Mr John Cole

  • Research Scientist (Immunology)

telephone: 0141 330 6267
email: John.Cole@glasgow.ac.uk

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2017 | 2016 | 2015 | 2014 | 2010
Number of items: 27.

2021

Cole, J. J., Faydaci, B. A., Mcguinness, D. , Shaw, R., Maciewicz, R. A., Robertson, N. A. and Goodyear, C. S. (2021) Searchlight: automated bulk RNA-seq exploration and visualisation using dynamically generated R scripts. BMC Bioinformatics, 22(1), 411. (doi: 10.1186/s12859-021-04321-2)

Cole, J. J. et al. (2021) No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing. Translational Psychiatry, 11, 404. (doi: 10.1038/s41398-021-01506-4) (PMID:34294682) (PMCID:PMC8298604)

Ansalone, C., Cole, J., Chilaka, S., Sunzini, F., Sood, S., Robertson, J., Siebert, S. , McInnes, I. B. and Goodyear, C. (2021) TNF is a homeostatic regulator of distinct epigenetically primed human osteoclast precursors. Annals of the Rheumatic Diseases, 80(6), pp. 748-757. (doi: 10.1136/annrheumdis-2020-219262) (PMID:33692019) (PMCID:PMC8142443)

Kästele, V. et al. (2021) Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection. Mucosal Immunology, 14(3), pp. 717-727. (doi: 10.1038/s41385-020-00366-3) (PMID:33414524) (PMCID:PMC8075955)

Baer, H. M. et al. (2021) P83 Understanding Differences in Serum and Mucosal Immunopathotypes in Crohn’s Disease. BSG Campus, 21-29 Jan 2021. (doi:10.1136/gutjnl-2020-bsgcampus.158)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12(1), 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

2020

Li, S. et al. (2020) A Synthetic Lethal Approach to Eradicate AML via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors. 62nd ASH Annual Meeting and Exposition, 5-8 Dec 2020. (doi:10.1182/blood-2020-143079)

Li, S. et al. (2020) 3102 – A Synthetic Lethality Approach to Eradicate AML via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors. 49th Annual Scientific Meeting of the ISEH (International Society for Experimental Hematology), 19-21 Aug 2020. (doi:10.1016/j.exphem.2020.09.115)

Johnsson, H., Cole, J., Wilson, G., Pingen, M., Mcmonagle, F., Holmes, S., Mcinnes, I., Siebert, S. and Graham, G. (2020) SAT0351 Chemokine Pathways Are Enriched in Psoriatic Arthritis (Psa) Skin Lesions with Increased Expression of Atypical Chemokine Receptor 2 (ACKR2). EULAR 2021, 2-5 June 2020. (doi:10.1136/annrheumdis-2020-eular.2980)

Rodgers, L. C., Cole, J., Rattigan, K. M., Barrett, M. P. , Kurian, N., McInnes, I. B. and Goodyear, C. S. (2020) The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion. Rheumatology, 59(4), pp. 869-878. (doi: 10.1093/rheumatology/kez378) (PMID:31497857)

Baer, H.M. et al. (2020) P014 Identification of Crohn’s Disease Immunopathotypes. 15th Congress of ECCO, Vienna, Austria, 12–15 Feb 2020. (doi:10.1093/ecco-jcc/jjz203.143)

2019

Thümmler, K. et al. (2019) Polarizing receptor activation dissociates Fibroblast Growth Factor 2 mediated inhibition of myelination from its neuroprotective potential. Acta Neuropathologica Communications, 7, 212. (doi: 10.1186/s40478-019-0864-6) (PMID:31856924) (PMCID:PMC6923900)

Smith, E. L., Somma, D., Kerrigan, D., McIntyre, Z., Cole, J. J., Liang, K. L., Kiely, P. A., Keeshan, K. and Carmody, R. J. (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80. Nucleic Acids Research, 47(21), pp. 11151-11161. (doi: 10.1093/nar/gkz873) (PMID:31598684) (PMCID:PMC6868378)

