Dr Shehab Ismail

  • Affiliate (Institute of Cancer Sciences)

Publications

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Jump to: 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008 | 2005 | 2004
Number of items: 36.

2021

Le, A. H., Yelland, T., Paul, N. R., Fort, L., Nikolaou, S., Ismail, S. and Machesky, L. M. (2021) CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation. Journal of Cell Biology, 220(9), e202012114. (doi: 10.1083/jcb.202012114) (PMID:34165494) (PMCID:PMC8236918)

Yelland, T., Garcia, E., Samarakoon, Y. and Ismail, S. (2021) The structural and biochemical characterization of UNC119B cargo binding and release mechanisms. Biochemistry, 60(25), pp. 1952-1963. (doi: 10.1021/acs.biochem.1c00251) (PMID:34130453) (PMCID:PMC8246649)

Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)

ElMaghloob, Y., Sot, B., McIlwraith, M. J., Garcia, E., Yelland, T. and Ismail, S. (2021) ARL3 activation requires the co-GEF BART and effector-mediated turnover. eLife, 10, e64624. (doi: 10.7554/elife.64624) (PMID:33438581) (PMCID:PMC7817177)

2020

Garcia Gonzalez, E. and Ismail, S. (2020) Spatiotemporal regulation of signaling: focus on T cell activation and the immunological synapse. International Journal of Molecular Sciences, 21(9), e3283. (doi: 10.3390/ijms21093283) (PMID:32384769) (PMCID:PMC7247333)

2019

Amato, C., Thomason, P. A., Davidson, A. J., Swaminathan, K., Ismail, S. , Machesky, L. M. and Insall, R. H. (2019) WASP restricts active Rac to maintain cells’ front-rear polarization. Current Biology, 29(24), pp. 4169-4182. (doi: 10.1016/j.cub.2019.10.036) (PMID:31786060) (PMCID:PMC6926487)

Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)

2018

Stephen, L. A., ElMaghloob, Y., McIlwraith, M. J., Yelland, T., Castro Sanchez, P., Roda-Navarro, P. and Ismail, S. (2018) The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK. Developmental Cell, 47(15), 122-132e4. (doi: 10.1016/j.devcel.2018.08.012) (PMID:30220567) (PMCID:PMC6179904)

Alkanderi, S. et al. (2018) ARL3 mutations cause Joubert syndrome by disrupting ciliary protein composition. American Journal of Human Genetics, 103(4), pp. 612-620. (doi: 10.1016/j.ajhg.2018.08.015) (PMID:30269812) (PMCID:PMC6174286)

Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)

2017

Stephen, L. A., Elmaghloob, Y. and Ismail, S. (2017) Maintaining protein composition in cilia. Biological Chemistry, 399(1), pp. 1-11. (doi: 10.1515/hsz-2017-0168) (PMID:28850540)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)

Murarka, S., Martín-Gago, P., Schultz-Fademrecht, C., Al Saabi, A., Baumann, M., Fansa, E. K., Ismail, S. , Nussbaumer, P., Wittinghofer, A. and Waldmann, H. (2017) Development of pyridazinone chemotypes targeting the PDEδ prenyl binding site. Chemistry: A European Journal, 23(25), pp. 6083-6093. (doi: 10.1002/chem.201603222) (PMID:27809361)

Gray, C. H., Konczal, J., Mezna, M., Ismail, S. , Bower, J. and Drysdale, M. (2017) A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB. Protein Expression and Purification, 132, pp. 75-84. (doi: 10.1016/j.pep.2017.01.010) (PMID:28137655) (PMCID:PMC5415301)

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi: 10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)

Martín-Gago, P. et al. (2017) A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angewandte Chemie (International Edition), 56(9), pp. 2423-2428. (doi: 10.1002/anie.201610957) (PMID:28106325)

Ismail, S. (2017) A GDI/GDF-like system for sorting and shuttling ciliary proteins. Small GTPases, 8(4), pp. 208-211. (doi: 10.1080/21541248.2016.1213782) (PMID:27487321)

