Dr Stacy Robertson

  • Project Manager (Institute of Cardiovascular & Medical Sciences)

telephone: 8428
email: Stacy.Robertson@glasgow.ac.uk

Institute of Cardiovascular & Medical Sciences, 126 University Place, G12 8TA

ORCID iDhttps://orcid.org/0000-0002-0747-5493

Biography

I graduated from the University of Aberdeen with a 1st class BSc (Hons) in Biomedical Sciences (Physiology) in 2007. I completed my PhD in 2012 under the supervision of Prof. Eleanor Davies and Dr Scott MacKenzie in ICAMs at the University of Glasgow. My PhD investigated the role of microRNAs on the regulation of steroid production in the adrenal gland.


After a short BBSRC-funded postdoctoral position modifying adenoviral vectors to alter vascular targeting with Prof. Andrew Baker at University of Glasgow I was awarded the Marcus Blackmore Research Fellowship at the Heart Research Institute, Sydney (Australia). Here, I studied microRNA expression in hypertension induced vascular complications and extracellular transport of microRNAs. I also investigated inflammasome activation in coronary artery disease patients, testing the use of the anti-inflammatory colchicine to suppress activation and used patient samples to help understand its action in monocytes. Finally, I collaborated on projects that investigated how High Density Lipoprotein (HDL) elicits its beneficial effects in vascular cells. During my time in Sydney, I also held a co-joint Associate Lecturer position at the University of Sydney.


I returned to ICAMs in 2016 to continue my postdoctoral training, initially on an MRC-funded project with Prof. Stuart Nicklin, investigating the protective effects of angiotensin-(1-9) in treating vascular injury. Currently, I am a Postdoctoral Research Associate in Prof. Eleanor Group, working on a H2020-funded project aiming to define specific omics signatures for endocrine hypertension.

Research interests

My main interests are in understanding  microRNA expression and function in the adrenal gland and vascular systems, my research predominantly focuses on understanding which microRNAs that are modulated by hormones involved in regulating blood pressure: aldosterone and angiotensin II; what pathways these microRNAs act on; and finally how microRNAs are transported between cells via extracellular particles. This is a growing area of research and has implications for basic mechanistic physiology, understanding causative pathways in endocrine hypertension and related end-organ damage, and has the potential to identify new biomarkers. 

Publications

List by: Type | Date

Jump to: 2021 | 2019 | 2018 | 2017 | 2016 | 2015 | 2013
Number of items: 12.

2021

MacKenzie, S. M. , Saunders, H., van Kralingen, J. C., Robertson, S. , Riddell, A. , Zennaro, M.-C. and Davies, E. (2021) Circulating microRNAs as diagnostic markers in primary aldosteronism. Cancers, 13(21), 5312. (doi: 10.3390/cancers13215312) (PMCID:PMC8582381)

2019

Cartland, S. P. et al. (2019) TRAIL-expressing monocyte/macrophages are critical for reducing inflammation and atherosclerosis. iScience, 12, pp. 41-52. (doi: 10.1016/j.isci.2018.12.037) (PMID:30665196) (PMCID:PMC6348195)

2018

Hourigan, S. T. et al. (2018) The regulation of miRNAs by reconstituted high-density lipoproteins in diabetes-impaired angiogenesis. Scientific Reports, 8, 13596. (doi: 10.1038/s41598-018-32016-x) (PMID:30206364) (PMCID:PMC6133943)

Cannizzo, C. M. et al. (2018) VEGFR2 is activated by high-density lipoproteins and plays a key role in the proangiogenic action of HDL in ischemia. FASEB Journal, 32(6), pp. 2911-2922. (doi: 10.1096/fj.201700617R) (PMID:29401597)

2017

Robertson, S., Diver, L. A., Alvarez-Madrazo, S., Livie, C., Ejaz, A., Fraser, R., Connell, J. M., MacKenzie, S. M. and Davies, E. (2017) Regulation of corticosteroidogenic genes by microRNAs. International Journal of Endocrinology, 2017, 2021903. (doi: 10.1155/2017/2021903) (PMID:28852406) (PMCID:PMC5568613)

Martínez, G. J., Barraclough, J. Y., Nakhla, S., Kienzle, V., Robertson, S., Mallat, Z., Celermajer, D. S. and Patel, S. (2017) Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients. Bioscience Reports, 37(1), BSR2016043. (doi: 10.1042/BSR20160430) (PMID:27913753) (PMCID:PMC5240586)

2016

Tan, J. T.M. et al. (2016) High-density lipoproteins rescue diabetes-impaired angiogenesis via scavenger receptor class B type I. Diabetes, 65(10), pp. 3091-3103. (doi: 10.2337/db15-1668) (PMID:27284113)

Tsatralis, T., Ridiandries, A., Robertson, S., Vanags, L. Z., Lam, Y. T., Tan, J. T. M., Ng, M. K. C. and Bursill, C. A. (2016) Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice. Lipids in Health and Disease, 15, 150. (doi: 10.1186/s12944-016-0322-4) (PMID:27600523) (PMCID:PMC5012086)

Robertson, S., Parker, A. L., Clarke, C., Duffy, M. R., Alba, R., Nicklin, S. A. and Baker, A. H. (2016) Retargeting FX binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop. Journal of General Virology, 97(8), pp. 1911-1916. (doi: 10.1099/jgv.0.000505) (PMID:27189759) (PMCID:PMC5156330)

