Dr Jurre Kamphorst

  • Affiliate (Institute of Cancer Sciences)

Research interests

Link to research page in CRUK Beatson Institute


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • The effect of tumour microenvironment on the metabolism of pancreatic cancer cells
    Cancer Research UK
    2014 - 2020
     
  • Investigating Ether Lipid Metabolism in Aggressive Oral Cancers
    Cancer Research UK
    2014 - 2016
     

Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007
Number of items: 34.

2019

McGregor, G. H. et al. (2019) Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic anti-tumor response. Cancer Research, (doi:10.1158/0008-5472.CAN-19-0644) (PMID:31562248) (Early Online Publication)

2018

Ackerman, D., Tumanov, S., Qiu, B., Michalopoulou, E., Spata, M., Azzam, A., Xie, H., Simon, M. C. and Kamphorst, J. J. (2018) Triglycerides promote lipid homeostasis during hypoxic stress by balancing fatty acid saturation. Cell Reports, 24(10), 2596-2605.e5. (doi:10.1016/j.celrep.2018.08.015) (PMID:30184495) (PMCID:PMC6137821)

Rath, N. et al. (2018) Rho kinase inhibition by AT13148 blocks pancreatic ductal adenocarinoma invasion and tumor growth. Cancer Research, 78(12), pp. 3321-3336. (doi:10.1158/0008-5472.CAN-17-1339) (PMID:29669760)

2017

Susanto, O. et al. (2017) LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells. Journal of Cell Science, 130(20), pp. 3455-3466. (doi:10.1242/jcs.207514) (PMID:28871044) (PMCID:PMC5665449)

Rajeshkumar, N.V. et al. (2017) Treatment of pancreatic cancer patient–derived xenograft panel with metabolic inhibitors reveals efficacy of phenformin. Clinical Cancer Research, 23(18), pp. 5639-5647. (doi:10.1158/1078-0432.CCR-17-1115) (PMID:28611197)

Kamphorst, J. J. and Lewis, I. A. (2017) Editorial overview: recent innovations in the metabolomics revolution. Current Opinion in Biotechnology, 43, iv-vii. (doi:10.1016/j.copbio.2017.01.005) (PMID:28126441)

Tumanov, S. and Kamphorst, J. J. (2017) Recent advances in expanding the coverage of the lipidome. Current Opinion in Biotechnology, 43, pp. 127-133. (doi:10.1016/j.copbio.2016.11.008) (PMID:27915214) (PMCID:PMC5312421)

Bulusu, V. et al. (2017) Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation. Cell Reports, 18(3), pp. 647-658. (doi:10.1016/j.celrep.2016.12.055) (PMID:28099844) (PMCID:5276806)

2016

Meiser, J. et al. (2016) Serine one-carbon catabolism with formate overflow. Science Advances, 2(10), e1601273. (doi:10.1126/sciadv.1601273) (PMID:27819051) (PMCID:PMC5091358)

Michalopoulou, E., Bulusu, V. and Kamphorst, J. J. (2016) Metabolic scavenging by cancer cells: when the going gets tough, the tough keep eating. British Journal of Cancer, 115(6), pp. 635-640. (doi:10.1038/bjc.2016.256) (PMID:27537393) (PMCID:PMC5023784)

Kamphorst, J. J. and Gottlieb, E. (2016) Cancer metabolism: Friendly neighbours feed tumour cells. Nature, 536(7617), pp. 401-402. (doi:10.1038/nature19420) (PMID:27509862)

Tumanov, S., Bulusu, V., Gottlieb, E. and Kamphorst, J. (2016) A rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis. Cancer and Metabolism, 4, 17. (doi:10.1186/s40170-016-0157-5) (PMID:27594997) (PMCID:PMC5009658)

Vazquez, A., Kamphorst, J. J. , Markert, E. K., Schug, Z. T., Tardito, S. and Gottlieb, E. (2016) Cancer metabolism at a glance. Journal of Cell Science, 129(18), pp. 3367-3373. (doi:10.1242/jcs.181016) (PMID:27635066)

2015

Buescher, J. M. et al. (2015) A roadmap for interpreting 13C metabolite labeling patterns from cells. Current Opinion in Biotechnology, 34, pp. 189-201. (doi:10.1016/j.copbio.2015.02.003) (PMID:25731751) (PMCID:PMC4552607)

Rajeshkumar, N. V. et al. (2015) Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function. Cancer Research, 75(16), pp. 3355-3364. (doi:10.1158/0008-5472.CAN-15-0108) (PMID:26113084) (PMCID:PMC4537812)

Kamphorst, J.J. et al. (2015) Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Research, 75(3), pp. 544-553. (doi:10.1158/0008-5472.CAN-14-2211) (PMID:25644265)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi:10.1016/j.ccell.2014.12.002) (PMID:25584894) (PMCID:PMC4297291)

