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Scientific Programme

FRIDAY 21st MAY 2021

13.00- 13.10 Welcome
Sally Marshall, President of EDNSG
13.10-13.30

Rising Star Lecture: Hiddo Lambers Heerspink, University of Groningen
Clinical trials in diabetic kidney disease: from one-size-fits-all to one-fit-for-everyone
Chair: Sally Marshall

SESSION 1 PODOCYTES AND GLOMERULAR FILTRATION
Chairs: Gabriella Gruden and Simon Satchell
13.30-13.50 Overview Lecture: Simon Satchell, University of Bristol
Mechanisms of glomerular filtration and disruption in diabetic kidney disease
13.50-14.00  Horizontal Transfer of Mitochondria from Mesenchymal Stem Cells to Podocytes through Tunnelling Nanotubes – Federica Barutta
14.00-14.10  Reversal of diabetic nephropathy in humans after 10 years of pancreas transplantation despite podocyte loss – Paola Fioretto
14.10-14.20  IGF1R suppression in the glomerular podocyte has beneficial and detrimental consequences dependent on level of inhibition. – Jennifer Hurcombe
14.20-14.30  Novel compounds found to regulate VEGF-A alternative splicing in diabetic podocytes – Monica Lamici Ayine
14.30-14.35 BREAK
SESSION 2 CARDIOVASCULAR ASPECTS OF DIABETIC KIDNEY DISEASE
Chairs: Daniel Gordin and Petter Bjørnstad
14.35-14.55 Invited Lecture: Rhian Touyz, University of Glasgow
Oxidative stress in diabetic kidney disease: preclinical research and translation to the clinic
14.55-15.05  Impact of microvascular burden on death in patients with diabetes hospitalized for coronavirus disease-2019 (COVID-19): the CORONADO study – Samy Hadjadj
15.05-15.15  Prognosis after first-ever myocardial infarction in type 1 diabetes is strongly affected by diabetic kidney disease – Patrik Smidtslund
15.15-15.25 Reduced levels of the anti-ageing hormone Klotho are associated with increased aortic stiffness in people with type 2 diabetes and kidney disease – Nikolaos Fountoulakis
15.25-15.35 Kidney hemodynamic profile and systemic vascular function in adults with type 2 diabetes: analyses of four clinical trials – Anna Hesp
15.35-15.40 BREAK
15.40-16.40 POSTER SESSION
Chairs: Federica Barutta and Hiddo Lambers Heerspink
Poster 1 Epigenetic analyses of diabetic kidney disease attributed to type 1 diabetes in European populations – Laura Smyth
Poster 2 Role of alternative splicing of the apoptosis gene, Bcl-x, in the pathogenesis of diabetic nephropathy – Megan Stevens
Poster 3 No association between blood glucose control and cerebrovascular disease in neurologically asymptomatic individuals with type 1 diabetes without severe DKD – Jussi Inkeri
Poster 4 Liraglutide downregulates ceramides and phospholipids: Results from the LiraFlame Randomized Controlled Trial – Emilie Zobel
Poster 5 Endothelial glycocalyx dimensions and cardiovascular risk factors in type 1 diabetes – Elisabeth Buur Stougaard
Poster 6 The emerging role of the mTORC2/Rictor signaling axis in autophagy dysregulation and diabetic kidney disease – Sahar Alkhansa
Poster 7 Sodium-glucose co-transporter 2 inhibition does not alter the pressure natriuretic response in Sprague Dawley rats – Natalie Jones
Poster 8 Identification of glomerular and cell type selective transcriptome changes in a hypertension-accelerated db/db mouse model of diabetic kidney disease – Frederikke Sembach
Poster 9 Urinary proteome and diabetic retinopathy in the Direct-Protect 1 and 2 trials – Viktor Rotbain Curovic
Poster 10 Identification of splice variants of human Nop-7-associated 2 (NSA2) and their potential role in diabetic nephropathy – Minjie Zhang
16.40-16.45 BREAK
SESSION 3 OMICS AND DIABETIC KIDNEY DISEASE
Chairs: Niina Sandholm and Matthias Kretzler
16.45-17.05 Overview Lecture: Matthias Kretzler, University of Michigan
Integrating -omics data  to develop targeted therapies for DKD across data types and continents
17.05-17.15 Transcriptomic pathway analysis points to enhancement of tubular fatty acid b-oxidation as a dominant response to intensive weight and metabolic control in experimental diabetic kidney disease – William Martin
17.15-17.25 Urinary complement proteome and 10-year risk of kidney failure in Type 1 diabetes – Zaipul I. Md Dom
17.25-17.35 Understanding molecular changes in diabetic kidney disease, using transcriptomics and proteomics in cell models – Abigail Lay
17.35-17.45 Urinary extracellular vesicles in diabetic kidney disease: Assessment of pre-analytical variables and development of a quality control targeting transcriptomic biomarker studies – Karina Barreiro
17.45-18.00 33rd Annual general meeting of the EDNSG

