Dr Lisa Hopcroft

  • Affiliate (Institute of Cancer Sciences)
  • Affiliate (College of Medical Veterinary & Life Sciences)

email: Lisa.Hopcroft@glasgow.ac.uk

R315 Level 3, Paul O'Gorman Research Centre, Gartnavel General Hospital, 21 Shelley Road, G12 0ZD

ORCID iDhttps://orcid.org/0000-0002-7022-1322

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2009 | 2008
Number of items: 29.

2018

Salomé, M. , Hopcroft, L. and Keeshan, K. (2018) Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis. Experimental Hematology, 66, 63-78.e13. (doi: 10.1016/j.exphem.2018.07.005) (PMID:30031847)

Mitchell, R. et al. (2018) Targeting BCR-ABL independent TKI resistance in chronic myeloid leukaemia by mTOR and autophagy inhibition. Journal of the National Cancer Institute, 110(5), pp. 467-478. (doi: 10.1093/jnci/djx236) (PMID:29165716) (PMCID:PMC5946859)

Pellicano, F. et al. (2018) Hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival. Blood, 131(14), pp. 1532-1544. (doi: 10.1182/blood-2017-05-783845) (PMID:29437554) (PMCID:PMC6027092)

Zhang, B. et al. (2018) Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia. Nature Medicine, 24, pp. 450-462. (doi: 10.1038/nm.4499) (PMID:29505034) (PMCID:PMC5965294)

2017

Tarafdar, A. et al. (2017) CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression. Blood, 129(2), pp. 199-208. (doi: 10.1182/blood-2016-09-742049) (PMID:27793879) (PMCID:PMC5305055)

Hopcroft, L. E. , Abraham, S. A. and Holyoake, T. L. (2017) Validating a network hub in leukaemia stem cells. Oncoscience, 4(1-2), pp. 3-4. (doi: 10.18632/oncoscience.339) (PMID:28484726) (PMCID:PMC5361640)

Jackson, L. , Gómez-Castañeda, E., Jørgensen, H. G., Hopcroft, L. E.M. , Rogers, S. , Holyoake, T. L. and Huang, X. (2017) Oncogene addiction in chronic myeloid leukaemia. In: eLS. John Wiley & Sons, Ltd, pp. 1-9. ISBN 9780470015902 (doi:10.1002/9780470015902.a0024464)

2016

Scott, M. T. et al. (2016) Epigenetic reprogramming sensitizes CML stem cells to combined EZH2 and tyrosine kinase inhibition. Cancer Discovery, 6(11), pp. 1248-1257. (doi: 10.1158/2159-8290.CD-16-0263) (PMID:27630125) (PMCID:PMC6538532)

Sinclair, A. et al. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), pp. 371-383. (doi: 10.1182/blood-2015-08-661785) (PMID:27222476) (PMCID:PMC4991087)

Abraham, S. A. et al. (2016) Dual targeting of P53 and C-MYC induces selective elimination of leukemic stem cells. Nature, 534(7607), pp. 341-346. (doi: 10.1038/nature18288) (PMID:27281222) (PMCID:PMC4913876)

Gómez-Castañeda, E., Hopcroft, L.E.M. , Rogers, S. , Jorgensen, H.G., Pellicano, F., Vetrie, D. , Copland, M. , Grimmond, S. and Holyoake, T.L. (2016) Uncovering the BCR-ABL1 Tyrosine Kinase Independent Signature in Chronic Myeloid Leukaemia Stem Cells. 36th World Congress of the International Society of Hematology, Glasgow, Scotland, 18-21 Apr 2016. (doi:10.1111/bjh.14019)

Jackson, L., Hopcroft, L.E.M. , Rogers, S. , Jorgensen, H., Pellicano, F., Wells, C., Mosbergen, R., Chen, T., Vetrie, D. and Holyoake, T.L. (2016) Identifying Genes and Pathways Deregulated in Chronic Myeloid Leukaemia Stem Cells Through Meta-Analysis of Transcriptomic Data. 36th World Congress of the International Society of Hematology, Glasgow, Scotland, 18-21 Apr 2016. (doi:10.1111/bjh.14019)