Cardaci, S. et al. (2015) Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nature Cell Biology, 17, pp. 1317-1326. (doi:10.1038/ncb3233) (PMID:26302408)

Tumanov, S., Bulusu, V. and Kamphorst, J. J. (2015) Analysis of fatty acid metabolism using stable isotope tracers and mass spectrometry. In: Metallo, C. M. (ed.) Metabolic Analysis Using Stable Isotopes. Series: Methods in enzymology (561). Elsevier, pp. 197-217. ISBN 9780128022931 (doi:10.1016/bs.mie.2015.05.017)

2014

Fan, J., Ye, J., Kamphorst, J. J. , Shlomi, T., Thompson, C. B. and Rabinowitz, J. D. (2014) Quantitative flux analysis reveals folate-dependent NADPH production. Nature, 510(7504), pp. 298-302. (doi:10.1038/nature13236) (PMID:24805240) (PMCID:PMC4104482)

Kamphorst, J. J. , Chung, M. K., Fan, J. and Rabinowitz, J. D. (2014) Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer and Metabolism, 2, 23. (doi:10.1186/2049-3002-2-23) (PMID:25671109) (PMCID:PMC4322440)

Kamphorst, J. J. and Murphy, D. J. (2014) The 2014 Beatson International Cancer Conference: Powering the Cancer Machine. Cancer and Metabolism, 2(1), 25. (doi:10.1186/2049-3002-2-25)

2013

Fan, J., Kamphorst, J.J. , Rabinowitz, J.D. and Shlomi, T. (2013) Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux. Journal of Biological Chemistry, 288(43), pp. 31363-31369. (doi:10.1074/jbc.M113.502740) (PMID:24030823) (PMCID:PMC3829450)

Kamphorst, J.J. , Cross, J.R., Fan, J., de Stanchina, E., Mathew, R., White, E.P., Thompson, C.B. and Rabinowitz, J.D. (2013) Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proceedings of the National Academy of Sciences of the United States of America, 110(22), pp. 8882-8887. (doi:10.1073/pnas.1307237110)

Commisso, C. et al. (2013) Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature, 497(7451), pp. 633-637. (doi:10.1038/nature12138)

Fan, J., Kamphorst, J.J. , Mathew, R., Chung, M.K., White, E., Shlomi, T. and Rabinowitz, J.D. (2013) Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Molecular Systems Biology, 9, 712. (doi:10.1038/msb.2013.65) (PMID:24301801) (PMCID:PMC3882799)

Guo, J.Y. et al. (2013) Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes and Development, 27(13), pp. 1447-1461. (doi:10.1101/gad.219642.113)

2012

Bray, K. et al. (2012) Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS ONE, 7(7), e41831. (doi:10.1371/journal.pone.0041831) (PMID:22848625) (PMCID:PMC3406086)

2011

Guo, J.Y. et al. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes and Development, 25(5), pp. 460-470. (doi:10.1101/gad.2016311) (PMID:21317241) (PMCID:PMC3049287)

Kamphorst, J.J. , Fan, J., Lu, W., White, E. and Rabinowitz, J.D. (2011) Liquid chromatography–high resolution mass spectrometry analysis of fatty acid metabolism. Analytical Chemistry, 83(23), pp. 9114-9122. (doi:10.1021/ac202220b)

2010

Castro-Perez, J. M., Kamphorst, J. , DeGroot, J., Lafeber, F., Goshawk, J., Yu, K., Shockcor, J. P., Vreeken, R. J. and Hankemeier, T. (2010) Comprehensive LC−MSELipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients. Journal of Proteome Research, 9(5), pp. 2377-2389. (doi:10.1021/pr901094j) (PMID:20355720)

2009

Kamphorst, J. J. , Tjaden, U. R., van der Heijden, R., DeGroot, J., van der Greef, J. and Hankemeier, T. (2009) Feasibility of electrodialysis as a fast and selective sample preparation method for the profiling of low-abundant peptides in biofluids. Electrophoresis, 30(13), pp. 2284-2292. (doi:10.1002/elps.200800500) (PMID:19569123)

2007

Kamphorst, J. J.e. , van der Heijden, R., DeGroot, J., Lafeber, F. P.J.G., Reijmers, T. H., van El, B., Tjaden, U. R., van der Greef, J. and Hankemeier, T. (2007) Profiling of endogenous peptides in human synovial fluid by nanoLC−MS: method validation and peptide identification. Journal of Proteome Research, 6(11), pp. 4388-4396. (doi:10.1021/pr0704534) (PMID:17929855)

Kamphorst, J. , Cucurull-Sanchez, L. and Jones, B. (2007) A performance evaluation of multiple classification models of human PEPT1 inhibitors and non-inhibitors. QSAR & Combinatorial Science, 26(2), pp. 220-226. (doi:10.1002/qsar.200630025)

This list was generated on Mon Oct 14 16:48:14 2019 BST.
Number of items: 34.

