Dr Claire Donald

  • Lecturer (Institute of Molecular Cell & Systems Biology)

Biography

Claire joined the University of Glasgow as a PhD student in 2011 in the lab of Professor Alain Kohl at the MRC-University of Glasgow Centre for Virus Research. Her research focused on the role of RNA interference in controlling arbovirus replication in mosquito-derived cell lines and the development of molecular tools to improve our understanding of this antiviral response in both vector and non-vector species. Her first post-doctoral position involved in vivo studies of mosquito- arbovirus interactions with a focus on gene function at the tissue level to understand the importance of tissue-specific antiviral strategies in Aedes aegypti. Claire then moved on to working with Zika virus and it’s interactions with host innate immune responses in order to better understand viral pathogenesis in mammals.    

Claire also enjoys engaging the public with science and developing interactive STEM activities.  


Research interests

Many mosquito species are anautogenous and require a blood meal from a vertebrate host in order to obtain essential nutrients necessary for egg production. This means that they are able to act as vectors for the spread important pathogens, such as arboviruses (arthropod-borne viruses), as well as bacteria or parasites which can cause disease in both humans and animals. Infection within the mosquito is not fully understood, although recent advances have improved our understanding of antiviral immune responses such as RNA Interference and Jak/STAT signalling.

I am interested in the interplays between the circadian rhythm, mosquito immunity and arbovirus replication. There is an increasing understanding that biological rhythms within mosquitoes are important factors for global human and animal health. My work focuses on Aedes aegypti as a major vector for many important arboviruses to improve our understanding of the mechanisms involved in controlling infections within mosquitoes.      


Publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011
Number of items: 18.

2020

Royle, J. , Ramírez-Santana, C., Akpunarlieva, S., Donald, C. L. , Gestuveo, R. J., Anaya, J.-M., Merits, A., Burchmore, R. , Kohl, A. and Varjak, M. (2020) Glucose-regulated protein 78 interacts with Zika virus envelope protein and contributes to a productive infection. Viruses, 12(5), 524. (doi: 10.3390/v12050524)

McFarlane, M. et al. (2020) The Aedes aegypti Domino orthologue p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression. mSphere, 5(2), e00081-20. (doi: 10.1128/mSphere.00081-20) (PMID:32269152) (PMCID:PMC7142294)

2019

Lima, M. C. et al. (2019) The transcriptional and protein profile from human infected neuroprogenitor cells is strongly correlated to Zika virus microcephaly cytokines phenotype evidencing a persistent inflammation in the CNS. Frontiers in Immunology, 10, 1928. (doi: 10.3389/fimmu.2019.01928) (PMID:31474994) (PMCID:PMC6707094)

Zhuang, X. et al. (2019) The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication. Nature Communications, 10(1), (doi: 10.1038/s41467-019-08299-7) (PMID:30670689) (PMCID:PMC6343007)

2018

Donald, C. L. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B. , Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. Viruses, 10(12), 694. (doi: 10.3390/v10120694) (PMID:30563205) (PMCID:PMC6316411)

Hertzog, J. et al. (2018) Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling. European Journal of Immunology, 48(7), pp. 1120-1136. (doi: 10.1002/eji.201847483) (PMID:29572905) (PMCID:PMC6055886)

López-Camacho, C. et al. (2018) Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, 9, 2441. (doi: 10.1038/s41467-018-04859-5) (PMID:29934593) (PMCID:PMC6015009)

Zmurko, J., Vasey, D. B., Donald, C. L. , Armstrong, A. A., McKee, M. L., Kohl, A. and Clayton, R. F. (2018) Mitigating the risk of Zika virus contamination of raw materials and cell lines in the manufacture of biologicals. Journal of General Virology, 99, pp. 219-229. (doi: 10.1099/jgv.0.000995) (PMID:29239715) (PMCID:PMC5882083)

2017

Royle, J., Donald, C. L. , Merits, A., Kohl, A. and Varjak, M. (2017) Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. Veterinary Journal, 230, pp. 62-64. (doi: 10.1016/j.tvjl.2017.10.009) (PMID:29102599) (PMCID:PMC5726355)

Varjak, M. , Donald, C. L. , Mottram, T. J., Sreenu, V. B. , Merits, A., Maringer, K., Schnettler, E. and Kohl, A. (2017) Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11(10), e0006010. (doi: 10.1371/journal.pntd.0006010) (PMID:29040304) (PMCID:PMC5667879)

Cumberworth, S., Clark, J. J., Kohl, A. and Donald, C. L. (2017) Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses. Cellular Microbiology, 19(5), e12737. (doi: 10.1111/cmi.12737) (PMID:28273394) (PMCID:PMC5413821)

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi: 10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

2016

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi: 10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

2015

Kean, J., Rainey, S., McFarlane, M. , Donald, C. , Schnettler, E., Kohl, A. and Pondeville, E. (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi: 10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

2014

McFarlane, M. et al. (2014) Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Neglected Tropical Diseases, 8(7), e2994. (doi: 10.1371/journal.pntd.0002994) (PMID:25058001) (PMCID:PMC4109886)

2013

Schnettler, E., Donald, C. L. , Human, S., Watson, M., Siu, R. W. C., McFarlane, M. , Fazakerley, J. K., Kohl, A. and Fragkoudis, R. (2013) Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells. Journal of General Virology, 94(Pt. 7), pp. 1680-1689. (doi: 10.1099/vir.0.053850-0) (PMID:23559478) (PMCID:PMC3709635)

2012

Donald, C. L. , Kohl, A. and Schnettler, E. (2012) New insights into control of arbovirus replication and spread by insect RNA interference pathways. Insects, 3(2), pp. 511-531. (doi: 10.3390/insects3020511)

2011

Siu, R. W.C. et al. (2011) Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: characterization, origin, and frequency-dependent functions of virus-derived small interfering RNAs. Journal of Virology, 85(6), pp. 2907-2917. (doi: 10.1128/JVI.02052-10)

This list was generated on Thu Jul 9 05:44:55 2020 BST.
Jump to: Articles
Number of items: 18.

