pp. 349-351. (doi: 10.1016/j.ccr.2008.10.009)
Merdek, K., Jaffe, A., Dutt, P., Olson, M. , Hall, A., Fanburg, B., Kayyali, U. and Toksov, D. (2008) α(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent. Biochemical and Biophysical Research Communications, 366(3), pp. 717-723. (doi: 10.1016/j.bbrc.2007.12.012)
Olson, M.F. (2008) Applications for ROCK kinase inhibition. Current Opinion in Cell Biology, 20(2), pp. 242-248. (doi: 10.1016/j.ceb.2008.01.002)
2007
Olson, M. F. (2007) Rock2. AFCS-Nature Molecule Pages, (doi: 10.1038/mp.a002089.01)
Chalmers, S., Olson, M. , MacMillan, D., Rainbow, R.D. and McCarron, J. (2007) Ion channels in smooth muscle: Regulation by the sarcoplasmic reticulum and mitochondria. Cell Calcium, 42(04-May), pp. 447-466. (doi: 10.1016/j.ceca.2007.05.010)
Graham, K. and Olson, M. F. (2007) The Ras signalling pathway as a target in cancer therapy. In: Groner, B. (ed.) Targeted Interference with Signal Transduction Events. Series: Recent results in cancer research (172). Springer: Berlin ; New York, pp. 125-153. ISBN 9783540312086 (doi: 10.1007/978-3-540-31209-3_8)
Mccarron, J., Olson, M. , Rainbow, R.D., MacMillan, D., and Chalmers, S., (2007) Ins(1,4,5)P-3 receptor regulation during 'quantal' Ca2+ release in smooth muscle. Trends in Pharmacological Sciences, 28(6), pp. 271-279. (doi: 10.1016/j.tips.2007.04.007)
Olson, M. (2007) Mechanisms of tumour cell invasion and metastasis. Journal of Molecular Medicine, 85(6), pp. 543-544. (doi: 10.1007/s00109-007-0189-y)
Scott, R. and Olson, M. (2007) LIM kinases: function, regulation and association with human disease. Journal of Molecular Medicine, 85(6), pp. 555-568. (doi: 10.1007/s00109-007-0165-6)
2006
Olson, M. F. (2006) Rock1. AFCS-Nature Molecule Pages, (doi: 10.1038/mp.a002088.01)
Coleman, M., Densham, R., Croft, D. and Olson, M. (2006) Stability of p21(Waf1)/(Cip1) CDK inhibitor protein is responsive to RhoA- mediated regulation of the actin cytoskeleton. Oncogene, 25(19), pp. 2708-2716. (doi: 10.1038/sj.onc.1209322)
Croft, D. and Olson, M. (2006) Conditional regulation of a ROCK-estrogen receptor fusion protein. Methods in Enzymology, 406, pp. 541-553. (doi: 10.1016/S0076-6879(06)06042-3)
Croft, D. and Olson, M. (2006) The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27(Kip1) levels by distinct mechanisms. Molecular and Cellular Biology, 26(12), pp. 4612-4627. (doi: 10.1128/MCB.02061-05)
Sahai, E. and Olson, M. (2006) Purification of TAT-C3 exoenzyme. Methods in Enzymology, 406, pp. 128-140. (doi: 10.1016/S0076-6879(06)06011-3)
Spence, H., McGarry, L., Chew, C., Carragher, N., Scott-Carragher, L., Yuan, Z., Croft, D., Olson, M. , Frame, M. and Ozanne, B. (2006) AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins. Molecular and Cellular Biology, 26(4), pp. 1480-1495. (doi: 10.1128/MCB.26.4.1480-1495.2006)
2005
Olson, M. F. (2005) Modeling human cancer: report on the Eighth Beatson International Cancer Conference. Cancer Research, 65(24), pp. 11247-11250. (doi: 10.1158/0008-5472.CAN-05-2713) (PMID:16357126)
Walker, K. and Olson, M. (2005) Targeting Ras and Rho GTPases as opportunities for cancer therapeutics. Current Opinion in Genetics and Development, 15(1), pp. 62-68. (doi: 10.1016/j.gde.2004.11.001) (PMID:15661535)
Croft, D., Coleman, M., Li, S., Robertson, D., Sullivan, T., Stewart, C. and Olson, M. (2005) Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration. Journal of Cell Biology, 168(2), pp. 245-255. (doi: 10.1083/jcb.200409049)
2004
Coleman, M., Marshall, C. and Olson, M. (2004) RAS and RHO GTPases in G1-phase cell-cycle regulation. Nature Reviews Molecular Cell Biology, 5(5), pp. 355-366. (doi: 10.1038/nrm1365)
Croft, D., Sahai, E., Mavria, G., Li, S., Tsai, J., Lee, W., Marshall, C. and Olson, M. (2004) Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Research, 64(24), pp. 8994-9001. (doi: 10.1158/0008-5472.CAN-04-2052)
Olson, M. (2004) Contraction reaction: mechanical regulation of Rho GTPase. Trends in Cell Biology, 14(3), pp. 111-114. (doi: 10.1016/j.tcb.2004.01.005)
Olson, M. (2004) Rac transformation - The actin connection. Cancer Biology and Therapy, 3(1), pp. 71-72. (doi: 10.4161/cbt.3.1.683) (PMID:14726705)
Tsavachidou, D., Coleman, M., Athanasiadis, G., Li, S., Licht, J., Olson, M. and Weber, B. (2004) SPRY2 is an inhibitor of the Ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant. Cancer Research, 64(16), pp. 5556-5559. (doi: 10.1158/0008-5472.CAN-04-1669)
