Dr Anna Kilbey
- Research Associate (Immunoprofiling FACS Specialist) (Institute of Cancer Sciences)
- Associate (School of Veterinary Medicine)
telephone:
01413305608
email:
Anna.Kilbey@glasgow.ac.uk
R332 Level 3, Henry Wellcome ICM, Garscube, Glasgow G61 1BD
Publications
2020
Suzuki, T., Hayman, L., Kilbey, A., Edwards, J. and Coffelt, S. B. (2020) Gut γδ T cells as guardians, disruptors and instigators of cancer. Immunological Reviews, 298(1), pp. 198-217. (doi: 10.1111/imr.12916) (PMID:32840001)
Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M. , Blyth, K. and Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)
2019
Loyola, L. et al. (2019) Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model. PLoS Pathogens, 15(12), e1008154. (doi: 10.1371/journal.ppat.1008154) (PMID:31815961) (PMCID:PMC6974304)
Hay, J. , Gilroy, K., Huser, C. , Kilbey, A., Mcdonald, A., MacCallum, A., Holroyd, A. , Cameron, E. and Neil, J. C. (2019) Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity. Journal of Cellular Biochemistry, 120(10), pp. 18332-18345. (doi: 10.1002/jcb.29143) (PMID:31257681) (PMCID:PMC6772115)
2018
Anderson, G. et al. (2018) RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. Journal of Cellular Biochemistry, 119(3), pp. 2750-2762. (doi: 10.1002/jcb.26443) (PMID:29052866) (PMCID:PMC5813226)
2017
Kilbey, A. et al. (2017) Runx1 orchestrates sphingolipid metabolism and glucocorticoid resistance in lymphomagenesis. Journal of Cellular Biochemistry, 118(6), pp. 1432-1441. (doi: 10.1002/jcb.25802) (PMID:27869314) (PMCID:PMC5408393)
Neil, J. C. , Gilroy, K., Borland, G., Hay, J. , Terry, A. and Kilbey, A. (2017) The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models. In: Groner, Y., Ito, Y., Liu, P., Neil, J. C., Speck, N. A. and van Wijnen, A. (eds.) RUNX Proteins in Development and Cancer. Series: Advances in experimental medicine and biology (962). Springer, pp. 247-264. ISBN 9789811032318 (doi:10.1007/978-981-10-3233-2_16)
Terry, A., Kilbey, A., Naseer, A., Levy, L. S., Ahmad, S., Watts, C., Mackay, N., Cameron, E. , Wilson, S. and Neil, J. C. (2017) Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis. Journal of Virology, 91(5), e02119-16. (doi: 10.1128/JVI.02119-16) (PMID:28031367) (PMCID:PMC5309941)
2016
Neil, J. C. , Borland, G. and Kilbey, A. (2016) Addiction to RUNX in lymphoma. Aging, 8(9), pp. 1832-1833. (doi: 10.18632/aging.101071) (PMID:27688195) (PMCID:PMC5076437)
Gilroy, K. L. et al. (2016) Gamma-retrovirus integration marks cell type-specific cancer genes: a novel profiling tool in cancer genomics. PLoS ONE, 11(4), e0154070. (doi: 10.1371/journal.pone.0154070) (PMID:27097319) (PMCID:PMC4838236)
Borland, G. et al. (2016) Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model. Oncotarget, 7(17), pp. 22973-22987. (doi: 10.18632/oncotarget.8554) (PMID:27056890) (PMCID:PMC5029604)
2015
Naseer, A. et al. (2015) Frequent infection of human cancer xenografts with murine endogenous retroviruses in vivo. Viruses, 7(4), pp. 2014-2029. (doi: 10.3390/v7042014) (PMID:25912714) (PMCID:PMC4411688)
2014
Huser, C. A. et al. (2014) Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis. PLoS Genetics, 10(2), e1004167. (doi: 10.1371/journal.pgen.1004167) (PMID:24586197) (PMCID:PMC3937229)
2010
Kilbey, A., Terry, A., Jenkins, A., Borland, G., Zhang, Q.F., Wakelam, M.J.O., Cameron, E.R. and Neil, J.C. (2010) Runx regulation of sphingolipid metabolism and survival signaling. Cancer Research, 70(14), pp. 5860-5869. (doi: 10.1158/0008-5472.CAN-10-0726)
Krapf, G., Kaindl, U., Kilbey, A., Fuka, G., Inthal, A., Joas, R., Mann, G., Neil, J.C. , Haas, O.A. and Panzer-Grümayer, E.R. (2010) ETV6/RUNX1 abrogates mitotic checkpoint function and targets its key player MAD2L1. Oncogene, 29(22), pp. 3307-3312. (doi: 10.1038/onc.2010.53)
2009
Wolyniec, K., Wotton, S., Kilbey, A., Jenkins, A., Terry, A., Peters, G., Stocking, C., Cameron, E.R. and Neil, J.C. (2009) RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress. Oncogene, 28(27), pp. 2502-2512. (doi: 10.1038/onc.2009.101)
2008
Wotton, S., Terry, A., Kilbey, A., Jenkins, A., Herzyk, P. , Cameron, E. and Neil, J.C. (2008) Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival. Oncogene, 27(44), pp. 5856-5866. (doi: 10.1038/onc.2008.195)
Kilbey, A., Terry, A., Cameron, E.R. and Neil, J.C. (2008) Oncogene-induced senescence: an essential role for Runx. Cell Cycle, 7(15), pp. 2333-2340.
