CSO Chief Scientist Office
- CISCO-21 - Prevention and early treatment of COVID-19 long term effects: a randomised clinical trial of resistance exercise. Professor Colin Berry and team have been awarded a Project Grant to examine therapy approaches to Long COVID. The study will do two things:
- Undertake a research trial of pragmatic resistance-based exercise for 220 people recovering from COVID-19.
- Create a platform for rapid trials of new treatments after COVID-19. This will cut the costs of doing future trials and allow more patients the opportunity to contribute to medical research that will improve outcomes for people recovering from COVID19.
- Award of £286,660
- (CISCO-19) Cardiovascular Imaging in SARS Coronavirus disease-19. Professor Colin Berry is leading CISCO-19 which will study which patients are at-risk of heart injury and why only some patients suffer heart problems with Covid-19. Our ‘Rapid Coronarvirus Research’ aims to immediately clarify the links between the heart and lung injury and related risk factors. Our research will support the development of novel preventive therapies. MRI scan costs in-kind. Applicants: Dr R Wereski, Clinical Fellow, UofE; Dr D Lowe, Clinical Informatics/A&E; Dr C Church, Pulmonary Vasc Disease; Dr K Mangion, Lecturer, Cardiology; Dr A Ho, MRC Centre for Virus Research; Dr G Roditi, Radiologist; Dr C Bagot, Haemostasis; Dr S Wright, Cardiac Pathologist; Prof A McConnachie, Robertson Centre for Biostatistics; Profs R Touyz, C Delles, N Sattar, Vasc Biomedicine - all Consultants NHS Greater Glasgow and Clyde Health Board / University of Glasgow. Award - £48, 618.
- OBELIX Study - Hypertension, inhibitors of the renin angiotensin system and Covid-19. Professor Rhian Touyz is leading the OBELIX Study which aims to look closely at the health of the vascular system of patients after being treated in hospital for COVID-19 (confirmed by PCR test) and compare them to patients who had a hospital admission for suspected COVID-19 (negative PCR test). See our project page for more information - £79,846.
- LONG TERM EFFECTS OF COVID-19 Project Grant: Prevention And Early Treatment Of COVID-19 Long Term Effects: A Randomised Clinical Trial Of Resistance Exercise. PI Professor Colin Berry, CoAs - David Anderson, Hannah Bayes, John Cleland, Stuart Gray, Tracy Ibbotson, Chim Lang, Kenneth Mangion, Frances Mair, Alex McConnachie, Naveed Sattar, Rod Taylor. Started 01.03.2021 for 2 years. Award - £286,660
- Longer term impact of COVID-19 infection people with diabetes. PI Dr Robbie Lindsay is leading this study, which aims to investigate whether people with diabetes have increased susceptibility to the longer term consequences of COVID-19. Award - £295,201
- Effects of COVID-19 Pandemic on Diabetes Risks and Outcomes In UK. Professor Naveed Sattar is leading the collaborative work on this grant which will highlight areas of diabetes care that need urgent attention to reduce risk of complications/inform strategies for future pandemics. See the project page for more information.
- EPSRC Impact Acceleration Account. “Cardiac endotypes in COVID-19: quantification and mechanisms of cardiac injury”. Xiaoyu Luo, Nicholas Hill, Colin Berry, Kenneth Mangion, Hao Gao, Dirk Husmeier. Award - £48,304, for 12 months from 1 January 2021.
Heart Research UK
- Longer-term effects of COVID-19 infection on blood vessels and blood pressure. Professor Sandosh Padmanabhan is leading the HRUK-funded study into the links between COVID-19 infection and high blood pressure which may help to improve the long-term outcomes for survivors of COVID-19.
- PHOSP-COVID: Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes. Professor Colin Berry is a partner in the £8.4million PHOSP-COVID Study which will investigate the physical and mental health impacts of hospitalised patients. Patients on the study will be assessed using techniques such as advanced imaging, data collection and analysis of blood and lung samples, creating a comprehensive picture of the impact COVID-19 has on longer term health outcomes. Follow PHOSP-COVID Study updates on Twitter.
- The COVID-HEART Study: Demographic, multi-morbidity and genetic impact on myocardial involvement and itsrecovery from COVID-19. Professor Colin Berry is Co-I on the COVID-HEART Study which, using an MRI scan of the heart, aims to investigate how often, and in what way, the heart becomes damaged, and how the heart recovers 6 months later. Award - £775,096
Wellcome Trust ISSF
- Developing COVID19 inhibitor peptides of the ACE2 – Spike Protein complex. Congratulations to PhD Student Connor Blair from the Baillie Lab on being awarded this Wellcome Trust ISSF grant and who is leading the project. For more information, see the project page.
- ACE2 signalling and host responses to SARS-CoV-2 in vascular cells - implications in cardiovascular toxicities in COVID-19. Congratulations to Dr Augusto Montezano on being awarded this grant and who is leading this collaborative project.
- A vascular biology sub-study nested in the Cardiovascular Imaging in SARS-CoV-2 (COVID-19) (CISCO-19) project. Congratulations to Dr Kenneth Mangion on being awarded this grant and who is leading the sub-study. Mangion K, Nicklin S, Touyz RM, Berry C. Award 312029-01 - £10,000 1.8.20 – 31.1.21
- Effects of Type I and Type III IFN on ACE2 and the immune response in vascular cells: implications in SARS-CoV-2 infection. Congratulations to Dr Francisco Rios on being awarded this grant and who is leading the project.
- Host Mitochondria dysfunction by viral hijacking as a key pathogenicity mechanism in COVID-19. Congratulations to Dr Ian Salt, CoI on this project, led by Prof Kostas Tokatlidis.