2003
Coleman, M., Marshall, C. and Olson, M. (2003) Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO Journal, 22(9), pp. 2036-2046. (doi: 10.1093/emboj/cdg189)
McMullan, R., Lax, S., Robertson, V., Radford, D., Broad, S., Watt, F., Rowles, A., Croft, D., Olson, M. and Hotchin, N. (2003) Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Current Biology, 13(24), pp. 2185-2189. (doi: 10.1016/j.cub.2003.11.050)
Morelli, A., Chiozzi, P., Chiesa, A., Ferrari, D., Sanz, J., Falzoni, S., Pinton, P., Rizzuto, R., Olson, M. and Di Virgilio, F. (2003) Extracellular ATP causes ROCK I-dependent bleb formation in P2X(7)-transfected HEK293 cells. Molecular Biology of the Cell, 14(7), pp. 2655-2664. (doi: 10.1091/mbc.02-04-0061)
Olson, M. (2003) GTPase signalling: New functions for diaphanous- related formins. Current Biology, 13(9), R360-R362. (doi: 10.1016/S0960-9822(03)00277-X)
2002
Olson, M. F. (2002) Gem GTPase: between a ROCK and a hard place. Current Biology, 12(14), R496-R498. (doi: 10.1016/S0960-9822(02)00968-5) (PMID:12176351)
Coleman, M. and Olson, M. (2002) Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death and Differentiation, 9(5), pp. 493-504. (doi: 10.1038/sj.cdd.4400987)
2001
Coleman, M., Sahai, E., Yeo, M., Bosch, M., Dewar, A. and Olson, M. (2001) Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nature Cell Biology, 3(4), pp. 339-345. (doi: 10.1038/35070009)
Sahai, E., Olson, M. and Marshall, C. (2001) Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO Journal, 20(4), pp. 755-766. (doi: 10.1093/emboj/20.4.755)
2000
Tong, X.-K. et al. (2000) The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain. EMBO Journal, 19(6), pp. 1263-1271. (doi: 10.1093/emboj/19.6.1263) (PMID:10716926) (PMCID:PMC305667)
Olson, M. F. and Marais, R. (2000) Ras protein signalling. Seminars in Immunology, 12(1), pp. 63-73. (doi: 10.1006/smim.2000.0208) (PMID:10723799)
D'Abaco, G. M. and Olson, M. F. (2000) Mouse embryo fibroblasts: a genetic model system for studying Rho- and Ras-dependent cell cycle progression. Methods in Enzymology, 325, pp. 415-425. (doi: 10.1016/S0076-6879(00)25462-1) (PMID:11036623)
1998
Marshall, C. J., Olson, M. F. and Paterson, H. F. (1998) Signals from Ras and Rho GTPases interact to regulate expresson of p21Waf1/Cip1. Nature, 394(6690), pp. 295-299. (doi: 10.1038/28425) (PMID:9685162)
Marais, R., Light, Y., Mason, C., Paterson, H., Olson, M. F. and Marshall, C. J. (1998) Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science, 280(5360), pp. 109-112. (doi: 10.1126/science.280.5360.109) (PMID:9525855)
1997
Olson, M. F. , Sterpetti, P., Nagata, K.-i., Toksoz, D. and Hall, A. (1997) Distinct roles for DH and PH domains in the Lbc oncogene. Oncogene, 15(23), pp. 2827-2831. (doi: 10.1038/sj.onc.1201594) (PMID:9419973)
Mittnacht, S., Paterson, H., Olson, M. F. and Marshall, C. J. (1997) Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein. Current Biology, 7(3), pp. 219-221. (doi: 10.1016/S0960-9822(97)70094-0) (PMID:9395436)
1996
Olson, M. F. , Pasteris, N. G., Gorski, J. L. and Hall, A. (1996) Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Current Biology, 6(12), pp. 1628-1633. (doi: 10.1016/S0960-9822(02)70786-0) (PMID:8994827)
Olson, M.F. (1996) Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease? Journal of Molecular Medicine, 74(10), pp. 563-571. (doi: 10.1007/s001090050060) (PMID:8912177)
1995
Olson, M. F. , Ashworth, A. and Hall, A. (1995) An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science, 269(5228), pp. 1270-1272. (doi: 10.1126/science.7652575) (PMID:7652575)
Zheng, Y., Olson, M. F. , Hall, A., Cerione, R. A. and Toksoz, D. (1995) Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. Journal of Biological Chemistry, 270(16), pp. 9031-9034. (doi: 10.1074/jbc.270.16.9031) (PMID:7721814)
Aspenström, P. and Olson, M. F. (1995) Yeast two-hybrid system to detect protein-protein interactions with rho GTPases. Methods in Enzymology, 256, pp. 228-241. (doi: 10.1016/0076-6879(95)56027-0) (PMID:7476436)
1994
Olson, M.F. and Schimmer, B.P. (1994) Receptor-G-protein coupling in desensitization-resistant mutant adrenal cells. Endocrinology, 134(1), pp. 7-10. (doi: 10.1210/en.134.1.7) (PMID:7903937)
1993