2007
Kilbey, A., Blyth, K. , Wotton, S., Terry, A., Jenkins, A., Bell, M., Hanlon, L., Cameron, E.R. and Neil, J.C. (2007) Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts. Cancer Research, 67(23), pp. 11263-11271. (doi: 10.1158/0008-5472.CAN-07-3016)
2004
Wotton, S. F., Blyth, K. , Kilbey, A., Jenkins, A., Terry, A., Bernardin-Fried, F., Friedman, A. D., Baxter, E. W., Neil, J. C. and Cameron, E. R. (2004) RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53. Oncogene, 23(32), pp. 5476-5486. (doi: 10.1038/sj.onc.1207729) (PMID:15133495)
2003
Cameron, E. R., Blyth, K. , Hanlon, L., Kilbey, A., Mackay, N., Stewart, M., Terry, A., Vaillant, F., Wotton, S. and Neil, J. C. (2003) The Runx genes as dominant oncogenes. Blood Cells, Molecules, and Diseases, 30, pp. 194-200. (doi: 10.1016/S1079-9796(03)00031-7)
2002
Wotton, S., Stewart, M., Blyth, K. , Vaillant, F., Kilbey, A., Neil, J. C. and Cameron, E. R. (2002) Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Cancer Research, 62(24), pp. 7181-7185. (PMID:12499254)
2001
Palmer, S., Brouillet, J.-P., Kilbey, A., Fulton, R., Walker, M., Crossley, M. and Bartholomew, C. (2001) Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins. Journal of Biological Chemistry, 276(28), pp. 25834-25840. (doi: 10.1074/jbc.M102343200)
1995
Barnett, S. C. , Rosario, M., Doyle, A., Kilbey, A., Lovatt, A. and Gillespie, D. A.F. (1995) Differential regulation of AP-1 and novel TRE-specific DNA-binding complexes during differentiation of oligodendrocyte-type-2-astrocyte (O-2A) progenitor cells. Development, 121(12), pp. 3969-77. (PMID:8575297)
Articles
Suzuki, T., Hayman, L., Kilbey, A., Edwards, J. and Coffelt, S. B. (2020) Gut γδ T cells as guardians, disruptors and instigators of cancer. Immunological Reviews, 298(1), pp. 198-217. (doi: 10.1111/imr.12916) (PMID:32840001)
Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M. , Blyth, K. and Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)
Loyola, L. et al. (2019) Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model. PLoS Pathogens, 15(12), e1008154. (doi: 10.1371/journal.ppat.1008154) (PMID:31815961) (PMCID:PMC6974304)
Hay, J. , Gilroy, K., Huser, C. , Kilbey, A., Mcdonald, A., MacCallum, A., Holroyd, A. , Cameron, E. and Neil, J. C. (2019) Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity. Journal of Cellular Biochemistry, 120(10), pp. 18332-18345. (doi: 10.1002/jcb.29143) (PMID:31257681) (PMCID:PMC6772115)
Anderson, G. et al. (2018) RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. Journal of Cellular Biochemistry, 119(3), pp. 2750-2762. (doi: 10.1002/jcb.26443) (PMID:29052866) (PMCID:PMC5813226)
Kilbey, A. et al. (2017) Runx1 orchestrates sphingolipid metabolism and glucocorticoid resistance in lymphomagenesis. Journal of Cellular Biochemistry, 118(6), pp. 1432-1441. (doi: 10.1002/jcb.25802) (PMID:27869314) (PMCID:PMC5408393)
Terry, A., Kilbey, A., Naseer, A., Levy, L. S., Ahmad, S., Watts, C., Mackay, N., Cameron, E. , Wilson, S. and Neil, J. C. (2017) Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis. Journal of Virology, 91(5), e02119-16. (doi: 10.1128/JVI.02119-16) (PMID:28031367) (PMCID:PMC5309941)
Neil, J. C. , Borland, G. and Kilbey, A. (2016) Addiction to RUNX in lymphoma. Aging, 8(9), pp. 1832-1833. (doi: 10.18632/aging.101071) (PMID:27688195) (PMCID:PMC5076437)
Gilroy, K. L. et al. (2016) Gamma-retrovirus integration marks cell type-specific cancer genes: a novel profiling tool in cancer genomics. PLoS ONE, 11(4), e0154070. (doi: 10.1371/journal.pone.0154070) (PMID:27097319) (PMCID:PMC4838236)
