2024

Hillson, L. V. S., McCulloch, A. K., Edwards, J. , Dunne, P. D., O'Cathail, S. M. and Roxburgh, C. S. (2024) Radiation-induced changes in gene expression in rectal cancer specimens. Clinical and Translational Oncology, (doi: 10.1007/s12094-023-03361-9) (PMID:38243085) (Early Online Publication)

2023

McMahon, R. K., O'Cathail, S. M. , Nair, H., Steele, C. W. , Platt, J. J., Digby, M., McDonald, A. C., Horgan, P. G. and Roxburgh, C. S.D. (2023) The neoadjuvant rectal score and a novel magnetic resonance imaging based neoadjuvant rectal score are stage independent predictors of long-term outcome in locally advanced rectal cancer. Colorectal Disease, 25(9), pp. 1783-1794. (doi: 10.1111/codi.16667) (PMID:37485654)

Beach, C. et al. (2023) Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments. Journal of Clinical Investigation, (Accepted for Publication)

Grocutt, L., Rutherford, A., Caldwell, D., Wilkinson, C., Chalmers, A.J. , Dempsey, L., Kelly, C. and O'Cathail, S.M. (2023) The impact of COVID-19 on radiotherapy services in Scotland, UK: a population-based study. Clinical Oncology, 35(2), e227-e234. (doi: 10.1016/j.clon.2022.11.018) (PMID:36528474) (PMCID:PMC9708615)

2022

O'Cathail, S.M. and Chalmers, A.J. (2022) Integrating novel cancer therapies with radiation - illuminating the tunnel. Clinical Oncology, 35(1), pp. 38-41. (doi: 10.1016/j.clon.2022.10.010) (PMID:36333159)

Devlin, L., Grocutt, L., Hunter, B., Chemu, H., Duffton, A., McDonald, A., Macleod, N., McLoone, P. and O'Cathail, S. M. (2022) The in-silico feasibility of dose escalated, hypofractionated radiotherapy for rectal cancer. Clinical and Translational Radiation Oncology, 36, pp. 24-30. (doi: 10.1016/j.ctro.2022.06.003) (PMID:35756193) (PMCID:PMC9218294)

Robinson, M., O'Cathail, S. , Duffton, A., Aitken, K. and Muirhead, R. (2022) Potential for isotoxic re-irradiation stereotactic ablative body radiotherapy in locally recurrent rectal cancer. Clinical Oncology, 34(9), pp. 571-577. (doi: 10.1016/j.clon.2022.04.007) (PMID:35504797)

2021

O'Cathail, S. M. , Wu, C.-H., Thomas, R., Hawkins, M. A., Maughan, T. S. and Lewis, A. (2021) NRF2 mediates therapeutic resistance to chemoradiation in colorectal cancer through a metabolic switch. Antioxidants, 10(9), 1380. (doi: 10.3390/antiox10091380)

Hanna, C. R. et al. (2021) Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT). Radiation Oncology, 16, 163. (doi: 10.1186/s13014-021-01888-1) (PMID:34446053)

Hanna, C. R. et al. (2021) Intensity modulated radiotherapy for rectal cancer in the UK in 2020. Clinical Oncology, 33(4), pp. 213-223. (doi: 10.1016/j.clon.2020.12.011) (PMID:33423883)

Hanna, C. R. , O'Cathail, S. M. , Graham, J., Adams, R. and Roxburgh, C. S.D. (2021) Immune checkpoint inhibition as a strategy in the neoadjuvant treatment of locally advanced rectal cancer. Journal of Immunotherapy and Precision Oncology, 4(2), (doi: 10.36401/JIPO-20-31)

2020

Smith, T., O'Cathail, S. M. , Silverman, S., Robinson, M., Tsang, Y., Harrison, M. and Hawkins, M. A. (2020) Stereotactic Body Radiotherapy re-irradiation for locally recurrent rectal cancer: outcomes and toxicity. Advances in Radiation Oncology, 5(6), pp. 1311-1319. (doi: 10.1016/j.adro.2020.07.017) (PMID:33305093) (PMCID:PMC7718547)

O'Cathail, S. M. , Smith, T., Owens, R., Zeniou, A., Tsang, Y., Holyoake, D. L.P., Murray, L., Harrison, M. and Hawkins, M. A. (2020) Superior outcomes of nodal metastases compared to visceral sites in oligometastatic colorectal cancer treated with stereotactic ablative radiotherapy. Radiotherapy and Oncology, 151, pp. 280-286. (doi: 10.1016/j.radonc.2020.08.012) (PMID:32866563) (PMCID:PMC7689579)

O'Cathail, S. M. , Wu, C.-H., Lewis, A., Holmes, C., Hawkins, M. A. and Maughan, T. (2020) NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer. Cancer Genetics, 248, pp. 1-10. (doi: 10.1016/j.cancergen.2020.08.006) (PMID:32871287)

O'Cathail, S.M. , Gilbert, D.C., Sebag-Montefiore, D. and Muirhead, R. (2020) Challenges and consequences of COVID-19 in the management of anorectal cancer: coming together through social distancing. Clinical Oncology, 32(7), pp. 413-416. (doi: 10.1016/j.clon.2020.04.009) (PMID:32359847) (PMCID:PMC7184022)

O'Cathail, S. M. et al. (2020) A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR). Radiation Oncology, 15, 151. (doi: 10.1186/s13014-020-01593-5) (PMID:32532291) (PMCID:PMC7291514)

Cooke, R., Camilleri, P., Chu, K.-Y., O'Cathail, S. M. , Robinson, M., Van Den Heuvel, F. and Hawkins, M. A. (2020) Stereotactic body radiotherapy for moderately central and ultra-central oligometastatic disease: initial outcomes. Technical Innovations and Patient Support in Radiation Oncology, 13, pp. 24-30. (doi: 10.1016/j.tipsro.2020.01.002) (PMID:32128460) (PMCID:PMC7042153)

2019

Rayner, E., Durin, M.-A., Thomas, R., Moralli, D., O'Cathail, S. M. , Tomlinson, I., Green, C. M. and Lewis, A. (2019) CRISPR-Cas9 causes chromosomal instability and rearrangements in cancer cell lines, detectable by cytogenetic methods. CRISPR Journal, 2(6), pp. 406-416. (doi: 10.1089/crispr.2019.0006) (PMID:31742432) (PMCID:PMC6919265)

O'Cathail, S.M. and Buffa, F.M. (2019) Science in focus: bioinformatics part 1 – lost in translation. Clinical Oncology, 31(6), pp. 337-340. (doi: 10.1016/j.clon.2019.03.043) (PMID:30975523)

2018

O'Cathail, S. M. , Karir, N. and Shah, K. (2018) Optimising volumetric arc radiotherapy for dental rehabilitation in oropharynx cancer – a retrospective dosimetry review and feasibility planning study. Oral Oncology, 76, pp. 16-21. (doi: 10.1016/j.oraloncology.2017.11.020) (PMID:29290281)

2017

O'Cathail, S. M. , Pokrovska, T. D., Maughan, T. S., Fisher, K. D., Seymour, L. W. and Hawkins, M. A. (2017) Combining oncolytic adenovirus with radiation—a paradigm for the future of radiosensitization. Frontiers in Oncology, 7, 153. (doi: 10.3389/fonc.2017.00153) (PMID:28791251) (PMCID:PMC5523729)

Muirhead, R., Drinkwater, K., O'Cathail, S.M. , Adams, R., Glynne-Jones, R., Harrison, M., Hawkins, M.A., Sebag-Montefiore, D. and Gilbert, D.C. (2017) Initial results from the Royal College of Radiologists' UK national audit of anal cancer radiotherapy 2015. Clinical Oncology, 29(3), pp. 188-197. (doi: 10.1016/j.clon.2016.10.005) (PMID:27810119) (PMCID:PMC5304408)

Cox, S. J., O'Cathail, S. M. , Coles, B., Crosby, T. and Mukherjee, S. (2017) Update on neoadjuvant regimens for patients with operable oesophageal/gastrooesophageal junction adenocarcinomas and squamous cell carcinomas. Current Oncology Reports, 19(1), 7. (doi: 10.1007/s11912-017-0559-8) (PMID:28213876) (PMCID:PMC5315732)

2015

Higgins, G. S., O'Cathail, S. M. , Muschel, R. J. and McKenna, W. G. (2015) Drug radiotherapy combinations: review of previous failures and reasons for future optimism. Cancer Treatment Reviews, 41(2), pp. 105-113. (doi: 10.1016/j.ctrv.2014.12.012) (PMID:25579753)

