Dr Paul Capewell

  • Research Associate (Institute of Biodiversity Animal Health & Comparative Medicine)
  • Associate (School of Veterinary Medicine)

Research interests

My primary research interests lie in parasitic/host interactions and the complex co-evolution that occurs as a result. My main research focus to date has been the ongoing evolutionary arms race between parasitic trypanosomes and their hosts (both mammalian and insect). Recently, I have began investigating the population genomics of the intestinal parasite Giardia lamblia, an important overlooked parasite endemic to Scotland.


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigating the epidemiology of endemic Giardia in Scotland using a whole genome sequencing approach
    Chief Scientist Office (CSO)
    2018 - 2021
     
  • Characterising Polyclonal T cell activation in animal trypanosomiasis
    Wellcome Trust
    2016 - 2018
     
  • The potential use of synthetic HDL as a therapy for African trypanosomiasis
    The Carnegie Trust for the Universities of Scotland
    2015 - 2015
     
  • Genetic Determinants of Trypanotolerance in Humans
    Tenovus Scotland
    2015 - 2015
     
  • Genetic Determinants of Trypanotolerance in Humans
    Wellcome Trust
    2014 - 2015
     

Publications

List by: Type | Date

Jump to: 2019 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010
Number of items: 19.

2019

Capewell, P. et al. (2019) Resolving the apparent transmission paradox of African sleeping sickness. PLOS Biology, 17(1), e3000105. (doi:10.1371/journal.pbio.3000105) (PMID:30633739)

2017

Cooper, A. et al. (2017) APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis. eLife, 6, e25461. (doi:10.7554/eLife.25461) (PMID:28537557) (PMCID:PMC5495568)

2016

Capewell, P. et al. (2016) The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, e17716. (doi:10.7554/eLife.17716) (PMID:27653219) (PMCID:PMC5065312)

Cooper, A., Capewell, P., Clucas, C., Veitch, N., Weir, W. , Thomson, R., Raper, J. and MacLeod, A. (2016) A primate APOL1 variant that kills Trypanosoma brucei gambiense. PLoS Neglected Tropical Diseases, 10(8), e0004903. (doi:10.1371/journal.pntd.0004903) (PMID:27494254) (PMCID:PMC4975595)

Weir, W. et al. (2016) Population genomics reveals the origin and asexual evolution of human infective trypanosomes. eLife, 5, e11473. (doi:10.7554/eLife.11473) (PMID:26809473) (PMCID:PMC4739771)

2015

Bühlmann, M., Walrad, P., Rico, E., Ivens, A., Capewell, P., Naguleswaran, A., Roditi, I. and Matthews, K. R. (2015) NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway. Nucleic Acids Research, 43(9), pp. 4491-4504. (doi:10.1093/nar/gkv330) (PMID:25873624) (PMCID:PMC4482084)

Capewell, P., Cooper, A., Clucas, C., Weir, W. and MacLeod, A. (2015) A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome. Parasitology, 142(S1), S108-S119. (doi:10.1017/S0031182014000602) (PMID:25656360) (PMCID:PMC4413828)

Capewell, P., Cooper, A., Clucas, C., Weir, W. , Vaikkinen, H., Morrison, L., Tait, A. and MacLeod, A. (2015) Exploiting genetic variation to discover genes involved in important disease phenotypes. Methods in Molecular Biology, 1201, pp. 91-107. (doi:10.1007/978-1-4939-1438-8_5) (PMID:25388109)

2014

Pickrell, W. O. et al. (2014) Human African Trypanosomiasis presenting at least 29 years after infection—what can this teach us about the pathogenesis and control of this neglected tropical disease? PLoS Neglected Tropical Diseases, 8(12), e3349. (doi:10.1371/journal.pntd.0003349)

2013

Kaboré, J., De Meeûs, T., MacLeod, A. , Ilboudo, H., Capewell, P., Camara, M., Gaston Belem, A.M., Bucheton, B. and Jamonneau, V. (2013) A protocol to improve genotyping of problematic microsatellite loci of Trypanosoma brucei gambiense from body fluids. Infection, Genetics and Evolution, 20, pp. 171-176. (doi:10.1016/j.meegid.2013.08.006)

