Dr Miguel Pineda

ARUK Research Fellow (Immunology)

telephone: 7187
email: Miguel.Pineda@glasgow.ac.uk

RB Level B612, Iii - Gbrc, University Place, Glasgow G12 8TA

ORCID iD https://orcid.org/0000-0001-5678-7752

Research interests

Why does chronic inflammation persist in the arthritic joint?

In health, synovial fibroblasts provide structural and nutritional support within the joint, but increasingly are recognized to serve as critical regulators of the inflammatory microenvironment in disease. Thus, despite fibroblasts are non-immune cells of stromal origin, they play a critical role in the perpetuation of inflammatory rheumatoid arthritis (RA).

Why do synovial fibroblasts adopt an inflammatory phenotype in RA? Functional glycomics, an exciting, emerging discipline focused on defining the structures and functional roles of glycans in biological systems, can offer new answers to this old question because glycans and complementary glycan-binding proteins are essential components in the language of cell-cell interactions in immunity.

My aim is to understand how the biological information contained in surface glycans controls the inflammatory response of synovial fibroblasts in RA. Ultimately, understanding changes in cell glycosylation in disease should provide further insight into the mechanisms underlying fibroblast-dependent inflammation and may confer novel stratified therapeutic approaches by virtue of discrete glycomic signatures.

Publications

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Number of items: 24.

2021

Wang, Y. et al. (2021) Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis. Nature Communications, 12, 2343. (doi: 10.1038/s41467-021-22365-z) (PMID:33879788)

Lupo, F., Ingersoll, M. A. and Pineda, M. (2021) The glycobiology of uropathogenic E. coli infection: the sweet and bitter role of sugars in urinary tract immunity. Immunology, (doi: 10.1111/imm.13330) (Early Online Publication)

2020

Crowe, J. et al. (2020) The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing. PLoS Pathogens, 16(3), e1008391. (doi: 10.1371/journal.ppat.1008391) (PMID:32163524) (PMCID:PMC7108737)

2019

Doonan, J., Tarafdar, A., Pineda, M. A. , Lumb, F. E., Crowe, J., Khan, A. M., Hoskisson, P. A., Harnett, M. M. and Harnett, W. (2019) The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis. Nature Communications, 10, 1554. (doi: 10.1038/s41467-019-09361-0) (PMID:30952846) (PMCID:PMC6451002)

2018

Li, K. et al. (2018) Apigenin C-glycosides of Microcos paniculata protects lipopolysaccharide induced apoptosis and inflammation in acute lung injury through TLR4 signaling pathway. Free Radical Biology and Medicine, 124, pp. 163-175. (doi: 10.1016/j.freeradbiomed.2018.06.009) (PMID:29890216)

Doonan, J., Lumb, F. E., Pineda, M. A. , Tarafdar, A., Crowe, J., Khan, A. M., Suckling, C. J., Harnett, M. M. and Harnett, W. (2018) Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis. Frontiers in Immunology, 9, 1016. (doi: 10.3389/fimmu.2018.01016) (PMID:29867986) (PMCID:PMC5967578)

2017

Lumb, F. E., Doonan, J., Bell, K. S., Pineda, M. A. , Corbet, M., Suckling, C. J., Harnett, M. M. and Harnett, W. (2017) Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62. Scientific Reports, 7(1), 1704. (doi: 10.1038/s41598-017-01651-1) (PMID:28490801) (PMCID:PMC5431997)

Harnett, M. M. , Pineda, M. A. , Latré de Laté, P., Eason, R. J., Besteiro, S., Harnett, W. and Langsley, G. (2017) From Christian de Duve to Yoshinori Ohsumi: more to autophagy than just dining at home. Biomedical Journal, 40(1), pp. 9-22. (doi: 10.1016/j.bj.2016.12.004) (PMID:28411887)

Laté de Laté, P., Pineda, M. , Harnett, M. , Harnett, W., Besteiro, S. and Langsley, G. (2017) Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells. Biomedical Journal, 40(1), pp. 23-30. (doi: 10.1016/j.bj.2017.01.001) (PMID:28411879)

2016

Eason, R. J., Bell, K. S., Marshall, F. A., Rodgers, D. T., Pineda, M. , Steiger, C. N., Al-Riyami, L., Harnett, W. and Harnett, M. M. (2016) The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosmal degradation of TLR-transducers, as exemplified by PKCδ. Scientific Reports, 6, 37276. (doi: 10.1038/srep37276) (PMID:27869138) (PMCID:PMC5116678)

