Dr Rheure Lopes

  • Research Associate (Institute of Cardiovascular & Medical Sciences)

Biography

Bachelor degree in nursing program from the Federal University of Mato Grosso - Brazil. During the master course in Biological Sciences (Pharmacology) at the Medical School of Ribeirao Preto (FMRP) – University of Sao Paulo (USP), he evaluated the role of Reactive Oxygen Species in apoptosis of vascular cells induced by testosterone. During his PhD at the FMRP-USP, it was investigated the role of nuclear factor E2–related factor 2 (Nrf2) downregulation, consequent to increased nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1)-derived reactive oxygen species (ROS), in impaired internal pudendal artery function in Diabetes. A one year PhD internship was done at the University of Glasgow (under the supervision of Prof Dr Rhian Touyz), where he investigated the involvement of Nrf2 in vascular dysfunction associated with hypertension.

Google Scholar


Research interests

Currently he works in the area of Cardiovascular Pharmacology with particular interest in vascular dysfunction associated with hypertension. Molecular mechanisms involving generation of ROS, apoptosis, calcium and sodium influx/channels and protein oxidation are currently been investigated in his work.


Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2012
Number of items: 26.

2019

Alves-Lopes, R. , Touyz, R. M. and Montezano, A. C. (2019) Cell biology of vessels. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 23-30. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_3)

2018

Neves, K. B. , Nguyen Dinh Cat, A., Alves-Lopes, R. , Harvey, K. Y., da Costa, R. M., Lobato, N. S., Montezano, A. C., Oliveira, A. M., Touyz, R. M. and Tostes, R. C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi:10.1152/ajpheart.00285.2018) (PMID:30216119)

Alves-Lopes, R. and Touyz, R. M. (2018) PARP-1 (poly[ADP-ribose] polymerase-1): a novel target in aortic aneurysm. Hypertension, 72(5), pp. 1087-1089. (doi:10.1161/HYPERTENSIONAHA.118.11830) (PMID:30354832) (PMCID:PMC6218001)

Neves, K. B. , Montezano, A. C., Alves-Lopes, R. , Bruder-Nascimento, T., Costa, R. M., Costa, R. S., Touyz, R. M. and Tostes, R. C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi:10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi:10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi:10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

Touyz, R. M. , Alves-Lopes, R. , Rios, F. J. , Camargo, L. L., Anagnostopoulou, A., Arner, A. and Montezano, A. C. (2018) Vascular smooth muscle contraction in hypertension. Cardiovascular Research, 114(4), pp. 529-539. (doi:10.1093/cvr/cvy023) (PMID:29394331) (PMCID:PMC5852517)

Souza-Silva, L., Alves-Lopes, R. , Silva Miguez, J., Dela Justina, V., Neves, K. B. , Mestriner, F. L., Tostes, R. C., Giachini, F. R. and Lima, V. V. (2018) Glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion/reactive oxygen species. Canadian Journal of Physiology and Pharmacology, 96(3), pp. 232-240. (doi:10.1139/cjpp-2017-0225) (PMID:28793197)

2017

Lucas-Herald, A. K. , Alves-Lopes, R. , Montezano, A. C., Ahmed, S. F. and Touyz, R. M. (2017) Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications. Clinical Science, 131(13), pp. 1405-1418. (doi:10.1042/CS20170090) (PMID:28645930) (PMCID:PMC5736922)

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F. , Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi:10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Carneiro, F. S., Alves-Lopes, R. , Neves, K. B. , Silva, M. A.B., Olivon, V. C., Ruginsk, S. G., Antunes-Rodrigues, J., Ramalho, L. N.Z. and Tostes, R. C. (2017) Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation. Asian Journal of Andrology, 19(5), pp. 526-532. (doi:10.4103/1008-682X.173935) (PMID:27391248) (PMCID:PMC5566844)

Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi:10.1007/978-1-4939-6625-7_27)

Montezano, A. C., Neves, K. B. , Lopes, R. A.M. and Rios, F. (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi:10.1007/978-1-4939-6625-7_26)

2016

Bruder-Nascimento, T. et al. (2016) NLRP3 inflammasome mediates aldosterone-induced vascular damage. Circulation, 134(23), pp. 1866-1880. (doi:10.1161/CIRCULATIONAHA.116.024369) (PMID:27803035)

Alves-Lopes, R. , Neves, K. B. , Montezano, A., Harvey, A., Carneiro, F. S., Touyz, R. and Tostes, R. C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi:10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)

Harvey, A., Montezano, A. C., Lopes, R. A. , Rios, F. and Touyz, R. (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Canadian Journal of Cardiology, 32(5), pp. 659-668. (doi:10.1016/j.cjca.2016.02.070) (PMID:27118293) (PMCID:PMC4906153)