Articles

McGregor, G. H. et al. (2019) Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic anti-tumor response. Cancer Research, (doi:10.1158/0008-5472.CAN-19-0644) (PMID:31562248) (Early Online Publication)

Ackerman, D., Tumanov, S., Qiu, B., Michalopoulou, E., Spata, M., Azzam, A., Xie, H., Simon, M. C. and Kamphorst, J. J. (2018) Triglycerides promote lipid homeostasis during hypoxic stress by balancing fatty acid saturation. Cell Reports, 24(10), 2596-2605.e5. (doi:10.1016/j.celrep.2018.08.015) (PMID:30184495) (PMCID:PMC6137821)

Rath, N. et al. (2018) Rho kinase inhibition by AT13148 blocks pancreatic ductal adenocarinoma invasion and tumor growth. Cancer Research, 78(12), pp. 3321-3336. (doi:10.1158/0008-5472.CAN-17-1339) (PMID:29669760)

Susanto, O. et al. (2017) LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells. Journal of Cell Science, 130(20), pp. 3455-3466. (doi:10.1242/jcs.207514) (PMID:28871044) (PMCID:PMC5665449)

Rajeshkumar, N.V. et al. (2017) Treatment of pancreatic cancer patient–derived xenograft panel with metabolic inhibitors reveals efficacy of phenformin. Clinical Cancer Research, 23(18), pp. 5639-5647. (doi:10.1158/1078-0432.CCR-17-1115) (PMID:28611197)

Kamphorst, J. J. and Lewis, I. A. (2017) Editorial overview: recent innovations in the metabolomics revolution. Current Opinion in Biotechnology, 43, iv-vii. (doi:10.1016/j.copbio.2017.01.005) (PMID:28126441)

Tumanov, S. and Kamphorst, J. J. (2017) Recent advances in expanding the coverage of the lipidome. Current Opinion in Biotechnology, 43, pp. 127-133. (doi:10.1016/j.copbio.2016.11.008) (PMID:27915214) (PMCID:PMC5312421)

Bulusu, V. et al. (2017) Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation. Cell Reports, 18(3), pp. 647-658. (doi:10.1016/j.celrep.2016.12.055) (PMID:28099844) (PMCID:5276806)

Meiser, J. et al. (2016) Serine one-carbon catabolism with formate overflow. Science Advances, 2(10), e1601273. (doi:10.1126/sciadv.1601273) (PMID:27819051) (PMCID:PMC5091358)

Michalopoulou, E., Bulusu, V. and Kamphorst, J. J. (2016) Metabolic scavenging by cancer cells: when the going gets tough, the tough keep eating. British Journal of Cancer, 115(6), pp. 635-640. (doi:10.1038/bjc.2016.256) (PMID:27537393) (PMCID:PMC5023784)

Kamphorst, J. J. and Gottlieb, E. (2016) Cancer metabolism: Friendly neighbours feed tumour cells. Nature, 536(7617), pp. 401-402. (doi:10.1038/nature19420) (PMID:27509862)

Tumanov, S., Bulusu, V., Gottlieb, E. and Kamphorst, J. (2016) A rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis. Cancer and Metabolism, 4, 17. (doi:10.1186/s40170-016-0157-5) (PMID:27594997) (PMCID:PMC5009658)

Vazquez, A., Kamphorst, J. J. , Markert, E. K., Schug, Z. T., Tardito, S. and Gottlieb, E. (2016) Cancer metabolism at a glance. Journal of Cell Science, 129(18), pp. 3367-3373. (doi:10.1242/jcs.181016) (PMID:27635066)

Buescher, J. M. et al. (2015) A roadmap for interpreting 13C metabolite labeling patterns from cells. Current Opinion in Biotechnology, 34, pp. 189-201. (doi:10.1016/j.copbio.2015.02.003) (PMID:25731751) (PMCID:PMC4552607)

Rajeshkumar, N. V. et al. (2015) Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function. Cancer Research, 75(16), pp. 3355-3364. (doi:10.1158/0008-5472.CAN-15-0108) (PMID:26113084) (PMCID:PMC4537812)

Kamphorst, J.J. et al. (2015) Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Research, 75(3), pp. 544-553. (doi:10.1158/0008-5472.CAN-14-2211) (PMID:25644265)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi:10.1016/j.ccell.2014.12.002) (PMID:25584894) (PMCID:PMC4297291)

Cardaci, S. et al. (2015) Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nature Cell Biology, 17, pp. 1317-1326. (doi:10.1038/ncb3233) (PMID:26302408)

