Dr Virginia Llopis-Hernandez

  • Research Associate (Institute of Molecular Cell & Systems Biology)

Biography

In 2010 I received my Bachelor in Biotechnology and in 2012 my Master degree in Biomedical Biotechnology from Universitat Politecnica de Valencia in SpainBetween 2012 and 2017 I pursued a PhD in Biomedical Biotechnology at the Universitat Politecnica de Valencia, obtained with European mention and honors. During my PhD my research activity was complemented by several internships, at the Centre for Cell Engineering at the University of Glasgow, 2012; a Marie-Curie-IAPP Program Secodment in Germany, 2013; and The Biomaterial Immuno-Engineering Lab at the University of Florida, 2014. I worked on investigating the role of fibronectin and growth factors on mediating cell-material interactions towards bone differentiation.

 

In 2017, I started as a Research Assistant in Professor Matthew Dalby reseach group where I have been working on growth factors and material-based strategies to engineer tissue repair and regeneration and with my own side project in 2019 on the discovery of metabolites involved in wound healing and fibrosis.

 


Research interests

My research takes a multi-disciplinary approach to the development of novel biomedical approaches to treat clinical problems, focusing on the use of growth factors and small molecules. 

 
Some of the lines of research that I have been working on are:
 
- Study and development of a material-driven fibronectin fibrillogenesis to efficiently present growth factors to improve bone regeneration using mesenchymal stem cells. This line of research has given place to several others including the improvement of the bioactivity of currently used biomaterials in clinics biomaterials (e.g. PEEK).
 
- Use of nanotopographies, ceramics, thermoresponsible scaffolds, liposomes and hydrogels to delivery growth factors in vitro and in vivo for bone regeneration using mesenchymal stem cells in vitro and murine in vivo models.
 
- Performance and use different techniques to sterilise bioactive coatings preventing them from being damaged
 
- Use of epidermal growth factors (e.g. PDGF-BB) to improve the wound healing. This work has been useful to determine a new line of research using a different biomaterial platform and approach.
 

Publications

List by: Type | Date

Jump to: 2019 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011
Number of items: 9.

2019

Cheng, Z. A. et al. (2019) Nanoscale coatings for ultralow dose BMP‐2‐driven regeneration of critical‐sized bone defects. Advanced Science, 6(2), 1800361. (doi:10.1002/advs.201800361) (PMID:30693176) (PMCID:PMC6343071)

2017

Anderson, H., Llopis-Hernandez, V. , Sweeten, P., Donnelly, H., Gurden, R., Orapiriyakul, W., Salmeron-Sanchez, M. , Dalby, M.J. and Tsimbouri, M.P. (2017) Nanoscale surface cues and cell behaviour. In: Hashmi, S. (ed.) Reference Module in Materials Science and Materials Engineering. Elsevier. ISBN 9780128035818 (doi:10.1016/B978-0-12-803581-8.10226-7)

2016

Llopis-Hernández, V. , Cantini, M. , González-García, C., Cheng, Z. A., Yang, J., Tsimbouri, P. M. , García, A. J., Dalby, M. J. and Salmerón-Sánchez, M. (2016) Material-driven fibronectin assembly for high-efficiency presentation of growth factors. Science Advances, 2(8), e1600188. (doi:10.1126/sciadv.1600188) (PMID:27574702) (PMCID:PMC5001810)

Coelho, N.M., Llopis-Hernandez, V. , Salmeron-Sanchez, M. and Altankov, G. (2016) Dynamic reorganization and enzymatic remodeling of type IV collagen at cell-biomaterial interface. In: Christov, C. Z. (ed.) Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods. Series: Advances in protein chemistry and structural biology (105). Elsevier, pp. 81-104. ISBN 9780128048252 (doi:10.1016/bs.apcsb.2016.06.001)

2015

Llopis-Hernandez, V., Cantini, M. , González-García, C. and Salmeron-Sanchez, M. (2015) Material-based strategies to engineer fibronectin matrices for regenerative medicine. International Materials Reviews, 60(5), pp. 245-264. (doi:10.1179/1743280414Y.0000000049)

2013

Llopis-Hernandez, V. , Rico, P., Moratal, D., Altankov, G. and Salmerón-Sánchez, M. (2013) Role of material-driven fibronectin fibrillogenesis in protein remodeling. BioResearch Open Access, 2(5), pp. 364-373. (doi:10.1089/biores.2013.0017)

2012

Cantini, M. , Gonzalez-Garcia, C., Llopis-Hernandez, V. and Salmerón-Sánchez, M. (2012) Material-driven fibronectin fibrillogenesis. In: Horbett, T., Brash, B. and Norde, N. (eds.) Proteins at Interfaces III State of the Art 2012. Series: ACS symposium series (1120). American Chemical Society: Washington DC, VA, USA, pp. 471-496. (doi:10.1021/bk-2012-1120.ch022)

2011

Llopis-Hernandez, V. , Rico, P., Ballaster-Beltran, J., Moratal, D. and Salmeron-Sanchez, M. (2011) Influence of Surface Chemistry on Cell Proteolytic Activity at the Material Interface. 24th European Conference on Biomaterials, EBS 2011, Dublin, Ireland, 4-8 Sept 2011.

