Dr Simon Kennedy

  • Senior Lecturer (Life Sciences Human Life Sciences)
  • Senate Assessor (Court), Senate Assessor (Senate Office)
  • Associate (Institute of Cardiovascular & Medical Sciences)

telephone: 01413304763
email: Simon.Kennedy@glasgow.ac.uk

Biography

Simon Kennedy is a Senior Lecturer at Glasgow University and has been involved in developing and using in vivo animal models of balloon injury and stenting for around 15years. He has published widely using these models to investigate mechanisms of cardiovascular pathophysiology. He has chaired symposia at local and international meetings and organized several specialized meetings on in vivo research. He is on the editorial board of the British Journal of Pharmacology and the review journal Pharmacology & Therapeutics and is a member of the British Pharmacological Society meetings committee. His work is supported by the British Heart Foundation, Medical Research Council and the EPSRC. His laboratory is one of the few in Europe which uses the pig model of coronary stenting.


Research interests

Member: Vascular Research 

 

 

Proliferative disorders, inflammation and cardioprotection in the cardiovascular system

My research centres on the study of vascular pathologies and therapy aimed at improving the outcome of interventional procedures such as vein grafting, balloon angioplasty and stent implantation. I am also interested in the control of vascular function and the effect of conditions such as hyperlipidaemia on this. Recent work has been to investigate the perivascular adipose tissue (PVAT) surrounding blood vessels and the effect of an enzyme known as AMPK which is expressed in the PVAT on modulating vascular function.


Research:

Vascular Pathophysiology
Interventional Procedures


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Emblation - Pre-Clinical Research Work
    Scottish Funding Council
    2016 - 2016
     
  • Angiotensin-(1-7) and angiotensin-(1-9): assessment as therapeutic targets in acute vascular injury and remodelling.
    Medical Research Council
    2014 - 2017
     
  • Investigation of Novel protein pathways which regulate vascular smooth muscle cell phenotype in neointimal hyperplasia
    Medical Research Council
    2013 - 2016
     
  • Optimal Design of Drug Eluting Stents
    Engineering and Physical Sciences Research Council
    2012 - 2015
     
  • Evaluation of Mirna and their therapeutic potential in a Mouse Model of In-Stent Restenosis
    British Heart Foundation
    2011 - 2014
     
  • Involvement of AMPK in calcium regulation in atherosclerotic blood vessels.
    British Heart Foundation
    2011 - 2014
     
  • Importance of mast cells in vein graft survival
    British Heart Foundation
    2010 - 2012
     
  • Involvement of chlorinated lipids in neointima formation.
    British Heart Foundation
    2008 - 2011
     
  • Optimisation and analysis of integrating and non-integrating lentiviruses for vascular gene transfer in vivo - application to in-stent restenosis with delivery of Nogo-B
    British Heart Foundation
    2008 - 2011
     
  • Modulation of calcium handling mechanisms in healthy and atherosclerotic vascular smooth muscle
    British Heart Foundation
    2007 - 2010
     
  • Cardio protection and the modulation of vascular tone by anandamide is mediated by sphingosine-1-phosphate
    British Heart Foundation
    2007 - 2009
     

Additional information

Invited International Presentations

  • 2011: London, UK - BPS Symposium
  • 2008: Inverness, Scotland - Departmental Seminar, UHI Millennium Institute
  • 2007: Robert Gordon's University, Aberdeen, Scotland - Departmental Seminar
  • 2007: Hamilton Island, Australia - Invited Communication, 9th ISRA meeting
  • 2007: Glasgow, Scotland - Symposium Chair, Life Sciences 2007 meeting
  • 2006: Ross Priory, Loch Lomand, Scotland - Synergy Meeting: Mathematical biology & Modelling
  • 2005: London, England - House of Commons poster reception. UK Science week- poster chosen for presentation
  • 2004: Brisbane, Australia - Co-chair and invited speaker at symposium. International Society for Heart Research
  • 2004: Kuala Lumpur - Departmental Seminar, International Medical University

Professional Learned Society

  • 2004 - present: Scottish Cardiovascular Forum - Committee member
  • 1994 - present: Royal Pharmaceutical Society - Member

Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2004 | 2003 | 1998
Number of items: 57.