2014

Ramaswami, R., O'Cathail, S. M. , Brindley, J. H., Silcocks, P., Mahmoud, S. and Palmieri, C. (2014) Activity of eribulin mesylate in heavily pretreated breast cancer granted accessvia the Cancer Drugs Fund. Future Oncology, 10(3), pp. 363-376. (doi: 10.2217/fon.13.210) (PMID:24367990)

Stavraka, C., Pinato, D. J., Turnbull, S. J., Flynn, M. J., Forster, M. D., O'Cathail, S. M. , Babar, S., Seckl, M. J., Kristeleit, R. S. and Blagden, S. P. (2014) Developing an objective marker to optimize patient selection and predict survival benefit in early-phase cancer trials. Cancer, 120(2), pp. 262-270. (doi: 10.1002/cncr.28381) (PMID:24399418)

Scarpa, A. et al. (2014) An inflammation based score can optimize the selection of patients with advanced cancer considered for early phase clinical trials. PLoS ONE, 9(1), e83279. (doi: 10.1371/journal.pone.0083279) (PMID:24409281) (PMCID:PMC3883636)

2013

O'Cathail, S. M. , Shaboodien, R., Mahmoud, S., Carty, K., O'Sullivan, P., Blagden, S., Gabra, H., Whear, S., Kwon, J. S. and Agarwal, R. (2013) Intravenous versus oral dexamethasone premedication in preventing paclitaxel infusion hypersensitivity reactions in gynecological malignancies. International Journal of Gynecologic Cancer, 23(7), pp. 1318-1325. (doi: 10.1097/IGC.0b013e31829f1799) (PMID:23907557)

2012

O'Cathail, S. and Stebbing, J. (2012) Ayurveda: alternative or complementary? Lancet Oncology, 13(9), p. 865. (doi: 10.1016/S1470-2045(12)70405-9) (PMID:22935233)

2011

O'Cathail, S.M. , O'Connell, O.J., Long, N., Morgan, M., Eustace, J.A., Plant, B.J. and Hourihane, J.O.'.B. (2011) Association of cigarette smoking with drug use and risk taking behaviour in Irish teenagers. Addictive Behaviors, 36(5), pp. 547-550. (doi: 10.1016/j.addbeh.2011.01.012) (PMID:21315520)

Articles

Hillson, L. V. S., McCulloch, A. K., Edwards, J. , Dunne, P. D., O'Cathail, S. M. and Roxburgh, C. S. (2024) Radiation-induced changes in gene expression in rectal cancer specimens. Clinical and Translational Oncology, (doi: 10.1007/s12094-023-03361-9) (PMID:38243085) (Early Online Publication)

Beach, C. et al. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133(23), e168277. (doi: 10.1172/JCI168277) (PMID:37824211) (PMCID:PMC10688992)

McMahon, R. K., O'Cathail, S. M. , Nair, H., Steele, C. W. , Platt, J. J., Digby, M., McDonald, A. C., Horgan, P. G. and Roxburgh, C. S.D. (2023) The neoadjuvant rectal score and a novel magnetic resonance imaging based neoadjuvant rectal score are stage independent predictors of long-term outcome in locally advanced rectal cancer. Colorectal Disease, 25(9), pp. 1783-1794. (doi: 10.1111/codi.16667) (PMID:37485654)

Grocutt, L., Rutherford, A., Caldwell, D., Wilkinson, C., Chalmers, A.J. , Dempsey, L., Kelly, C. and O'Cathail, S.M. (2023) The impact of COVID-19 on radiotherapy services in Scotland, UK: a population-based study. Clinical Oncology, 35(2), e227-e234. (doi: 10.1016/j.clon.2022.11.018) (PMID:36528474) (PMCID:PMC9708615)

O'Cathail, S.M. and Chalmers, A.J. (2022) Integrating novel cancer therapies with radiation - illuminating the tunnel. Clinical Oncology, 35(1), pp. 38-41. (doi: 10.1016/j.clon.2022.10.010) (PMID:36333159)

Devlin, L., Grocutt, L., Hunter, B., Chemu, H., Duffton, A., McDonald, A., Macleod, N., McLoone, P. and O'Cathail, S. M. (2022) The in-silico feasibility of dose escalated, hypofractionated radiotherapy for rectal cancer. Clinical and Translational Radiation Oncology, 36, pp. 24-30. (doi: 10.1016/j.ctro.2022.06.003) (PMID:35756193) (PMCID:PMC9218294)