Olson, M.F. , Krolczyk, A.J., Gorman, K.B., Steinberg, R.A. and Schimmer, B.P. (1993) Molecular basis for the 3',5'-cyclic adenosine monophosphate resistance of Kin mutant Y1 adrenocortical tumor cells. Molecular Endocrinology, 7(4), pp. 477-487. (doi: 10.1210/me.7.4.477) (PMID:8388994)
1992
Olson, M.F. and Schimmer, B.P. (1992) Heterologous desensitization of the human dopamine D1 receptor in Y1 adrenal cells and in a desensitization-resistant Y1 mutant. Molecular Endocrinology, 6(7), pp. 1095-1102. (doi: 10.1210/me.6.7.1095) (PMID:1354841)
1991
Olson, M. F. , Tsao, J., Pon, D. J. and Schimmer, B. P. (1991) Regulation of adenylyl cyclase activity by β-adrenergic agonists in a desensitization-resistant mutant cell line. Molecular Endocrinology, 5(1), pp. 34-41. (doi: 10.1210/mend-5-1-34) (PMID:1850109)
Olson, M. F. , Tsao, J., Pon, D. J. and Schimmer, B. P. (1991) Agonist-induced desensitization of adenylyl cyclase in Y1 adrenocortical tumor cells. Endocrine Research, 17(1-2), pp. 19-42. (doi: 10.1080/07435809109027187) (PMID:1679008)
Articles
Ruscetta, V. M., Seaton, T. J., Shakeel, A., Vasconcelos, S. N. S., Viirre, R. D., Adler, M. J. and Olson, M. F. (2023) Opportunities and challenges for the development of MRCK kinases inhibitors as potential cancer chemotherapeutics. Cells, 12(4), 534. (doi: 10.3390/cells12040534) (PMID:36831201) (PMCID:PMC9954052)
Li, X., McLain, C., Samuel, M. S., Olson, M. F. and Radice, G. L. (2023) Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through α5 integrin signaling. Development, 150(2), dev201013. (doi: 10.1242/dev.201013) (PMID:36621002)
Olson, M. F. (2023) Actin-myosin cytoskeleton regulation and function. Cells, 12(1), 9. (doi: 10.3390/cells12010009) (PMID:36611802) (PMCID:PMC9818783)
Naylor, G., Julian, L., Watson-Bryce, S., Mullin, M., Nibbs, R. J. and Olson, M. F. (2022) Immunogenic death of hepatocellular carcinoma cells in mice expressing caspase-resistant ROCK1 is not replicated by ROCK inhibitors. Cancers, 14(23), 5943. (doi: 10.3390/cancers14235943)
Haikazian, S. and Olson, M. F. (2022) MICAL1 monooxygenase in autosomal dominant lateral temporal epilepsy: role in cytoskeletal regulation and relation to cancer. Genes, 13(5), 715. (doi: 10.3390/genes13050715)
Tonon, F. et al. (2022) 5-azacytidine downregulates the proliferation and migration of hepatocellular carcinoma cells in vitro and in vivo by targeting miR-139-5p/ROCK2 pathway. Cancers, 14(7), 1630. (doi: 10.3390/cancers14071630) (PMID:35406401) (PMCID:PMC8996928)
McGarry, D. J., Armstrong, G., Castino, G., Mason, S., Clark, W., Shaw, R., McGarry, L., Blyth, K. and Olson, M. F. (2021) MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours. Cancer Letters, 519, pp. 226-236. (doi: 10.1016/j.canlet.2021.07.039) (PMID:34314753)
Olson, M. F. and Machesky, L. M. (2021) MICAL2 fine-tunes Arp2/3 for actin branching. Journal of Cell Biology, 220(8), e202106176. (doi: 10.1083/jcb.202106176) (PMID:34264264)
Masre, S. F., Rath, N., Olson, M. F. and Greenhalgh, D. A. (2020) Epidermal ROCK2-induces AKT1/GSK3β/β-catenin, NFκB and dermal tenascin-C; but enhanced differentiation and p53/p21 inhibit papilloma. Carcinogenesis, 41(10), pp. 1409-1420. (doi: 10.1093/carcin/bgz205) (PMID:31907522) (PMCID:PMC7566339)
Unbekandt, M., Lilla, S., Zanivan, S. R. and Olson, M. F. (2020) The CDC42 effector protein MRCKß autophosphorylates on Threonine 1108. Small GTPases, 11(6), pp. 451-460. (doi: 10.1080/21541248.2018.1564472) (PMID:30667325) (PMCID:PMC7549636)
Vennin, C., Rath, N., Pajic, M., Olson, M. F. and Timpson, P. (2020) Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy. Small GTPases, 11(1), pp. 45-52. (doi: 10.1080/21541248.2017.1345712) (PMID:28972449)
Rudzka, D. A. et al. (2019) Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization. Journal of Cell Science, 132(11), jcs224071. (doi: 10.1242/jcs.224071) (PMID:31152052) (PMCID:PMC6589089)
Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)
Chim, Y. H., Mason, L. M., Rath, N., Olson, M. F. , Tassieri, M. and Yin, H. (2018) A one-step procedure to probe the viscoelastic properties of cells by Atomic Force Microscopy. Scientific Reports, 8, 14462. (doi: 10.1038/s41598-018-32704-8) (PMID:30262873) (PMCID:PMC6160452)
Rath, N. et al. (2018) Rho kinase inhibition by AT13148 blocks pancreatic ductal adenocarinoma invasion and tumor growth. Cancer Research, 78(12), pp. 3321-3336. (doi: 10.1158/0008-5472.CAN-17-1339) (PMID:29669760) (PMCID:PMC6005347)