Asghar, S., Litherland, G., Meek, D., Cole, J., Lockhart, J., Goodyear, C. S. and Crilly, A. (2019) Differential Effects of Exosomes Derived from Separate Osteoarthritis Synovial Compartments: Implications for Erosive Cartilage Disease. 2019 OARSI World Congress on Osteoarthritis, Toronto, Canada, 2-5 May 2019. (doi:10.1016/j.joca.2019.02.295)

Rodgers, L.C., Cole, J., Rattigan, K., Barrett, M.P., Kurian, N., McInnes, I.B. and Goodyear, C.S. (2019) P108/O28 Fatty Acid Oxidation Can Drive Human Monocyte Derived CCL20 in the RA Synovial Environment. 39th European Workshop for Rheumatology Research, Lyon, France, 28 Feb-2 March 2019. (doi:10.1136/annrheumdis-2018-EWRR2019.96)

2017

Rai, T. S., Glass, M., Cole, J. J., Rather, M., Marsden, M., Neilson, M., Brock, C., Humphreys, I. R., Everett, R. D. and Adams, P. D. (2017) Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Research, 45(20), pp. 11673-11683. (doi: 10.1093/nar/gkx771) (PMID:28981850) (PMCID:PMC5691367)

van Tuyn, J. et al. (2017) Oncogene-expressing senescent melanocytes upregulate MhC class II, a candidate melanoma suppressor function. Journal of Investigative Dermatology, 137(10), pp. 2197-2207. (doi: 10.1016/j.jid.2017.05.030) (PMID:28647344) (PMCID:PMC5613751)

Cole, J. J. et al. (2017) Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions. Genome Biology, 18, 58. (doi: 10.1186/s13059-017-1185-3) (PMID:28351383) (PMCID:PMC5370462)

2016

Nelson, D. M. et al. (2016) Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biology, 17, 158. (doi: 10.1186/s13059-016-1017-x) (PMID:27457071) (PMCID:PMC4960804)

Correia-Melo, C. et al. (2016) Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO Journal, 35, pp. 724-742. (doi: 10.15252/embj.201592862) (PMID:26848154) (PMCID:PMC4818766)

2015

Latif, A.-L., Cole, J. J., Monteiro Campos, J., Clark, W., McGarry, L., Brock, C., Newcombe, A., Keeshan, K. , Copland, M. and Adams, P. D. (2015) Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia. Blood, 126(23), p. 674. (doi: 10.1182/blood.V126.23.674.674)

MacKenzie, D. J., Robertson, N. A., Cole, J. and Adams, P. (2015) Su1996 oncogenic BRAFV600e downregulates DNMT3B and does not directly induce the CpG island hypermethylator phenotype in human colorectal adenocarcinoma. Gastroenterology, 148(4), S570. (doi: 10.1016/S0016-5085(15)31925-9)

Dikovskaya, D. et al. (2015) Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest. Cell Reports, 12(9), pp. 1483-1496. (doi: 10.1016/j.celrep.2015.07.055) (PMID:26299965) (PMCID:PMC4562906)

2014

Lund, K., Cole, J., VanderKraats, N. D., McBryan, T., Pchelintsev, N. A., Clark, W., Copland, M. , Edwards, J. R. and Adams, P. (2014) DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML. Genome Biology, 15(7), p. 406. (doi: 10.1186/s13059-014-0406-2)

Lund, K., Cole, J., McBryan, T., Copland, M. and Adams, P. (2014) Investigating effects of epigenetic modulation in acute myeloid leukaemia. Lancet, 383(Supl 1), S70. (doi: 10.1016/S0140-6736(14)60333-0) (PMID:19345831) (PMCID:PMC2866651)

Rai, T. S. et al. (2014) HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes and Development, 28(24), pp. 2712-2725. (doi: 10.1101/gad.247528.114) (PMID:25512559) (PMCID:PMC4265675)

2010

Wilson, R.H., Moran, C.N., Cole, J., Pitsiladis, Y.P. and Bailey, M.E.S. (2010) Evolutionary history of the ADRB2 gene in humans. American Journal of Human Genetics, 86(3), pp. 490-493. (doi: 10.1016/j.ajhg.2010.01.031) (PMID:20215008) (PMCID:PMC2833374)

This list was generated on Sat Oct 16 05:50:15 2021 BST.
Number of items: 27.

