Dr Suzannah Rihn

  • Research Fellow (Centre for Virus Research)

Research interests

My research investigates the robustness of viruses, with a focus on HIV-1. In addition to trying to identify novel immune challenges that HIV-1 may face, we examine how the virus navigates between divergent needs to both conserve fitness and function but to also overcome diverse and fluctuating immune and environmental pressures  

 

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Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Host and Viral Determinants of Interferon Resistance During HIV-1 Transmission
    Medical Research Council
    2018 - 2020
     
  • The role of ISGs in HIV-1 transmision
    Medical Research Council
    2018 - 2020
     
  • Inhibition of HIV-1 by Type II Interferon
    Wellcome Trust
    2017 - 2021
     

Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 14.

2019

Rihn, S. J. et al. (2019) TRIM69 inhibits Vesicular Stomatitis Indiana Virus (VSIV). Journal of Virology, (Accepted for Publication)

2018

Feng, J. et al. (2018) Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20. Journal of Virology, 92(13), e02140-17. (doi:10.1128/JVI.02140-17) (PMID:29695422) (PMCID:PMC6002717)

2017

Rihn, S. J. , Foster, T. L., Busnadiego, I., Aziz, M. A., Hughes, J. , Neil, S. J.D. and Wilson, S. J. (2017) The envelope gene of transmitted HIV-1 resists a late interferon gamma-induced block. Journal of Virology, 91(7), e02254-16. (doi:10.1128/JVI.02254-16) (PMID:28100611) (PMCID:PMC5355616)

2016

Kane, M., Zang, T. M., Rihn, S. J. , Zhang, F., Kueck, T., Alim, M., Schoggins, J., Rice, C. M., Wilson, S. J. and Bieniasz, P. D. (2016) Identification of interferon-stimulated genes with antiretroviral activity. Cell Host and Microbe, 20(3), pp. 392-405. (doi:10.1016/j.chom.2016.08.005) (PMID:27631702) (PMCID:PMC5026698)

2015

Rihn, S. J. , Hughes, J. , Wilson, S. J. and Bieniasz, P. D. (2015) Uneven genetic robustness of HIV-1 integrase. Journal of Virology, 89(1), pp. 552-567. (doi:10.1128/JVI.02451-14)

2014

Busnadiego, I. et al. (2014) Host and viral determinants of Mx2 antiretroviral activity. Journal of Virology, 88(14), pp. 7738-7752. (doi:10.1128/JVI.00214-14) (PMID:24760893) (PMCID:PMC4097781)

2013

Rihn, S.J. , Wilson, S.J. , Loman, N.J., Alim, M., Bakker, S.E., Bhella, D. , Gifford, R.J., Rixon, F.J. and Bieniasz, P.D. (2013) Extreme genetic fragility of the HIV-1 capsid. PLoS Pathogens, 9(6), e1003461. (doi:10.1371/journal.ppat.1003461) (PMID:23818857) (PMCID:PMC3688543)

2012

Meredith, M.M. et al. (2012) Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. Journal of Experimental Medicine, 209(9), pp. 1583-1593. (doi:10.1084/jem.20121003) (PMID:22851594) (PMCID:PMC3428942))

2011

Alter, G., Jost, S., Rihn, S. , Reyor, L. L., Nolan, B. E., Ghebremichael, M., Bosch, R., Altfeld, M. and Lauer, G. M. (2011) Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance. Journal of Hepatology, 55(2), pp. 278-288. (doi:10.1016/j.jhep.2010.11.030) (PMID:21168454) (PMCID:PMC3729214)

2010

Nolting, A. et al. (2010) MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction. Virology, 406(1), pp. 12-20. (doi:10.1016/j.virol.2010.05.014) (PMID:20667578) (PMCID:MC2932841)

Alter, G., Kavanagh, D., Rihn, S. , Luteijn, R., Brooks, D., Oldstone, M., van Lunzen, J. and Altfeld, M. (2010) IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. Journal of Clinical Investigation, 120(6), pp. 1905-1913. (doi:10.1172/JCI40913) (PMID:20440075) (PMCID:PMC2877944)

2009

Liu, Q., Sun, Y., Rihn, S. , Nolting, A., Tsoukas, P.N., Jost, S., Cohen, K., Walker, B. and Alter, G. (2009) Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection. Journal of Virology, 83(17), pp. 8705-8712. (doi:10.1128/JVI.02666-08) (PMID:19553339) (PMCID:PMC2738177)

Alter, G., Rihn, S. , Walter, K., Nolting, A., Martin, M., Rosenberg, E. S., Miller, J. S., Carrington, M. and Altfeld, M. (2009) HLA Class I Subtype-Dependent Expansion of KIR3DS1+ and KIR3DL1+ NK Cells during Acute Human Immunodeficiency Virus Type 1 Infection. Journal of Virology, 83(13), pp. 6798-6805. (doi:10.1128/JVI.00256-09) (PMID:19386717) (PMCID:PMC2698561)

2008

Alter, G. et al. (2008) Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T Cells in human immunodeficiency virus Type 1 infection. Journal of Virology, 82(19), pp. 9668-9677. (doi:10.1128/JVI.00341-08) (PMID:18579582) (PMCID:PMC2546972)

This list was generated on Tue Sep 17 16:25:08 2019 BST.
Jump to: Articles
Number of items: 14.