Unbekandt, M. et al. (2018) Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer. Cancer Research, 78(8), pp. 2096-2114. (doi: 10.1158/0008-5472.CAN-17-2870) (PMID:29382705) (PMCID:PMC5901721)
Olson, M. F. (2018) Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors. Small GTPases, 9(3), pp. 203-215. (doi: 10.1080/21541248.2016.1218407) (PMID:27548350) (PMCID:PMC5927519)
Rudzka, D. A., Clark, W., Hedley, A., Kalna, G. and Olson, M. F. (2017) Transcriptomic profiling of human breast and melanoma cells selected by migration through narrow constraints. Scientific Data, 4, 170172. (doi: 10.1038/sdata.2017.172) (PMID:29135975) (PMCID:PMC5685158)
Masre, S.F., Rath, N., Olson, M.F. and Greenhalgh, D.A. (2017) ROCK2/rasHa cooperation induce malignant conversion via p53 loss, elevated NF-κβ and tenascin C-associated rigidity but p21 inhibits ROCK2/NF-κβ-mediated progression. Oncogene, 36, pp. 2529-2542. (doi: 10.1038/onc.2016.402) (PMID:27991921)
Rath, N. et al. (2017) ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Molecular Medicine, 9(2), pp. 198-218. (doi: 10.15252/emmm.201606743) (PMID:28031255) (PMCID:PMC5286371)
Samuel, M. S., Rath, N., Masre, S. F., Boyle, S. T., Greenhalgh, D. A. , Kochetkova, M., Bryson, S., Stevenson, D. and Olson, M. F. (2016) Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein. Genesis, 54(12), pp. 636-646. (doi: 10.1002/dvg.22988) (PMID:27775859)
McGarry, D. J. and Olson, M. F. (2016) Coping with loss: cell adaptation to cytoskeleton disruption. Developmental Cell, 39(1), pp. 3-4. (doi: 10.1016/j.devcel.2016.09.020) (PMID:27728780)
McGarry, D. J., Shchepinova, M. M., Lillla, S., Hartley, R. C. and Olson, M. F. (2016) A cell-permeable biscyclooctyne as a novel probe for the identification of protein sulfenic acids. ACS Chemical Biology, 11(12), pp. 3300-3304. (doi: 10.1021/acschembio.6b00742) (PMID:27792307)
Rath, N., Kalna, G., Clark, W. and Olson, M. F. (2016) ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells. Scientific Data, 3, p. 160101. (doi: 10.1038/sdata.2016.101) (PMID:27824338) (PMCID:PMC5100681)
Rath, N. and Olson, M. (2016) Regulation of pancreatic cancer aggressiveness by stromal stiffening. Nature Medicine, 22(5), pp. 462-463. (doi: 10.1038/nm.4099) (PMID:27149218)
Mardilovich, K. et al. (2015) LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget, 6(36), pp. 38469-38486. (doi: 10.18632/oncotarget.6288) (PMID:26540348) (PMCID:PMC4770715)
Charles, M. D. et al. (2015) Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties. Journal of Medicinal Chemistry, 58(20), pp. 8309-8313. (doi: 10.1021/acs.jmedchem.5b01242) (PMID:26356364)
Julian, L. and Olson, M. F. (2015) Apoptotic membrane dynamics in health and disease. Cell Health and Cytoskeleton, 2015(7), pp. 133-142. (doi: 10.2147/CHC.S57893)
Giancotti, F. G., Haynes, C. M., Machesky, L. M. , Olson, M. F. and Overholtzer, M. (2015) Alan Hall 1952–2015. Nature Cell Biology, 17(7), pp. 839-840. (doi: 10.1038/ncb3190) (PMID:26005836)
Cameron, J. M., Gabrielsen, M. , Chim, Y. H., Munro, J., McGhee, E. J., Sumpton, D., Eaton, P., Anderson, K. I., Yin, H. and Olson, M. F. (2015) Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation. Current Biology, 25(11), pp. 1520-1525. (doi: 10.1016/j.cub.2015.04.020)
Mardilovich, K., Gabrielsen, M. , McGarry, L., Orange, C., Patel, R., Shanks, E., Edwards, J. and Olson, M. F. (2015) Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation. Molecular Cancer Therapeutics, 14(1), pp. 246-258. (doi: 10.1158/1535-7163.MCT-14-0447)
Rudzka, D. A., Cameron, J. M. and Olson, M. F. (2015) Reactive oxygen species and hydrogen peroxide generation in cell migration. Communicative and Integrative Biology, 8(5), e1074360. (doi: 10.1080/19420889.2015.1074360) (PMID:27066166) (PMCID:PMC4802769)
Rudzka, D. A. and Olson, M. F. (2015) Microtrack migration: insights into 3D cell motility: focus on 'comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks'. American Journal of Physiology: Cell Physiology, 308(6), C434-C435. (doi: 10.1152/ajpcell.00016.2015) (PMID:25608531)
Lourenco, F.C. et al. (2014) Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. Gut, 63(3), pp. 480-493. (doi: 10.1136/gutjnl-2012-303883)
Unbekandt, M. and Olson, M. F. (2014) The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer. Journal of Molecular Medicine, 92(3), pp. 217-225. (doi: 10.1007/s00109-014-1133-6)