Fan, J., Ye, J., Kamphorst, J. J. , Shlomi, T., Thompson, C. B. and Rabinowitz, J. D. (2014) Quantitative flux analysis reveals folate-dependent NADPH production. Nature, 510(7504), pp. 298-302. (doi:10.1038/nature13236) (PMID:24805240) (PMCID:PMC4104482)

Kamphorst, J. J. , Chung, M. K., Fan, J. and Rabinowitz, J. D. (2014) Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer and Metabolism, 2, 23. (doi:10.1186/2049-3002-2-23) (PMID:25671109) (PMCID:PMC4322440)

Kamphorst, J. J. and Murphy, D. J. (2014) The 2014 Beatson International Cancer Conference: Powering the Cancer Machine. Cancer and Metabolism, 2(1), 25. (doi:10.1186/2049-3002-2-25)

Fan, J., Kamphorst, J.J. , Rabinowitz, J.D. and Shlomi, T. (2013) Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux. Journal of Biological Chemistry, 288(43), pp. 31363-31369. (doi:10.1074/jbc.M113.502740) (PMID:24030823) (PMCID:PMC3829450)

Kamphorst, J.J. , Cross, J.R., Fan, J., de Stanchina, E., Mathew, R., White, E.P., Thompson, C.B. and Rabinowitz, J.D. (2013) Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proceedings of the National Academy of Sciences of the United States of America, 110(22), pp. 8882-8887. (doi:10.1073/pnas.1307237110)

Commisso, C. et al. (2013) Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature, 497(7451), pp. 633-637. (doi:10.1038/nature12138)

Fan, J., Kamphorst, J.J. , Mathew, R., Chung, M.K., White, E., Shlomi, T. and Rabinowitz, J.D. (2013) Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Molecular Systems Biology, 9, 712. (doi:10.1038/msb.2013.65) (PMID:24301801) (PMCID:PMC3882799)

Guo, J.Y. et al. (2013) Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes and Development, 27(13), pp. 1447-1461. (doi:10.1101/gad.219642.113)

Bray, K. et al. (2012) Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS ONE, 7(7), e41831. (doi:10.1371/journal.pone.0041831) (PMID:22848625) (PMCID:PMC3406086)

Guo, J.Y. et al. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes and Development, 25(5), pp. 460-470. (doi:10.1101/gad.2016311) (PMID:21317241) (PMCID:PMC3049287)

Kamphorst, J.J. , Fan, J., Lu, W., White, E. and Rabinowitz, J.D. (2011) Liquid chromatography–high resolution mass spectrometry analysis of fatty acid metabolism. Analytical Chemistry, 83(23), pp. 9114-9122. (doi:10.1021/ac202220b)

Castro-Perez, J. M., Kamphorst, J. , DeGroot, J., Lafeber, F., Goshawk, J., Yu, K., Shockcor, J. P., Vreeken, R. J. and Hankemeier, T. (2010) Comprehensive LC−MSELipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients. Journal of Proteome Research, 9(5), pp. 2377-2389. (doi:10.1021/pr901094j) (PMID:20355720)

Kamphorst, J. J. , Tjaden, U. R., van der Heijden, R., DeGroot, J., van der Greef, J. and Hankemeier, T. (2009) Feasibility of electrodialysis as a fast and selective sample preparation method for the profiling of low-abundant peptides in biofluids. Electrophoresis, 30(13), pp. 2284-2292. (doi:10.1002/elps.200800500) (PMID:19569123)

Kamphorst, J. J.e. , van der Heijden, R., DeGroot, J., Lafeber, F. P.J.G., Reijmers, T. H., van El, B., Tjaden, U. R., van der Greef, J. and Hankemeier, T. (2007) Profiling of endogenous peptides in human synovial fluid by nanoLC−MS: method validation and peptide identification. Journal of Proteome Research, 6(11), pp. 4388-4396. (doi:10.1021/pr0704534) (PMID:17929855)

Kamphorst, J. , Cucurull-Sanchez, L. and Jones, B. (2007) A performance evaluation of multiple classification models of human PEPT1 inhibitors and non-inhibitors. QSAR & Combinatorial Science, 26(2), pp. 220-226. (doi:10.1002/qsar.200630025)

Book Sections

Tumanov, S., Bulusu, V. and Kamphorst, J. J. (2015) Analysis of fatty acid metabolism using stable isotope tracers and mass spectrometry. In: Metallo, C. M. (ed.) Metabolic Analysis Using Stable Isotopes. Series: Methods in enzymology (561). Elsevier, pp. 197-217. ISBN 9780128022931 (doi:10.1016/bs.mie.2015.05.017)

This list was generated on Mon Oct 14 16:48:14 2019 BST.