Capewell, P., Clucas, C., DeJesus, E., Kieft, R., Hajduk, S., Veitch, N., Steketee, P.C., Cooper, A., Weir, W. and MacLeod, A. (2013) The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. PLoS Pathogens, 9(10), e1003686. (doi:10.1371/journal.ppat.1003686) (PMID:24098129) (PMCID:PMC3789759)

Capewell, P., Cooper, A., Duffy, C.W., Tait, A., Turner, C.M.R., Gibson, W., Mehlitz, D. and MacLeod, A. (2013) Human and animal trypanosomes in Côte d'Ivoire form a single breeding population. PLoS ONE, 8(7), e67852. (doi:10.1371/journal.pone.0067852) (PMID:23844111) (PMCID:PMC3699513)

Goodhead, I. et al. (2013) Whole-genome sequencing of trypanosoma brucei reveals introgression between subspecies that is associated with virulence. mBio, 4(4), e00197-13. (doi:10.1128/mBio.00197-13)

2012

Bullard, W., Kieft, R., Capewell, P., Veitch, N. J., Macleod, A. and Hajduk, S. (2012) Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors. Virulence, 3(1), pp. 72-76. (doi:10.4161/viru.3.1.18295) (PMID:22286709) (PMCID:PMC3337153)

Bullard, W., Kieft, R., Capewell, P., Veitch, N.J., MacLeod, A. and Hajduk, S.L. (2012) Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum. Virulence, 3(1), pp. 72-76. (doi:10.4161/viru.3.1.18295)

Harrington, J.M., Scelsi, C., Hartel, A., Jones, N.G., Engstler, M., Capewell, P., MacLeod, A. and Hajduk, S. (2012) Novel African trypanocidal agents: membrane rigidifying peptides. PLoS ONE, 7(9), e44384. (doi:10.1371/journal.pone.0044384) (PMID:22970207) (PMCID:PMC3436892)

Kieft, R., Stephens, N.A., Capewell, P., MacLeod, A. and Hajduk, S.L. (2012) Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei. Molecular and Biochemical Parasitology, 183(1), pp. 8-14. (doi:10.1016/j.molbiopara.2011.12.004)

2011

Capewell, P., Veitch, N.J., Turner, C.M.R., Raper, J., Berriman, M., Hajduk, S.L. and MacLeod, A. (2011) Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by Trypanolytic factor 1. PLoS Neglected Tropical Diseases, 5(9), e1287. (doi:10.1371/journal.pntd.0001287)

2010

Kieft, R., Capewell, P., Turner, C.M.R., Veitch, N.J., MacLeod, A. and Hajduk, S. (2010) Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor. Proceedings of the National Academy of Sciences of the United States of America, 107(37), pp. 16137-16141. (doi:10.1073/pnas.1007074107)

This list was generated on Mon Feb 18 03:48:28 2019 GMT.
Jump to: Articles
Number of items: 19.

Articles

Capewell, P. et al. (2019) Resolving the apparent transmission paradox of African sleeping sickness. PLOS Biology, 17(1), e3000105. (doi:10.1371/journal.pbio.3000105) (PMID:30633739)

Cooper, A. et al. (2017) APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis. eLife, 6, e25461. (doi:10.7554/eLife.25461) (PMID:28537557) (PMCID:PMC5495568)

Capewell, P. et al. (2016) The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, e17716. (doi:10.7554/eLife.17716) (PMID:27653219) (PMCID:PMC5065312)

Cooper, A., Capewell, P., Clucas, C., Veitch, N., Weir, W. , Thomson, R., Raper, J. and MacLeod, A. (2016) A primate APOL1 variant that kills Trypanosoma brucei gambiense. PLoS Neglected Tropical Diseases, 10(8), e0004903. (doi:10.1371/journal.pntd.0004903) (PMID:27494254) (PMCID:PMC4975595)

Weir, W. et al. (2016) Population genomics reveals the origin and asexual evolution of human infective trypanosomes. eLife, 5, e11473. (doi:10.7554/eLife.11473) (PMID:26809473) (PMCID:PMC4739771)

Bühlmann, M., Walrad, P., Rico, E., Ivens, A., Capewell, P., Naguleswaran, A., Roditi, I. and Matthews, K. R. (2015) NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway. Nucleic Acids Research, 43(9), pp. 4491-4504. (doi:10.1093/nar/gkv330) (PMID:25873624) (PMCID:PMC4482084)