2019

Greig, F. H. et al. (2019) Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse. European Journal of Pharmacology, 842, pp. 1-9. (doi:10.1016/j.ejphar.2018.10.027) (PMID:30359564)

2018

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S., Palmer, T. M. and Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, 5276. (doi:10.1038/s41598-018-23420-4) (PMID:29588466) (PMCID:PMC5869674)

Almabrouk, T. A.M. , White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M. , Salt, I. P. and Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, 51. (doi:10.3389/fphys.2018.00051) (PMID:29479319) (PMCID:PMC5812172)

2017

Almabrouk, T. A. M. , Ugusman, A. B., Katwan, O. J., Salt, I. P. and Kennedy, S. (2017) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release. British Journal of Pharmacology, 174(20), pp. 3398-3410. (doi:10.1111/bph.13633) (PMID:27668984)

Kennedy, S. and Salt, I. P. (2017) Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? British Journal of Pharmacology, 174(20), pp. 3385-3387. (doi:10.1111/bph.13969) (PMID:28940457)

Wu, J., Lawrence, C., Wadsworth, R. M. and Kennedy, S. (2017) Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice. Vessel Plus, 2017(1), pp. 137-144. (doi:10.20517/2574-1209.2017.15)

Greig, F. H., Kennedy, S., Gibson, G., Ramos, J. W. and Nixon, G. F. (2017) PEA-15 (phosphoprotein enriched in astrocytes 15) is a protective mediator in the vasculature and is regulated during neointimal hyperplasia. Journal of the American Heart Association, 6(9), e006936. (doi:10.1161/JAHA.117.006936) (PMID:28893763) (PMCID:PMC5634313)

Ewart, M.-A., Ugusman, A., Vishwanath, A., Almabrouk, T. A.M., Alganga, H. S.F., Katwan, O. J., Hubanova, P., Currie, S. and Kennedy, S. (2017) Changes in IP3 receptor expression and function in aortic smooth muscle of atherosclerotic mice. Journal of Vascular Research, 54(2), pp. 68-78. (doi:10.1159/000461581) (PMID:28365690) (PMCID:PMC5804831)

Houston, S. A., Ugusman, A., Gnanadesika, S. and Kennedy, S. (2017) An investigation of the antiplatelet effects of succinobucol (AGI-1067). Platelets, 28(3), pp. 295-300. (doi:10.1080/09537104.2016.1218456) (PMID:27681689)

McGinty, S. , McCormick, C., McKittrick, C., Kennedy, S., Oldroyd, K., Wheel, M., Scullion, B., Pontrelli, G. and McKee, S. (2017) Combining Mathematical Modelling with In-Vitro Experiments to Predict In-Vivo Drug-Eluting Stent Kinetics. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 1011-1014. ISBN 9780956291448

2016

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S. and Pyne, N. J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling, 28(8), pp. 946-955. (doi:10.1016/j.cellsig.2016.03.014) (PMID:27063355) (PMCID:PMC4913619)

McCormick, C., Jones, R. L., Wadsworth, R. M., Mullen, A. B. and Kennedy, S. (2016) A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery. Pharmacology and Pharmacy, 7(6), pp. 226-235. (doi:10.4236/pp.2016.76029)

McKittrick, C.M., Kennedy, S., Oldroyd, K.G., Mcginty, S. and McCormick, C. (2016) Modelling the impact of atherosclerosis on drug release and distribution from coronary stents. Annals of Biomedical Engineering, 44(2), pp. 477-487. (doi:10.1007/s10439-015-1456-7) (PMID:26384667) (PMCID:PMC4764635)

Watt, J., Kennedy, S., Ahmed, N., Hayhurst, J., McClure, J. D. , Berry, C. , Wadsworth, R. M. and Oldroyd, K. G. (2016) The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD. Open Heart, 3(1), e000342. (doi:10.1136/openhrt-2015-000342) (PMID:26848395) (PMCID:PMC4731840)

2015

Greig, F. H., Ewart, M.-A., McNaughton, E., Cooney, J., Spickett, C. M. and Kennedy, S. (2015) The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Vascular Pharmacology, 74, pp. 93-102. (doi:10.1016/j.vph.2015.07.010) (PMID:26196300) (PMCID:PMC4673085)

Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S. and Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling. PeerJ, 3, e1192. (doi:10.7717/peerj.1192) (PMID:26312183) (PMCID:PMC4548472)

Mckinney, C.A., Kennedy, S., Baillie, G.S. , Milligan, G. and Nicklin, S.A. (2015) Angiotensin-(1-7) and angiotensin-(1-9) inhibit vascular smooth muscle cell growth and migration in vitro and vascular remodelling in vivo. Atherosclerosis, 241(1), e44. (doi:10.1016/j.atherosclerosis.2015.04.158)

McDonald, R. A. et al. (2015) Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation. Journal of the American College of Cardiology, 65(21), pp. 2314-2327. (doi:10.1016/j.jacc.2015.03.549) (PMID:26022821) (PMCID:PMC4444526)

Greig, F. H., Hutchison, L., Spickett, C. M. and Kennedy, S. (2015) Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation. Clinical Science, 128, pp. 579-592. (doi:10.1042/CS20140578) (PMID:25524654)

