Dr Rheure Lopes
- Research Associate (Institute of Cardiovascular & Medical Sciences)
Bachelor degree in nursing program from the Federal University of Mato Grosso - Brazil. During the master course in Biological Sciences (Pharmacology) at the Medical School of Ribeirao Preto (FMRP) – University of Sao Paulo (USP), he evaluated the role of Reactive Oxygen Species in apoptosis of vascular cells induced by testosterone. During his PhD at the FMRP-USP, it was investigated the role of nuclear factor E2–related factor 2 (Nrf2) downregulation, consequent to increased nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1)-derived reactive oxygen species (ROS), in impaired internal pudendal artery function in Diabetes. A one year PhD internship was done at the University of Glasgow (under the supervision of Prof Dr Rhian Touyz), where he investigated the involvement of Nrf2 in vascular dysfunction associated with hypertension.
Currently he works in the area of Cardiovascular Pharmacology with particular interest in vascular dysfunction associated with hypertension. Molecular mechanisms involving generation of ROS, apoptosis, calcium and sodium influx/channels and protein oxidation are currently been investigated in his work.