Professor Christopher Linington

  • Chair in Neuroimmunology (Immunology)
  • Associate - Life Sciences (School of Life Sciences)

telephone: 01413308143
email: Christopher.Linington@glasgow.ac.uk

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • the functional significance of fibroblast growth factor 9 in the pathogenesis of progressive multiple sclerosis
    Hertie Foundation
    2017 - 2017
     
  • Pro-inflammatory feedback loops in progressive multiple sclerosis: a role for the intrathecal antibody repertoire
    Multiple Sclerosis Society
    2016 - 2019
     
  • ZikaPLAN
    European Commission
    2016 - 2019
     
  • The role of the myelinic channel in axonal support
    Multiple Sclerosis Society
    2016 - 2019
     
  • Humboldt Research Award
    Alexander von Humboldt Foundation
    2014 - 2015
     
  • Molecular imaging of antibody-dependent effector mechanisms in multiple sclerosis
    Naomi Bramson Trust
    2014 - 2017
     
  • Development of a in vitro screening system to minimise animal use in the search for factors that modulate (re)myelination
    National Centre for the Replacement of Animals Research
    2013 - 2014
     
  • Modulation of HB-EGF signaling in the nervous system: a new strategy to stimulate tissue repair in multiple sclerosis
    The R S Macdonald Charitable Trust
    2013 - 2015
     
  • Specifity of demyeliminating autoantibodies in multiple sclerosis.
    Multiple Sclerosis Society
    2013 - 2016
     
  • Defining the clinical relevance of demyelinating and axopathic autoantibodies in multiple sclerosis.
    Action Medical Research
    2013 - 2014
     
  • Neurofascin specific autoantibodies and the pathogenesis of MS
    Multiple Sclerosis Society
    2010 - 2013
     
  • Diagnostic/prognostic of intra-thecal antibody responses
    The R S Macdonald Charitable Trust
    2010 - 2012
     
  • Axonal damage and inhibition of myelination in MS
    Hertie Foundation
    2010 - 2012
     
  • Autoimmunity to axonal and axo-glial proteins in the pathogenesis of axonal dysfunction and degeneration in MS
    Multiple Sclerosis Society
    2008 - 2009
     
  • Diet and autoimmunity: modulation of the myelin oligodendrocyte glycoprotein specific T cell repertoire by the milk protein butyrophilin
    Wellcome Trust
    2008 - 2011
     
  • The functional significance of autoimmune responses to transient axonal glycoprotein-1 in the pathogenesis of cortical lesions
    Multiple Sclerosis Society
    2008 - 2011
     

Publications

List by: Type | Date

Jump to: 2017 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 23.

2017

Lagumersindez-Denis, N. et al. (2017) Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathologica, 134(1), pp. 15-34. (doi:10.1007/s00401-017-1706-x) (PMID:28386765)

Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi:10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)

2015

Lindner, M. et al. (2015) Fibroblast growth factor signaling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9 environment by Fibroblast Growth Factor 9. Brain, 2015(138), pp. 1875-1893. (doi:10.1093/brain/awv102) (PMID:25907862)

Hansell, C. A., MacLellan, L. M., Oldham, R. S., Doonan, J., Chapple, K. J., Anderson, E. J., Linington, C., McInnes, I. B. , Nibbs, R. J. and Goodyear, C. S. (2015) The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens. Immunology and Cell Biology, 93(2), pp. 167-176. (doi:10.1038/icb.2014.90) (PMID:25348934) (PMCID:PMC4340511)

Flytzani, S., Guerreiro-Cacais, A. O., N’diaye, M., Lindner, M., Linington, C., Meinl, E., Stridh, P., Jagodic, M. and Olsson, T. (2015) MOG-induced experimental autoimmune encephalomyelitis in the rat species triggers anti-neurofascin antibody response that is genetically regulated. Journal of Neuroinflammation, 12, 194. (doi:10.1186/s12974-015-0417-2) (PMID:26511327) (PMCID:PMC4625640)

2014

Hochmeister, S., Pekar, T., Lindner, M., Kitic, M., Haindl, M., Storch, M., Fazekas, F. and Linington, C. (2014) Maternal neurofascin-specific autoantibodies bind to structures of the fetal nervous system during pregnancy, but have no long term effect on development in the rat. PLoS ONE, 9(1), e85393. (doi:10.1371/journal.pone.0085393) (PMID:24465550) (PMCID:PMC3896359)

Mohan, H. et al. (2014) Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathologica Communications, 2, 178. (doi:10.1186/s40478-014-0168-9) (PMID:25589163) (PMCID:PMC4359505)

2013

Davies, A.L. et al. (2013) Neurological deficits caused by tissue hypoxia in neuroinflammatory disease. Annals of Neurology, 74(6), pp. 815-825. (doi:10.1002/ana.24006)

Lindner, M., Ng, J.K.M., Hochmeister, S., Meinl, E. and Linington, C. (2013) Neurofascin 186 specific autoantibodies induce axonal injury and exacerbate disease severity in experimental autoimmune encephalomyelitis. Experimental Neurology, 247, pp. 259-266. (doi:10.1016/j.expneurol.2013.05.005)