Michie, A.M. , Tarafdar, A., Gallipoli, P., Pellicano, F., Hopcroft, L. , Korfi, K., Cassels, J., Jorgensen, H.J., Vetrie, D. and Holyoake, T.L. (2016) CML Cells Actively Evade Host Immune Surveillance Through Cytokine-Mediated Downregulation of MHC-I I Expression. 36th World Congress of the International Society of Hematology, Glasgow, Scotland, 18-21 Apr 2016. p. 117. (doi:10.1111/bjh.14019)

Zhang, B., Chu, S., Agarwal, P., Campbell, V. L., Hopcroft, L. , Jørgensen, H. G., Lin, A., Gaal, K., Holyoake, T. L. and Bhatia, R. (2016) Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor treated CML stem cells. Blood, 128(23), pp. 2671-2682. (doi: 10.1182/blood-2015-11-679928) (PMID:27621307) (PMCID:PMC5146743)

2015

Hopcroft, L. E. M. , Calderhead, B., Gallipoli, P., Holyoake, T. L. and Girolami, M. A. (2015) Bayesian inference for model selection: an application to aberrant signalling pathways in chronic myeloid leukaemia. In: Markowetz, F. and Boutros, M. (eds.) Systems Genetics: Linking Phenotypes to Genotypes. Series: Cambridge series in systems genetics. Cambridge University Press, pp. 161-190. ISBN 9781107013841

2014

Gallipoli, P., Cook, A., Rhodes, S. , Hopcroft, L. , Wheadon, H. , Whetton, A. D., Jorgensen, H. G., Bhatia, R. and Holyoake, T. L. (2014) JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi: 10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)

Abraham, S., Hopcroft, L. , Bhatia, R., Koschmieder, S., Whetton, A. and Holyoake, T. (2014) Models to study chronic myeloid leukemia cancer stem cells. In: Rajasekhar, V. (ed.) Cancer Stem Cells. Wiley-Blackwell. ISBN 9781118356166 (doi:10.1002/9781118356203.ch9)

Pellicano, F. et al. (2014) The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem Cells, 32(9), pp. 2324-2337. (doi: 10.1002/stem.1748) (PMID:24806995) (PMCID:PMC4282530)

Toofan, P., Irvine, D., Hopcroft, L. , Copland, M. and Wheadon, H. (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi: 10.1042/BST20140037)

2013

Abraham, S., Hopcroft, L. , Carrick, E., Williamson, A., Pierce, A., Cassels, J., Pellicano, F., Whetton, A. and Holyoake, T. L. (2013) p53 and c-Myc are critical signaling hubs that maintain chronic myeloid leukemia. In: 55th American Society of Hematology Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 Dec 2013, p. 1465.

Rhodes, S. , Copland, M. , Hopcroft, L. , Sayeski, P. and Wheadon, H. (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

2011

Izarzugaza, J. M. G., Hopcroft, L. E. M. , Baresic, A., Orengo, C. A., Martin, A. C. R. and Valencia, A. (2011) Characterization of pathogenic germline mutations in human protein kinases. BMC Bioinformatics, 12(Sup. 4), S1. (doi: 10.1186/1471-2105-12-S4-S1)

2010

Hopcroft, L. E.M. , McBride, M. W. , Harris, K. J., Sampson, A. K., McClure, J. D. , Graham, D. , Young, G., Holyoake, T. L., Girolami, M. A. and Dominiczak, A. F. (2010) Predictive response-relevant clustering of expression data provides insights into disease processes. Nucleic Acids Research, 38(20), pp. 6831-6840. (doi: 10.1093/nar/gkq550)

Baresić, A., Hopcroft, L. E. M. , Rogers, H. H., Hurst, J. M. and Martin, A. C.R. (2010) Compensated pathogenic deviations: analysis of structural effects. Journal of Molecular Biology, 396(1), pp. 19-30. (doi: 10.1016/j.jmb.2009.11.002)

McBride, M. , Hopcroft, L. , Harris, K., McClure, J. , Graham, D. , Girolami, M. and Dominiczak, M. (2010) Insights into Salt-Sensitive Hypertension Using Response-Relevant Clustering. In: 20th Annual Meeting of the European Society of Hypertension, Oslo, Norway, 18-21 June, E342-E342.