Llopis-Hernandez, V. , Rico, P., Ballester-Beltrán, J., Moratal, D. and Salmerón-Sánchez, M. (2011) Role of surface chemistry in protein remodeling at the cell-material interface. PLoS ONE, 6(5), e19610. (doi:10.1371/journal.pone.0019610)

This list was generated on Sat Jul 20 08:51:26 2019 BST.
Number of items: 9.

Articles

Cheng, Z. A. et al. (2019) Nanoscale coatings for ultralow dose BMP‐2‐driven regeneration of critical‐sized bone defects. Advanced Science, 6(2), 1800361. (doi:10.1002/advs.201800361) (PMID:30693176) (PMCID:PMC6343071)

Llopis-Hernández, V. , Cantini, M. , González-García, C., Cheng, Z. A., Yang, J., Tsimbouri, P. M. , García, A. J., Dalby, M. J. and Salmerón-Sánchez, M. (2016) Material-driven fibronectin assembly for high-efficiency presentation of growth factors. Science Advances, 2(8), e1600188. (doi:10.1126/sciadv.1600188) (PMID:27574702) (PMCID:PMC5001810)

Llopis-Hernandez, V., Cantini, M. , González-García, C. and Salmeron-Sanchez, M. (2015) Material-based strategies to engineer fibronectin matrices for regenerative medicine. International Materials Reviews, 60(5), pp. 245-264. (doi:10.1179/1743280414Y.0000000049)

Llopis-Hernandez, V. , Rico, P., Moratal, D., Altankov, G. and Salmerón-Sánchez, M. (2013) Role of material-driven fibronectin fibrillogenesis in protein remodeling. BioResearch Open Access, 2(5), pp. 364-373. (doi:10.1089/biores.2013.0017)

Llopis-Hernandez, V. , Rico, P., Ballester-Beltrán, J., Moratal, D. and Salmerón-Sánchez, M. (2011) Role of surface chemistry in protein remodeling at the cell-material interface. PLoS ONE, 6(5), e19610. (doi:10.1371/journal.pone.0019610)

Book Sections

Anderson, H., Llopis-Hernandez, V. , Sweeten, P., Donnelly, H., Gurden, R., Orapiriyakul, W., Salmeron-Sanchez, M. , Dalby, M.J. and Tsimbouri, M.P. (2017) Nanoscale surface cues and cell behaviour. In: Hashmi, S. (ed.) Reference Module in Materials Science and Materials Engineering. Elsevier. ISBN 9780128035818 (doi:10.1016/B978-0-12-803581-8.10226-7)

Coelho, N.M., Llopis-Hernandez, V. , Salmeron-Sanchez, M. and Altankov, G. (2016) Dynamic reorganization and enzymatic remodeling of type IV collagen at cell-biomaterial interface. In: Christov, C. Z. (ed.) Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods. Series: Advances in protein chemistry and structural biology (105). Elsevier, pp. 81-104. ISBN 9780128048252 (doi:10.1016/bs.apcsb.2016.06.001)

Cantini, M. , Gonzalez-Garcia, C., Llopis-Hernandez, V. and Salmerón-Sánchez, M. (2012) Material-driven fibronectin fibrillogenesis. In: Horbett, T., Brash, B. and Norde, N. (eds.) Proteins at Interfaces III State of the Art 2012. Series: ACS symposium series (1120). American Chemical Society: Washington DC, VA, USA, pp. 471-496. (doi:10.1021/bk-2012-1120.ch022)

Conference or Workshop Item

Llopis-Hernandez, V. , Rico, P., Ballaster-Beltran, J., Moratal, D. and Salmeron-Sanchez, M. (2011) Influence of Surface Chemistry on Cell Proteolytic Activity at the Material Interface. 24th European Conference on Biomaterials, EBS 2011, Dublin, Ireland, 4-8 Sept 2011.

This list was generated on Sat Jul 20 08:51:26 2019 BST.