 

SATURDAY 22nd MAY 2021

08.30-08.40 Welcome
Sally Marshall, President of EDNSG
SESSION 4 NOVEL PATHWAYS AND THERAPEUTIC ASPECTS
Chairs: Karin Jandeleit-Dahm and Christian Delles
08.40-09.00 Invited Lecture: Roland Schmieder, University of Erlangen
Device-based interventions for chronic kidney disease and diabetic nephropathy
09.00-09.10 Early mineralocorticoid receptor antagonism in diabetic nephropathy limits albuminuria by preserving the glomerular endothelial glycocalyx – Michael Crompton
09.10-09.20 Dapagliflozin acutely improves renal cortical oxygenation in individuals with Type 1 diabetes and albuminuria– Jens Christian Laursen
09.20-09.30 sNogo-B upregulates Tie-1 receptor: implication for VEGFA/VEGFR2 signalling in diabetic nephropathy – Carlo Ricciardi
09.30-09.40 Periodic fasting and diabetic nephropathy: a prospective randomized controlled study in patients with type 2 diabetes – Alba Sulaj
09.40-09.45 BREAK
SESSION 5 FROM INFLAMMATION TO FIBROSIS
Chairs: Samy Hadjadj and Frederik Persson
09.45-10.05 Invited Lecture: Nuria Montserrat, Institute for Bioengineering Catalonia
Stem cells and organoids: New avenues in diabetic nephropathy research
10.05-10.15 Youth-onset Type 2 diabetes is associated with more deVere structural lesions on kidney biopsy than adult-onset Type 2 diabetes – Petter Bjornstad
10.15-10.25 Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo – Sonja Lindfors
10.25-10.35 NETosis Contributes to the Pathogenesis of Diabetic Kidney Disease: Proposed Mechanistic Pathway – Rachel Njeim
10.35-10.45 Calpain-mediated autophagy blockade enhances renal injury in diabetes and hypertension – Olivia Lenoir
10.45-10.50 BREAK
SESSION 6 RENAL FUNCTION AND RAPID RENAL FUNCTION DECLINE
Chairs: Gemma Currie and Luigi Gnudi
10.50-11.10 Overview Lecture: Mark Cooper, University of Melbourne
Early management of progressive renal disease in diabetes
11.10-11.20 High plasma concentrations of folic acid are associated with increased risk of graft failure in renal transplant recipients with Type 2 diabetes – Jose L. Flores-Guerrero
11.20-11.30 Diagnostic performance of four estimation equations of glomerular filtration rate in determining chronic kidney disease stage in adults with diabetes – Neda Zafari
11.30-11.40 The impact of central obesity on the association between liver fat fraction and albuminuria – Erika B Parente
11.40-11.50 African-Caribbean ethnicity increases the risk of kidney disease progression in people with type 1 diabetes  – Antonella Corcillo
11.50-12.00

Closing Session
Chair: Sally Marshall


Best Communication Prizes
Closing remarks