McGinty, S. , Wheel, M., McKee, S., McCormick, C., McKittrick, C., Kennedy, S. and Oldroyd, K. (2015) Can Anisotropy Enhance the Spatial Uniformity of Drug Distribution in Biological Tissue? In: 4th International Conference on Computational & Mathematical Biomedical Engineering, Paris, France, 29 June - 1 July 2015, pp. 194-197. ISBN 9780956291431

2014

Farmer, D. G.S., Ewart, M.-A., Mair, K. M. and Kennedy, S. (2014) Soluble receptor for advanced glycation end products (sRAGE) attenuates haemodynamic changes to chronic hypoxia in the mouse. Pulmonary Pharmacology and Therapeutics, 29(1), pp. 7-14. (doi:10.1016/j.pupt.2014.01.002)

Ewart, M.-A., Kennedy, S., MacMillan, D., Raja, A. L.N., Watt, I. M. and Currie, S. (2014) Altered vascular smooth muscle function in the ApoE knockout mouse during the progression of atherosclerosis. Atherosclerosis, 234(1), pp. 154-161. (doi:10.1016/j.atherosclerosis.2014.02.014)

Almabrouk, T.A.M. , Ewart, M.-A., Salt, I.P. and Kennedy, S. (2014) Perivascular fat, AMP-activated protein kinase and vascular diseases. British Journal of Pharmacology, 171(3), pp. 595-617. (doi:10.1111/bph.12479) (PMID:24490856) (PMCID:PMC3969075)

2013

McDonald, R. A. et al. (2013) miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation. European Heart Journal, 34(22), pp. 1636-1643. (doi:10.1093/eurheartj/eht105)

Kennedy, S., Wu, J., Wadsworth, R.M., Lawrence, C.E. and Maffia, P. (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138(1), pp. 53-65. (doi:10.1016/j.pharmthera.2013.01.001)

Watt, J., Kennedy, S., McCormick, C., Agbani, E.O., McPhaden, A., Mullen, A., Czudaj, P., Behnisch, B., Wadsworth, R.M. and Oldroyd, K.G. (2013) Succinobucol-eluting stents increase neointimal thickening and peri-strut inflammation in a porcine coronary model. Catheterization and Cardiovascular Interventions, 81(4), pp. 698-708. (doi:10.1002/ccd.24473)

2012

Ewart, M.-A. and Kennedy, S. (2012) Diabetic cardiovascular disease AMP-activated protein kinase (AMPK) as a therapeutic target. Cardiovascular and Hematological Agents in Medicinal Chemistry, 10(3), pp. 190-211. (doi:10.2174/187152512802651015)

Watt, J., Ewart, M.-A., Greig, F. H., Oldroyd, K. G., Wadsworth, R. M. and Kennedy, S. (2012) The effect of reactive oxygen species on whole blood aggregation and the endothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Research, 130(2), pp. 210-215. (doi:10.1016/j.thromres.2012.03.024)

Greig, F. H., Kennedy, S. and Spickett, C. M. (2012) Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation. Free Radical Biology and Medicine, 52(2), pp. 266-280. (doi:10.1016/j.freeradbiomed.2011.10.481)

Watt, J., Ewart, M.-A., Greig, F.H., Oldroyd, K.G., Wadsworth, R.M. and Kennedy, S. (2012) The effect of reactive oxygen species on whole blood aggregation and the enothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Research, 130(2), pp. 210-215. (doi:10.1016/j.thromres.2012.03.024)

2011

Ialenti, A. et al. (2011) Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), pp. 2448-2454. (doi:10.1161/ATVBAHA.111.230078) (PMID:21852559)

Ewart, M.-A. and Kennedy, S. (2011) AMPK and vasculoprotection. Pharmacology and Therapeutics, 131(2), pp. 242-253. (doi:10.1016/j.pharmthera.2010.11.002)

Wu, J., Wadsworth, R.M. and Kennedy, S. (2011) Inhibition of inducible Nitric Oxide synthase promotes vein graft neoadventitial inflammation and remodelling. Journal of Vascular Research, 48(2), pp. 141-149. (doi:10.1159/000316968)

2010

Grassia, G. et al. (2010) The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(12), pp. 2458-2466. (doi:10.1161/ATVBAHA.110.215467)

Guglielmotti, A., Grassia, G., Gordon, P., Maddaluno, M., Di Lauro, M.V., Biondi, G., Colombo, A., Ialenti, A., Maffia, P. and Kennedy, S. (2010) Bindarit, an inhibitor of monocyte chemoattractant proteins (MCPs) production, reduces in-stent restenosis in porcine coronary arteries. In: American Heart Association Scientific Session 2010, Chicago, IL, 13-17 Nov 2010, A11429.