Articles

Rihn, S. J. et al. (2019) TRIM69 inhibits Vesicular Stomatitis Indiana Virus (VSIV). Journal of Virology, (Accepted for Publication)

Feng, J. et al. (2018) Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20. Journal of Virology, 92(13), e02140-17. (doi:10.1128/JVI.02140-17) (PMID:29695422) (PMCID:PMC6002717)

Rihn, S. J. , Foster, T. L., Busnadiego, I., Aziz, M. A., Hughes, J. , Neil, S. J.D. and Wilson, S. J. (2017) The envelope gene of transmitted HIV-1 resists a late interferon gamma-induced block. Journal of Virology, 91(7), e02254-16. (doi:10.1128/JVI.02254-16) (PMID:28100611) (PMCID:PMC5355616)

Kane, M., Zang, T. M., Rihn, S. J. , Zhang, F., Kueck, T., Alim, M., Schoggins, J., Rice, C. M., Wilson, S. J. and Bieniasz, P. D. (2016) Identification of interferon-stimulated genes with antiretroviral activity. Cell Host and Microbe, 20(3), pp. 392-405. (doi:10.1016/j.chom.2016.08.005) (PMID:27631702) (PMCID:PMC5026698)

Rihn, S. J. , Hughes, J. , Wilson, S. J. and Bieniasz, P. D. (2015) Uneven genetic robustness of HIV-1 integrase. Journal of Virology, 89(1), pp. 552-567. (doi:10.1128/JVI.02451-14)

Busnadiego, I. et al. (2014) Host and viral determinants of Mx2 antiretroviral activity. Journal of Virology, 88(14), pp. 7738-7752. (doi:10.1128/JVI.00214-14) (PMID:24760893) (PMCID:PMC4097781)

Rihn, S.J. , Wilson, S.J. , Loman, N.J., Alim, M., Bakker, S.E., Bhella, D. , Gifford, R.J., Rixon, F.J. and Bieniasz, P.D. (2013) Extreme genetic fragility of the HIV-1 capsid. PLoS Pathogens, 9(6), e1003461. (doi:10.1371/journal.ppat.1003461) (PMID:23818857) (PMCID:PMC3688543)

Meredith, M.M. et al. (2012) Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. Journal of Experimental Medicine, 209(9), pp. 1583-1593. (doi:10.1084/jem.20121003) (PMID:22851594) (PMCID:PMC3428942))

Alter, G., Jost, S., Rihn, S. , Reyor, L. L., Nolan, B. E., Ghebremichael, M., Bosch, R., Altfeld, M. and Lauer, G. M. (2011) Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance. Journal of Hepatology, 55(2), pp. 278-288. (doi:10.1016/j.jhep.2010.11.030) (PMID:21168454) (PMCID:PMC3729214)

Nolting, A. et al. (2010) MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction. Virology, 406(1), pp. 12-20. (doi:10.1016/j.virol.2010.05.014) (PMID:20667578) (PMCID:MC2932841)

Alter, G., Kavanagh, D., Rihn, S. , Luteijn, R., Brooks, D., Oldstone, M., van Lunzen, J. and Altfeld, M. (2010) IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. Journal of Clinical Investigation, 120(6), pp. 1905-1913. (doi:10.1172/JCI40913) (PMID:20440075) (PMCID:PMC2877944)

Liu, Q., Sun, Y., Rihn, S. , Nolting, A., Tsoukas, P.N., Jost, S., Cohen, K., Walker, B. and Alter, G. (2009) Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection. Journal of Virology, 83(17), pp. 8705-8712. (doi:10.1128/JVI.02666-08) (PMID:19553339) (PMCID:PMC2738177)

Alter, G., Rihn, S. , Walter, K., Nolting, A., Martin, M., Rosenberg, E. S., Miller, J. S., Carrington, M. and Altfeld, M. (2009) HLA Class I Subtype-Dependent Expansion of KIR3DS1+ and KIR3DL1+ NK Cells during Acute Human Immunodeficiency Virus Type 1 Infection. Journal of Virology, 83(13), pp. 6798-6805. (doi:10.1128/JVI.00256-09) (PMID:19386717) (PMCID:PMC2698561)

Alter, G. et al. (2008) Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T Cells in human immunodeficiency virus Type 1 infection. Journal of Virology, 82(19), pp. 9668-9677. (doi:10.1128/JVI.00341-08) (PMID:18579582) (PMCID:PMC2546972)

This list was generated on Tue Sep 17 16:25:08 2019 BST.


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