Our infrastructure for research has been substantially enhanced by the commissioning in 2006 of the BHF Glasgow Cardiovascular Research Centre (BHF GCRC). This state-of-the art facility was developed as a result of an award of £5M from the BHF, and a substantial fundraising effort from the University of Glasgow (circa £10M). It provides 7,700 m2 of laboratory space, animal research accommodation, and a dedicated Clinical Research Facility. The bulk of the academics and labs are located within the BHF GCRC, with others in the close-by West Medical & Davidson Buildings. Glasgow Royal Infirmary and the Golden Jubilee National hospitals also house clinical staff and associated facilities.
The laboratories are well resourced with major research facilities including:
- Optical Imaging Facilities - Wide field rapid imaging (>1KHz), single-photon and two-photon confocal microscopes and FRET/BRET microscope systems are all supported for both cell biology and biophysics projects
- Magnetic Resonance Imaging/Spectroscopy - BHF-funded 3.0 Tesla Siemens MRI Scanner dedicated to research is housed within the BHF GCRC (BHF MRI Facility). The near-by Glasgow Experimental MRI centre has two high field 7.0 Tesla small bore scanners (Pharmascan 7T and Biospin) for imaging and spectroscopy
- Cell Biology Facilities - The labs have extensive containment facilities that support cell and gene therapy projects. These facilities support many cutting edge cell biology projects
- In Vivo/Surgical Facilities - There are several units including one located in the BHF GCRC, these suites support a range of surgical/ in vivo procedures.
- High Throughput Genotyping - Our Institute (ICAMS) supports an Illumina Beadarray Scanner that can process up to 610,000 SNPs for detecting metabolic/cardiovascular/atherosclerotic disease traits and an OpenArray system currently used to validate SNP loci (16 to 256 SNPs) identified from GWAS data (20,000 patient samples) and also offers the ability to carry out genome-wide microRNA screens.
The BHF GCRC is linked directly to the Glasgow Biomedical Research Centre providing labs for Inflammation, Infection and Immunity. The building houses facilities for radioisotope tracer development, and stable isotope detection by mass spectroscopy. In an MRC-funded protein purification facility there is an Envision multiplate system, to produce active recombinant protein and develop enzyme assays suitable for High Throughput Screens HTS; fluorescence, fluorescence polarisation, colorimetic etc).