Julian, L. and Olson, M. F. (2014) Rho-associated coiled-coil containing kinases (ROCK). Small GTPases, 5(2), e29846. (doi: 10.4161/sgtp.29846) (PMID:25010901) (PMCID:PMC4114931)
Prater, M. D. et al. (2014) Mammary stem cells have myoepithelial cell properties. Nature Cell Biology, 16(10), pp. 942-950. (doi: 10.1038/ncb3025) (PMID:25173976) (PMCID:PMC4183554)
Unbekandt, M. et al. (2014) A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Communication and Signaling, 12, 54. (doi: 10.1186/s12964-014-0054-x) (PMID:25288205) (PMCID:PMC4195943)
Ibbetson, S. J., Pyne, N. T., Pollard, A. N., Olson, M. F. and Samuel, M. S. (2013) Mechanotransduction pathways promoting tumor progression are activated in invasive human squamous cell carcinoma. American Journal of Pathology, 183(3), pp. 930-937. (doi: 10.1016/j.ajpath.2013.05.014) (PMID:23830873)
Klejnot, M., Gabrielsen, M. , Cameron, J., Mleczak, A., Talapatra, S.K., Kozielski, F., Pannifer, A. and Olson, M.F. (2013) Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding. Acta Crystallographica. Section D: Biological Crystallography, 69(9), pp. 1780-1788. (doi: 10.1107/S0907444913014418)
Masre, S.F., Olson, M.F. and Greenhalgh, D.A. (2013) Inducible ROCK 2 activation increases primary keratinocyte differentiation but co-operates with rasHa activation in transgenic mouse skin carcinogenesis. Journal of Investigative Dermatology, 133(S1), S57-S57. (doi: 10.1038/jid.2013.96)
Gabrielsen, M. , Schuldt, M., Munro, J., Borucka, D., Cameron, J., Baugh, M., Mleczak, A., Lilla, S., Morrice, N. and Olson, M.F. (2013) Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target. Cell Communication and Signaling, 11(58), (doi: 10.1186/1478-811X-11-58)
Mleczak, A., Millar, S., Tooze, S.A., Olson, M.F. and Chan, E.Y.W. (2013) Regulation of autophagosome formation by Rho kinase. Cellular Signalling, 25(1), pp. 1-11. (doi: 10.1016/j.cellsig.2012.09.010)
Olson, M.F. (2013) Finding the shape-shifter genes. Nature Cell Biology, 15, pp. 723-725. (doi: 10.1038/ncb2792)
Wickman, G.R. et al. (2013) Blebs produced by actin–myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs. Cell Death and Differentiation, 20, pp. 1293-1305. (doi: 10.1038/cdd.2013.69)
Rath, N. and Olson, M.F. (2012) Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy. EMBO Reports, 13(10), pp. 900-908. (doi: 10.1038/embor.2012.127)
Jamieson, T. et al. (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. Journal of Clinical Investigation, 122(9), pp. 3127-3144. (doi: 10.1172/JCI61067)
Mardilovich, K., Olson, M.F. and Baugh, M. (2012) Targeting Rho GTPase signaling for cancer therapy. Future Oncology, 8(2), pp. 165-177. (doi: 10.2217/fon.11.143)
Boomkamp, S.D., Riehle, M.O. , Wood, J., Olson, M.F. and Barnett, S.C. (2012) The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination. Glia, 60(3), pp. 441-456. (doi: 10.1002/glia.22278)
Mezna, M., Wong, A.C., Ainger, M., Scott, R.W., Hammonds, T. and Olson, M.F. (2012) Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption. Journal of Biomolecular Screening, 17(4), pp. 460-468. (doi: 10.1177/1087057111430529)
Wickman, G., Julian, L. and Olson, M.F. (2012) How apoptotic cells aid in the removal of their own cold dead bodies. Cell Death and Differentiation, 19(5), pp. 735-742. (doi: 10.1038/cdd.2012.25)
Wood, J.M. and Olson, M.F. (2012) Collective migration: spatial tension relief. Current Biology, 22(4), R125-R127. (doi: 10.1016/j.cub.2012.01.026)
Scott, R. W., Crighton, D. and Olson, M. F. (2011) Modeling and imaging 3-dimensional collective cell invasion. Journal of Visualized Experiments(58), e3525. (doi: 10.3791/3525) (PMID:22157886) (PMCID:PMC3346048)
Samuel, M.S. and Olson, M.F. (2011) Actomyosin contractililty: force power drives tumor growth. Cell Cycle, 10(20), pp. 3409-3410. (doi: 10.4161/cc.10.20.17722)
Heikkila, T. et al. (2011) Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. PLoS ONE, 6(9), e24825. (doi: 10.1371/journal.pone.0024825)
Croft, D. R. and Olson, M. F. (2011) Transcriptional regulation of Rho GTPase signaling. Transcription, 2(5), pp. 211-215. (doi: 10.4161/trns.2.5.16904) (PMID:22231116) (PMCID:PMC3265777)
Croft, D.R. et al. (2011) p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Research, 21(4), pp. 666-682. (doi: 10.1038/cr.2010.154)