Robinson, M., O'Cathail, S. , Duffton, A., Aitken, K. and Muirhead, R. (2022) Potential for isotoxic re-irradiation stereotactic ablative body radiotherapy in locally recurrent rectal cancer. Clinical Oncology, 34(9), pp. 571-577. (doi: 10.1016/j.clon.2022.04.007) (PMID:35504797)

O'Cathail, S. M. , Wu, C.-H., Thomas, R., Hawkins, M. A., Maughan, T. S. and Lewis, A. (2021) NRF2 mediates therapeutic resistance to chemoradiation in colorectal cancer through a metabolic switch. Antioxidants, 10(9), 1380. (doi: 10.3390/antiox10091380)

Hanna, C. R. et al. (2021) Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT). Radiation Oncology, 16, 163. (doi: 10.1186/s13014-021-01888-1) (PMID:34446053)

Hanna, C. R. et al. (2021) Intensity modulated radiotherapy for rectal cancer in the UK in 2020. Clinical Oncology, 33(4), pp. 213-223. (doi: 10.1016/j.clon.2020.12.011) (PMID:33423883)

Hanna, C. R. , O'Cathail, S. M. , Graham, J., Adams, R. and Roxburgh, C. S.D. (2021) Immune checkpoint inhibition as a strategy in the neoadjuvant treatment of locally advanced rectal cancer. Journal of Immunotherapy and Precision Oncology, 4(2), (doi: 10.36401/JIPO-20-31)

Smith, T., O'Cathail, S. M. , Silverman, S., Robinson, M., Tsang, Y., Harrison, M. and Hawkins, M. A. (2020) Stereotactic Body Radiotherapy re-irradiation for locally recurrent rectal cancer: outcomes and toxicity. Advances in Radiation Oncology, 5(6), pp. 1311-1319. (doi: 10.1016/j.adro.2020.07.017) (PMID:33305093) (PMCID:PMC7718547)

O'Cathail, S. M. , Smith, T., Owens, R., Zeniou, A., Tsang, Y., Holyoake, D. L.P., Murray, L., Harrison, M. and Hawkins, M. A. (2020) Superior outcomes of nodal metastases compared to visceral sites in oligometastatic colorectal cancer treated with stereotactic ablative radiotherapy. Radiotherapy and Oncology, 151, pp. 280-286. (doi: 10.1016/j.radonc.2020.08.012) (PMID:32866563) (PMCID:PMC7689579)

O'Cathail, S. M. , Wu, C.-H., Lewis, A., Holmes, C., Hawkins, M. A. and Maughan, T. (2020) NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer. Cancer Genetics, 248, pp. 1-10. (doi: 10.1016/j.cancergen.2020.08.006) (PMID:32871287)

O'Cathail, S.M. , Gilbert, D.C., Sebag-Montefiore, D. and Muirhead, R. (2020) Challenges and consequences of COVID-19 in the management of anorectal cancer: coming together through social distancing. Clinical Oncology, 32(7), pp. 413-416. (doi: 10.1016/j.clon.2020.04.009) (PMID:32359847) (PMCID:PMC7184022)

O'Cathail, S. M. et al. (2020) A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR). Radiation Oncology, 15, 151. (doi: 10.1186/s13014-020-01593-5) (PMID:32532291) (PMCID:PMC7291514)

Cooke, R., Camilleri, P., Chu, K.-Y., O'Cathail, S. M. , Robinson, M., Van Den Heuvel, F. and Hawkins, M. A. (2020) Stereotactic body radiotherapy for moderately central and ultra-central oligometastatic disease: initial outcomes. Technical Innovations and Patient Support in Radiation Oncology, 13, pp. 24-30. (doi: 10.1016/j.tipsro.2020.01.002) (PMID:32128460) (PMCID:PMC7042153)

Rayner, E., Durin, M.-A., Thomas, R., Moralli, D., O'Cathail, S. M. , Tomlinson, I., Green, C. M. and Lewis, A. (2019) CRISPR-Cas9 causes chromosomal instability and rearrangements in cancer cell lines, detectable by cytogenetic methods. CRISPR Journal, 2(6), pp. 406-416. (doi: 10.1089/crispr.2019.0006) (PMID:31742432) (PMCID:PMC6919265)

