Search our staff research interests:
Principal Investigators & Research Fellows
Research interests: My group apply the techniques of electron-cryomicroscopy and image analysis to the study of viruses, providing an exciting opportunity to visualise the process of virus infection at cellular scale and at macromolecular resolution. I am also the CVR's public engagement champion.
Research interests: Many human viruses utilise or suppress ubiquitin and ubiquitin-like pathways during infection, enhancing their replication. I'm interested in how viruses engage with these pathways with respect to cellular antiviral immunity, to develop novel avenues for therapeutic intervention.
Research interests: I am interested in the content, function and evolution of herpesvirus genomes. My current work is on human cytomegalovirus, the leading infectious cause of abnormalities in newborn babies and a serious risk to people with weakened immune systems, such as transplant recipients.
Research interests: My research addresses the ecology and evolution of viruses. This work is based on the principle that understanding long-term evolution and origin of viral species will allow the threat posed by contemporary viruses to be assessed and countered more effectively.
Research interests: My group investigates the links between human papillomavirus (HPV) infectious lifecyle & epithelial differentiation and how HPV-associated tumour progression is achieved. Our studies range from basic molecular & cellular virology to clinical studies in HPV testing & therapeutics.
Research interests: My research focuses on companion animal virology and immunology with a view to understanding disease pathogenesis, correlates of immunity to infection and the development of novel approaches to the diagnosis, prevention and treatment of viral diseases.
Research Interests: I am interested in the molecular biology of influenza viruses, in particular the ways in which viral and host proteins function together during an infection. Our work aims to relate changes in influenza virion composition to infectivity, and to examine how viral replication is regulated by protein phosphorylation.
Research interests: Our group investigates the role of viruses in human leukaemia and lymphoma. Much of this work focuses on Hodgkin lymphoma and the causal links with Epstein-Barr virus. We also investigate canine lymphoma; human herpesvirus-6; and non-viral aspects of Hodgkin lymphoma pathogenesis.
Research interests: Our group works on RNA interference pathways, immune signalling pathways and virus/host interactions in arthropod vectors by using arboviruses or virus-derived replicons from all major families. We also work on Wolbachia-mediated inhibition of RNA virus replication in insect cells. A separate area of work investigates arbovirus replication and virus-host interactions in vertebrate cells.
Research interests: Our group study the functions of virus and host components during hepatitis C infection, particularly during viral RNA replication and virion assembly. We also develop systems to study clinical HCV infection as part of the Glasgow HCV Network and HCV Research UK.
Research interests: Our work investigates the molecular and evolutionary mechanisms that underpin host switching and viral emergence through two lines of investigation, influenza emergence & the virome of disease, by integrating multiple disciplines, from classical virology to mathematical modelling.
Research interests: My research group's work stems from a longtime interest in retroviruses, particularly as agents of cancer. This work led to the identification of cellular oncogenes and tumour suppressor genes important in cancers of non-viral etiology, with RUNX/CBF genes being our current focus
Research interests: Our laboratory studies the biology and pathogenesis of livestock diseases induced by emerging arboviruses such as bluetongue virus (BTV) and Schmallenberg virus (SBV).
Research interests: Our group study molecular aspects of hepatitis C virus infection and replication, specifically mechanisms of virus entry; neutralizing antibodies & vaccine development; virus-host interactions and identifying factors contributing to virus-associated progression of liver disease.
Research interests: Mosquitoes are vectors of arboviruses such as dengue and chikungunya. Our group is deciphering arbovirus-mosquito in vivo interactions. with this aim, we also develop genetic tools including the Gal4/UAS system, to characterize host gene function at the tissue-level.
Research interests: My research investigates the robustness of viruses, with a focus on HIV-1. In addition to trying to identify novel immune challenges that HIV-1 may face, we examine how the virus navigates between divergent needs to both conserve fitness and function but to also overcome diverse and fluctuating immune and environmental pressures.
Research interests: My research focuses on the computational study of virus evolution and infection within and between individuals, populations or different host species. We’re particularly interested in viral genome evolution and virus-host interactions at the molecular level, and how virus dependency on an intracellular system (eukaryotic cell or bacterium) is influenced by host-system organisation and how this co-evolutionary entanglement mediates: host specificity, transmission ’success’ and virulence, the emergence of new human pathogens/host switching, and the composition of the virome/microbiome.
Research interests: My group will investigate the mechanisms of Wolbachia-mediated arbovirus inhibition in mosquitoes. We have shown that mosquitoes infected with Wolbachia become resistant to arboviruses like Dengue and Chikungunya. Hence, Wolbachia could be used as a novel vector-control strategy.
Research interests: My work explores the ecology and evolution of emerging infectious diseases. Using rabies virus in bats, my group explores questions about when, where and how viruses jump between host species, with the aim to inform control efforts that limit zoonotic cross-species transmission.
Research interests: My laboratory is focussed on the study of emerging viral infections with 2 main themes - acute hepatitis C infection and new and emerging infections in sub-Saharan Africa.
Research interests: Our research is examining the spread of morbilliviruses (e.g. PPRV and CDV) between livestock and wildlife species. By identifying the reservoirs of infection and the routes of transmission between hosts, these studies will generate epidemiological and biological data to inform strategies for virus control and eradication by vaccination.
Research interests: My group focuses on identifying and characterising novel interferon stimulated genes (ISGs) involved in intrinsic immunity. Using ISG-expression libraries we study a diverse range of retroviruses where multiple ISGs have redefined our understanding of species-species restriction.
Research interests: Our philosophy is to ensure that the capabilities in genomics and bioinformatics are fully integrated with expert understanding of specific viral systems. A central focus is the analysis of high-throughput sequence (HTS) data to address important questions relating to viral genomics, transcriptomics, diversity, evolution and transmission. These activities include the development of novel bioinformatic tools and the investigation of viral and host gene transcription during infection.
Research interests: The Bunyavirus family includes a number of pathogens of clinical and veterinary significance as well as recently emerged viruses. Our ultimate aim is to understand the intimate molecular details of virus replication in these disparate cell types that account for the different outcomes of infection using a multidisciplinary approach, and selected important representative viruses.