Dr Rheure Lopes

  • Research Associate (Institute of Cardiovascular & Medical Sciences)

Biography

Bachelor degree in nursing program from the Federal University of Mato Grosso - Brazil. During the master course in Biological Sciences (Pharmacology) at the Medical School of Ribeirao Preto (FMRP) – University of Sao Paulo (USP), he evaluated the role of Reactive Oxygen Species in apoptosis of vascular cells induced by testosterone. During his PhD at the FMRP-USP, it was investigated the role of nuclear factor E2–related factor 2 (Nrf2) downregulation, consequent to increased nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1)-derived reactive oxygen species (ROS), in impaired internal pudendal artery function in Diabetes. A one year PhD internship was done at the University of Glasgow (under the supervision of Prof Dr Rhian Touyz), where he investigated the involvement of Nrf2 in vascular dysfunction associated with hypertension.

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Research interests

Currently he works in the area of Cardiovascular Pharmacology with particular interest in vascular dysfunction associated with hypertension. Molecular mechanisms involving generation of ROS, apoptosis, calcium and sodium influx/channels and protein oxidation are currently been investigated in his work.


Publications

List by: Type | Date

Jump to: 2018 | 2017
Number of items: 5.

2018

Neves, K. B. , Montezano, A. C., Alves-Lopes, R. , Bruder-Nascimento, T., Costa, R. M., Costa, R. S., Touyz, R. M. and Tostes, R. C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi:10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)

Neves, K. B. , Rios, F. J., Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi:10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

2017

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F., Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi:10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi:10.1007/978-1-4939-6625-7_27)

Montezano, A. C., Neves, K. B. , Lopes, R. A.M. and Rios, F. (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi:10.1007/978-1-4939-6625-7_26)

This list was generated on Mon May 20 20:17:47 2019 BST.
Number of items: 5.

Articles

Neves, K. B. , Montezano, A. C., Alves-Lopes, R. , Bruder-Nascimento, T., Costa, R. M., Costa, R. S., Touyz, R. M. and Tostes, R. C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi:10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)

Neves, K. B. , Rios, F. J., Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi:10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F., Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi:10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Book Sections

Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi:10.1007/978-1-4939-6625-7_27)

Montezano, A. C., Neves, K. B. , Lopes, R. A.M. and Rios, F. (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi:10.1007/978-1-4939-6625-7_26)

This list was generated on Mon May 20 20:17:47 2019 BST.