Crighton, D. and Olson, M. F. (2011) Trailblazing LIM kinases take the lead in collective tumor cell invasion. BioArchitecture, 1(1), pp. 5-8. (doi: 10.4161/bioa.1.1.14628) (PMID:21866254) (PMCID:PMC3158634)
Morin, P., Wickman, G., Munro, J., Inman, G.J. and Olson, M.F. (2011) Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion. European Journal of Cell Biology, 90(1), pp. 13-25. (doi: 10.1016/j.ejcb.2010.09.009) (PMID:21074289)
Samuel, M.S. et al. (2011) Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth. Cancer Cell, 19(6), pp. 776-791. (doi: 10.1016/j.ccr.2011.05.008)
Samuel, M.S., Lourenço, F.C. and Olson, M.F. (2011) K-Ras mediated murine epidermal tumorigenesis Is dependent upon and associated with elevated Rac1 activity. PLoS ONE, 6(2), e17143. (doi: 10.1371/journal.pone.0017143)
Sleebs, B.E., Levit, A., Street, I.P., Falk, H., Hammonds, T., Wong, A.C., Charles, M.D., Olson, M.F. and Baell, J.B. (2011) Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors. MedChemComm, 2(10), p. 977. (doi: 10.1039/C1MD00137J)
Timpson, P. et al. (2011) Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53. Cancer Research, 71(3), pp. 747-757. (doi: 10.1158/0008-5472.CAN-10-2267)
Lochhead, P., Wickman, G., Mezna, M. and Olson, M. (2010) Activating ROCK1 somatic mutations in human cancer. Oncogene, 29(17), pp. 2591-2598. (doi: 10.1038/onc.2010.3)
Olson, M.F. (2010) Follow the leader: LIM kinases pave the way for collective tumor cell invasion. Cell Cycle, 9(22), pp. 4417-4418. (doi: 10.4161/cc.9.22.14049)
Samuel, M.S. and Olson, M.F. (2010) Dying Alone: A Tale of Rho. Cell Stem Cell, 7(2), pp. 135-136. (doi: 10.1016/j.stem.2010.07.002)
Scott, R.W. et al. (2010) LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. Journal of Cell Biology, 191(1), pp. 169-185. (doi: 10.1083/jcb.201002041)
Brady, S. C., Coleman, M. L., Munro, J., Feller, S. M., Morrice, N. A. and Olson, M. F. (2009) Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation. Cancer Research, 69(17), pp. 6773-6781. (doi: 10.1158/0008-5472.CAN-08-4447)
Densham, R., O'Neill, E., Munro, J., Konig, I., Anderson, K., Kolch, W. and Olson, M. (2009) MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability. Molecular and Cellular Biology, 29(24), pp. 6380-6390. (doi: 10.1128/MCB.00116-09)
Morin, P., Flors, C. and Olson, M.F. (2009) Constitutively active RhoA inhibits proliferation by retarding G1 to S phase cell cycle progression and impairing cytokinesis. European Journal of Cell Biology, 88(9), pp. 495-507. (doi: 10.1016/j.ejcb.2009.04.005)
Olson, M.F. and Sahai, E. (2009) The actin cytoskeleton in cancer cell motility. Clinical and Experimental Metastasis, 26(4), pp. 273-287. (doi: 10.1007/s10585-008-9174-2)
Samuel, M.S., Munro, J., Bryson, S., Forrow, S., Stevenson, D. and Olson, M.F. (2009) Tissue selective expression of conditionally-regulated ROCK by gene targeting to a defined locus. Genesis, 47(7), pp. 440-446. (doi: 10.1002/dvg.20519)
Croft, D. and Olson, M. (2008) Regulating the Conversion between Rounded and Elongated Modes of Cancer Cell Movement. Cancer Cell, 14(5), pp. 349-351. (doi: 10.1016/j.ccr.2008.10.009)
Merdek, K., Jaffe, A., Dutt, P., Olson, M. , Hall, A., Fanburg, B., Kayyali, U. and Toksov, D. (2008) α(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent. Biochemical and Biophysical Research Communications, 366(3), pp. 717-723. (doi: 10.1016/j.bbrc.2007.12.012)
Olson, M.F. (2008) Applications for ROCK kinase inhibition. Current Opinion in Cell Biology, 20(2), pp. 242-248. (doi: 10.1016/j.ceb.2008.01.002)
Olson, M. F. (2007) Rock2. AFCS-Nature Molecule Pages, (doi: 10.1038/mp.a002089.01)
Chalmers, S., Olson, M. , MacMillan, D., Rainbow, R.D. and McCarron, J. (2007) Ion channels in smooth muscle: Regulation by the sarcoplasmic reticulum and mitochondria. Cell Calcium, 42(04-May), pp. 447-466. (doi: 10.1016/j.ceca.2007.05.010)
Mccarron, J., Olson, M. , Rainbow, R.D., MacMillan, D., and Chalmers, S., (2007) Ins(1,4,5)P-3 receptor regulation during 'quantal' Ca2+ release in smooth muscle. Trends in Pharmacological Sciences, 28(6), pp. 271-279. (doi: 10.1016/j.tips.2007.04.007)
Olson, M. (2007) Mechanisms of tumour cell invasion and metastasis. Journal of Molecular Medicine, 85(6), pp. 543-544. (doi: 10.1007/s00109-007-0189-y)
Scott, R. and Olson, M. (2007) LIM kinases: function, regulation and association with human disease. Journal of Molecular Medicine, 85(6), pp. 555-568. (doi: 10.1007/s00109-007-0165-6)