Barnett, S.C. and Linington, C. (2013) Myelination: do astrocytes play a role? Neuroscientist, 19(5), pp. 442-450. (doi:10.1177/1073858412465655)

2012

Willison, H.J. and Linington, C. (2012) Antibodies to MOG in NMO: a seasoned veteran finds a new role. Neurology, 79(12), pp. 1198-1199. (doi:10.1212/WNL.0b013e31826aadaf)

Jiang, H.-R. et al. (2012) IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages. European Journal of Immunology, 42(7), pp. 1804-1814. (doi:10.1002/eji.201141947)

Elliott, C. et al. (2012) Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain, 135(6), pp. 1819-1833. (doi:10.1093/brain/aws105)

Zujovic, V., Doucerain, C., Hidalgo, A., Bachelin, C., Lachapelle, F., Weissert, R., Stadelmann, C., Linington, C. and Evercooren, A.B.-V. (2012) Exogenous schwann cells migrate, remyelinate and promote clinical recovery in experimental auto-immune encephalomyelitis. PLoS ONE, 7(9), e42667. (doi:10.1371/journal.pone.0042667) (PMID:22984406) (PMCID:PMC3439443)

2011

Nash, B., Thomson, C.E., Linington, C., Arthur, A.T., McClure, J.D., McBride, M.W. and Barnett, S.C. (2011) Functional duality of astrocytes in myelination. Journal of Neuroscience, 31(37), pp. 13028-13038. (doi:10.1523/JNEUROSCI.1449-11.2011)

Brennan, K.M. et al. (2011) Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. Journal of Neuroimmunology, 238(1-2), pp. 87-95. (doi:10.1016/j.jneuroim.2011.08.002)

2010

Derfuss, T., Linington, C., Hohlfeld, R. and Meinl, E. (2010) Axo-glial antigens as targets in multiple sclerosis: implications for axonal and grey matter injury. Journal of Molecular Medicine, 88(8), pp. 753-761. (doi:10.1007/s00109-010-0632-3)

Sinha, S., Subramanian, S., Emerson-Webber, A., Lindner, M., Burrows, G. G., Grafe, M., Linington, C., Vandenbark, A. A., Bernard, C. C. A. and Offner, H. (2010) Recombinant TCR Ligand Reverses Clinical Signs and CNS Damage of EAE Induced by Recombinant Human MOG. Journal of Neuroimmune Pharmacology, 5(2), pp. 231-239. (doi:10.1007/s11481-009-9175-1)

Weber, M.S. et al. (2010) B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity. Annals of Neurology, 68(3), pp. 369-383. (doi:10.1002/ana.22081)

2009

Derfuss, T. et al. (2009) Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proceedings of the National Academy of Sciences of the United States of America, 106(20), pp. 8302-8307. (doi:10.1073/pnas.0901496106)

2008

Breithaupt, C., Schäfer, B., Pellkofer, H., Huber, R., Linington, C. and Jacob, U. (2008) Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents. Journal of Immunology, 181(2), pp. 1255-1263.

Bourquin, C., van der Haar, M., Anz, D., Sandholzer, N., Neumaier, I., Endres, S., Skerra, A., Schwab, M. and Linington, C. (2008) DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis. European Journal of Pharmacology, 588(1), pp. 99-105. (doi:10.1016/j.ejphar.2008.04.026)

Huizinga, R., Linington, C. and Amor, S. (2008) Resistance is futile: antineuronal autoimmunity in multiple sclerosis. Trends in Immunology, 29(2), pp. 54-60. (doi:10.1016/j.it.2007.11.002)

This list was generated on Sat Jul 21 20:19:38 2018 BST.
Jump to: Articles
Number of items: 23.

Articles

Lagumersindez-Denis, N. et al. (2017) Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathologica, 134(1), pp. 15-34. (doi:10.1007/s00401-017-1706-x) (PMID:28386765)

Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi:10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)

Lindner, M. et al. (2015) Fibroblast growth factor signaling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9 environment by Fibroblast Growth Factor 9. Brain, 2015(138), pp. 1875-1893. (doi:10.1093/brain/awv102) (PMID:25907862)

Hansell, C. A., MacLellan, L. M., Oldham, R. S., Doonan, J., Chapple, K. J., Anderson, E. J., Linington, C., McInnes, I. B. , Nibbs, R. J. and Goodyear, C. S. (2015) The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens. Immunology and Cell Biology, 93(2), pp. 167-176. (doi:10.1038/icb.2014.90) (PMID:25348934) (PMCID:PMC4340511)

Flytzani, S., Guerreiro-Cacais, A. O., N’diaye, M., Lindner, M., Linington, C., Meinl, E., Stridh, P., Jagodic, M. and Olsson, T. (2015) MOG-induced experimental autoimmune encephalomyelitis in the rat species triggers anti-neurofascin antibody response that is genetically regulated. Journal of Neuroinflammation, 12, 194. (doi:10.1186/s12974-015-0417-2) (PMID:26511327) (PMCID:PMC4625640)

