Characterising novel target proteins of the salicylidene antihydrazide "anti-virulence" inhibitors

Characterising novel target proteins of the salicylidene antihydrazide "anti-virulence" inhibitors

 

The project is focused on the mode of action of the salicylidene acylhydrazides compounds, so called "anti-virulence" molecules that interfere with bacterial virulence factors without actually killing the pathogen.  in this way selection for resistance is markedly reduced, a major advantage compared to traditional antibiotics. 

The aim is to define the mechanism of action of the anti-virulence compounds including identifying the target proteins, solving their high-resolution structures and using these data to improve the specificity and effectiveness of the salicylidene acylhydrazides.   The project is in collaboration with Professor Mikael Elofsson a chemical biologist at the University of Umea, Sweden who identified the original compounds using high throughput screen.