Dr Matthew Sinton

  • Affiliate Researcher (School of Biodiversity, One Health & Veterinary Medicine)

Biography

​Prior to starting as a postdoctoral research associate, I was a PhD student at the University of Edinburgh. During my PhD, I helped to develop a new human pluripotent stem cell model of non-alcoholic fatty liver disease (NAFLD). Using this model, I was able to explore the effects of hepatic lipid accumulation (steatosis) on mitochondrial energy metabolism. During this project, we found that, in response to steatosis, the mitochondrial TCA cycle is compromised, leading to engagement of a metabolic shunt, the purine nucleotide cycle, enabling cells to maintain energy homeostasis. My excitement about metabolism was what drew me to the field of immunometabolism and understanding the links between host metabolic status and the quality of the immune response.

In addition to my interests within the lab, I founded an organisation, The STEM Village, which aims to increase visibility of the LGBTQ+ community working in or studying STEM topics. I am a very strong believer that there should be equity in the workplace, with no individual made to feel as if they are not the “right sort of person” to work in an academic environment. As part of this initiative, we recently hosted a global symposium, which was endorsed by the Scottish First Minister, Nicola Sturgeon, and the 1990s music legend MC Hammer! We also have an ongoing immunology seminar series, where we showcase the research of LGBTQ+ immunologists to the wider immunology society.

Follow the STEM Village on Twitter: @theSTEMvillage

Research interests

Research groups

Publications

List by: Type | Date

Jump to: 2023 | 2022 | 2021 | 2020 | 2019
Number of items: 12.

2023

Quintana, J. F. et al. (2023) The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection. PLoS Biology, 21(11), e3002389. (doi: 10.1371/journal.pbio.3002389) (PMID:37983289) (PMCID:PMC10723712)

Sinton, M. C. et al. (2023) IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 14, 7070. (doi: 10.1038/s41467-023-42918-8) (PMID:37923768) (PMCID:PMC10624677)

Quintana, J. F. et al. (2023) γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nature Communications, 14, 5279. (doi: 10.1038/s41467-023-40962-y) (PMID:37644007) (PMCID:PMC10465518)

Kasarinaite, A., Sinton, M. , Saunders, P. T. K. and Hay, D. C. (2023) The influence of sex hormones in liver function and disease. Cells, 12(12), 1604. (doi: 10.3390/cells12121604) (PMID:37371074) (PMCID:PMC10296738)

2022

Sinton, M. C. (2022) Perspectives of a gay scientist: the importance of being visible. Immunology and Cell Biology, 100(10), pp. 757-758. (doi: 10.1111/imcb.12574) (PMID:35849026)

Quintana, J. F. et al. (2022) Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection. Nature Communications, 13, 5752. (doi: 10.1038/s41467-022-33542-z) (PMID:36180478) (PMCID:PMC9525673)

2021

Fitzgerald, E., Sinton, M. C. , Wernig-Zorc, S., Morton, N. M., Holmes, M. C., Boardman, J. P. and Drake, A. J. (2021) Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress. Epigenetics and Chromatin, 14, 31. (doi: 10.1186/s13072-021-00405-8) (PMID:34193254) (PMCID:PMC8247254)

Sinton, M. C. , Meseguer-Ripolles, J., Lucendo-Villarin, B., Drake, A. J. and Hay, D. C. (2021) Modeling human hepatic steatosis in pluripotent stem cell-derived hepatocytes. STAR Protocols, 2(2), 100493. (doi: 10.1016/j.xpro.2021.100493) (PMID:33997813) (PMCID:PMC8091923)

Sinton, M. et al. (2021) A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis. iScience, 24(1), 101931. (doi: 10.1016/j.isci.2020.101931) (PMID:33409477) (PMCID:PMC7773967)

Sinton, M. C. , Baines, K. N., Thornalley, K. A., Ilangovan, V. and Kurt, M. (2021) Increasing the visibility of LGBTQ+ researchers in STEM. Lancet, 397(10269), pp. 77-79. (doi: 10.1016/S0140-6736(20)32626-X) (PMID:33340457)

2020

Suchacki, K. J. et al. (2020) Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis. Nature Communications, 11, 3097. (doi: 10.1038/s41467-020-16878-2) (PMID:32555194) (PMCID:PMC7303125)

2019

Sinton, M. C. , Hay, D. C. and Drake, A. J. (2019) Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome. Clinical Epigenetics, 11, 104. (doi: 10.1186/s13148-019-0702-5) (PMID:31319896) (PMCID:PMC6637519)

This list was generated on Fri Apr 19 14:12:59 2024 BST.
Jump to: Articles
Number of items: 12.

