Centre for Neuroscience

The Centre for Neuroscience (CN) acts as a bridge from basic neuroscience to both clinical neuroscience and experimental psychology. The centre focuses on topical translational themes: Spinal cord and brainstem circuits that underlie pain, motor control and breathing; psychiatric and neuro-developmental conditions such as schizophrenia, stress and Rett syndrome; molecular mechanisms of synaptic transmission and plasticity; circadian rhythms; visual perception; cyclic nucleotide signal transduction; neural circuit basis of information processing, learning, and decision-making.

History: The CN was formed in 2010, together with the INP, to provide a focus for preclinical and translational neuroscience, and hence to exploit the evolving opportunities for translational and inter-disciplinary research within INP.

Principal investigators: Hachisuka, Hughes, Maxwell, Riddell, Todd, Weir (Spinal Cord Group), Craig, KohlMorris, Sampaio.

Application of cutting-edge approaches:  Anatomical (e.g. immunocytochemistry, tract-tracing, confocal/electron microscopy), electrophysiological (in vivo and in vitro recording, patch-clamp, optogenetics), molecular biological (molecular genetics, functional genomics), behavioural (cognition, learning, decision-making, pain, respiration, stress), and imaging (multi-photon and mini-scope in vivo).

Grant highlights: (Since 2008): £9.6 M have been obtained in competitive funding (Wellcome, BBSRC, MRC, Pfizer, Scottish enterprise), including two recent project grants (BBSRC, MRC) and part of a Wellcome Strategic Award on spinal pain pathways to Todd (overall £5.8M).

Publication highlights: (2008-2013): The Centre has published more than 220 papers, cited 3300 times including leading Journals (Nat Rev Drug Discov article, Nature, Nat Rev Neurosci).

Sample Publications: