Dr Xu Huang

  • Lecturer (Paul O'Gorman Leukaemia Research Centre)

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • PROJECT S19-13 - A pre-clinical study to validate an epigenetic based therapy for precision medicine of acute myeloid leukaemia (AML)
    Tenovus Scotland
    2019 - 2021
     
  • Delineation of the critical epigenetic regulatory machinery selective for acute myeloid leukaemia stem cell function
    Leuka
    2016 - 2018
     
  • ISSF Catalyst: Identification & validation of downstream targets of the histone demethylase KDM4A(JMJD2A) in Acute Myeloid Leukaemia (AML)
    Wellcome Trust
    2015 - 2016
     

Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2015 | 2014 | 2013 | 2012 | 2011 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2000
Number of items: 28.

2019

Monaghan, L., Massett, M. E., Bunschoten, R. P., Hoose, A. , Pirvan, P.-A., Liskamp, R. M. , Jørgensen, H. G. and Huang, X. (2019) The emerging role of H3K9me3 as a potential therapeutic target in acute myeloid leukaemia. Frontiers in Oncology, (Accepted for Publication)

Anselmi, L. et al. (2019) Targeting Metabolic Vulnerabilities and Aberrant Signal Transduction Pathways in Paediatric T‐cell Acute Lymphoblastic Leukaemia (T‐ALL). 59th Annual Scientific Meeting of the British Society for Hematology, Glasgow, UK, 1-3 April 2019.

Massett, M. E., Michie, A. M., Vetrie, D. and Huang, X. (2019) Targeting H3K9me3 as Novel Therapeutic Strategy in MLLr‐AML. 59th Annual Scientific Meeting of the British Society for Hematology, Glasgow, UK, 1-3 April 2019.

2018

Massett, M. E., Mannion, N., Monaghan, L., Bittencourt-Silvestre, J., Marmiroli, S., Liskamp, R. M.J., Michie, A. M., Vetrie, D. and Huang, X. (2018) The Histone Demethylase KDM4A Is Required to Sustain H3K9me3/H3K27me3 Epigenetic States and Oncogenesis in MLL-AF9 Acute Myeloid Leukemia. 60th ASH Annual Meeting, San Diego, CA, USA, 1-4 Dec 2018.

2017

Jackson, L. , Gómez-Castañeda, E., Jørgensen, H. G., Hopcroft, L. E.M. , Rogers, S. , Holyoake, T. L. and Huang, X. (2017) Oncogene addiction in chronic myeloid leukaemia. In: eLS. John Wiley & Sons, Ltd, pp. 1-9. ISBN 9780470015902 (doi:10.1002/9780470015902.a0024464)

2015

Somerville, T. D.D., Wiseman, D. H., Spencer, G. J., Huang, X. , Lynch, J. T., Leong, H. S., Williams, E. L., Cheesman, E. and Somervaille, T. C.P. (2015) Frequent derepression of the mesenchymal transcription factor gene FOXC1 in acute myeloid leukemia. Cancer Cell, 28(3), pp. 329-342. (doi:10.1016/j.ccell.2015.07.017) (PMID:26373280)

Jude, J.G., Spencer, G.J., Huang, X. , Somerville, T.D.D., Jones, D.R., Divecha, N. and Somervaille, T.C.P. (2015) A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival. Oncogene, 34, pp. 1253-1262. (doi:10.1038/onc.2014.77) (PMID:24681948)

2014

Lynch, J. T., Spencer, G. J., Harris, W. J., Maiques-Díaz, A., Ciceri, F., Huang, X. and Somervaille, T. C.P. (2014) Pharmacological Inhibitors of LSD1 Promote Differentiation of Myeloid Leukemia Cells through a Mechanism Independent of Histone Demethylation. 56th ASH Annual Meeting, San Francisco, CA, USA, 6-9 Dec 2014.

Somerville, T. D.D., Huang, X. , Lynch, J. T., Spencer, G. J. and Somervaille, T. C.P. (2014) FOXC1 Is Derepressed to Functional Effect in Human Acute Myeloid Leukemia. 56th ASH Annual Meeting, San Francisco, CA, USA, 6-9 Dec 2014.

Flume, R., Huang, X. , Ramazzotti, G., Mongiorgi, S., Santi, P., Somervaille, T. C.P. and Divecha, N. (2014) Phospholipase C beta 1 (PLCb1) in Acute Myeloid Leukemia (AML): A Novel Potential Therapeutic Target. 68th Meeting of the Italian Society of Anatomy and Histology, Ancona, Italy, 18-20 Sept 2014.

Huang, X. , Spencer, G. J., Lynch, J.T., Ciceri, F., Somerville, T.D.D. and Somervaille, T.C.P. (2014) Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells. Leukemia, 28(5), pp. 1081-1091. (doi:10.1038/leu.2013.316)

2013

Greystoke, B. F., Huang, X. , Wilks, D. P., Atkinson, S. and Somervaille, T. C. P. (2013) Very high frequencies of leukaemia-initiating cells in precursor T-acute lymphoblastic leukaemia may be obscured by cryopreservation. British Journal of Haematology, 163(4), pp. 538-541. (doi:10.1111/bjh.12511)

Lynch, J.T., Somerville, T.,D.,D.,, Spencer, G.,J.,, Huang, X. and Somervaille, T.C.P. (2013) TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell Death and Disease, 4(4), e573. (doi:10.1038/cddis.2013.107)

2012

Huang, X. and Somervaille, T. C.P. (2012) Enhancers of Polycomb EPC1 and EPC2 Prevent Accumulation of MYC to Sustain the Oncogenic Potential of MLL Leukemia Stem Cells. 54th ASH Annual Meeting, Atlanta, GA, USA, 8-11 Dec 2012.

Harris, W. J. et al. (2012) The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell, 21(4), pp. 473-487. (doi:10.1016/j.ccr.2012.03.014)

2011

Harris, W. J., Huang, X. , Lynch, J. T. and Somervaille, T. C.P. (2011) Pharmacological Inhibition or Genetic Knockdown of Kdm1a (Lsd1 or Aof2) Induces Differentiation of MLL Acute Myeloid Leukaemia Stem Cells. 53rd ASH Annual Meeting, San Diego, CA, USA, 10-13 Dec 2011.

2008

Huang, X. , Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., Mcburnie, W., Fleming, S. and Alessi, D. R. (2008) Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochemical Journal, 412(2), pp. 211-221. (doi:10.1042/BJ20080557)

2007

Huang, X. , Pearce, L. R., Boudeau, J., Pawłowski, R., Wullschleger, S., Deak, M., Ibrahim, A. F. M., Gourlay, R., Magnuson, M. A. and Alessi, D. R. (2007) Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochemical Journal, 405(3), p. 513. (doi:10.1042/BJ20070540)

2006

Gärtner, A., Huang, X. and Hall, A. (2006) Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3β) independently of Akt/PKB serine phosphorylation. Journal of Cell Science, 119(19), pp. 3927-3934. (doi:10.1242/​jcs.03159)

2005

Huang, X. , Lipina, C., Finlay, D., McManus, E. J., Alessi, D. R. and Sutherland, C. (2005) Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3. Biochemical Journal, 392(3), pp. 633-639. (doi:10.1042/BJ20051046)

Zhao, Y., Shi, Y., Zhao, W., Huang, X. , Wang, D., Brown, N., Brand, J. and Zhao, J. (2005) CcbP, a calcium-binding protein from Anabaena sp. PCC 7120, provides evidence that calcium ions regulate heterocyst differentiation. Proceedings of the National Academy of Sciences of the United States of America, 102(16), pp. 5744-5748. (doi:10.1073/pnas.0501782102)

2004

Huang, X. , Dong, Y. and Zhao, J. (2004) HetR homodimer is a DNA-binding protein required for heterocyst differentiation, and the DNA-binding activity is inhibited by PatS. Proceedings of the National Academy of Sciences of the United States of America, 101(14), pp. 4848-4853. (doi:10.1073/pnas.0400429101)

2003

Yang, J., Dong, C., Huang, X. and Zhao, J. (2003) Sulfonation of polyvinylidene difluoride resin and its application in extraction of restriction enzymes from DNA digestion solutions. Analytical Biochemistry, 322(1), pp. 99-103. (doi:10.1016/S0003-2697(03)00463-9)

2002

Li, T., Huang, X. , Zhou, R., Liu, Y., Li, B., Nomura, C. and Zhao, J. (2002) Differential expression and localization of Mn and Fe superoxide dismutases in the heterocystous cyanobacterium Anabaena sp. strain PCC 7120. Journal of Bacteriology, 184(18), pp. 5096-5103. (doi:10.1128/JB.184.18.5096-5103.2002)

Ying, L., Huang, X. , Huang, B., Xie, J., Zhao, J. and Sheng Zhao, X. (2002) Fluorescence emission and absorption spectra of single Anabaena sp. strain PCC7120 cells. Photochemistry and Photobiology, 76(3), pp. 310-313. (doi:10.1562/0031-8655(2002)0760310FEAASO2.0.CO2)

Ying, L.-Z., Huang, X. , Huang, B., Zhao, J.-D. and Zhao, X.-S. (2002) Spectra of single cyanobacterial cells. Acta Physico-Chimica Sinica, 18(8), pp. 673-675.

Li, B., Huang, X. and Zhao, J. (2002) Expression of hetN during heterocyst differentiation and its inhibition of hetR up-regulation in the cyanobacterium Anabaena sp. PCC 7120. FEBS Letters, 517(1-3), pp. 87-91. (doi:10.1016/S0014-5793(02)02582-6)

2000

Dong, Y., Huang, X. , Wu, X.-Y. and Zhao, J. (2000) Identification of the active site of HetR protease and its requirement for heterocyst differentiation in the cyanobacterium Anabaena sp. strain PCC 7120. Journal of Bacteriology, 182(6), pp. 1575-1579. (doi:10.1128/JB.182.6.1575-1579.2000)

This list was generated on Thu Sep 19 12:11:28 2019 BST.
Number of items: 28.

Articles

Monaghan, L., Massett, M. E., Bunschoten, R. P., Hoose, A. , Pirvan, P.-A., Liskamp, R. M. , Jørgensen, H. G. and Huang, X. (2019) The emerging role of H3K9me3 as a potential therapeutic target in acute myeloid leukaemia. Frontiers in Oncology, (Accepted for Publication)

Somerville, T. D.D., Wiseman, D. H., Spencer, G. J., Huang, X. , Lynch, J. T., Leong, H. S., Williams, E. L., Cheesman, E. and Somervaille, T. C.P. (2015) Frequent derepression of the mesenchymal transcription factor gene FOXC1 in acute myeloid leukemia. Cancer Cell, 28(3), pp. 329-342. (doi:10.1016/j.ccell.2015.07.017) (PMID:26373280)

Jude, J.G., Spencer, G.J., Huang, X. , Somerville, T.D.D., Jones, D.R., Divecha, N. and Somervaille, T.C.P. (2015) A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival. Oncogene, 34, pp. 1253-1262. (doi:10.1038/onc.2014.77) (PMID:24681948)

Huang, X. , Spencer, G. J., Lynch, J.T., Ciceri, F., Somerville, T.D.D. and Somervaille, T.C.P. (2014) Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells. Leukemia, 28(5), pp. 1081-1091. (doi:10.1038/leu.2013.316)

Greystoke, B. F., Huang, X. , Wilks, D. P., Atkinson, S. and Somervaille, T. C. P. (2013) Very high frequencies of leukaemia-initiating cells in precursor T-acute lymphoblastic leukaemia may be obscured by cryopreservation. British Journal of Haematology, 163(4), pp. 538-541. (doi:10.1111/bjh.12511)

Lynch, J.T., Somerville, T.,D.,D.,, Spencer, G.,J.,, Huang, X. and Somervaille, T.C.P. (2013) TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell Death and Disease, 4(4), e573. (doi:10.1038/cddis.2013.107)

Harris, W. J. et al. (2012) The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell, 21(4), pp. 473-487. (doi:10.1016/j.ccr.2012.03.014)

Huang, X. , Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., Mcburnie, W., Fleming, S. and Alessi, D. R. (2008) Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochemical Journal, 412(2), pp. 211-221. (doi:10.1042/BJ20080557)

Huang, X. , Pearce, L. R., Boudeau, J., Pawłowski, R., Wullschleger, S., Deak, M., Ibrahim, A. F. M., Gourlay, R., Magnuson, M. A. and Alessi, D. R. (2007) Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochemical Journal, 405(3), p. 513. (doi:10.1042/BJ20070540)

Gärtner, A., Huang, X. and Hall, A. (2006) Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3β) independently of Akt/PKB serine phosphorylation. Journal of Cell Science, 119(19), pp. 3927-3934. (doi:10.1242/​jcs.03159)

Huang, X. , Lipina, C., Finlay, D., McManus, E. J., Alessi, D. R. and Sutherland, C. (2005) Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3. Biochemical Journal, 392(3), pp. 633-639. (doi:10.1042/BJ20051046)

Zhao, Y., Shi, Y., Zhao, W., Huang, X. , Wang, D., Brown, N., Brand, J. and Zhao, J. (2005) CcbP, a calcium-binding protein from Anabaena sp. PCC 7120, provides evidence that calcium ions regulate heterocyst differentiation. Proceedings of the National Academy of Sciences of the United States of America, 102(16), pp. 5744-5748. (doi:10.1073/pnas.0501782102)

Huang, X. , Dong, Y. and Zhao, J. (2004) HetR homodimer is a DNA-binding protein required for heterocyst differentiation, and the DNA-binding activity is inhibited by PatS. Proceedings of the National Academy of Sciences of the United States of America, 101(14), pp. 4848-4853. (doi:10.1073/pnas.0400429101)

Yang, J., Dong, C., Huang, X. and Zhao, J. (2003) Sulfonation of polyvinylidene difluoride resin and its application in extraction of restriction enzymes from DNA digestion solutions. Analytical Biochemistry, 322(1), pp. 99-103. (doi:10.1016/S0003-2697(03)00463-9)

Li, T., Huang, X. , Zhou, R., Liu, Y., Li, B., Nomura, C. and Zhao, J. (2002) Differential expression and localization of Mn and Fe superoxide dismutases in the heterocystous cyanobacterium Anabaena sp. strain PCC 7120. Journal of Bacteriology, 184(18), pp. 5096-5103. (doi:10.1128/JB.184.18.5096-5103.2002)

Ying, L., Huang, X. , Huang, B., Xie, J., Zhao, J. and Sheng Zhao, X. (2002) Fluorescence emission and absorption spectra of single Anabaena sp. strain PCC7120 cells. Photochemistry and Photobiology, 76(3), pp. 310-313. (doi:10.1562/0031-8655(2002)0760310FEAASO2.0.CO2)

Ying, L.-Z., Huang, X. , Huang, B., Zhao, J.-D. and Zhao, X.-S. (2002) Spectra of single cyanobacterial cells. Acta Physico-Chimica Sinica, 18(8), pp. 673-675.

Li, B., Huang, X. and Zhao, J. (2002) Expression of hetN during heterocyst differentiation and its inhibition of hetR up-regulation in the cyanobacterium Anabaena sp. PCC 7120. FEBS Letters, 517(1-3), pp. 87-91. (doi:10.1016/S0014-5793(02)02582-6)

Dong, Y., Huang, X. , Wu, X.-Y. and Zhao, J. (2000) Identification of the active site of HetR protease and its requirement for heterocyst differentiation in the cyanobacterium Anabaena sp. strain PCC 7120. Journal of Bacteriology, 182(6), pp. 1575-1579. (doi:10.1128/JB.182.6.1575-1579.2000)

Book Sections

Jackson, L. , Gómez-Castañeda, E., Jørgensen, H. G., Hopcroft, L. E.M. , Rogers, S. , Holyoake, T. L. and Huang, X. (2017) Oncogene addiction in chronic myeloid leukaemia. In: eLS. John Wiley & Sons, Ltd, pp. 1-9. ISBN 9780470015902 (doi:10.1002/9780470015902.a0024464)

Conference or Workshop Item

Anselmi, L. et al. (2019) Targeting Metabolic Vulnerabilities and Aberrant Signal Transduction Pathways in Paediatric T‐cell Acute Lymphoblastic Leukaemia (T‐ALL). 59th Annual Scientific Meeting of the British Society for Hematology, Glasgow, UK, 1-3 April 2019.

Massett, M. E., Michie, A. M., Vetrie, D. and Huang, X. (2019) Targeting H3K9me3 as Novel Therapeutic Strategy in MLLr‐AML. 59th Annual Scientific Meeting of the British Society for Hematology, Glasgow, UK, 1-3 April 2019.

Massett, M. E., Mannion, N., Monaghan, L., Bittencourt-Silvestre, J., Marmiroli, S., Liskamp, R. M.J., Michie, A. M., Vetrie, D. and Huang, X. (2018) The Histone Demethylase KDM4A Is Required to Sustain H3K9me3/H3K27me3 Epigenetic States and Oncogenesis in MLL-AF9 Acute Myeloid Leukemia. 60th ASH Annual Meeting, San Diego, CA, USA, 1-4 Dec 2018.

Lynch, J. T., Spencer, G. J., Harris, W. J., Maiques-Díaz, A., Ciceri, F., Huang, X. and Somervaille, T. C.P. (2014) Pharmacological Inhibitors of LSD1 Promote Differentiation of Myeloid Leukemia Cells through a Mechanism Independent of Histone Demethylation. 56th ASH Annual Meeting, San Francisco, CA, USA, 6-9 Dec 2014.

Somerville, T. D.D., Huang, X. , Lynch, J. T., Spencer, G. J. and Somervaille, T. C.P. (2014) FOXC1 Is Derepressed to Functional Effect in Human Acute Myeloid Leukemia. 56th ASH Annual Meeting, San Francisco, CA, USA, 6-9 Dec 2014.

Flume, R., Huang, X. , Ramazzotti, G., Mongiorgi, S., Santi, P., Somervaille, T. C.P. and Divecha, N. (2014) Phospholipase C beta 1 (PLCb1) in Acute Myeloid Leukemia (AML): A Novel Potential Therapeutic Target. 68th Meeting of the Italian Society of Anatomy and Histology, Ancona, Italy, 18-20 Sept 2014.

Huang, X. and Somervaille, T. C.P. (2012) Enhancers of Polycomb EPC1 and EPC2 Prevent Accumulation of MYC to Sustain the Oncogenic Potential of MLL Leukemia Stem Cells. 54th ASH Annual Meeting, Atlanta, GA, USA, 8-11 Dec 2012.

Harris, W. J., Huang, X. , Lynch, J. T. and Somervaille, T. C.P. (2011) Pharmacological Inhibition or Genetic Knockdown of Kdm1a (Lsd1 or Aof2) Induces Differentiation of MLL Acute Myeloid Leukaemia Stem Cells. 53rd ASH Annual Meeting, San Diego, CA, USA, 10-13 Dec 2011.

This list was generated on Thu Sep 19 12:11:28 2019 BST.