Rios, F. J. , Lopes, R. A. , Neves, K. B., Camargo, L. L., Montezano, A. C. and Touyz, R. M. (2016) Off-target vascular effects of cholesteryl ester transfer protein inhibitors involve redox-sensitive and signal transducer and activator of transcription 3-dependent pathways. Journal of Pharmacology and Experimental Therapeutics, 357(2), pp. 415-422. (doi:10.1124/jpet.115.230748) (PMID:26941168)

Rios, F. J. , Harvey, A., Lopes, R. A. , Montezano, A. C. and Touyz, R. (2016) Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis. Hypertension, 67, pp. 272-274. (doi:10.1161/HYPERTENSIONAHA.115.06220) (PMID:26693817)

Rodrigues, F. L., Lopes, R. A. M. , Fais, R. S., de Oliveira, L., Prado, C. M., Tostes, R. C. and Carneiro, F. S. (2016) Erectile dysfunction in heart failure rats is associated with increased neurogenic contractions in cavernous tissue and internal pudendal artery. Life Sciences, 145, pp. 9-18. (doi:10.1016/j.lfs.2015.12.005) (PMID:26682935)

2015

Lopes, R. , Neves, K. , Tostes, R., Montezano, A. and Touyz, R. (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi:10.1161/hypertensionaha.115.06163) (PMID:26503970)

Silva, M. A. B. et al. (2015) Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus. Clinical Science, 129(7), pp. 533-545. (doi:10.1042/cs20140758) (PMID:25967696)

Silva, M. A.B., Bruder-Nascimento, T., Cau, S. B.A., Lopes, R. A.M. , Mestriner, F. L.A.C., Fais, R. S., Touyz, R. M. and Tostes, R. C. (2015) Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling. Frontiers in Physiology, 6, 269. (doi:10.3389/fphys.2015.00269)

2014

Emoto, N. et al. (2014) 25 years of endothelin research: the next generation. Life Sciences, 118(2), pp. 77-86. (doi:10.1016/j.lfs.2014.07.035) (PMID:25238993)

Matsumoto, T., Lopes, R. A.M. , Taguchi, K., Kobayashi, T. and Tostes, R. C. (2014) Linking the beneficial effects of current therapeutic approaches in diabetes to the vascular endothelin system. Life Sciences, 118(2), pp. 129-135. (doi:10.1016/j.lfs.2013.12.216) (PMID:24418002)

Lopes, R. A. M. , Neves, K. B. , Pestana, C. R., Queiroz, A. L., Zanotto, C. Z., Chignalia, A. Z., Valim, Y. M., Silveira, L. R., Curti, C. and Tostes, R. C. (2014) Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvement. American Journal of Physiology: Heart and Circulatory Physiology, 306(11), H1485-H1494. (doi:10.1152/ajpheart.00809.2013) (PMID:24658017)

2012

Lopes, R. A.M. , Neves, K. B. , Carneiro, F. S. and Tostes, R. C. (2012) Testosterone and vascular function in aging. Frontiers in Physiology, 3, 89. (doi:10.3389/fphys.2012.00089) (PMID:22514541) (PMCID:PMC3322529)

This list was generated on Fri Sep 20 07:12:13 2019 BST.
Number of items: 26.

Articles

Neves, K. B. , Nguyen Dinh Cat, A., Alves-Lopes, R. , Harvey, K. Y., da Costa, R. M., Lobato, N. S., Montezano, A. C., Oliveira, A. M., Touyz, R. M. and Tostes, R. C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi:10.1152/ajpheart.00285.2018) (PMID:30216119)

Alves-Lopes, R. and Touyz, R. M. (2018) PARP-1 (poly[ADP-ribose] polymerase-1): a novel target in aortic aneurysm. Hypertension, 72(5), pp. 1087-1089. (doi:10.1161/HYPERTENSIONAHA.118.11830) (PMID:30354832) (PMCID:PMC6218001)

Neves, K. B. , Montezano, A. C., Alves-Lopes, R. , Bruder-Nascimento, T., Costa, R. M., Costa, R. S., Touyz, R. M. and Tostes, R. C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi:10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi:10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi:10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

Touyz, R. M. , Alves-Lopes, R. , Rios, F. J. , Camargo, L. L., Anagnostopoulou, A., Arner, A. and Montezano, A. C. (2018) Vascular smooth muscle contraction in hypertension. Cardiovascular Research, 114(4), pp. 529-539. (doi:10.1093/cvr/cvy023) (PMID:29394331) (PMCID:PMC5852517)

Souza-Silva, L., Alves-Lopes, R. , Silva Miguez, J., Dela Justina, V., Neves, K. B. , Mestriner, F. L., Tostes, R. C., Giachini, F. R. and Lima, V. V. (2018) Glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion/reactive oxygen species. Canadian Journal of Physiology and Pharmacology, 96(3), pp. 232-240. (doi:10.1139/cjpp-2017-0225) (PMID:28793197)

Lucas-Herald, A. K. , Alves-Lopes, R. , Montezano, A. C., Ahmed, S. F. and Touyz, R. M. (2017) Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications. Clinical Science, 131(13), pp. 1405-1418. (doi:10.1042/CS20170090) (PMID:28645930) (PMCID:PMC5736922)

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F. , Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi:10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Carneiro, F. S., Alves-Lopes, R. , Neves, K. B. , Silva, M. A.B., Olivon, V. C., Ruginsk, S. G., Antunes-Rodrigues, J., Ramalho, L. N.Z. and Tostes, R. C. (2017) Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation. Asian Journal of Andrology, 19(5), pp. 526-532. (doi:10.4103/1008-682X.173935) (PMID:27391248) (PMCID:PMC5566844)

Bruder-Nascimento, T. et al. (2016) NLRP3 inflammasome mediates aldosterone-induced vascular damage. Circulation, 134(23), pp. 1866-1880. (doi:10.1161/CIRCULATIONAHA.116.024369) (PMID:27803035)

Alves-Lopes, R. , Neves, K. B. , Montezano, A., Harvey, A., Carneiro, F. S., Touyz, R. and Tostes, R. C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi:10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)

Harvey, A., Montezano, A. C., Lopes, R. A. , Rios, F. and Touyz, R. (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Canadian Journal of Cardiology, 32(5), pp. 659-668. (doi:10.1016/j.cjca.2016.02.070) (PMID:27118293) (PMCID:PMC4906153)

Rios, F. J. , Lopes, R. A. , Neves, K. B., Camargo, L. L., Montezano, A. C. and Touyz, R. M. (2016) Off-target vascular effects of cholesteryl ester transfer protein inhibitors involve redox-sensitive and signal transducer and activator of transcription 3-dependent pathways. Journal of Pharmacology and Experimental Therapeutics, 357(2), pp. 415-422. (doi:10.1124/jpet.115.230748) (PMID:26941168)

Rios, F. J. , Harvey, A., Lopes, R. A. , Montezano, A. C. and Touyz, R. (2016) Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis. Hypertension, 67, pp. 272-274. (doi:10.1161/HYPERTENSIONAHA.115.06220) (PMID:26693817)

Rodrigues, F. L., Lopes, R. A. M. , Fais, R. S., de Oliveira, L., Prado, C. M., Tostes, R. C. and Carneiro, F. S. (2016) Erectile dysfunction in heart failure rats is associated with increased neurogenic contractions in cavernous tissue and internal pudendal artery. Life Sciences, 145, pp. 9-18. (doi:10.1016/j.lfs.2015.12.005) (PMID:26682935)

Lopes, R. , Neves, K. , Tostes, R., Montezano, A. and Touyz, R. (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi:10.1161/hypertensionaha.115.06163) (PMID:26503970)

Silva, M. A. B. et al. (2015) Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus. Clinical Science, 129(7), pp. 533-545. (doi:10.1042/cs20140758) (PMID:25967696)

Silva, M. A.B., Bruder-Nascimento, T., Cau, S. B.A., Lopes, R. A.M. , Mestriner, F. L.A.C., Fais, R. S., Touyz, R. M. and Tostes, R. C. (2015) Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling. Frontiers in Physiology, 6, 269. (doi:10.3389/fphys.2015.00269)

Emoto, N. et al. (2014) 25 years of endothelin research: the next generation. Life Sciences, 118(2), pp. 77-86. (doi:10.1016/j.lfs.2014.07.035) (PMID:25238993)

Matsumoto, T., Lopes, R. A.M. , Taguchi, K., Kobayashi, T. and Tostes, R. C. (2014) Linking the beneficial effects of current therapeutic approaches in diabetes to the vascular endothelin system. Life Sciences, 118(2), pp. 129-135. (doi:10.1016/j.lfs.2013.12.216) (PMID:24418002)

Lopes, R. A. M. , Neves, K. B. , Pestana, C. R., Queiroz, A. L., Zanotto, C. Z., Chignalia, A. Z., Valim, Y. M., Silveira, L. R., Curti, C. and Tostes, R. C. (2014) Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvement. American Journal of Physiology: Heart and Circulatory Physiology, 306(11), H1485-H1494. (doi:10.1152/ajpheart.00809.2013) (PMID:24658017)

Lopes, R. A.M. , Neves, K. B. , Carneiro, F. S. and Tostes, R. C. (2012) Testosterone and vascular function in aging. Frontiers in Physiology, 3, 89. (doi:10.3389/fphys.2012.00089) (PMID:22514541) (PMCID:PMC3322529)

Book Sections

Alves-Lopes, R. , Touyz, R. M. and Montezano, A. C. (2019) Cell biology of vessels. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 23-30. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_3)

Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi:10.1007/978-1-4939-6625-7_27)

Montezano, A. C., Neves, K. B. , Lopes, R. A.M. and Rios, F. (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi:10.1007/978-1-4939-6625-7_26)

This list was generated on Fri Sep 20 07:12:13 2019 BST.