Olson, M. F. (2006) Rock1. AFCS-Nature Molecule Pages, (doi: 10.1038/mp.a002088.01)
Coleman, M., Densham, R., Croft, D. and Olson, M. (2006) Stability of p21(Waf1)/(Cip1) CDK inhibitor protein is responsive to RhoA- mediated regulation of the actin cytoskeleton. Oncogene, 25(19), pp. 2708-2716. (doi: 10.1038/sj.onc.1209322)
Croft, D. and Olson, M. (2006) Conditional regulation of a ROCK-estrogen receptor fusion protein. Methods in Enzymology, 406, pp. 541-553. (doi: 10.1016/S0076-6879(06)06042-3)
Croft, D. and Olson, M. (2006) The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27(Kip1) levels by distinct mechanisms. Molecular and Cellular Biology, 26(12), pp. 4612-4627. (doi: 10.1128/MCB.02061-05)
Sahai, E. and Olson, M. (2006) Purification of TAT-C3 exoenzyme. Methods in Enzymology, 406, pp. 128-140. (doi: 10.1016/S0076-6879(06)06011-3)
Spence, H., McGarry, L., Chew, C., Carragher, N., Scott-Carragher, L., Yuan, Z., Croft, D., Olson, M. , Frame, M. and Ozanne, B. (2006) AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins. Molecular and Cellular Biology, 26(4), pp. 1480-1495. (doi: 10.1128/MCB.26.4.1480-1495.2006)
Olson, M. F. (2005) Modeling human cancer: report on the Eighth Beatson International Cancer Conference. Cancer Research, 65(24), pp. 11247-11250. (doi: 10.1158/0008-5472.CAN-05-2713) (PMID:16357126)
Walker, K. and Olson, M. (2005) Targeting Ras and Rho GTPases as opportunities for cancer therapeutics. Current Opinion in Genetics and Development, 15(1), pp. 62-68. (doi: 10.1016/j.gde.2004.11.001) (PMID:15661535)
Croft, D., Coleman, M., Li, S., Robertson, D., Sullivan, T., Stewart, C. and Olson, M. (2005) Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration. Journal of Cell Biology, 168(2), pp. 245-255. (doi: 10.1083/jcb.200409049)
Coleman, M., Marshall, C. and Olson, M. (2004) RAS and RHO GTPases in G1-phase cell-cycle regulation. Nature Reviews Molecular Cell Biology, 5(5), pp. 355-366. (doi: 10.1038/nrm1365)
Croft, D., Sahai, E., Mavria, G., Li, S., Tsai, J., Lee, W., Marshall, C. and Olson, M. (2004) Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Research, 64(24), pp. 8994-9001. (doi: 10.1158/0008-5472.CAN-04-2052)
Olson, M. (2004) Contraction reaction: mechanical regulation of Rho GTPase. Trends in Cell Biology, 14(3), pp. 111-114. (doi: 10.1016/j.tcb.2004.01.005)
Olson, M. (2004) Rac transformation - The actin connection. Cancer Biology and Therapy, 3(1), pp. 71-72. (doi: 10.4161/cbt.3.1.683) (PMID:14726705)
Tsavachidou, D., Coleman, M., Athanasiadis, G., Li, S., Licht, J., Olson, M. and Weber, B. (2004) SPRY2 is an inhibitor of the Ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant. Cancer Research, 64(16), pp. 5556-5559. (doi: 10.1158/0008-5472.CAN-04-1669)
Coleman, M., Marshall, C. and Olson, M. (2003) Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO Journal, 22(9), pp. 2036-2046. (doi: 10.1093/emboj/cdg189)
McMullan, R., Lax, S., Robertson, V., Radford, D., Broad, S., Watt, F., Rowles, A., Croft, D., Olson, M. and Hotchin, N. (2003) Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Current Biology, 13(24), pp. 2185-2189. (doi: 10.1016/j.cub.2003.11.050)
Morelli, A., Chiozzi, P., Chiesa, A., Ferrari, D., Sanz, J., Falzoni, S., Pinton, P., Rizzuto, R., Olson, M. and Di Virgilio, F. (2003) Extracellular ATP causes ROCK I-dependent bleb formation in P2X(7)-transfected HEK293 cells. Molecular Biology of the Cell, 14(7), pp. 2655-2664. (doi: 10.1091/mbc.02-04-0061)
Olson, M. (2003) GTPase signalling: New functions for diaphanous- related formins. Current Biology, 13(9), R360-R362. (doi: 10.1016/S0960-9822(03)00277-X)
Olson, M. F. (2002) Gem GTPase: between a ROCK and a hard place. Current Biology, 12(14), R496-R498. (doi: 10.1016/S0960-9822(02)00968-5) (PMID:12176351)
Coleman, M. and Olson, M. (2002) Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death and Differentiation, 9(5), pp. 493-504. (doi: 10.1038/sj.cdd.4400987)
Coleman, M., Sahai, E., Yeo, M., Bosch, M., Dewar, A. and Olson, M. (2001) Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nature Cell Biology, 3(4), pp. 339-345. (doi: 10.1038/35070009)
Sahai, E., Olson, M. and Marshall, C. (2001) Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO Journal, 20(4), pp. 755-766. (doi: 10.1093/emboj/20.4.755)
Tong, X.-K. et al. (2000) The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain. EMBO Journal, 19(6), pp. 1263-1271. (doi: 10.1093/emboj/19.6.1263) (PMID:10716926) (PMCID:PMC305667)