Shedden, L., Kennedy, S., Wadsworth, R. and Connolly, P. (2010) Towards a self-reporting coronary artery stent—Measuring neointimal growth associated with in-stent restenosis using electrical impedance techniques. Biosensors and Bioelectronics, 26(2), pp. 661-666. (doi:10.1016/j.bios.2010.06.073) (PMID:20667708)

McCormick, C., Jones, R.L., Kennedy, S. and Wadsworth, R.M. (2010) Activation of prostanoid EP receptors by prostacyclin analogues in rabbit iliac artery: Implications for anti-restenotic potential. European Journal of Pharmacology, 641(2-3), pp. 160-167. (doi:10.1016/j.ejphar.2010.04.035)

Mair, K.M., Robinson, E., Kane, K.A., Pyne, S., Brett, R.R., Pyne, N.J. and Kennedy, S. (2010) Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. British Journal of Pharmacology, 161(1), pp. 176-192. (doi:10.1111/j.1476-5381.2010.00878.x)

2009

Lim, S.Y., Wainwright, C.L., Kennedy, S. and Kane, K.A. (2009) Activation of protease activated receptor-2 induces delayed cardioprotection in anesthetized mice. Cardiovascular Drugs and Therapy, 23(6), pp. 519-520. (doi:10.1007/s10557-007-6073-8)

Farmer, D.G.S. and Kennedy, S. (2009) RAGE, vascular tone and vascular disease. Pharmacology and Therapeutics, 124(2), pp. 185-194. (doi:10.1016/j.pharmthera.2009.06.013)

Kennedy, S., Kane, K.A., Pyne, N.J. and Pyne, S. (2009) Targeting sphingosine-1-phosphate signalling for cardioprotection. Current Opinion in Pharmacology, 9(2), pp. 194-201. (doi:10.1016/j.coph.2008.11.002)

2008

Dever, G.J., Benson, R., Wainwright, C.L., Kennedy, S. and Spickett, C.M. (2008) Phospholipid chlorohydrin induces leukocyte adhesion to ApoE−/− mouse arteries via upregulation of P-selectin. Free Radical Biology and Medicine, 44(3), pp. 452-463. (doi:10.1016/j.freeradbiomed.2007.10.038)

Erridge, C., Kennedy, S., Spickett, C.M. and Webb, D.J. (2008) Oxidised phospholipid inhibition of toll-like receptor (TLR) signalling is restricted to TLR2 and TLR4 - roles for CD14, LPS-binding protein and MD2 as targets for specificity of inhibition. Journal of Biological Chemistry, 283(36), pp. 24748-24759. (doi:10.1074/jbc.M800352200)

Watt, J., Wadsworth, R., Kennedy, S. and Oldroyd, K. (2008) Pro-healing drug-eluting stents: a role for antioxidants? Clinical Science, 114(4), pp. 265-273. (doi:10.1042/CS20070207)

2007

Dever, G., Spickett, C.M., Kennedy, S., Rush, C., Tennant, G., Monopoli, A. and Wainwright, C.L. (2007) The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S-[1α(βS*,δS*), 2α ,6α,8 β-(R*),8aα]]-1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy) butyl Ester)], Reduces Splenocyte Adhesion and Reactive Oxygen Species Generation in Normal and Atherosclerotic Mice. Journal of Pharmacology and Experimental Therapeutics, 320(1), pp. 419-426. (doi:10.1124/jpet.106.109298)

Coats, P., Kennedy, S., Pynea, S., Wainwright, C.L. and Wadsworth, R.M. (2007) Inhibition of non-Ras protein farnesylation reduces in-stent restenosis. Atherosclerosis, 197(2), pp. 515-523. (doi:10.1016/j.atherosclerosis.2007.06.007)

Dever, G., Wainwright, C.L., Kennedy, S. and Spickett, C.M. (2007) Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion. Acta Biochimica Polonica, 53(4), pp. 761-768.

Kennedy, S., Burke, S.G., Preston, A.A. and McPhaden, A.R. (2007) Nitric oxide generation by NO donors is enhanced following balloon injury in the porcine coronary artery. Endothelium: Journal of Endothelial Cell Research, 14, pp. 105-113.

Maffia, P. , Zinselmeyer, B.H., Ialenti, A., Kennedy, S., Baker, A.H., McInnes, I. , Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi:10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)

McCormick, C., Wadsworth, R.M., Jones, R.L. and Kennedy, S. (2007) Prostacyclin analogues: the next drug-eluting stent? Biochemical Society Transactions, 35(5), pp. 910-911. (doi:10.1042/BST0350910)

Tennant, G.M., Wadsworth, R.M. and Kennedy, S. (2007) PAR-2 mediates increased inflammatory cell adhesion and neointima formation following vascular injury in the mouse. Atherosclerosis, 198(1), pp. 57-64.