2016

Papke, B. et al. (2016) Identification of pyrazolopyridazinones as PDEδ inhibitors. Nature Communications, 7, 11360. (doi: 10.1038/ncomms11360) (PMID:27094677) (PMCID:PMC4843002)

Fansa, E. K., Kösling, S. K., Zent, E., Wittinghofer, A. and Ismail, S. (2016) PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity. Nature Communications, 7, 11366. (doi: 10.1038/ncomms11366) (PMID:27063844) (PMCID:PMC5512577)

Stephen, L. A. and Ismail, S. (2016) Shuttling and sorting lipid-modified cargo into the cilia. Biochemical Society Transactions, 44(5), pp. 1273-1280. (doi: 10.1042/BST20160122) (PMID:27911709)

2015

Fansa, E. K., O'Reilly, N. J., Ismail, S. and Wittinghofer, A. (2015) The N‐ and C‐terminal ends of RPGR can bind to PDE 6δ. EMBO Reports, 16(12), pp. 1583-1585. (doi: 10.15252/embr.201541404) (PMID:26553937) (PMCID:PMC4693519)

Kapoor, S., Fansa, E. K., Möbitz, S., Ismail, S. A. , Winter, R., Wittinghofer, A. and Weise, K. (2015) Effect of the N-terminal helix and nucleotide loading on the membrane and effector binding of Arl2/3. Biophysical Journal, 109(8), pp. 1619-1629. (doi: 10.1016/j.bpj.2015.08.033) (PMID:26488653) (PMCID:PMC4624342)

2014

Bravo-Rodriguez, K., Ismail-Ali, A. F., Klopries, S., Kushnir, S., Ismail, S. , Fansa, E. K., Wittinghofer, A., Schulz, F. and Sanchez-Garcia, E. (2014) Predicted Incorporation of Non-native Substrates by a Polyketide Synthase Yields Bioactive Natural Product Derivatives. ChemBioChem, 15(13), pp. 1991-1997. (doi: 10.1002/cbic.201402206) (PMID:25044264)

Zimmermann, G., Schultz-Fademrecht, C., Küchler, P., Murarka, S., Ismail, S. , Triola, G., Nussbaumer, P., Wittinghofer, A. and Waldmann, H. (2014) Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the pdeδ Prenyl binding site. Journal of Medicinal Chemistry, 57(12), pp. 5435-5448. (doi: 10.1021/jm500632s) (PMID:24884780)

Suladze, S., Ismail, S. and Winter, R. (2014) Thermodynamic, dynamic and solvational properties of PDEδ binding to farnesylated cystein: A model study for uncovering the molecular mechanism of PDEδ interaction with prenylated proteins. Journal of Physical Chemistry B, 118(4), pp. 966-975. (doi: 10.1021/jp411466r) (PMID:24401043)

2013

Zimmermann, G. et al. (2013) Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling. Nature, 497(7451), pp. 638-642. (doi: 10.1038/nature12205) (PMID:23698361)

Wätzlich, D., Vetter, I., Gotthardt, K., Miertzschke, M., Chen, Y.-X., Wittinghofer, A. and Ismail, S. (2013) The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo. EMBO Reports, 14(5), pp. 465-472. (doi: 10.1038/embor.2013.37) (PMID:23559067) (PMCID:PMC3642377)

2012

Ismail, S. , Chen, Y.C., Rusinnova, A.R., Chandra, A.C., Bierbaum, M.B., Gremer, L.G., Triola, G.T., Waldmann, H.W., Batiaens, P.B. and Winttinghofer, A.W. (2012) Arl3 regulates a transport system for farnesylated cargo. Cilia, 1(S1), P71. (doi: 10.1186/2046-2530-1-S1-P71) (PMCID:PMC3555812)