Articles

Cole, J. J., Faydaci, B. A., Mcguinness, D. , Shaw, R., Maciewicz, R. A., Robertson, N. A. and Goodyear, C. S. (2021) Searchlight: automated bulk RNA-seq exploration and visualisation using dynamically generated R scripts. BMC Bioinformatics, 22(1), 411. (doi: 10.1186/s12859-021-04321-2)

Cole, J. J. et al. (2021) No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing. Translational Psychiatry, 11, 404. (doi: 10.1038/s41398-021-01506-4) (PMID:34294682) (PMCID:PMC8298604)

Ansalone, C., Cole, J., Chilaka, S., Sunzini, F., Sood, S., Robertson, J., Siebert, S. , McInnes, I. B. and Goodyear, C. (2021) TNF is a homeostatic regulator of distinct epigenetically primed human osteoclast precursors. Annals of the Rheumatic Diseases, 80(6), pp. 748-757. (doi: 10.1136/annrheumdis-2020-219262) (PMID:33692019) (PMCID:PMC8142443)

Kästele, V. et al. (2021) Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection. Mucosal Immunology, 14(3), pp. 717-727. (doi: 10.1038/s41385-020-00366-3) (PMID:33414524) (PMCID:PMC8075955)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12(1), 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

Rodgers, L. C., Cole, J., Rattigan, K. M., Barrett, M. P. , Kurian, N., McInnes, I. B. and Goodyear, C. S. (2020) The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion. Rheumatology, 59(4), pp. 869-878. (doi: 10.1093/rheumatology/kez378) (PMID:31497857)

Thümmler, K. et al. (2019) Polarizing receptor activation dissociates Fibroblast Growth Factor 2 mediated inhibition of myelination from its neuroprotective potential. Acta Neuropathologica Communications, 7, 212. (doi: 10.1186/s40478-019-0864-6) (PMID:31856924) (PMCID:PMC6923900)

Smith, E. L., Somma, D., Kerrigan, D., McIntyre, Z., Cole, J. J., Liang, K. L., Kiely, P. A., Keeshan, K. and Carmody, R. J. (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80. Nucleic Acids Research, 47(21), pp. 11151-11161. (doi: 10.1093/nar/gkz873) (PMID:31598684) (PMCID:PMC6868378)

Rai, T. S., Glass, M., Cole, J. J., Rather, M., Marsden, M., Neilson, M., Brock, C., Humphreys, I. R., Everett, R. D. and Adams, P. D. (2017) Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Research, 45(20), pp. 11673-11683. (doi: 10.1093/nar/gkx771) (PMID:28981850) (PMCID:PMC5691367)

van Tuyn, J. et al. (2017) Oncogene-expressing senescent melanocytes upregulate MhC class II, a candidate melanoma suppressor function. Journal of Investigative Dermatology, 137(10), pp. 2197-2207. (doi: 10.1016/j.jid.2017.05.030) (PMID:28647344) (PMCID:PMC5613751)

Cole, J. J. et al. (2017) Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions. Genome Biology, 18, 58. (doi: 10.1186/s13059-017-1185-3) (PMID:28351383) (PMCID:PMC5370462)

Nelson, D. M. et al. (2016) Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biology, 17, 158. (doi: 10.1186/s13059-016-1017-x) (PMID:27457071) (PMCID:PMC4960804)

Correia-Melo, C. et al. (2016) Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO Journal, 35, pp. 724-742. (doi: 10.15252/embj.201592862) (PMID:26848154) (PMCID:PMC4818766)

Latif, A.-L., Cole, J. J., Monteiro Campos, J., Clark, W., McGarry, L., Brock, C., Newcombe, A., Keeshan, K. , Copland, M. and Adams, P. D. (2015) Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia. Blood, 126(23), p. 674. (doi: 10.1182/blood.V126.23.674.674)