2006

Kennedy, S., Wadsworth, R.M. and Wainwright, C.L. (2006) Locally administered antiproliferative drugs inhibit hypercontractility to serotonin in balloon-injured pig coronary artery. Vascular Pharmacology, 44, pp. 363-371. (doi:10.1016/j.vph.2006.01.012)

Lim, S.Y., Tennant, G.M., Kennedy, S., Wainwright, C.L. and Kane, K.A. (2006) Activation of mouse protease-activated receptor-2 induces lymphocyte adhesion and generation of reactive oxygen species. British Journal of Pharmacology, 149, pp. 591-599. (doi:10.1038/sj.bjp.0706905)

2004

Kennedy, S., Preston, A., McPhaden, A., Miller, A., Wainwright, C. and Wadsworth, R. (2004) Correlation of changes in nitric oxide synthase, superoxide dismutase and nitrotyrosine with endothelial regeneration and neointimal hyperplasia in the balloon-injured rabbit subclavian artery. Coronary Artery Disease, 15(6), pp. 337-346. (doi:10.1097/00019501-200409000-00007)

2003

Kennedy, S., Wadsworth, R.M. and Wainwright, C.L. (2003) Effect of antiproliferative agents on vascular function in nonnal and in vitro balloon-injured porcine coronary arteries. European Journal of Pharmacology, 481(1), pp. 101-107. (doi:10.1016/j.ejphar.2003.09.010)

Kennedy, S., Fournet-Bourguignon, M.-P., Breugnot, C., Castedo-Delrieu, M., Lesage, L., Reure, H., Briant, C., Leonce, S., Vilaine, J.-P. and Vanhoutte, P. M. (2003) Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of apolipoprotein-B-100 without a modification in the uptake of oxidized LDL. Journal of Vascular Research, 40(4), (doi:10.1159/000072817)

1998

Kennedy, S., Work, L. , Ferris, P., Miller, A.M., McManus, B., Wadsworth, R.M. and Wainwright, C.L. (1998) Role of nitric oxide and free radicals in the contractile response to non-preactivated leukocytes. European Journal of Pharmacology, 345(3), pp. 269-277. (doi:10.1016/S0014-2999(98)00007-7)

This list was generated on Fri Dec 14 07:56:09 2018 GMT.
Number of items: 57.

Articles

Greig, F. H. et al. (2019) Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse. European Journal of Pharmacology, 842, pp. 1-9. (doi:10.1016/j.ejphar.2018.10.027) (PMID:30359564)

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S., Palmer, T. M. and Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, 5276. (doi:10.1038/s41598-018-23420-4) (PMID:29588466) (PMCID:PMC5869674)

Almabrouk, T. A.M. , White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M. , Salt, I. P. and Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, 51. (doi:10.3389/fphys.2018.00051) (PMID:29479319) (PMCID:PMC5812172)

Almabrouk, T. A. M. , Ugusman, A. B., Katwan, O. J., Salt, I. P. and Kennedy, S. (2017) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release. British Journal of Pharmacology, 174(20), pp. 3398-3410. (doi:10.1111/bph.13633) (PMID:27668984)

Kennedy, S. and Salt, I. P. (2017) Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? British Journal of Pharmacology, 174(20), pp. 3385-3387. (doi:10.1111/bph.13969) (PMID:28940457)

Wu, J., Lawrence, C., Wadsworth, R. M. and Kennedy, S. (2017) Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice. Vessel Plus, 2017(1), pp. 137-144. (doi:10.20517/2574-1209.2017.15)

Greig, F. H., Kennedy, S., Gibson, G., Ramos, J. W. and Nixon, G. F. (2017) PEA-15 (phosphoprotein enriched in astrocytes 15) is a protective mediator in the vasculature and is regulated during neointimal hyperplasia. Journal of the American Heart Association, 6(9), e006936. (doi:10.1161/JAHA.117.006936) (PMID:28893763) (PMCID:PMC5634313)

Ewart, M.-A., Ugusman, A., Vishwanath, A., Almabrouk, T. A.M., Alganga, H. S.F., Katwan, O. J., Hubanova, P., Currie, S. and Kennedy, S. (2017) Changes in IP3 receptor expression and function in aortic smooth muscle of atherosclerotic mice. Journal of Vascular Research, 54(2), pp. 68-78. (doi:10.1159/000461581) (PMID:28365690) (PMCID:PMC5804831)

Houston, S. A., Ugusman, A., Gnanadesika, S. and Kennedy, S. (2017) An investigation of the antiplatelet effects of succinobucol (AGI-1067). Platelets, 28(3), pp. 295-300. (doi:10.1080/09537104.2016.1218456) (PMID:27681689)

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S. and Pyne, N. J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling, 28(8), pp. 946-955. (doi:10.1016/j.cellsig.2016.03.014) (PMID:27063355) (PMCID:PMC4913619)