Ismail, S. A. , Chen, Y.-X., Miertzschke, M., Vetter, I. R., Koerner, C. and Wittinghofer, A. (2012) Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. EMBO Journal, 31(20), pp. 4085-4094. (doi: 10.1038/emboj.2012.257) (PMID:22960633) (PMCID:PMC3474929)

Chandra, A. et al. (2012) Erratum: The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nature Cell Biology, 14(3), p. 329. (doi: 10.1038/ncb2462)

Chandra, A. et al. (2012) The GDI-like solubilizing factor PDE [delta] sustains the spatial organization and signalling of Ras family proteins. Nature Cell Biology, 14, pp. 148-158. (doi: 10.1038/ncb2394) (PMID:22179043)

2011

Ismail, S. A. , Chen, Y.-X., Rusinova, A., Chandra, A., Bierbaum, M., Gremer, L., Triola, G., Waldmann, H., Bastiaens, P. I. H. and Wittinghofer, A. (2011) Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nature Chemical Biology, 7(12), pp. 942-949. (doi: 10.1038/nchembio.686) (PMID:22002721)

2010

Ismail, S. A. , Vetter, I. R., Sot, B. and Wittinghofer, A. (2010) The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism. Cell, 141(5), pp. 812-821. (doi: 10.1016/j.cell.2010.03.051) (PMID:20510928)

2008

Veltel, S., Kravchenko, A., Ismail, S. and Wittinghofer, A. (2008) Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. FEBS Letters, 582(17), pp. 2501-2507. (doi: 10.1016/j.febslet.2008.05.053) (PMID:18588884)

2005

Ismail, S.A. and Park, H.W. (2005) Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallographica Section D: Biological Crystallography, 61(11), pp. 1508-1513. (doi: 10.1107/S0907444905026740) (PMID:16239728)

2004

Aziz, R. K., Ismail, S. A. , Park, H.-W. and Kotb, M. (2004) Post-proteomic identification of a novel phage-encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes. Molecular Microbiology, 54(1), pp. 184-197. (doi: 10.1111/j.1365-2958.2004.04255.x) (PMID:15458415)

This list was generated on Thu Sep 23 03:44:09 2021 BST.
Jump to: Articles
Number of items: 36.

Articles

Le, A. H., Yelland, T., Paul, N. R., Fort, L., Nikolaou, S., Ismail, S. and Machesky, L. M. (2021) CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation. Journal of Cell Biology, 220(9), e202012114. (doi: 10.1083/jcb.202012114) (PMID:34165494) (PMCID:PMC8236918)

Yelland, T., Garcia, E., Samarakoon, Y. and Ismail, S. (2021) The structural and biochemical characterization of UNC119B cargo binding and release mechanisms. Biochemistry, 60(25), pp. 1952-1963. (doi: 10.1021/acs.biochem.1c00251) (PMID:34130453) (PMCID:PMC8246649)

Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)

ElMaghloob, Y., Sot, B., McIlwraith, M. J., Garcia, E., Yelland, T. and Ismail, S. (2021) ARL3 activation requires the co-GEF BART and effector-mediated turnover. eLife, 10, e64624. (doi: 10.7554/elife.64624) (PMID:33438581) (PMCID:PMC7817177)

Garcia Gonzalez, E. and Ismail, S. (2020) Spatiotemporal regulation of signaling: focus on T cell activation and the immunological synapse. International Journal of Molecular Sciences, 21(9), e3283. (doi: 10.3390/ijms21093283) (PMID:32384769) (PMCID:PMC7247333)

Amato, C., Thomason, P. A., Davidson, A. J., Swaminathan, K., Ismail, S. , Machesky, L. M. and Insall, R. H. (2019) WASP restricts active Rac to maintain cells’ front-rear polarization. Current Biology, 29(24), pp. 4169-4182. (doi: 10.1016/j.cub.2019.10.036) (PMID:31786060) (PMCID:PMC6926487)

Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)