2009

Izarzugaza, J. M.G., Baresic, A., McMillan, L. E.M. , Yeats, C., Clegg, A. B., Orengo, C. A., Martin, A. C.R. and Valencia, A. (2009) An integrated approach to the interpretation of single amino acid polymorphisms within the framework of CATH and Gene3D. BMC Bioinformatics, 10(Sup. 8), S5. (doi: 10.1186/1471-2105-10-S8-S5)

Hurst, J. M., McMillan, L. E. M. , Porter, C. T., Allen, J., Fakorede, A. and Martin, A. C. R. (2009) The SAAPdb web resource: a large-scale structural analysis of mutant proteins. Human Mutation, 30(4), pp. 616-624. (doi: 10.1002/humu.20898)

Harris, K., McMillan, L. and Girolami, M. (2009) Inferring meta-covariates in classification. In: 4th IAPR International Conference on Pattern Recognition in Bioinformatics, Sheffield, UK, 7-9 Sept 2009, pp. 150-161. (doi:10.1007/978-3-642-04031-3_14)

2008

McMillan, L. E.M. and Martin, A. C.R. (2008) Automatically extracting functionally equivalent proteins from SwissProt. BMC Bioinformatics, 9, p. 418. (doi: 10.1186/1471-2105-9-418)

This list was generated on Thu Sep 23 06:26:40 2021 BST.
Number of items: 29.

Articles

Salomé, M. , Hopcroft, L. and Keeshan, K. (2018) Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis. Experimental Hematology, 66, 63-78.e13. (doi: 10.1016/j.exphem.2018.07.005) (PMID:30031847)

Mitchell, R. et al. (2018) Targeting BCR-ABL independent TKI resistance in chronic myeloid leukaemia by mTOR and autophagy inhibition. Journal of the National Cancer Institute, 110(5), pp. 467-478. (doi: 10.1093/jnci/djx236) (PMID:29165716) (PMCID:PMC5946859)

Pellicano, F. et al. (2018) Hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival. Blood, 131(14), pp. 1532-1544. (doi: 10.1182/blood-2017-05-783845) (PMID:29437554) (PMCID:PMC6027092)

Zhang, B. et al. (2018) Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia. Nature Medicine, 24, pp. 450-462. (doi: 10.1038/nm.4499) (PMID:29505034) (PMCID:PMC5965294)

Tarafdar, A. et al. (2017) CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression. Blood, 129(2), pp. 199-208. (doi: 10.1182/blood-2016-09-742049) (PMID:27793879) (PMCID:PMC5305055)

Hopcroft, L. E. , Abraham, S. A. and Holyoake, T. L. (2017) Validating a network hub in leukaemia stem cells. Oncoscience, 4(1-2), pp. 3-4. (doi: 10.18632/oncoscience.339) (PMID:28484726) (PMCID:PMC5361640)

Scott, M. T. et al. (2016) Epigenetic reprogramming sensitizes CML stem cells to combined EZH2 and tyrosine kinase inhibition. Cancer Discovery, 6(11), pp. 1248-1257. (doi: 10.1158/2159-8290.CD-16-0263) (PMID:27630125) (PMCID:PMC6538532)

Sinclair, A. et al. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), pp. 371-383. (doi: 10.1182/blood-2015-08-661785) (PMID:27222476) (PMCID:PMC4991087)

