Dr Miguel Pineda
- ARUK Research Fellow (Immunology)
Why does chronic inflammation persist in the arthritic joint?
In health, synovial fibroblasts provide structural and nutritional support within the joint, but increasingly are recognized to serve as critical regulators of the inflammatory microenvironment in disease. Thus, despite fibroblasts are non-immune cells of stromal origin, they play a critical role in the perpetuation of inflammatory rheumatoid arthritis (RA).
Why do synovial fibroblasts adopt an inflammatory phenotype in RA? Functional glycomics, an exciting, emerging discipline focused on defining the structures and functional roles of glycans in biological systems, can offer new answers to this old question because glycans and complementary glycan-binding proteins are essential components in the language of cell-cell interactions in immunity.
My aim is to understand how the biological information contained in surface glycans controls the inflammatory response of synovial fibroblasts in RA. Ultimately, understanding changes in cell glycosylation in disease should provide further insight into the mechanisms underlying fibroblast-dependent inflammation and may confer novel stratified therapeutic approaches by virtue of discrete glycomic signatures.
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Developing three-dimensional microenvironments for synovial fibroblasts culture
The Carnegie Trust for the Universities of Scotland
2018 - 2019
- Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients
Cancer Research UK
2018 - 2018
- Harnessing glycan-dependent pathways in synovial fibroblasts to control chronic joint inflammation?
Arthritis Research UK
2016 - 2021