Stephen, L. A., ElMaghloob, Y., McIlwraith, M. J., Yelland, T., Castro Sanchez, P., Roda-Navarro, P. and Ismail, S. (2018) The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK. Developmental Cell, 47(15), 122-132e4. (doi: 10.1016/j.devcel.2018.08.012) (PMID:30220567) (PMCID:PMC6179904)

Alkanderi, S. et al. (2018) ARL3 mutations cause Joubert syndrome by disrupting ciliary protein composition. American Journal of Human Genetics, 103(4), pp. 612-620. (doi: 10.1016/j.ajhg.2018.08.015) (PMID:30269812) (PMCID:PMC6174286)

Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)

Stephen, L. A., Elmaghloob, Y. and Ismail, S. (2017) Maintaining protein composition in cilia. Biological Chemistry, 399(1), pp. 1-11. (doi: 10.1515/hsz-2017-0168) (PMID:28850540)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)

Murarka, S., Martín-Gago, P., Schultz-Fademrecht, C., Al Saabi, A., Baumann, M., Fansa, E. K., Ismail, S. , Nussbaumer, P., Wittinghofer, A. and Waldmann, H. (2017) Development of pyridazinone chemotypes targeting the PDEδ prenyl binding site. Chemistry: A European Journal, 23(25), pp. 6083-6093. (doi: 10.1002/chem.201603222) (PMID:27809361)

Gray, C. H., Konczal, J., Mezna, M., Ismail, S. , Bower, J. and Drysdale, M. (2017) A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB. Protein Expression and Purification, 132, pp. 75-84. (doi: 10.1016/j.pep.2017.01.010) (PMID:28137655) (PMCID:PMC5415301)

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi: 10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)

Martín-Gago, P. et al. (2017) A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angewandte Chemie (International Edition), 56(9), pp. 2423-2428. (doi: 10.1002/anie.201610957) (PMID:28106325)

Ismail, S. (2017) A GDI/GDF-like system for sorting and shuttling ciliary proteins. Small GTPases, 8(4), pp. 208-211. (doi: 10.1080/21541248.2016.1213782) (PMID:27487321)

Papke, B. et al. (2016) Identification of pyrazolopyridazinones as PDEδ inhibitors. Nature Communications, 7, 11360. (doi: 10.1038/ncomms11360) (PMID:27094677) (PMCID:PMC4843002)

Fansa, E. K., Kösling, S. K., Zent, E., Wittinghofer, A. and Ismail, S. (2016) PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity. Nature Communications, 7, 11366. (doi: 10.1038/ncomms11366) (PMID:27063844) (PMCID:PMC5512577)

Stephen, L. A. and Ismail, S. (2016) Shuttling and sorting lipid-modified cargo into the cilia. Biochemical Society Transactions, 44(5), pp. 1273-1280. (doi: 10.1042/BST20160122) (PMID:27911709)

Fansa, E. K., O'Reilly, N. J., Ismail, S. and Wittinghofer, A. (2015) The N‐ and C‐terminal ends of RPGR can bind to PDE 6δ. EMBO Reports, 16(12), pp. 1583-1585. (doi: 10.15252/embr.201541404) (PMID:26553937) (PMCID:PMC4693519)

Kapoor, S., Fansa, E. K., Möbitz, S., Ismail, S. A. , Winter, R., Wittinghofer, A. and Weise, K. (2015) Effect of the N-terminal helix and nucleotide loading on the membrane and effector binding of Arl2/3. Biophysical Journal, 109(8), pp. 1619-1629. (doi: 10.1016/j.bpj.2015.08.033) (PMID:26488653) (PMCID:PMC4624342)

Bravo-Rodriguez, K., Ismail-Ali, A. F., Klopries, S., Kushnir, S., Ismail, S. , Fansa, E. K., Wittinghofer, A., Schulz, F. and Sanchez-Garcia, E. (2014) Predicted Incorporation of Non-native Substrates by a Polyketide Synthase Yields Bioactive Natural Product Derivatives. ChemBioChem, 15(13), pp. 1991-1997. (doi: 10.1002/cbic.201402206) (PMID:25044264)

