Dr Manikhandan Mudaliar
- Honorary Research Fellow (School of Infection & Immunity)
email:
Manikhandan.Mudaliar@glasgow.ac.uk
CEREVANCE, LTD., 418 Cambridge Science Park, Cambridge, CB4 0PZ
Publications
2020
Daly, R. et al. (2020) Changes in plasma itaconate elevation in early rheumatoid arthritis patients elucidates disease activity associated macrophage activation. Metabolites, 10(6), 241. (doi: 10.3390/metabo10060241) (PMID:32531990) (PMCID:PMC7344783)
2018
Page, M. M., Schuster, E. F., Mudaliar, M. , Herzyk, P. , Withers, D. J. and Selman, C. (2018) Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice. Aging, 10(5), pp. 1027-1052. (doi: 10.18632/aging.101446) (PMID:29779018) (PMCID:PMC5990393)
2017
Rodie, M.E., Mudaliar, M.A.V. , Herzyk, P. , McMillan, M., Boroujerdi, M., Chudleigh, S., Tobias, E.S. and Ahmed, S.F. (2017) Androgen-responsive non-coding small RNAs extend the potential of HCG stimulation to act as a bioassay of androgen sufficiency. European Journal of Endocrinology, 177(4), pp. 339-346. (doi: 10.1530/EJE-17-0404) (PMID:28733293)
Mwenechanya, R. et al. (2017) Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana. PLoS Neglected Tropical Diseases, 11(6), e0005649. (doi: 10.1371/journal.pntd.0005649) (PMID:28622334) (PMCID:PMC5498063)
Mudaliar, M. , Thomas, F. C. and Eckersall, P. D. (2017) Omic approaches to a better understanding of mastitis in dairy cows. In: Ametaj, B. N. (ed.) Periparturient Diseases of Dairy Cows: a Systems Biology Approach. Springer: Cham, pp. 139-183. ISBN 9783319430317 (doi: 10.1007/978-3-319-43033-1_8)
2016
Mudaliar, M. et al. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics. Molecular BioSystems, 12(9), pp. 2748-2761. (doi: 10.1039/C6MB00290K) (PMID:27412694) (PMCID:PMC5048399)
Thomas, F., Mudaliar, M. , Tassi, R., Mcneilly, T., Burchmore, R. , Burgess, K., Herzyk, P. , Zadoks, R. and Eckersall, P. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 3. Untargeted metabolomics. Molecular BioSystems, 12(9), pp. 2762-2769. (doi: 10.1039/C6MB00289G) (PMID:27412568)
Thomas, F., Mullen, W. , Tassi, R., Ramírez-Torres, A., Mudaliar, M. , Mcneilly, T., Zadoks, R. , Burchmore, R. and Eckersall, P. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 1. High abundance proteins, acute phase proteins and peptidomics. Molecular BioSystems, 12(9), pp. 2735-2747. (doi: 10.1039/C6MB00239K) (PMID:27412456) (PMCID:PMC5048397)
2015
Lindner, M. et al. (2015) Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9. Brain, 138(7), pp. 1875-1893. (doi: 10.1093/brain/awv102) (PMID:25907862) (PMCID:PMC7185739)
Mudaliar, M. , Thomas, F., McLaughlin, M. , Burchmore, R. , Wilson, D., Herzyk, P. , Eckersall, P. and Zadoks, R. (2015) Using label-free quantitative proteomics and untargeted metabolomics to study bovine mastitis. In: Science with Impact – BSAS Annual Conference 2015, University of Chester, UK, 14-15 Apr 2015, p. 70. (doi: 10.1017/S2040470015000023)
2014
Mudaliar, M. , Thomas, F., McLaughlin, M. , Burchmore, R. , Herzyk, P. , Eckersall, P. and Zadoks, R. (2014) Integrative label-free quantitative proteomics study in mastitis. In: Final Showcase Meeting of Farm Animal Proteomics, Milan, Italy, 17-18 Nov 2014, pp. 98-101. ISBN 9789086868100 (doi: 10.3920/978-90-8686-810-0)
Atrih, A., Mudaliar, M. A. V. , Zakikhani, P., Lamont, D. J., Huang, J. T.-J., Bray, S. E., Barton, G., Fleming, S. and Nabi, G. (2014) Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling. British Journal of Cancer, 110(6), pp. 1622-1633. (doi: 10.1038/bjc.2014.24)
