Middle-aged men with multimorbidity at greatest risk of death

Issued: Wed, 14 Mar 2018 13:54:00 GMT

Multimorbidity – the presence of two or more long-term health conditions – has a greater impact on risk of all causes of death in middle aged men, as opposed to older populations, according to new research.

The study, led by GPPC and published in BMC Medicine, found that multimorbidity is associated with a higher risk of death from cancer, vascular conditions and all causes of death – even after accounting for lifestyle or demographic factors. The effect of multiple long-term conditions (LTCs) on higher mortality risk was largest among men between 37-49 years.

The study used the UK Biobank cohort and found that the type of LTC, as opposed to the number of LTC, may have an important role to play in understanding the relationship between multimorbidity and death.

Corresponding author Professor Frances Mair, said:

“This is the first study to examine the relationship of multimorbidity with cancer mortality and we have shown a dose-response relationship between number of LTCs and cancer mortality.”

Lead author Dr Bhautesh Jani, said:

“Younger participants, especially men, were observed to have a relatively higher risk of mortality with increasing number of LTCs, and that certain combinations of conditions were associated with a particularly higher risk of death. Going forward, further research is needed to study the impact and management of multimorbidity in middle aged adults, as they may be at higher risk of early death.”   

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