Robertson, S., Martínez, G. J., Payet, C. A., Barraclough, J. Y., Celermajer, D. S., Bursill, C. and Patel, S. (2016) Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation. Clinical Science, 130(14), pp. 1237-1246. (doi: 10.1042/CS20160090) (PMID:27129183)

2015

Martínez, G. J., Robertson, S., Barraclough, J., Xia, Q., Mallat, Z., Bursill, C., Celermajer, D. S. and Patel, S. (2015) Colchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome. Journal of the American Heart Association, 4(8), e002128. (doi: 10.1161/JAHA.115.002128) (PMID:26304941) (PMCID:PMC4599469)

2013

Robertson, S., MacKenzie, S. M. , Alvarez-Madrazo, S., Diver, L. A., Lin, J., Stewart, P. M., Fraser, R., Connell, J. M. and Davies, E. (2013) MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension, 62(3), pp. 572-578. (doi: 10.1161/HYPERTENSIONAHA.113.01102) (PMID:23836801)

This list was generated on Tue Dec 7 09:38:05 2021 GMT.
Jump to: Articles
Number of items: 12.

Articles

MacKenzie, S. M. , Saunders, H., van Kralingen, J. C., Robertson, S. , Riddell, A. , Zennaro, M.-C. and Davies, E. (2021) Circulating microRNAs as diagnostic markers in primary aldosteronism. Cancers, 13(21), 5312. (doi: 10.3390/cancers13215312) (PMCID:PMC8582381)

Cartland, S. P. et al. (2019) TRAIL-expressing monocyte/macrophages are critical for reducing inflammation and atherosclerosis. iScience, 12, pp. 41-52. (doi: 10.1016/j.isci.2018.12.037) (PMID:30665196) (PMCID:PMC6348195)

Hourigan, S. T. et al. (2018) The regulation of miRNAs by reconstituted high-density lipoproteins in diabetes-impaired angiogenesis. Scientific Reports, 8, 13596. (doi: 10.1038/s41598-018-32016-x) (PMID:30206364) (PMCID:PMC6133943)

Cannizzo, C. M. et al. (2018) VEGFR2 is activated by high-density lipoproteins and plays a key role in the proangiogenic action of HDL in ischemia. FASEB Journal, 32(6), pp. 2911-2922. (doi: 10.1096/fj.201700617R) (PMID:29401597)

Robertson, S., Diver, L. A., Alvarez-Madrazo, S., Livie, C., Ejaz, A., Fraser, R., Connell, J. M., MacKenzie, S. M. and Davies, E. (2017) Regulation of corticosteroidogenic genes by microRNAs. International Journal of Endocrinology, 2017, 2021903. (doi: 10.1155/2017/2021903) (PMID:28852406) (PMCID:PMC5568613)

Martínez, G. J., Barraclough, J. Y., Nakhla, S., Kienzle, V., Robertson, S., Mallat, Z., Celermajer, D. S. and Patel, S. (2017) Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients. Bioscience Reports, 37(1), BSR2016043. (doi: 10.1042/BSR20160430) (PMID:27913753) (PMCID:PMC5240586)

Tan, J. T.M. et al. (2016) High-density lipoproteins rescue diabetes-impaired angiogenesis via scavenger receptor class B type I. Diabetes, 65(10), pp. 3091-3103. (doi: 10.2337/db15-1668) (PMID:27284113)

Tsatralis, T., Ridiandries, A., Robertson, S., Vanags, L. Z., Lam, Y. T., Tan, J. T. M., Ng, M. K. C. and Bursill, C. A. (2016) Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice. Lipids in Health and Disease, 15, 150. (doi: 10.1186/s12944-016-0322-4) (PMID:27600523) (PMCID:PMC5012086)

Robertson, S., Parker, A. L., Clarke, C., Duffy, M. R., Alba, R., Nicklin, S. A. and Baker, A. H. (2016) Retargeting FX binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop. Journal of General Virology, 97(8), pp. 1911-1916. (doi: 10.1099/jgv.0.000505) (PMID:27189759) (PMCID:PMC5156330)

Robertson, S., Martínez, G. J., Payet, C. A., Barraclough, J. Y., Celermajer, D. S., Bursill, C. and Patel, S. (2016) Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation. Clinical Science, 130(14), pp. 1237-1246. (doi: 10.1042/CS20160090) (PMID:27129183)

Martínez, G. J., Robertson, S., Barraclough, J., Xia, Q., Mallat, Z., Bursill, C., Celermajer, D. S. and Patel, S. (2015) Colchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome. Journal of the American Heart Association, 4(8), e002128. (doi: 10.1161/JAHA.115.002128) (PMID:26304941) (PMCID:PMC4599469)

Robertson, S., MacKenzie, S. M. , Alvarez-Madrazo, S., Diver, L. A., Lin, J., Stewart, P. M., Fraser, R., Connell, J. M. and Davies, E. (2013) MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension, 62(3), pp. 572-578. (doi: 10.1161/HYPERTENSIONAHA.113.01102) (PMID:23836801)

This list was generated on Tue Dec 7 09:38:05 2021 GMT.