Dr Margus Varjak

  • Research Associate (Centre for Virus Research)

Research interests

CVR logo 

Member of the Kohl Group.


Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2010
Number of items: 18.

2018

Donald, C. L. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B. , Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. Viruses, 10(12), 694. (doi:10.3390/v10120694) (PMID:30563205) (PMCID:PMC6316411)

Varjak, M. , Leggewie, M. and Schnettler, E. (2018) The antiviral piRNA response in mosquitoes? Journal of General Virology, 99(12), pp. 1551-1562. (doi:10.1099/jgv.0.001157) (PMID:30372405)

Mutso, M. et al. (2018) Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus. Viruses, 10(5), 226. (doi:10.3390/v10050226) (PMID:29702546)

Varjak, M. , Dietrich, I., Sreenu, V. B. , Till, B. E., Merits, A., Kohl, A. and Schnettler, E. (2018) Spindle-E acts antivirally against alphaviruses in mosquito cells. Viruses, 10(2), 88. (doi:10.3390/v10020088) (PMID:29463033) (PMCID:PMC5850395)

Lourenço-de-Oliveira, R., Marques, J. T., Sreenu, V. B. , Nten, C. A., Guimarães Rocha Aguiarr, E. R., Varjak, M. , Kohl, A. and Failloux, A.-B. (2018) Culex quinquefasciatus mosquitoes do not support replication of Zika virus. Journal of General Virology, 99, pp. 258-264. (doi:10.1099/jgv.0.000949) (PMID:29076805) (PMCID:PMC5882084)

2017

Royle, J., Donald, C. L. , Merits, A., Kohl, A. and Varjak, M. (2017) Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. Veterinary Journal, 230, pp. 62-64. (doi:10.1016/j.tvjl.2017.10.009) (PMID:29102599) (PMCID:PMC5726355)

Varjak, M. , Donald, C. L. , Mottram, T. J., Sreenu, V. B. , Merits, A., Maringer, K., Schnettler, E. and Kohl, A. (2017) Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11(10), e0006010. (doi:10.1371/journal.pntd.0006010) (PMID:29040304) (PMCID:PMC5667879)

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi:10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

Mottram, T. J., Li, P. , Dietrich, I., Shi, X. , Brennan, B. , Varjak, M. and Kohl, A. (2017) Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids. PLoS Neglected Tropical Diseases, 11(12), e0006155. (doi:10.1371/journal.pntd.0006155) (PMID:29267287) (PMCID:PMC5764413)

2016

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi:10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Karlas, A. et al. (2016) A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nature Communications, 7, p. 11320. (PMID:27177310) (PMCID:PMC4865845)

Rainey, S. M. et al. (2016) Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways. PLoS Pathogens, 12(4), e1005536. (doi:10.1371/journal.ppat.1005536) (PMID:27089431) (PMCID:PMC4835223)

2015

Utt, A., Das, P. K., Varjak, M. , Lulla, V., Lulla, A. and Merits, A. (2015) Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2. Journal of Virology, 89(6), pp. 3145-62. (PMID:25552719) (PMCID:PMC4337533)

2013

Varjak, M. , Saul, S., Arike, L., Lulla, A., Peil, L. and Merits, A. (2013) Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus. Journal of Virology, 87(18), pp. 10295-10312. (doi:10.1128/JVI.01105-13) (PMID:23864636) (PMCID:PMC3754020)

2012

Panas, M. D., Varjak, M. , Lulla, A., Eng, K. E., Merits, A., Karlsson Hedestam, G. B. and McInerney, G. M. (2012) Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection. Molecular Biology of the Cell, 23(24), pp. 4701-4712. (doi:10.1091/mbc.E12-08-0619) (PMID:23087212) (PMCID:PMC3521679)

Rodriguez-Andres, J. et al. (2012) Phenoloxidase activity acts as a mosquito innate immune response against infection with semliki forest virus. PLoS Pathogens, 8(11), e1002977. (doi:10.1371/journal.ppat.1002977) (PMID:23144608) (PMCID:PMC3493465)

2011

Pohjala, L., Utt, A., Varjak, M. , Lulla, A., Merits, A., Ahola, T. and Tammela, P. (2011) Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays. PLoS ONE, 6(12), e28923. (doi:10.1371/journal.pone.0028923) (PMID:22205980) (PMCID:PMC3242765)

2010

Varjak, M. , Zusinaite, E. and Merits, A. (2010) Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region. Journal of Virology, 84(5), pp. 2352-2364. (doi:10.1128/JVI.01540-09) (PMID:20015978) (PMCID:PMC2820926)

This list was generated on Tue Oct 22 12:37:51 2019 BST.
Jump to: Articles
Number of items: 18.