2015

Al-Riyami, L., Rodgers, D. T., Rzepecka, J., Pineda, M. A. , Suckling, C. J., Harnett, M. M. and Harnett, W. (2015) Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation. Experimental Parasitology, 158, pp. 18-22. (doi: 10.1016/j.exppara.2015.03.025) (PMID:25836375) (PMCID:PMC4659540)

Rodgers, D. T., Pineda, M. A. , Suckling, C. J., Harnett, W. and Harnett, M. M. (2015) Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus. Lupus, 24(13), pp. 1437-1442. (doi: 10.1177/0961203315591031) (PMID:26085597) (PMCID:PMC4616909)

Pineda, M. A. , Cuervo, H., Fresno, M., Soto, M. and Bonay, P. (2015) Lack of galectin-3 prevents cardiac fibrosis and effective immune responses in a murine model of Trypanosoma cruzi infection. Journal of Infectious Diseases, 212(7), pp. 1160-1171. (doi: 10.1093/infdis/jiv185) (PMID:25805753)

Rzepecka, J. et al. (2015) Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome. Journal of Autoimmunity, 60, pp. 59-73. (doi: 10.1016/j.jaut.2015.04.005) (PMID:25975491) (PMCID:PMC4459730)

Pineda, M.A. , Eason, R.J., Harnett, M.M. and Harnett, W. (2015) From the worm to the pill, the parasitic worm product ES-62 raises new horizons in the treatment of rheumatoid arthritis. Lupus, 24(4-5), pp. 400-411. (doi: 10.1177/0961203314560004) (PMID:25801883)

Rodgers, D. T., McGrath, M. A., Pineda, M. A. , Al-Riyami, L., Rzepecka, J., Lumb, F., Harnett, W. and Harnett, M. M. (2015) The parasitic worm product, ES-62 targets MyD88-dependent effector mechanisms to suppress ANA production and proteinuria in MRL/Lpr mice. Arthritis and Rheumatology, 67(4), pp. 1023-1035. (doi: 10.1002/art.39004) (PMID:25546822) (PMCID:PMC4409857)

Pineda, M.A. , Corvo, L., Soto, M., Fresno, M. and Bonay, P. (2015) Interactions of human galectins with Trypanosoma cruzi: vinding profile correlate with genetic clustering of lineages. Glycobiology, 25(2), pp. 197-210. (doi: 10.1093/glycob/cwu103) (PMID:25267603)

2014

Pineda, M. A. , Al-Riyami, L., Harnett, W. and Harnett, M. M. (2014) Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis. Clinical and Experimental Immunology, 177(1), pp. 13-23. (doi: 10.1111/cei.12252) (PMID:24666108) (PMCID:PMC4089150)

Pineda, M. A. , Rodgers, D. T., Al-Riyami, L., Harnett, W. and Harnett, M. M. (2014) ES-62 protects against collagen-induced arthritis by resetting IL-22 towards resolution of inflammation in the joints. Arthritis and Rheumatology, 66(6), pp. 1492-1503. (doi: 10.1002/art.38392) (PMID:24497523)

Pineda, M. A. , Lumb, F., Harnett, M. M. and Harnett, W. (2014) ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae. Molecular and Biochemical Parasitology, 194(1-2), pp. 1-8. (doi: 10.1016/j.molbiopara.2014.03.003)

Rodgers, D.T., Pineda, M.A. , McGrath, M.A., Al-Riyami, L., Harnett, W. and Harnett, M.M. (2014) Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints. Immunology, 141(3), pp. 457-466. (doi: 10.1111/imm.12208) (PMID:24708419) (PMCID:PMC3930382)

Harnett, M. , Harnett, W. and Pineda, M. A. (2014) The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of Collagen-Induced Arthritis. Inflammation and Cell Signaling, 1(5), e308. (doi: 10.14800/ics.308)

2013

Al-Riyami, L., Pineda, M.A. , Rzepecka, J., Huggan, J.K., Khalaf, A.I., Suckling, C.J., Scott, F.J., Rodgers, D.T., Harnett, M.M. and Harnett, W. (2013) Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the acanthocheilonema viteae product es-62 prevents development of collagen-induced arthritis. Journal of Medicinal Chemistry, 56(24), pp. 9982-10002. (doi: 10.1021/jm401251p)

2012

Pineda, M.A. , McGrath, M.A., Smith, P.C., Al-Riyami, L., Rzepecka, J., Gracie, J.A., Harnett, W. and Harnett, M.M. (2012) The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites. Arthritis and Rheumatism, 64(10), pp. 3168-3178. (doi: 10.1002/art.34581) (PMID:22729944)

This list was generated on Sun May 16 05:48:29 2021 BST.

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