The CVR is the UK's largest grouping of human and veterinary virologists. Its mission is to carry out multidisciplinary research on viruses and viral diseases of human and animals, and to translate the knowledge gained for the improvement of human and animal health. The CVR has excellent facilities for conducting research in molecular biology and virology located in a new purpose-built research building at the Garscube campus of the University of Glasgow. The CVR is a core component of the Institute of Infection, Immunity & Inflammation within the College of Medical, Veterinary and Life Sciences at the University of Glasgow.
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The Hutchinson Group studies the molecular biology of influenza viruses. We are particularly interested in how variations in influenza virion composition affect the replication of this serious pathogen. We are currently looking for an enthusiastic, creative and motivated postdoctoral researcher to work with us on this.
As a successful candidate you will have the opportunity to tailor research projects to your own skills and interests. Options include working to extend and develop existing studies of variation among influenza virions, and developing new approaches to study how variation among virions influences the spread of an infection within a host. The research you design is likely to involve a combination of molecular virology, imaging, and proteomics.
You will be an enthusiastic, motivated and organised scientist willing to work as part of a team studying the molecular biology of influenza viruses. You will have a desire to undertake cutting-edge scientific research and the ability to produce work suitable for publication in international peer-reviewed journals. Excellent communication skills are essential, along with the ability to present results clearly and logically. Working co-operatively as part of a team as well as independently is also critical.
Salary will be on the University’s Research and Teaching Grade, level 6 £28,660 - £32,236/level 7 £35,210 - £39,610 per annum.
As an applicant you are encouraged to contact Ed Hutchinson informally to discuss how your own experience and interests could best support work in this exciting and challenging area (by e-mail at Edward.Hutchinson@glasgow.ac.uk).
This post is offered on a full time basis (35 hours) and has funding up to 31 March 2021.
For further details and to submit an electronic application online visit: https://www.gla.ac.uk/it/iframe/jobs/ and look for Job Reference No 026655
Closing date: 11 July 2019
MRC-University of Glasgow Centre for Virus Research (CVR) Industrial Partnership PhD (IPP) Studentship (JEOL UK)
Title: Cryo-EM of virus-host interaction
Annual Stipend: £17,009
Start Date: October 2019. Duration: 3.5 years
Application Deadline: 21st June 2019
Interview Date: 30th July 2019
Cryogenic transmission electron microscopy has recently emerged as a powerful tool for the structural analysis of macromolecular complexes at close to atomic resolution. This project will investigate the structures of medically important viruses as they interact with host-encoded ligands, such as cellular-receptors and components of the innate immune-system. With a particular focus on asymmetrically organised features of icosahedral viruses, we aim to produce atomistic descriptions of these interactions, with a view to defining potential targets for intervention, or improving our understanding of virus biology.
The MRC-University of Glasgow Centre for Virus Research is home to Scotland’s national cryo-EM Centre; the Scottish Centre for Macromolecular Imaging. A significant aim of this studentship is to exploit the new capabilities of SCMI. The centre’s primary instrument is the newly designed JEOL CryoARM 300 - a fully automated 300 keV cryomicroscope that is equipped with a cold-FEG emitter, phase-plates, in-column energy filter and a Direct Electron DE64 camera.
The project is an Industrial Partnership PhD (IPP) studentship which combines the experience and expertise of academic researchers (Bhella Group Spagnolo MRC-UoG CVR) with the microscope manufacturer JEOL and will provide an opportunity to undertake a mini-project in Japan, working closely with JEOL applications specialists.
"The discoveries and therapies of the future are only possible if we nurture our promising talent in the present" - Massimo Palmarini, CVR Director
The CVR is based in the vibrant research community of the University of Glasgow and is the largest dedicated virology centre in the UK, bringing together investigators and scientists with a wealth of experience, knowledge and expertise. Nurturing the next generation of virology researchers is a key mission statement of the CVR. We have therefore created a specialized PhD programme to include an intensive training course to support the development of the next generation of world leaders in virology research. This course aims to ensure that all students have a fundamental understanding of modern virology and consists of lectures, seminars, and practical tutorials delivered by leading virologists from the University of Glasgow.
JEOL (UK) Ltd are a leading supplier of scanning electron microscopes (SEMs), transmission electron microscopes (TEMs), scanning probe microscopes (SPMs), mass spectrometers, NMR spectrometers, and semiconductor tools for scientific and industrial purposes. They provide applications-specific solutions from routine analysis of organic and inorganic specimens to breakthroughs in nanotechnological development.
A minimum 2:1 BSc degree in life-sciences, chemistry or physics is required. Previous laboratory experience in structural biology is advantageous.
Eligibility for payment of full Tuition Fees
This Programme will support full tuition fees, RCUK Rates for candidates from the UK and EU. The Programme is unable to support the tuition fees for non-Home/EU candidates.
The deadline for applications is 21st June 2019.
Please follow the link to Apply Online
When applying, please ensure the following details are entered:
Title: MVLS - Cryo-EM of virus-host interactions
Supervisors: Prof David Bhella and Dr Laura Spagnolo
For the ‘Support Documents’ section, applicants are asked to upload the following:
- Personal Statement/Covering letter (1 A4 page maximum)
- 2 references on headed paper (academic and/or professional) or submitted directly to us (firstname.lastname@example.org)
- Final or current degree transcripts including grades (and an official translation, if needed) – scanned copy in colour of the original document.
- Degree certificates (and an official translation, if needed): scanned copy in colour of the original document.
We recommend that you also email the essential documents above (CV, personal statement/covering letter and references) directly to email@example.com
Following selection for interview, you will be invited to come to Glasgow to visit the CVR on 30th July 2019 for a panel interview. Reasonable travel and accommodation expenses will be reimbursed. Please be available on this date.
Whilst at the CVR, time will be spent visiting the laboratories, meeting current CVR PhD students (and being interviewed!). If you receive an offer, we will ask you to decide to join the CVR within a reasonable and negotiable timeframe (according to your circumstances) at the beginning of October 2019.
Any questions about the IPP studentship or eligibility requirements should be directed to David.Bhella@glasgow.ac.uk