McCormick, C., Jones, R. L., Wadsworth, R. M., Mullen, A. B. and Kennedy, S. (2016) A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery. Pharmacology and Pharmacy, 7(6), pp. 226-235. (doi:10.4236/pp.2016.76029)

McKittrick, C.M., Kennedy, S., Oldroyd, K.G., Mcginty, S. and McCormick, C. (2016) Modelling the impact of atherosclerosis on drug release and distribution from coronary stents. Annals of Biomedical Engineering, 44(2), pp. 477-487. (doi:10.1007/s10439-015-1456-7) (PMID:26384667) (PMCID:PMC4764635)

Watt, J., Kennedy, S., Ahmed, N., Hayhurst, J., McClure, J. D. , Berry, C. , Wadsworth, R. M. and Oldroyd, K. G. (2016) The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD. Open Heart, 3(1), e000342. (doi:10.1136/openhrt-2015-000342) (PMID:26848395) (PMCID:PMC4731840)

Greig, F. H., Ewart, M.-A., McNaughton, E., Cooney, J., Spickett, C. M. and Kennedy, S. (2015) The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Vascular Pharmacology, 74, pp. 93-102. (doi:10.1016/j.vph.2015.07.010) (PMID:26196300) (PMCID:PMC4673085)

Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S. and Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling. PeerJ, 3, e1192. (doi:10.7717/peerj.1192) (PMID:26312183) (PMCID:PMC4548472)

Mckinney, C.A., Kennedy, S., Baillie, G.S. , Milligan, G. and Nicklin, S.A. (2015) Angiotensin-(1-7) and angiotensin-(1-9) inhibit vascular smooth muscle cell growth and migration in vitro and vascular remodelling in vivo. Atherosclerosis, 241(1), e44. (doi:10.1016/j.atherosclerosis.2015.04.158)

McDonald, R. A. et al. (2015) Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation. Journal of the American College of Cardiology, 65(21), pp. 2314-2327. (doi:10.1016/j.jacc.2015.03.549) (PMID:26022821) (PMCID:PMC4444526)

Greig, F. H., Hutchison, L., Spickett, C. M. and Kennedy, S. (2015) Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation. Clinical Science, 128, pp. 579-592. (doi:10.1042/CS20140578) (PMID:25524654)

Farmer, D. G.S., Ewart, M.-A., Mair, K. M. and Kennedy, S. (2014) Soluble receptor for advanced glycation end products (sRAGE) attenuates haemodynamic changes to chronic hypoxia in the mouse. Pulmonary Pharmacology and Therapeutics, 29(1), pp. 7-14. (doi:10.1016/j.pupt.2014.01.002)

Ewart, M.-A., Kennedy, S., MacMillan, D., Raja, A. L.N., Watt, I. M. and Currie, S. (2014) Altered vascular smooth muscle function in the ApoE knockout mouse during the progression of atherosclerosis. Atherosclerosis, 234(1), pp. 154-161. (doi:10.1016/j.atherosclerosis.2014.02.014)

Almabrouk, T.A.M. , Ewart, M.-A., Salt, I.P. and Kennedy, S. (2014) Perivascular fat, AMP-activated protein kinase and vascular diseases. British Journal of Pharmacology, 171(3), pp. 595-617. (doi:10.1111/bph.12479) (PMID:24490856) (PMCID:PMC3969075)

McDonald, R. A. et al. (2013) miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation. European Heart Journal, 34(22), pp. 1636-1643. (doi:10.1093/eurheartj/eht105)

Kennedy, S., Wu, J., Wadsworth, R.M., Lawrence, C.E. and Maffia, P. (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138(1), pp. 53-65. (doi:10.1016/j.pharmthera.2013.01.001)

Watt, J., Kennedy, S., McCormick, C., Agbani, E.O., McPhaden, A., Mullen, A., Czudaj, P., Behnisch, B., Wadsworth, R.M. and Oldroyd, K.G. (2013) Succinobucol-eluting stents increase neointimal thickening and peri-strut inflammation in a porcine coronary model. Catheterization and Cardiovascular Interventions, 81(4), pp. 698-708. (doi:10.1002/ccd.24473)

Ewart, M.-A. and Kennedy, S. (2012) Diabetic cardiovascular disease AMP-activated protein kinase (AMPK) as a therapeutic target. Cardiovascular and Hematological Agents in Medicinal Chemistry, 10(3), pp. 190-211. (doi:10.2174/187152512802651015)

Watt, J., Ewart, M.-A., Greig, F. H., Oldroyd, K. G., Wadsworth, R. M. and Kennedy, S. (2012) The effect of reactive oxygen species on whole blood aggregation and the endothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Research, 130(2), pp. 210-215. (doi:10.1016/j.thromres.2012.03.024)