Speakman, C. M., Domke, T. C.E., Wongpaiboonwattana, W., Sanders, K., Mudaliar, M. , van Aalten, D. M.F., Barton, G. J. and Stavridis, M. P. (2014) Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naïve to primed cell transition. Stem Cells, 32(10), pp. 2605-2615. (doi: 10.1002/stem.1761)
2013
MacKenzie, K.F. et al. (2013) PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. Journal of Immunology, 190(2), pp. 565-577. (doi: 10.4049/jimmunol.1202462)
Hupp, T. et al. (2013) Comparative transcriptional analysis of canine and human diffuse large B cell lymphoma (DLBCL). Molecular signatures of NF-κB activation and sub-classification of DLBCL. In: 1st Meeting of the European Canine Lymphoma Group, Lugano, Switzerland,, 22 Jun 2013,
Mudaliar, M. et al. (2013) Comparative gene expression profiling identifies common molecular signatures of NF-κB activation in canine and human diffuse large B cell lymphoma (DLBCL). PLoS ONE, 8(9), e72591. (doi: 10.1371/journal.pone.0072591) (PMID:24023754) (PMCID:PMC3762807)
2012
Lee, C.M., Mudaliar, M.A.V. , Haggart, D.R., Wolf, C.R., Miele, G., Vass, J.K., Higham, D.J. and Crowther, D. (2012) Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology. PLoS ONE, 7(12), e48238. (doi: 10.1371/journal.pone.0048238) (PMID:23272042) (PMCID:PMC3522745)
2011
Vass, J.K., Higham, D.J., Mudaliar, M.A.V. , Mao, X. and Crowther, D.J. (2011) Discretization provides a conceptually simple tool to build expression networks. PLoS ONE, 6(4), e18634. (doi: 0.1371/journal.pone.0018634)
2009
Pundir, R.K., Kathiravan, P., Singh, P.K. and Mudaliar, M. (2009) Bargur cattle: status, characteristics and performance. Indian Journal of Animal Sciences, 79(7), pp. 681-685.
Articles
Daly, R. et al. (2020) Changes in plasma itaconate elevation in early rheumatoid arthritis patients elucidates disease activity associated macrophage activation. Metabolites, 10(6), 241. (doi: 10.3390/metabo10060241) (PMID:32531990) (PMCID:PMC7344783)
Page, M. M., Schuster, E. F., Mudaliar, M. , Herzyk, P. , Withers, D. J. and Selman, C. (2018) Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice. Aging, 10(5), pp. 1027-1052. (doi: 10.18632/aging.101446) (PMID:29779018) (PMCID:PMC5990393)
Rodie, M.E., Mudaliar, M.A.V. , Herzyk, P. , McMillan, M., Boroujerdi, M., Chudleigh, S., Tobias, E.S. and Ahmed, S.F. (2017) Androgen-responsive non-coding small RNAs extend the potential of HCG stimulation to act as a bioassay of androgen sufficiency. European Journal of Endocrinology, 177(4), pp. 339-346. (doi: 10.1530/EJE-17-0404) (PMID:28733293)
Mwenechanya, R. et al. (2017) Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana. PLoS Neglected Tropical Diseases, 11(6), e0005649. (doi: 10.1371/journal.pntd.0005649) (PMID:28622334) (PMCID:PMC5498063)
Mudaliar, M. et al. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics. Molecular BioSystems, 12(9), pp. 2748-2761. (doi: 10.1039/C6MB00290K) (PMID:27412694) (PMCID:PMC5048399)
Thomas, F., Mudaliar, M. , Tassi, R., Mcneilly, T., Burchmore, R. , Burgess, K., Herzyk, P. , Zadoks, R. and Eckersall, P. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 3. Untargeted metabolomics. Molecular BioSystems, 12(9), pp. 2762-2769. (doi: 10.1039/C6MB00289G) (PMID:27412568)