MacKenzie, D. J., Robertson, N. A., Cole, J. and Adams, P. (2015) Su1996 oncogenic BRAFV600e downregulates DNMT3B and does not directly induce the CpG island hypermethylator phenotype in human colorectal adenocarcinoma. Gastroenterology, 148(4), S570. (doi: 10.1016/S0016-5085(15)31925-9)

Dikovskaya, D. et al. (2015) Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest. Cell Reports, 12(9), pp. 1483-1496. (doi: 10.1016/j.celrep.2015.07.055) (PMID:26299965) (PMCID:PMC4562906)

Lund, K., Cole, J., VanderKraats, N. D., McBryan, T., Pchelintsev, N. A., Clark, W., Copland, M. , Edwards, J. R. and Adams, P. (2014) DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML. Genome Biology, 15(7), p. 406. (doi: 10.1186/s13059-014-0406-2)

Lund, K., Cole, J., McBryan, T., Copland, M. and Adams, P. (2014) Investigating effects of epigenetic modulation in acute myeloid leukaemia. Lancet, 383(Supl 1), S70. (doi: 10.1016/S0140-6736(14)60333-0) (PMID:19345831) (PMCID:PMC2866651)

Rai, T. S. et al. (2014) HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes and Development, 28(24), pp. 2712-2725. (doi: 10.1101/gad.247528.114) (PMID:25512559) (PMCID:PMC4265675)

Wilson, R.H., Moran, C.N., Cole, J., Pitsiladis, Y.P. and Bailey, M.E.S. (2010) Evolutionary history of the ADRB2 gene in humans. American Journal of Human Genetics, 86(3), pp. 490-493. (doi: 10.1016/j.ajhg.2010.01.031) (PMID:20215008) (PMCID:PMC2833374)

Conference or Workshop Item

Baer, H. M. et al. (2021) P83 Understanding Differences in Serum and Mucosal Immunopathotypes in Crohn’s Disease. BSG Campus, 21-29 Jan 2021. (doi:10.1136/gutjnl-2020-bsgcampus.158)

Li, S. et al. (2020) A Synthetic Lethal Approach to Eradicate AML via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors. 62nd ASH Annual Meeting and Exposition, 5-8 Dec 2020. (doi:10.1182/blood-2020-143079)

Li, S. et al. (2020) 3102 – A Synthetic Lethality Approach to Eradicate AML via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors. 49th Annual Scientific Meeting of the ISEH (International Society for Experimental Hematology), 19-21 Aug 2020. (doi:10.1016/j.exphem.2020.09.115)

Johnsson, H., Cole, J., Wilson, G., Pingen, M., Mcmonagle, F., Holmes, S., Mcinnes, I., Siebert, S. and Graham, G. (2020) SAT0351 Chemokine Pathways Are Enriched in Psoriatic Arthritis (Psa) Skin Lesions with Increased Expression of Atypical Chemokine Receptor 2 (ACKR2). EULAR 2021, 2-5 June 2020. (doi:10.1136/annrheumdis-2020-eular.2980)

Baer, H.M. et al. (2020) P014 Identification of Crohn’s Disease Immunopathotypes. 15th Congress of ECCO, Vienna, Austria, 12–15 Feb 2020. (doi:10.1093/ecco-jcc/jjz203.143)

Asghar, S., Litherland, G., Meek, D., Cole, J., Lockhart, J., Goodyear, C. S. and Crilly, A. (2019) Differential Effects of Exosomes Derived from Separate Osteoarthritis Synovial Compartments: Implications for Erosive Cartilage Disease. 2019 OARSI World Congress on Osteoarthritis, Toronto, Canada, 2-5 May 2019. (doi:10.1016/j.joca.2019.02.295)

Rodgers, L.C., Cole, J., Rattigan, K., Barrett, M.P., Kurian, N., McInnes, I.B. and Goodyear, C.S. (2019) P108/O28 Fatty Acid Oxidation Can Drive Human Monocyte Derived CCL20 in the RA Synovial Environment. 39th European Workshop for Rheumatology Research, Lyon, France, 28 Feb-2 March 2019. (doi:10.1136/annrheumdis-2018-EWRR2019.96)

This list was generated on Sat Oct 16 05:50:15 2021 BST.