Abraham, S. A. et al. (2016) Dual targeting of P53 and C-MYC induces selective elimination of leukemic stem cells. Nature, 534(7607), pp. 341-346. (doi: 10.1038/nature18288) (PMID:27281222) (PMCID:PMC4913876)

Zhang, B., Chu, S., Agarwal, P., Campbell, V. L., Hopcroft, L. , Jørgensen, H. G., Lin, A., Gaal, K., Holyoake, T. L. and Bhatia, R. (2016) Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor treated CML stem cells. Blood, 128(23), pp. 2671-2682. (doi: 10.1182/blood-2015-11-679928) (PMID:27621307) (PMCID:PMC5146743)

Gallipoli, P., Cook, A., Rhodes, S. , Hopcroft, L. , Wheadon, H. , Whetton, A. D., Jorgensen, H. G., Bhatia, R. and Holyoake, T. L. (2014) JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi: 10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)

Pellicano, F. et al. (2014) The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem Cells, 32(9), pp. 2324-2337. (doi: 10.1002/stem.1748) (PMID:24806995) (PMCID:PMC4282530)

Toofan, P., Irvine, D., Hopcroft, L. , Copland, M. and Wheadon, H. (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi: 10.1042/BST20140037)

Izarzugaza, J. M. G., Hopcroft, L. E. M. , Baresic, A., Orengo, C. A., Martin, A. C. R. and Valencia, A. (2011) Characterization of pathogenic germline mutations in human protein kinases. BMC Bioinformatics, 12(Sup. 4), S1. (doi: 10.1186/1471-2105-12-S4-S1)

Hopcroft, L. E.M. , McBride, M. W. , Harris, K. J., Sampson, A. K., McClure, J. D. , Graham, D. , Young, G., Holyoake, T. L., Girolami, M. A. and Dominiczak, A. F. (2010) Predictive response-relevant clustering of expression data provides insights into disease processes. Nucleic Acids Research, 38(20), pp. 6831-6840. (doi: 10.1093/nar/gkq550)

Baresić, A., Hopcroft, L. E. M. , Rogers, H. H., Hurst, J. M. and Martin, A. C.R. (2010) Compensated pathogenic deviations: analysis of structural effects. Journal of Molecular Biology, 396(1), pp. 19-30. (doi: 10.1016/j.jmb.2009.11.002)

Izarzugaza, J. M.G., Baresic, A., McMillan, L. E.M. , Yeats, C., Clegg, A. B., Orengo, C. A., Martin, A. C.R. and Valencia, A. (2009) An integrated approach to the interpretation of single amino acid polymorphisms within the framework of CATH and Gene3D. BMC Bioinformatics, 10(Sup. 8), S5. (doi: 10.1186/1471-2105-10-S8-S5)

Hurst, J. M., McMillan, L. E. M. , Porter, C. T., Allen, J., Fakorede, A. and Martin, A. C. R. (2009) The SAAPdb web resource: a large-scale structural analysis of mutant proteins. Human Mutation, 30(4), pp. 616-624. (doi: 10.1002/humu.20898)

McMillan, L. E.M. and Martin, A. C.R. (2008) Automatically extracting functionally equivalent proteins from SwissProt. BMC Bioinformatics, 9, p. 418. (doi: 10.1186/1471-2105-9-418)

Book Sections

Jackson, L. , Gómez-Castañeda, E., Jørgensen, H. G., Hopcroft, L. E.M. , Rogers, S. , Holyoake, T. L. and Huang, X. (2017) Oncogene addiction in chronic myeloid leukaemia. In: eLS. John Wiley & Sons, Ltd, pp. 1-9. ISBN 9780470015902 (doi:10.1002/9780470015902.a0024464)

Hopcroft, L. E. M. , Calderhead, B., Gallipoli, P., Holyoake, T. L. and Girolami, M. A. (2015) Bayesian inference for model selection: an application to aberrant signalling pathways in chronic myeloid leukaemia. In: Markowetz, F. and Boutros, M. (eds.) Systems Genetics: Linking Phenotypes to Genotypes. Series: Cambridge series in systems genetics. Cambridge University Press, pp. 161-190. ISBN 9781107013841