Olson, M. F. and Marais, R. (2000) Ras protein signalling. Seminars in Immunology, 12(1), pp. 63-73. (doi: 10.1006/smim.2000.0208) (PMID:10723799)
D'Abaco, G. M. and Olson, M. F. (2000) Mouse embryo fibroblasts: a genetic model system for studying Rho- and Ras-dependent cell cycle progression. Methods in Enzymology, 325, pp. 415-425. (doi: 10.1016/S0076-6879(00)25462-1) (PMID:11036623)
Marshall, C. J., Olson, M. F. and Paterson, H. F. (1998) Signals from Ras and Rho GTPases interact to regulate expresson of p21Waf1/Cip1. Nature, 394(6690), pp. 295-299. (doi: 10.1038/28425) (PMID:9685162)
Marais, R., Light, Y., Mason, C., Paterson, H., Olson, M. F. and Marshall, C. J. (1998) Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science, 280(5360), pp. 109-112. (doi: 10.1126/science.280.5360.109) (PMID:9525855)
Olson, M. F. , Sterpetti, P., Nagata, K.-i., Toksoz, D. and Hall, A. (1997) Distinct roles for DH and PH domains in the Lbc oncogene. Oncogene, 15(23), pp. 2827-2831. (doi: 10.1038/sj.onc.1201594) (PMID:9419973)
Mittnacht, S., Paterson, H., Olson, M. F. and Marshall, C. J. (1997) Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein. Current Biology, 7(3), pp. 219-221. (doi: 10.1016/S0960-9822(97)70094-0) (PMID:9395436)
Olson, M. F. , Pasteris, N. G., Gorski, J. L. and Hall, A. (1996) Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Current Biology, 6(12), pp. 1628-1633. (doi: 10.1016/S0960-9822(02)70786-0) (PMID:8994827)
Olson, M.F. (1996) Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease? Journal of Molecular Medicine, 74(10), pp. 563-571. (doi: 10.1007/s001090050060) (PMID:8912177)
Olson, M. F. , Ashworth, A. and Hall, A. (1995) An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science, 269(5228), pp. 1270-1272. (doi: 10.1126/science.7652575) (PMID:7652575)
Zheng, Y., Olson, M. F. , Hall, A., Cerione, R. A. and Toksoz, D. (1995) Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. Journal of Biological Chemistry, 270(16), pp. 9031-9034. (doi: 10.1074/jbc.270.16.9031) (PMID:7721814)
Aspenström, P. and Olson, M. F. (1995) Yeast two-hybrid system to detect protein-protein interactions with rho GTPases. Methods in Enzymology, 256, pp. 228-241. (doi: 10.1016/0076-6879(95)56027-0) (PMID:7476436)
Olson, M.F. and Schimmer, B.P. (1994) Receptor-G-protein coupling in desensitization-resistant mutant adrenal cells. Endocrinology, 134(1), pp. 7-10. (doi: 10.1210/en.134.1.7) (PMID:7903937)
Olson, M.F. , Krolczyk, A.J., Gorman, K.B., Steinberg, R.A. and Schimmer, B.P. (1993) Molecular basis for the 3',5'-cyclic adenosine monophosphate resistance of Kin mutant Y1 adrenocortical tumor cells. Molecular Endocrinology, 7(4), pp. 477-487. (doi: 10.1210/me.7.4.477) (PMID:8388994)
Olson, M.F. and Schimmer, B.P. (1992) Heterologous desensitization of the human dopamine D1 receptor in Y1 adrenal cells and in a desensitization-resistant Y1 mutant. Molecular Endocrinology, 6(7), pp. 1095-1102. (doi: 10.1210/me.6.7.1095) (PMID:1354841)
Olson, M. F. , Tsao, J., Pon, D. J. and Schimmer, B. P. (1991) Regulation of adenylyl cyclase activity by β-adrenergic agonists in a desensitization-resistant mutant cell line. Molecular Endocrinology, 5(1), pp. 34-41. (doi: 10.1210/mend-5-1-34) (PMID:1850109)
Olson, M. F. , Tsao, J., Pon, D. J. and Schimmer, B. P. (1991) Agonist-induced desensitization of adenylyl cyclase in Y1 adrenocortical tumor cells. Endocrine Research, 17(1-2), pp. 19-42. (doi: 10.1080/07435809109027187) (PMID:1679008)
Book Sections
Wickman, G., Samuel, M.S., Lochhead, P.A. and Olson, M.F. (2010) The Rho-Regulated ROCK Kinases in Cancer. In: van Golen, K. (ed.) The Rho GTPases in Cancer. Part 3. Springer, pp. 163-192. ISBN 9781441911117
Graham, K. and Olson, M. F. (2007) The Ras signalling pathway as a target in cancer therapy. In: Groner, B. (ed.) Targeted Interference with Signal Transduction Events. Series: Recent results in cancer research (172). Springer: Berlin ; New York, pp. 125-153. ISBN 9783540312086 (doi: 10.1007/978-3-540-31209-3_8)
Conference or Workshop Item
Masre, S. F., Linkov, N., Olson, M. F. and Greenhalgh, D. A. (2018) Accelerated differentiation and p21/p53 responses to ROCK-mediated p-AKT/p-GSK3β/β-catenin overexpression prevent papillomas in transgenic mice. BSID Annual Meeting 2018, London, UK, 26-28 Mar 2018.