Articles

Donald, C. L. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B. , Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. Viruses, 10(12), 694. (doi:10.3390/v10120694) (PMID:30563205) (PMCID:PMC6316411)

Varjak, M. , Leggewie, M. and Schnettler, E. (2018) The antiviral piRNA response in mosquitoes? Journal of General Virology, 99(12), pp. 1551-1562. (doi:10.1099/jgv.0.001157) (PMID:30372405)

Mutso, M. et al. (2018) Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus. Viruses, 10(5), 226. (doi:10.3390/v10050226) (PMID:29702546)

Varjak, M. , Dietrich, I., Sreenu, V. B. , Till, B. E., Merits, A., Kohl, A. and Schnettler, E. (2018) Spindle-E acts antivirally against alphaviruses in mosquito cells. Viruses, 10(2), 88. (doi:10.3390/v10020088) (PMID:29463033) (PMCID:PMC5850395)

Lourenço-de-Oliveira, R., Marques, J. T., Sreenu, V. B. , Nten, C. A., Guimarães Rocha Aguiarr, E. R., Varjak, M. , Kohl, A. and Failloux, A.-B. (2018) Culex quinquefasciatus mosquitoes do not support replication of Zika virus. Journal of General Virology, 99, pp. 258-264. (doi:10.1099/jgv.0.000949) (PMID:29076805) (PMCID:PMC5882084)

Royle, J., Donald, C. L. , Merits, A., Kohl, A. and Varjak, M. (2017) Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. Veterinary Journal, 230, pp. 62-64. (doi:10.1016/j.tvjl.2017.10.009) (PMID:29102599) (PMCID:PMC5726355)

Varjak, M. , Donald, C. L. , Mottram, T. J., Sreenu, V. B. , Merits, A., Maringer, K., Schnettler, E. and Kohl, A. (2017) Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11(10), e0006010. (doi:10.1371/journal.pntd.0006010) (PMID:29040304) (PMCID:PMC5667879)

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi:10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

Mottram, T. J., Li, P. , Dietrich, I., Shi, X. , Brennan, B. , Varjak, M. and Kohl, A. (2017) Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids. PLoS Neglected Tropical Diseases, 11(12), e0006155. (doi:10.1371/journal.pntd.0006155) (PMID:29267287) (PMCID:PMC5764413)

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi:10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Karlas, A. et al. (2016) A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nature Communications, 7, p. 11320. (PMID:27177310) (PMCID:PMC4865845)

Rainey, S. M. et al. (2016) Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways. PLoS Pathogens, 12(4), e1005536. (doi:10.1371/journal.ppat.1005536) (PMID:27089431) (PMCID:PMC4835223)

Utt, A., Das, P. K., Varjak, M. , Lulla, V., Lulla, A. and Merits, A. (2015) Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2. Journal of Virology, 89(6), pp. 3145-62. (PMID:25552719) (PMCID:PMC4337533)

Varjak, M. , Saul, S., Arike, L., Lulla, A., Peil, L. and Merits, A. (2013) Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus. Journal of Virology, 87(18), pp. 10295-10312. (doi:10.1128/JVI.01105-13) (PMID:23864636) (PMCID:PMC3754020)

Panas, M. D., Varjak, M. , Lulla, A., Eng, K. E., Merits, A., Karlsson Hedestam, G. B. and McInerney, G. M. (2012) Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection. Molecular Biology of the Cell, 23(24), pp. 4701-4712. (doi:10.1091/mbc.E12-08-0619) (PMID:23087212) (PMCID:PMC3521679)

Rodriguez-Andres, J. et al. (2012) Phenoloxidase activity acts as a mosquito innate immune response against infection with semliki forest virus. PLoS Pathogens, 8(11), e1002977. (doi:10.1371/journal.ppat.1002977) (PMID:23144608) (PMCID:PMC3493465)

Pohjala, L., Utt, A., Varjak, M. , Lulla, A., Merits, A., Ahola, T. and Tammela, P. (2011) Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays. PLoS ONE, 6(12), e28923. (doi:10.1371/journal.pone.0028923) (PMID:22205980) (PMCID:PMC3242765)

Varjak, M. , Zusinaite, E. and Merits, A. (2010) Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region. Journal of Virology, 84(5), pp. 2352-2364. (doi:10.1128/JVI.01540-09) (PMID:20015978) (PMCID:PMC2820926)

This list was generated on Tue Oct 22 12:37:51 2019 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • MAPP
    European Commission
    2015 - 2017
     

Research datasets

Jump to: 2018
Number of items: 1.

2018

Donald, C. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B., Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. [Data Collection]

This list was generated on Tue Oct 22 08:43:24 2019 BST.