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telephone:
01413306897
email:
Sharon.Burns@glasgow.ac.uk
School of Cancer Sciences,, Wolfson Wohl Cancer Research Centre,, Garscube Estate,, Switchback Road,, Glasgow,, G61 1BD
Cairney, C. J. et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genetics, 13(8), e1006942. (doi: 10.1371/journal.pgen.1006942) (PMID:28806777) (PMCID:PMC5570495)
Bilsland, A. E. et al. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia, 17(9), pp. 704-715. (doi: 10.1016/j.neo.2015.08.009) (PMID:26476078) (PMCID:PMC4611071)
Lafferty-Whyte, K., Bilsland, A. , Hoare, S.F., Burns, S., Zaffaroni, N., Cairney, C.J. and Keith, W.N. (2010) TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression. Neoplasia, 12(5), pp. 405-414.
Lafferty-Whyte, K. et al. (2010) Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma. BMC Genomics, 11(1), p. 532. (doi: 10.1186/1471-2164-11-532)
Bilsland, A.E., Hoare, S.F., Stevenson, K.H., Plumb, J.A., Gomez-Roman, N. , Cairney, C.J., Burns, S., Lafferty-Whyte, K., Hammonds, T. and Keith, W.N. (2009) Dynamic telomerase gene suppression via network effects of GSK3 inhibition. PLoS ONE, 4(7), e6459. (doi: 10.1371/journal.pone.0006459)
Glasspool, R.M., Burns, S., Hoare, S.F., Svensson, C. and Keith, W.N. (2005) The hTERT and hTERC telomerase gene promoters are activated by the second Exon of the adenoviral protein, E1A, identifying the transcriptional co-repressor CtBP as a potential repressor of both genes. Neoplasia, 7(6), pp. 614-622. (doi: 10.1593/neo.04766)
Oien, K.A. , McGregor, F., Butler, S., Ferrier, R.K., Downie, I., Bryce, S., Burns, S. and Keith, W.N. (2004) Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation. Journal of Pathology, 203(3), pp. 789-797. (doi: 10.1002/path.1583)
Hoare, S.F., Bryce, L.A., Wisman, G.B.A., Burns, S., Going, J.J., van der Zee, A.G.J. and Keith, W.N. (2001) Lack of telomerase RNA gene hTERC expression in alternative lengthening of telomeres cells is associated with methylation of the hTERC promoter. Cancer Research, 61(1), pp. 27-32.
Cairney, C. J. et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genetics, 13(8), e1006942. (doi: 10.1371/journal.pgen.1006942) (PMID:28806777) (PMCID:PMC5570495)
Bilsland, A. E. et al. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia, 17(9), pp. 704-715. (doi: 10.1016/j.neo.2015.08.009) (PMID:26476078) (PMCID:PMC4611071)
Lafferty-Whyte, K., Bilsland, A. , Hoare, S.F., Burns, S., Zaffaroni, N., Cairney, C.J. and Keith, W.N. (2010) TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression. Neoplasia, 12(5), pp. 405-414.
Lafferty-Whyte, K. et al. (2010) Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma. BMC Genomics, 11(1), p. 532. (doi: 10.1186/1471-2164-11-532)
Bilsland, A.E., Hoare, S.F., Stevenson, K.H., Plumb, J.A., Gomez-Roman, N. , Cairney, C.J., Burns, S., Lafferty-Whyte, K., Hammonds, T. and Keith, W.N. (2009) Dynamic telomerase gene suppression via network effects of GSK3 inhibition. PLoS ONE, 4(7), e6459. (doi: 10.1371/journal.pone.0006459)
Glasspool, R.M., Burns, S., Hoare, S.F., Svensson, C. and Keith, W.N. (2005) The hTERT and hTERC telomerase gene promoters are activated by the second Exon of the adenoviral protein, E1A, identifying the transcriptional co-repressor CtBP as a potential repressor of both genes. Neoplasia, 7(6), pp. 614-622. (doi: 10.1593/neo.04766)
Oien, K.A. , McGregor, F., Butler, S., Ferrier, R.K., Downie, I., Bryce, S., Burns, S. and Keith, W.N. (2004) Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation. Journal of Pathology, 203(3), pp. 789-797. (doi: 10.1002/path.1583)
Hoare, S.F., Bryce, L.A., Wisman, G.B.A., Burns, S., Going, J.J., van der Zee, A.G.J. and Keith, W.N. (2001) Lack of telomerase RNA gene hTERC expression in alternative lengthening of telomeres cells is associated with methylation of the hTERC promoter. Cancer Research, 61(1), pp. 27-32.
Cairney, C., Godwin, L., Bilsland, A., Burns, S., Stevenson, K., McGarry, L., Revie, J., Moore, J., Wiggans, C., Collinson, R., Mudd, C., Tsonou, E., Sadaie, M., Bennet, D., Narita, M., Torrance, C. and Keith, N. (2017) A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds. [Data Collection]
Bilsland, A., Pugliese, A., Liu, Y., Revie, J., Burns, S., McCormick, C., Cairney, C., Bower, J., Drysdale, M., Narita, M., Sadaie, M. and Keith, N. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. [Data Collection]
Lafferty-Whyte, K., Bilsland, A., Hoare, S., Burns, S., Zaffaroni, N., Cairney, C. and Keith, N. (2010) TCEAL7 Inhibition of c-Myc Activity in Alternative Lengthening of Telomeres Regulates hTERT Expression. [Data Collection]