Borland, G. et al. (2016) Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model. Oncotarget, 7(17), pp. 22973-22987. (doi: 10.18632/oncotarget.8554) (PMID:27056890) (PMCID:PMC5029604)
Naseer, A. et al. (2015) Frequent infection of human cancer xenografts with murine endogenous retroviruses in vivo. Viruses, 7(4), pp. 2014-2029. (doi: 10.3390/v7042014) (PMID:25912714) (PMCID:PMC4411688)
Huser, C. A. et al. (2014) Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis. PLoS Genetics, 10(2), e1004167. (doi: 10.1371/journal.pgen.1004167) (PMID:24586197) (PMCID:PMC3937229)
Kilbey, A., Terry, A., Jenkins, A., Borland, G., Zhang, Q.F., Wakelam, M.J.O., Cameron, E.R. and Neil, J.C. (2010) Runx regulation of sphingolipid metabolism and survival signaling. Cancer Research, 70(14), pp. 5860-5869. (doi: 10.1158/0008-5472.CAN-10-0726)
Krapf, G., Kaindl, U., Kilbey, A., Fuka, G., Inthal, A., Joas, R., Mann, G., Neil, J.C. , Haas, O.A. and Panzer-Grümayer, E.R. (2010) ETV6/RUNX1 abrogates mitotic checkpoint function and targets its key player MAD2L1. Oncogene, 29(22), pp. 3307-3312. (doi: 10.1038/onc.2010.53)
Wolyniec, K., Wotton, S., Kilbey, A., Jenkins, A., Terry, A., Peters, G., Stocking, C., Cameron, E.R. and Neil, J.C. (2009) RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress. Oncogene, 28(27), pp. 2502-2512. (doi: 10.1038/onc.2009.101)
Wotton, S., Terry, A., Kilbey, A., Jenkins, A., Herzyk, P. , Cameron, E. and Neil, J.C. (2008) Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival. Oncogene, 27(44), pp. 5856-5866. (doi: 10.1038/onc.2008.195)
Kilbey, A., Terry, A., Cameron, E.R. and Neil, J.C. (2008) Oncogene-induced senescence: an essential role for Runx. Cell Cycle, 7(15), pp. 2333-2340.
Kilbey, A., Blyth, K. , Wotton, S., Terry, A., Jenkins, A., Bell, M., Hanlon, L., Cameron, E.R. and Neil, J.C. (2007) Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts. Cancer Research, 67(23), pp. 11263-11271. (doi: 10.1158/0008-5472.CAN-07-3016)
Wotton, S. F., Blyth, K. , Kilbey, A., Jenkins, A., Terry, A., Bernardin-Fried, F., Friedman, A. D., Baxter, E. W., Neil, J. C. and Cameron, E. R. (2004) RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53. Oncogene, 23(32), pp. 5476-5486. (doi: 10.1038/sj.onc.1207729) (PMID:15133495)
Cameron, E. R., Blyth, K. , Hanlon, L., Kilbey, A., Mackay, N., Stewart, M., Terry, A., Vaillant, F., Wotton, S. and Neil, J. C. (2003) The Runx genes as dominant oncogenes. Blood Cells, Molecules, and Diseases, 30, pp. 194-200. (doi: 10.1016/S1079-9796(03)00031-7)
Wotton, S., Stewart, M., Blyth, K. , Vaillant, F., Kilbey, A., Neil, J. C. and Cameron, E. R. (2002) Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Cancer Research, 62(24), pp. 7181-7185. (PMID:12499254)
Palmer, S., Brouillet, J.-P., Kilbey, A., Fulton, R., Walker, M., Crossley, M. and Bartholomew, C. (2001) Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins. Journal of Biological Chemistry, 276(28), pp. 25834-25840. (doi: 10.1074/jbc.M102343200)
Barnett, S. C. , Rosario, M., Doyle, A., Kilbey, A., Lovatt, A. and Gillespie, D. A.F. (1995) Differential regulation of AP-1 and novel TRE-specific DNA-binding complexes during differentiation of oligodendrocyte-type-2-astrocyte (O-2A) progenitor cells. Development, 121(12), pp. 3969-77. (PMID:8575297)
Book Sections
Neil, J. C. , Gilroy, K., Borland, G., Hay, J. , Terry, A. and Kilbey, A. (2017) The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models. In: Groner, Y., Ito, Y., Liu, P., Neil, J. C., Speck, N. A. and van Wijnen, A. (eds.) RUNX Proteins in Development and Cancer. Series: Advances in experimental medicine and biology (962). Springer, pp. 247-264. ISBN 9789811032318 (doi:10.1007/978-981-10-3233-2_16)