Zimmermann, G., Schultz-Fademrecht, C., Küchler, P., Murarka, S., Ismail, S. , Triola, G., Nussbaumer, P., Wittinghofer, A. and Waldmann, H. (2014) Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the pdeδ Prenyl binding site. Journal of Medicinal Chemistry, 57(12), pp. 5435-5448. (doi: 10.1021/jm500632s) (PMID:24884780)

Suladze, S., Ismail, S. and Winter, R. (2014) Thermodynamic, dynamic and solvational properties of PDEδ binding to farnesylated cystein: A model study for uncovering the molecular mechanism of PDEδ interaction with prenylated proteins. Journal of Physical Chemistry B, 118(4), pp. 966-975. (doi: 10.1021/jp411466r) (PMID:24401043)

Zimmermann, G. et al. (2013) Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling. Nature, 497(7451), pp. 638-642. (doi: 10.1038/nature12205) (PMID:23698361)

Wätzlich, D., Vetter, I., Gotthardt, K., Miertzschke, M., Chen, Y.-X., Wittinghofer, A. and Ismail, S. (2013) The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo. EMBO Reports, 14(5), pp. 465-472. (doi: 10.1038/embor.2013.37) (PMID:23559067) (PMCID:PMC3642377)

Ismail, S. , Chen, Y.C., Rusinnova, A.R., Chandra, A.C., Bierbaum, M.B., Gremer, L.G., Triola, G.T., Waldmann, H.W., Batiaens, P.B. and Winttinghofer, A.W. (2012) Arl3 regulates a transport system for farnesylated cargo. Cilia, 1(S1), P71. (doi: 10.1186/2046-2530-1-S1-P71) (PMCID:PMC3555812)

Ismail, S. A. , Chen, Y.-X., Miertzschke, M., Vetter, I. R., Koerner, C. and Wittinghofer, A. (2012) Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. EMBO Journal, 31(20), pp. 4085-4094. (doi: 10.1038/emboj.2012.257) (PMID:22960633) (PMCID:PMC3474929)

Chandra, A. et al. (2012) Erratum: The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nature Cell Biology, 14(3), p. 329. (doi: 10.1038/ncb2462)

Chandra, A. et al. (2012) The GDI-like solubilizing factor PDE [delta] sustains the spatial organization and signalling of Ras family proteins. Nature Cell Biology, 14, pp. 148-158. (doi: 10.1038/ncb2394) (PMID:22179043)

Ismail, S. A. , Chen, Y.-X., Rusinova, A., Chandra, A., Bierbaum, M., Gremer, L., Triola, G., Waldmann, H., Bastiaens, P. I. H. and Wittinghofer, A. (2011) Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nature Chemical Biology, 7(12), pp. 942-949. (doi: 10.1038/nchembio.686) (PMID:22002721)

Ismail, S. A. , Vetter, I. R., Sot, B. and Wittinghofer, A. (2010) The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism. Cell, 141(5), pp. 812-821. (doi: 10.1016/j.cell.2010.03.051) (PMID:20510928)

Veltel, S., Kravchenko, A., Ismail, S. and Wittinghofer, A. (2008) Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. FEBS Letters, 582(17), pp. 2501-2507. (doi: 10.1016/j.febslet.2008.05.053) (PMID:18588884)

Ismail, S.A. and Park, H.W. (2005) Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallographica Section D: Biological Crystallography, 61(11), pp. 1508-1513. (doi: 10.1107/S0907444905026740) (PMID:16239728)

Aziz, R. K., Ismail, S. A. , Park, H.-W. and Kotb, M. (2004) Post-proteomic identification of a novel phage-encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes. Molecular Microbiology, 54(1), pp. 184-197. (doi: 10.1111/j.1365-2958.2004.04255.x) (PMID:15458415)

This list was generated on Thu Sep 23 03:44:09 2021 BST.