O'Cathail, S.M. and Buffa, F.M. (2019) Science in focus: bioinformatics part 1 – lost in translation. Clinical Oncology, 31(6), pp. 337-340. (doi: 10.1016/j.clon.2019.03.043) (PMID:30975523)

O'Cathail, S. M. , Karir, N. and Shah, K. (2018) Optimising volumetric arc radiotherapy for dental rehabilitation in oropharynx cancer – a retrospective dosimetry review and feasibility planning study. Oral Oncology, 76, pp. 16-21. (doi: 10.1016/j.oraloncology.2017.11.020) (PMID:29290281)

O'Cathail, S. M. , Pokrovska, T. D., Maughan, T. S., Fisher, K. D., Seymour, L. W. and Hawkins, M. A. (2017) Combining oncolytic adenovirus with radiation—a paradigm for the future of radiosensitization. Frontiers in Oncology, 7, 153. (doi: 10.3389/fonc.2017.00153) (PMID:28791251) (PMCID:PMC5523729)

Muirhead, R., Drinkwater, K., O'Cathail, S.M. , Adams, R., Glynne-Jones, R., Harrison, M., Hawkins, M.A., Sebag-Montefiore, D. and Gilbert, D.C. (2017) Initial results from the Royal College of Radiologists' UK national audit of anal cancer radiotherapy 2015. Clinical Oncology, 29(3), pp. 188-197. (doi: 10.1016/j.clon.2016.10.005) (PMID:27810119) (PMCID:PMC5304408)

Cox, S. J., O'Cathail, S. M. , Coles, B., Crosby, T. and Mukherjee, S. (2017) Update on neoadjuvant regimens for patients with operable oesophageal/gastrooesophageal junction adenocarcinomas and squamous cell carcinomas. Current Oncology Reports, 19(1), 7. (doi: 10.1007/s11912-017-0559-8) (PMID:28213876) (PMCID:PMC5315732)

Higgins, G. S., O'Cathail, S. M. , Muschel, R. J. and McKenna, W. G. (2015) Drug radiotherapy combinations: review of previous failures and reasons for future optimism. Cancer Treatment Reviews, 41(2), pp. 105-113. (doi: 10.1016/j.ctrv.2014.12.012) (PMID:25579753)

Ramaswami, R., O'Cathail, S. M. , Brindley, J. H., Silcocks, P., Mahmoud, S. and Palmieri, C. (2014) Activity of eribulin mesylate in heavily pretreated breast cancer granted accessvia the Cancer Drugs Fund. Future Oncology, 10(3), pp. 363-376. (doi: 10.2217/fon.13.210) (PMID:24367990)

Stavraka, C., Pinato, D. J., Turnbull, S. J., Flynn, M. J., Forster, M. D., O'Cathail, S. M. , Babar, S., Seckl, M. J., Kristeleit, R. S. and Blagden, S. P. (2014) Developing an objective marker to optimize patient selection and predict survival benefit in early-phase cancer trials. Cancer, 120(2), pp. 262-270. (doi: 10.1002/cncr.28381) (PMID:24399418)

Scarpa, A. et al. (2014) An inflammation based score can optimize the selection of patients with advanced cancer considered for early phase clinical trials. PLoS ONE, 9(1), e83279. (doi: 10.1371/journal.pone.0083279) (PMID:24409281) (PMCID:PMC3883636)

O'Cathail, S. M. , Shaboodien, R., Mahmoud, S., Carty, K., O'Sullivan, P., Blagden, S., Gabra, H., Whear, S., Kwon, J. S. and Agarwal, R. (2013) Intravenous versus oral dexamethasone premedication in preventing paclitaxel infusion hypersensitivity reactions in gynecological malignancies. International Journal of Gynecologic Cancer, 23(7), pp. 1318-1325. (doi: 10.1097/IGC.0b013e31829f1799) (PMID:23907557)

O'Cathail, S. and Stebbing, J. (2012) Ayurveda: alternative or complementary? Lancet Oncology, 13(9), p. 865. (doi: 10.1016/S1470-2045(12)70405-9) (PMID:22935233)

O'Cathail, S.M. , O'Connell, O.J., Long, N., Morgan, M., Eustace, J.A., Plant, B.J. and Hourihane, J.O.'.B. (2011) Association of cigarette smoking with drug use and risk taking behaviour in Irish teenagers. Addictive Behaviors, 36(5), pp. 547-550. (doi: 10.1016/j.addbeh.2011.01.012) (PMID:21315520)