Cell Engineering

Cell Engineering

The Centre for Cell Engineering (CCE) is a multidisciplinary, collaborative group of international standing working in tissue engineering. The group consists of biologists, bioengineers, clinicians, chemists and physicists.

The aim of research at CCE is the development of tissue engineering approaches to treat disease, investigate the underpinning molecular signalling events, and support the reduction refinement and replacement of animal experimentation (3Rs).

In collaboration across the physical sciences and medicine we develop technologies to control cell fate in 2D and 3D by engineering the cellular micro- and nanoenvironment. The aim is to apply our findings to improve lifelong health and wellbeing by translating basic research to the clinic. To support this the Glasgow Orthopedic Research Initiative (GLORI) was formed, which organises annual meetings and workshops to foster the exchange between scientists and clinicians.

Manipulations of the cell environment with the nanotoolbox that we develop (self organising protein networks, nanoparticles, topography, nanokicking) can direct stem cell differentiation and tissue repair. The molecular processes of how cells respond to these interventions in their environment are being investigated in collaboration with Glasgow Polyomics.

Models of tissue and disease include 3D stem cell and cancer spheroids for drug screening, in vitro models of peripheral nerve injury, in vitro co-culture model of implant infection, and lung epithelium in co-culture with bacteria.

Applications developed include a bioreactor system “Nanokicking” stem cells into bone differentiation, surfaces that aid bone repair by organising biopolymer networks, nanotopographies to differentiate or maintain stem cells, acoustic cell sorting, peripheral nerve repair and nanoparticles for gene therapy.

Cell Engineering research staff:

Catherine Berry

Dr Catherine Berry

Lecturer (Institute of Molecular Cell and Systems Biology)

Research interests: Cell-nanoparticle interactions, using various nanoparticles (eg. quantum dots, gold and magnetic) conjugated to cell penetrating peptides with the aim of targeted cell uptake to the nucleus.

Matthew Dalby

Professor Matthew Dalby

Professor of Cell Engineering (Institute of Molecular Cell and Systems Biology)

Research interests: - Adult stem cell interactions with nanotopography, dynamic (cell responsive) surfaces, 3D hydrogels and growth factors organising interfaces. - Metabolomics for stem cells. - Stem cell mechanotransduction.

Mathis Riehle

Dr Mathis Riehle

Reader (Institute of Molecular Cell and Systems Biology)

Research interests: To investigate the molecular mechanisms how cells interact with surfaces using devices made by micro- and nanofabrication with a specific chemical, topographic or mechanical surface design.