Articles

Quintana, J. F. et al. (2023) The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection. PLoS Biology, 21(11), e3002389. (doi: 10.1371/journal.pbio.3002389) (PMID:37983289) (PMCID:PMC10723712)

Sinton, M. C. et al. (2023) IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 14, 7070. (doi: 10.1038/s41467-023-42918-8) (PMID:37923768) (PMCID:PMC10624677)

Quintana, J. F. et al. (2023) γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nature Communications, 14, 5279. (doi: 10.1038/s41467-023-40962-y) (PMID:37644007) (PMCID:PMC10465518)

Kasarinaite, A., Sinton, M. , Saunders, P. T. K. and Hay, D. C. (2023) The influence of sex hormones in liver function and disease. Cells, 12(12), 1604. (doi: 10.3390/cells12121604) (PMID:37371074) (PMCID:PMC10296738)

Sinton, M. C. (2022) Perspectives of a gay scientist: the importance of being visible. Immunology and Cell Biology, 100(10), pp. 757-758. (doi: 10.1111/imcb.12574) (PMID:35849026)

Quintana, J. F. et al. (2022) Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection. Nature Communications, 13, 5752. (doi: 10.1038/s41467-022-33542-z) (PMID:36180478) (PMCID:PMC9525673)

Fitzgerald, E., Sinton, M. C. , Wernig-Zorc, S., Morton, N. M., Holmes, M. C., Boardman, J. P. and Drake, A. J. (2021) Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress. Epigenetics and Chromatin, 14, 31. (doi: 10.1186/s13072-021-00405-8) (PMID:34193254) (PMCID:PMC8247254)

Sinton, M. C. , Meseguer-Ripolles, J., Lucendo-Villarin, B., Drake, A. J. and Hay, D. C. (2021) Modeling human hepatic steatosis in pluripotent stem cell-derived hepatocytes. STAR Protocols, 2(2), 100493. (doi: 10.1016/j.xpro.2021.100493) (PMID:33997813) (PMCID:PMC8091923)

Sinton, M. et al. (2021) A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis. iScience, 24(1), 101931. (doi: 10.1016/j.isci.2020.101931) (PMID:33409477) (PMCID:PMC7773967)

Sinton, M. C. , Baines, K. N., Thornalley, K. A., Ilangovan, V. and Kurt, M. (2021) Increasing the visibility of LGBTQ+ researchers in STEM. Lancet, 397(10269), pp. 77-79. (doi: 10.1016/S0140-6736(20)32626-X) (PMID:33340457)

Suchacki, K. J. et al. (2020) Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis. Nature Communications, 11, 3097. (doi: 10.1038/s41467-020-16878-2) (PMID:32555194) (PMCID:PMC7303125)

Sinton, M. C. , Hay, D. C. and Drake, A. J. (2019) Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome. Clinical Epigenetics, 11, 104. (doi: 10.1186/s13148-019-0702-5) (PMID:31319896) (PMCID:PMC6637519)

This list was generated on Fri Apr 19 14:12:59 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Characterising the metabolic response of brown adipocytes to infection with Influenza A virus
    Society for Endocrinology
    2022 - 2022
     
  • Defining the host metabolic response to infection with Trypanosoma brucei
    Society for Endocrinology
    2022 - 2022
     
  • Understanding immunological control of adipose tissue function in Human African Trypanosomiasis
    Wellcome Trust
    2021 - 2022
     

Professional activities & recognition

Selected international presentations

  • 2020: Keystone: Obesity & NAFLD: Mechanisms & Therapeutics (Banff, Canada)
  • 2019: EMBO/EMBL Symposia: Metabolism Meets Epigenetics (Heidelberg, Germany)
  • 2022: Harvard Medical School (Boston, USA)

A head and shoulders shot of Matthew Sinton outdoors with flowers in the background