Hochmeister, S., Pekar, T., Lindner, M., Kitic, M., Haindl, M., Storch, M., Fazekas, F. and Linington, C. (2014) Maternal neurofascin-specific autoantibodies bind to structures of the fetal nervous system during pregnancy, but have no long term effect on development in the rat. PLoS ONE, 9(1), e85393. (doi:10.1371/journal.pone.0085393) (PMID:24465550) (PMCID:PMC3896359)

Mohan, H. et al. (2014) Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathologica Communications, 2, 178. (doi:10.1186/s40478-014-0168-9) (PMID:25589163) (PMCID:PMC4359505)

Davies, A.L. et al. (2013) Neurological deficits caused by tissue hypoxia in neuroinflammatory disease. Annals of Neurology, 74(6), pp. 815-825. (doi:10.1002/ana.24006)

Lindner, M., Ng, J.K.M., Hochmeister, S., Meinl, E. and Linington, C. (2013) Neurofascin 186 specific autoantibodies induce axonal injury and exacerbate disease severity in experimental autoimmune encephalomyelitis. Experimental Neurology, 247, pp. 259-266. (doi:10.1016/j.expneurol.2013.05.005)

Barnett, S.C. and Linington, C. (2013) Myelination: do astrocytes play a role? Neuroscientist, 19(5), pp. 442-450. (doi:10.1177/1073858412465655)

Willison, H.J. and Linington, C. (2012) Antibodies to MOG in NMO: a seasoned veteran finds a new role. Neurology, 79(12), pp. 1198-1199. (doi:10.1212/WNL.0b013e31826aadaf)

Jiang, H.-R. et al. (2012) IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages. European Journal of Immunology, 42(7), pp. 1804-1814. (doi:10.1002/eji.201141947)

Elliott, C. et al. (2012) Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain, 135(6), pp. 1819-1833. (doi:10.1093/brain/aws105)

Zujovic, V., Doucerain, C., Hidalgo, A., Bachelin, C., Lachapelle, F., Weissert, R., Stadelmann, C., Linington, C. and Evercooren, A.B.-V. (2012) Exogenous schwann cells migrate, remyelinate and promote clinical recovery in experimental auto-immune encephalomyelitis. PLoS ONE, 7(9), e42667. (doi:10.1371/journal.pone.0042667) (PMID:22984406) (PMCID:PMC3439443)

Nash, B., Thomson, C.E., Linington, C., Arthur, A.T., McClure, J.D., McBride, M.W. and Barnett, S.C. (2011) Functional duality of astrocytes in myelination. Journal of Neuroscience, 31(37), pp. 13028-13038. (doi:10.1523/JNEUROSCI.1449-11.2011)

Brennan, K.M. et al. (2011) Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. Journal of Neuroimmunology, 238(1-2), pp. 87-95. (doi:10.1016/j.jneuroim.2011.08.002)

Derfuss, T., Linington, C., Hohlfeld, R. and Meinl, E. (2010) Axo-glial antigens as targets in multiple sclerosis: implications for axonal and grey matter injury. Journal of Molecular Medicine, 88(8), pp. 753-761. (doi:10.1007/s00109-010-0632-3)

Sinha, S., Subramanian, S., Emerson-Webber, A., Lindner, M., Burrows, G. G., Grafe, M., Linington, C., Vandenbark, A. A., Bernard, C. C. A. and Offner, H. (2010) Recombinant TCR Ligand Reverses Clinical Signs and CNS Damage of EAE Induced by Recombinant Human MOG. Journal of Neuroimmune Pharmacology, 5(2), pp. 231-239. (doi:10.1007/s11481-009-9175-1)

Weber, M.S. et al. (2010) B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity. Annals of Neurology, 68(3), pp. 369-383. (doi:10.1002/ana.22081)

Derfuss, T. et al. (2009) Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proceedings of the National Academy of Sciences of the United States of America, 106(20), pp. 8302-8307. (doi:10.1073/pnas.0901496106)

Breithaupt, C., Schäfer, B., Pellkofer, H., Huber, R., Linington, C. and Jacob, U. (2008) Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents. Journal of Immunology, 181(2), pp. 1255-1263.

Bourquin, C., van der Haar, M., Anz, D., Sandholzer, N., Neumaier, I., Endres, S., Skerra, A., Schwab, M. and Linington, C. (2008) DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis. European Journal of Pharmacology, 588(1), pp. 99-105. (doi:10.1016/j.ejphar.2008.04.026)

Huizinga, R., Linington, C. and Amor, S. (2008) Resistance is futile: antineuronal autoimmunity in multiple sclerosis. Trends in Immunology, 29(2), pp. 54-60. (doi:10.1016/j.it.2007.11.002)

This list was generated on Sat Jul 21 20:19:38 2018 BST.