Greig, F. H., Kennedy, S. and Spickett, C. M. (2012) Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation. Free Radical Biology and Medicine, 52(2), pp. 266-280. (doi:10.1016/j.freeradbiomed.2011.10.481)

Watt, J., Ewart, M.-A., Greig, F.H., Oldroyd, K.G., Wadsworth, R.M. and Kennedy, S. (2012) The effect of reactive oxygen species on whole blood aggregation and the enothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Research, 130(2), pp. 210-215. (doi:10.1016/j.thromres.2012.03.024)

Ialenti, A. et al. (2011) Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), pp. 2448-2454. (doi:10.1161/ATVBAHA.111.230078) (PMID:21852559)

Ewart, M.-A. and Kennedy, S. (2011) AMPK and vasculoprotection. Pharmacology and Therapeutics, 131(2), pp. 242-253. (doi:10.1016/j.pharmthera.2010.11.002)

Wu, J., Wadsworth, R.M. and Kennedy, S. (2011) Inhibition of inducible Nitric Oxide synthase promotes vein graft neoadventitial inflammation and remodelling. Journal of Vascular Research, 48(2), pp. 141-149. (doi:10.1159/000316968)

Grassia, G. et al. (2010) The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(12), pp. 2458-2466. (doi:10.1161/ATVBAHA.110.215467)

Shedden, L., Kennedy, S., Wadsworth, R. and Connolly, P. (2010) Towards a self-reporting coronary artery stent—Measuring neointimal growth associated with in-stent restenosis using electrical impedance techniques. Biosensors and Bioelectronics, 26(2), pp. 661-666. (doi:10.1016/j.bios.2010.06.073) (PMID:20667708)

McCormick, C., Jones, R.L., Kennedy, S. and Wadsworth, R.M. (2010) Activation of prostanoid EP receptors by prostacyclin analogues in rabbit iliac artery: Implications for anti-restenotic potential. European Journal of Pharmacology, 641(2-3), pp. 160-167. (doi:10.1016/j.ejphar.2010.04.035)

Mair, K.M., Robinson, E., Kane, K.A., Pyne, S., Brett, R.R., Pyne, N.J. and Kennedy, S. (2010) Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. British Journal of Pharmacology, 161(1), pp. 176-192. (doi:10.1111/j.1476-5381.2010.00878.x)

Lim, S.Y., Wainwright, C.L., Kennedy, S. and Kane, K.A. (2009) Activation of protease activated receptor-2 induces delayed cardioprotection in anesthetized mice. Cardiovascular Drugs and Therapy, 23(6), pp. 519-520. (doi:10.1007/s10557-007-6073-8)

Farmer, D.G.S. and Kennedy, S. (2009) RAGE, vascular tone and vascular disease. Pharmacology and Therapeutics, 124(2), pp. 185-194. (doi:10.1016/j.pharmthera.2009.06.013)

Kennedy, S., Kane, K.A., Pyne, N.J. and Pyne, S. (2009) Targeting sphingosine-1-phosphate signalling for cardioprotection. Current Opinion in Pharmacology, 9(2), pp. 194-201. (doi:10.1016/j.coph.2008.11.002)

Dever, G.J., Benson, R., Wainwright, C.L., Kennedy, S. and Spickett, C.M. (2008) Phospholipid chlorohydrin induces leukocyte adhesion to ApoE−/− mouse arteries via upregulation of P-selectin. Free Radical Biology and Medicine, 44(3), pp. 452-463. (doi:10.1016/j.freeradbiomed.2007.10.038)

Erridge, C., Kennedy, S., Spickett, C.M. and Webb, D.J. (2008) Oxidised phospholipid inhibition of toll-like receptor (TLR) signalling is restricted to TLR2 and TLR4 - roles for CD14, LPS-binding protein and MD2 as targets for specificity of inhibition. Journal of Biological Chemistry, 283(36), pp. 24748-24759. (doi:10.1074/jbc.M800352200)

Watt, J., Wadsworth, R., Kennedy, S. and Oldroyd, K. (2008) Pro-healing drug-eluting stents: a role for antioxidants? Clinical Science, 114(4), pp. 265-273. (doi:10.1042/CS20070207)

Dever, G., Spickett, C.M., Kennedy, S., Rush, C., Tennant, G., Monopoli, A. and Wainwright, C.L. (2007) The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S-[1α(βS*,δS*), 2α ,6α,8 β-(R*),8aα]]-1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy) butyl Ester)], Reduces Splenocyte Adhesion and Reactive Oxygen Species Generation in Normal and Atherosclerotic Mice. Journal of Pharmacology and Experimental Therapeutics, 320(1), pp. 419-426. (doi:10.1124/jpet.106.109298)

Coats, P., Kennedy, S., Pynea, S., Wainwright, C.L. and Wadsworth, R.M. (2007) Inhibition of non-Ras protein farnesylation reduces in-stent restenosis. Atherosclerosis, 197(2), pp. 515-523. (doi:10.1016/j.atherosclerosis.2007.06.007)

Dever, G., Wainwright, C.L., Kennedy, S. and Spickett, C.M. (2007) Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion. Acta Biochimica Polonica, 53(4), pp. 761-768.