Capewell, P., Cooper, A., Clucas, C., Weir, W. and MacLeod, A. (2015) A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome. Parasitology, 142(S1), S108-S119. (doi:10.1017/S0031182014000602) (PMID:25656360) (PMCID:PMC4413828)

Capewell, P., Cooper, A., Clucas, C., Weir, W. , Vaikkinen, H., Morrison, L., Tait, A. and MacLeod, A. (2015) Exploiting genetic variation to discover genes involved in important disease phenotypes. Methods in Molecular Biology, 1201, pp. 91-107. (doi:10.1007/978-1-4939-1438-8_5) (PMID:25388109)

Pickrell, W. O. et al. (2014) Human African Trypanosomiasis presenting at least 29 years after infection—what can this teach us about the pathogenesis and control of this neglected tropical disease? PLoS Neglected Tropical Diseases, 8(12), e3349. (doi:10.1371/journal.pntd.0003349)

Kaboré, J., De Meeûs, T., MacLeod, A. , Ilboudo, H., Capewell, P., Camara, M., Gaston Belem, A.M., Bucheton, B. and Jamonneau, V. (2013) A protocol to improve genotyping of problematic microsatellite loci of Trypanosoma brucei gambiense from body fluids. Infection, Genetics and Evolution, 20, pp. 171-176. (doi:10.1016/j.meegid.2013.08.006)

Capewell, P., Clucas, C., DeJesus, E., Kieft, R., Hajduk, S., Veitch, N., Steketee, P.C., Cooper, A., Weir, W. and MacLeod, A. (2013) The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. PLoS Pathogens, 9(10), e1003686. (doi:10.1371/journal.ppat.1003686) (PMID:24098129) (PMCID:PMC3789759)

Capewell, P., Cooper, A., Duffy, C.W., Tait, A., Turner, C.M.R., Gibson, W., Mehlitz, D. and MacLeod, A. (2013) Human and animal trypanosomes in Côte d'Ivoire form a single breeding population. PLoS ONE, 8(7), e67852. (doi:10.1371/journal.pone.0067852) (PMID:23844111) (PMCID:PMC3699513)

Goodhead, I. et al. (2013) Whole-genome sequencing of trypanosoma brucei reveals introgression between subspecies that is associated with virulence. mBio, 4(4), e00197-13. (doi:10.1128/mBio.00197-13)

Bullard, W., Kieft, R., Capewell, P., Veitch, N. J., Macleod, A. and Hajduk, S. (2012) Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors. Virulence, 3(1), pp. 72-76. (doi:10.4161/viru.3.1.18295) (PMID:22286709) (PMCID:PMC3337153)

Bullard, W., Kieft, R., Capewell, P., Veitch, N.J., MacLeod, A. and Hajduk, S.L. (2012) Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum. Virulence, 3(1), pp. 72-76. (doi:10.4161/viru.3.1.18295)

Harrington, J.M., Scelsi, C., Hartel, A., Jones, N.G., Engstler, M., Capewell, P., MacLeod, A. and Hajduk, S. (2012) Novel African trypanocidal agents: membrane rigidifying peptides. PLoS ONE, 7(9), e44384. (doi:10.1371/journal.pone.0044384) (PMID:22970207) (PMCID:PMC3436892)

Kieft, R., Stephens, N.A., Capewell, P., MacLeod, A. and Hajduk, S.L. (2012) Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei. Molecular and Biochemical Parasitology, 183(1), pp. 8-14. (doi:10.1016/j.molbiopara.2011.12.004)

Capewell, P., Veitch, N.J., Turner, C.M.R., Raper, J., Berriman, M., Hajduk, S.L. and MacLeod, A. (2011) Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by Trypanolytic factor 1. PLoS Neglected Tropical Diseases, 5(9), e1287. (doi:10.1371/journal.pntd.0001287)

Kieft, R., Capewell, P., Turner, C.M.R., Veitch, N.J., MacLeod, A. and Hajduk, S. (2010) Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor. Proceedings of the National Academy of Sciences of the United States of America, 107(37), pp. 16137-16141. (doi:10.1073/pnas.1007074107)

This list was generated on Mon Feb 18 03:48:28 2019 GMT.