Thomas, F., Mullen, W. , Tassi, R., Ramírez-Torres, A., Mudaliar, M. , Mcneilly, T., Zadoks, R. , Burchmore, R. and Eckersall, P. (2016) Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 1. High abundance proteins, acute phase proteins and peptidomics. Molecular BioSystems, 12(9), pp. 2735-2747. (doi: 10.1039/C6MB00239K) (PMID:27412456) (PMCID:PMC5048397)
Lindner, M. et al. (2015) Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9. Brain, 138(7), pp. 1875-1893. (doi: 10.1093/brain/awv102) (PMID:25907862) (PMCID:PMC7185739)
Atrih, A., Mudaliar, M. A. V. , Zakikhani, P., Lamont, D. J., Huang, J. T.-J., Bray, S. E., Barton, G., Fleming, S. and Nabi, G. (2014) Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling. British Journal of Cancer, 110(6), pp. 1622-1633. (doi: 10.1038/bjc.2014.24)
Speakman, C. M., Domke, T. C.E., Wongpaiboonwattana, W., Sanders, K., Mudaliar, M. , van Aalten, D. M.F., Barton, G. J. and Stavridis, M. P. (2014) Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naïve to primed cell transition. Stem Cells, 32(10), pp. 2605-2615. (doi: 10.1002/stem.1761)
MacKenzie, K.F. et al. (2013) PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. Journal of Immunology, 190(2), pp. 565-577. (doi: 10.4049/jimmunol.1202462)
Mudaliar, M. et al. (2013) Comparative gene expression profiling identifies common molecular signatures of NF-κB activation in canine and human diffuse large B cell lymphoma (DLBCL). PLoS ONE, 8(9), e72591. (doi: 10.1371/journal.pone.0072591) (PMID:24023754) (PMCID:PMC3762807)
Lee, C.M., Mudaliar, M.A.V. , Haggart, D.R., Wolf, C.R., Miele, G., Vass, J.K., Higham, D.J. and Crowther, D. (2012) Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology. PLoS ONE, 7(12), e48238. (doi: 10.1371/journal.pone.0048238) (PMID:23272042) (PMCID:PMC3522745)
Vass, J.K., Higham, D.J., Mudaliar, M.A.V. , Mao, X. and Crowther, D.J. (2011) Discretization provides a conceptually simple tool to build expression networks. PLoS ONE, 6(4), e18634. (doi: 0.1371/journal.pone.0018634)
Pundir, R.K., Kathiravan, P., Singh, P.K. and Mudaliar, M. (2009) Bargur cattle: status, characteristics and performance. Indian Journal of Animal Sciences, 79(7), pp. 681-685.
Book Sections
Mudaliar, M. , Thomas, F. C. and Eckersall, P. D. (2017) Omic approaches to a better understanding of mastitis in dairy cows. In: Ametaj, B. N. (ed.) Periparturient Diseases of Dairy Cows: a Systems Biology Approach. Springer: Cham, pp. 139-183. ISBN 9783319430317 (doi: 10.1007/978-3-319-43033-1_8)
Conference Proceedings
Mudaliar, M. , Thomas, F., McLaughlin, M. , Burchmore, R. , Wilson, D., Herzyk, P. , Eckersall, P. and Zadoks, R. (2015) Using label-free quantitative proteomics and untargeted metabolomics to study bovine mastitis. In: Science with Impact – BSAS Annual Conference 2015, University of Chester, UK, 14-15 Apr 2015, p. 70. (doi: 10.1017/S2040470015000023)
Mudaliar, M. , Thomas, F., McLaughlin, M. , Burchmore, R. , Herzyk, P. , Eckersall, P. and Zadoks, R. (2014) Integrative label-free quantitative proteomics study in mastitis. In: Final Showcase Meeting of Farm Animal Proteomics, Milan, Italy, 17-18 Nov 2014, pp. 98-101. ISBN 9789086868100 (doi: 10.3920/978-90-8686-810-0)
Hupp, T. et al. (2013) Comparative transcriptional analysis of canine and human diffuse large B cell lymphoma (DLBCL). Molecular signatures of NF-κB activation and sub-classification of DLBCL. In: 1st Meeting of the European Canine Lymphoma Group, Lugano, Switzerland,, 22 Jun 2013,