Articles

Royle, J. , Ramírez-Santana, C., Akpunarlieva, S., Donald, C. L. , Gestuveo, R. J., Anaya, J.-M., Merits, A., Burchmore, R. , Kohl, A. and Varjak, M. (2020) Glucose-regulated protein 78 interacts with Zika virus envelope protein and contributes to a productive infection. Viruses, 12(5), 524. (doi: 10.3390/v12050524)

McFarlane, M. et al. (2020) The Aedes aegypti Domino orthologue p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression. mSphere, 5(2), e00081-20. (doi: 10.1128/mSphere.00081-20) (PMID:32269152) (PMCID:PMC7142294)

Lima, M. C. et al. (2019) The transcriptional and protein profile from human infected neuroprogenitor cells is strongly correlated to Zika virus microcephaly cytokines phenotype evidencing a persistent inflammation in the CNS. Frontiers in Immunology, 10, 1928. (doi: 10.3389/fimmu.2019.01928) (PMID:31474994) (PMCID:PMC6707094)

Zhuang, X. et al. (2019) The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication. Nature Communications, 10(1), (doi: 10.1038/s41467-019-08299-7) (PMID:30670689) (PMCID:PMC6343007)

Donald, C. L. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B. , Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. Viruses, 10(12), 694. (doi: 10.3390/v10120694) (PMID:30563205) (PMCID:PMC6316411)

Hertzog, J. et al. (2018) Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling. European Journal of Immunology, 48(7), pp. 1120-1136. (doi: 10.1002/eji.201847483) (PMID:29572905) (PMCID:PMC6055886)

López-Camacho, C. et al. (2018) Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, 9, 2441. (doi: 10.1038/s41467-018-04859-5) (PMID:29934593) (PMCID:PMC6015009)

Zmurko, J., Vasey, D. B., Donald, C. L. , Armstrong, A. A., McKee, M. L., Kohl, A. and Clayton, R. F. (2018) Mitigating the risk of Zika virus contamination of raw materials and cell lines in the manufacture of biologicals. Journal of General Virology, 99, pp. 219-229. (doi: 10.1099/jgv.0.000995) (PMID:29239715) (PMCID:PMC5882083)

Royle, J., Donald, C. L. , Merits, A., Kohl, A. and Varjak, M. (2017) Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. Veterinary Journal, 230, pp. 62-64. (doi: 10.1016/j.tvjl.2017.10.009) (PMID:29102599) (PMCID:PMC5726355)

Varjak, M. , Donald, C. L. , Mottram, T. J., Sreenu, V. B. , Merits, A., Maringer, K., Schnettler, E. and Kohl, A. (2017) Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11(10), e0006010. (doi: 10.1371/journal.pntd.0006010) (PMID:29040304) (PMCID:PMC5667879)

Cumberworth, S., Clark, J. J., Kohl, A. and Donald, C. L. (2017) Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses. Cellular Microbiology, 19(5), e12737. (doi: 10.1111/cmi.12737) (PMID:28273394) (PMCID:PMC5413821)

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi: 10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi: 10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Kean, J., Rainey, S., McFarlane, M. , Donald, C. , Schnettler, E., Kohl, A. and Pondeville, E. (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi: 10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

McFarlane, M. et al. (2014) Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Neglected Tropical Diseases, 8(7), e2994. (doi: 10.1371/journal.pntd.0002994) (PMID:25058001) (PMCID:PMC4109886)

Schnettler, E., Donald, C. L. , Human, S., Watson, M., Siu, R. W. C., McFarlane, M. , Fazakerley, J. K., Kohl, A. and Fragkoudis, R. (2013) Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells. Journal of General Virology, 94(Pt. 7), pp. 1680-1689. (doi: 10.1099/vir.0.053850-0) (PMID:23559478) (PMCID:PMC3709635)

Donald, C. L. , Kohl, A. and Schnettler, E. (2012) New insights into control of arbovirus replication and spread by insect RNA interference pathways. Insects, 3(2), pp. 511-531. (doi: 10.3390/insects3020511)

Siu, R. W.C. et al. (2011) Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: characterization, origin, and frequency-dependent functions of virus-derived small interfering RNAs. Journal of Virology, 85(6), pp. 2907-2917. (doi: 10.1128/JVI.02052-10)

This list was generated on Thu Jul 9 05:44:55 2020 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigating the role of the circadian rhythm in modulating arbovirus infection in mosquitoes.
    The Carnegie Trust for the Universities of Scotland
    2020 - 2021
     

Teaching

MSc Food Security, Acting Deputy Coordinator


Research datasets

Jump to: 2020 | 2018
Number of items: 2.

2020

Royle, J., Ramírez-Santana, C., Akpunarlieva, S., Donald, C. , Gestuveo, R., Anaya, J.-M., Merits, A., Burchmore, R. , Kohl, A. and Varjak, M. (2020) Glucose-Regulated Protein 78 interacts with Zika virus envelope protein and contributes to a productive infection. [Data Collection]

2018

Donald, C. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B., Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. [Data Collection]

This list was generated on Thu Jul 9 03:51:32 2020 BST.