Kennedy, S., Burke, S.G., Preston, A.A. and McPhaden, A.R. (2007) Nitric oxide generation by NO donors is enhanced following balloon injury in the porcine coronary artery. Endothelium: Journal of Endothelial Cell Research, 14, pp. 105-113.

Maffia, P. , Zinselmeyer, B.H., Ialenti, A., Kennedy, S., Baker, A.H., McInnes, I. , Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi:10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)

McCormick, C., Wadsworth, R.M., Jones, R.L. and Kennedy, S. (2007) Prostacyclin analogues: the next drug-eluting stent? Biochemical Society Transactions, 35(5), pp. 910-911. (doi:10.1042/BST0350910)

Tennant, G.M., Wadsworth, R.M. and Kennedy, S. (2007) PAR-2 mediates increased inflammatory cell adhesion and neointima formation following vascular injury in the mouse. Atherosclerosis, 198(1), pp. 57-64.

Kennedy, S., Wadsworth, R.M. and Wainwright, C.L. (2006) Locally administered antiproliferative drugs inhibit hypercontractility to serotonin in balloon-injured pig coronary artery. Vascular Pharmacology, 44, pp. 363-371. (doi:10.1016/j.vph.2006.01.012)

Lim, S.Y., Tennant, G.M., Kennedy, S., Wainwright, C.L. and Kane, K.A. (2006) Activation of mouse protease-activated receptor-2 induces lymphocyte adhesion and generation of reactive oxygen species. British Journal of Pharmacology, 149, pp. 591-599. (doi:10.1038/sj.bjp.0706905)

Kennedy, S., Preston, A., McPhaden, A., Miller, A., Wainwright, C. and Wadsworth, R. (2004) Correlation of changes in nitric oxide synthase, superoxide dismutase and nitrotyrosine with endothelial regeneration and neointimal hyperplasia in the balloon-injured rabbit subclavian artery. Coronary Artery Disease, 15(6), pp. 337-346. (doi:10.1097/00019501-200409000-00007)

Kennedy, S., Wadsworth, R.M. and Wainwright, C.L. (2003) Effect of antiproliferative agents on vascular function in nonnal and in vitro balloon-injured porcine coronary arteries. European Journal of Pharmacology, 481(1), pp. 101-107. (doi:10.1016/j.ejphar.2003.09.010)

Kennedy, S., Fournet-Bourguignon, M.-P., Breugnot, C., Castedo-Delrieu, M., Lesage, L., Reure, H., Briant, C., Leonce, S., Vilaine, J.-P. and Vanhoutte, P. M. (2003) Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of apolipoprotein-B-100 without a modification in the uptake of oxidized LDL. Journal of Vascular Research, 40(4), (doi:10.1159/000072817)

Kennedy, S., Work, L. , Ferris, P., Miller, A.M., McManus, B., Wadsworth, R.M. and Wainwright, C.L. (1998) Role of nitric oxide and free radicals in the contractile response to non-preactivated leukocytes. European Journal of Pharmacology, 345(3), pp. 269-277. (doi:10.1016/S0014-2999(98)00007-7)

Conference Proceedings

McGinty, S. , McCormick, C., McKittrick, C., Kennedy, S., Oldroyd, K., Wheel, M., Scullion, B., Pontrelli, G. and McKee, S. (2017) Combining Mathematical Modelling with In-Vitro Experiments to Predict In-Vivo Drug-Eluting Stent Kinetics. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 1011-1014. ISBN 9780956291448

McGinty, S. , Wheel, M., McKee, S., McCormick, C., McKittrick, C., Kennedy, S. and Oldroyd, K. (2015) Can Anisotropy Enhance the Spatial Uniformity of Drug Distribution in Biological Tissue? In: 4th International Conference on Computational & Mathematical Biomedical Engineering, Paris, France, 29 June - 1 July 2015, pp. 194-197. ISBN 9780956291431

Guglielmotti, A., Grassia, G., Gordon, P., Maddaluno, M., Di Lauro, M.V., Biondi, G., Colombo, A., Ialenti, A., Maffia, P. and Kennedy, S. (2010) Bindarit, an inhibitor of monocyte chemoattractant proteins (MCPs) production, reduces in-stent restenosis in porcine coronary arteries. In: American Heart Association Scientific Session 2010, Chicago, IL, 13-17 Nov 2010, A11429.

This list was generated on Fri Dec 14 07:56:09 2018 GMT.