Abraham, S., Hopcroft, L. , Bhatia, R., Koschmieder, S., Whetton, A. and Holyoake, T. (2014) Models to study chronic myeloid leukemia cancer stem cells. In: Rajasekhar, V. (ed.) Cancer Stem Cells. Wiley-Blackwell. ISBN 9781118356166 (doi:10.1002/9781118356203.ch9)

Conference or Workshop Item

Gómez-Castañeda, E., Hopcroft, L.E.M. , Rogers, S. , Jorgensen, H.G., Pellicano, F., Vetrie, D. , Copland, M. , Grimmond, S. and Holyoake, T.L. (2016) Uncovering the BCR-ABL1 Tyrosine Kinase Independent Signature in Chronic Myeloid Leukaemia Stem Cells. 36th World Congress of the International Society of Hematology, Glasgow, Scotland, 18-21 Apr 2016. (doi:10.1111/bjh.14019)

Jackson, L., Hopcroft, L.E.M. , Rogers, S. , Jorgensen, H., Pellicano, F., Wells, C., Mosbergen, R., Chen, T., Vetrie, D. and Holyoake, T.L. (2016) Identifying Genes and Pathways Deregulated in Chronic Myeloid Leukaemia Stem Cells Through Meta-Analysis of Transcriptomic Data. 36th World Congress of the International Society of Hematology, Glasgow, Scotland, 18-21 Apr 2016. (doi:10.1111/bjh.14019)

Michie, A.M. , Tarafdar, A., Gallipoli, P., Pellicano, F., Hopcroft, L. , Korfi, K., Cassels, J., Jorgensen, H.J., Vetrie, D. and Holyoake, T.L. (2016) CML Cells Actively Evade Host Immune Surveillance Through Cytokine-Mediated Downregulation of MHC-I I Expression. 36th World Congress of the International Society of Hematology, Glasgow, Scotland, 18-21 Apr 2016. p. 117. (doi:10.1111/bjh.14019)

Conference Proceedings

Abraham, S., Hopcroft, L. , Carrick, E., Williamson, A., Pierce, A., Cassels, J., Pellicano, F., Whetton, A. and Holyoake, T. L. (2013) p53 and c-Myc are critical signaling hubs that maintain chronic myeloid leukemia. In: 55th American Society of Hematology Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 Dec 2013, p. 1465.

Rhodes, S. , Copland, M. , Hopcroft, L. , Sayeski, P. and Wheadon, H. (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

McBride, M. , Hopcroft, L. , Harris, K., McClure, J. , Graham, D. , Girolami, M. and Dominiczak, M. (2010) Insights into Salt-Sensitive Hypertension Using Response-Relevant Clustering. In: 20th Annual Meeting of the European Society of Hypertension, Oslo, Norway, 18-21 June, E342-E342.

Harris, K., McMillan, L. and Girolami, M. (2009) Inferring meta-covariates in classification. In: 4th IAPR International Conference on Pattern Recognition in Bioinformatics, Sheffield, UK, 7-9 Sept 2009, pp. 150-161. (doi:10.1007/978-3-642-04031-3_14)

This list was generated on Thu Sep 23 06:26:40 2021 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • A systems biology approach to identify leukaemic stem cell/niche interations in CML
    The Kay Kendall Leukaemia Fund
    2017 - 2021
     
  • Exposing the interdependent mechanisms of the leukaemic stem cell and the leukaemic niche in chronic myeloid leukaemia using integrative network and systems biology
    Leuka
    2017 - 2018
     
  • Exploring gene expression in individual CML stem cells to predict response to therapy in newly diagnosed patients
    Tenovus Scotland
    2016 - 2017
     
  • Single cell RNA sequencing on primative human leukaemic stem cell population to identify novel biomarkers involved in drug resistance and future immunotherapy
    Wellcome Trust
    2016 - 2018