parasitic worm

Our portfolio covers many aspects of parasitology research from molecules to cells and whole organisms to populations. Research activities are based around skills in molecular biology, biochemistry, immunology, epidemiology, population genetics and mathematical modelling and involve both laboratory-based projects and fieldwork.

Overview

Parasites are fascinating organisms, because of their capacity to live and replicate within the host environment. How parasites adapt and survive is the focus of much study with the potential to generate new and important discoveries that can impact upon control. Most organisms harbor parasites and much of our research is aimed at understanding how parasites cause disease and how best to control disease in both humans and animals. Improving upon existing treatments and understanding mechanisms of drug resistance are important aspects of this work. In addition, the epidemiology, ecology and population genetics of parasitic pathogens are important areas of research that significantly impact upon transmission and control.

Our research portfolio covers a range of tropical parasites that cause important diseases, including Plasmodium ssp (malaria), Trypanosoma ssp (sleeping sickness), Leishmania ssp (leishmaniasis) and Theileria (East coast fever/theileriosis), along with filarial worms, the cause of elephantiasis. We also study parasites that are endemic in the UK such as Toxoplasma gondii and important gastro-intestinal parasites of livestock that cause significant economic loss to the agricultural industry and are important for global food security. Many important parasites are transmitted by vectors, and we have growing strengths in vector biology, most notably mosquitoes and ticks. We aim to apply our findings to informing control programmes and to translate our findings into better diagnostics, drugs and vaccines.

Study options

PhD programmes are usually 3 to 4 years long (submission of the thesis is expected within 4 years of commencing study). Students undertake individual research projects in the area of expertise of their supervisor(s), although many projects on offer are interdisciplinary.

Your choice of projects is diverse, reflecting the range of expertise of potential supervisors. The University of Glasgow provides an excellent environment for parasitology research, housing the largest group of parasitologists in the UK, studying all aspects of parasitic disease from gene to population. Parasitology is housed within two institutes, Infection, Immunity and Inflammation and Biodiversity, Animal Health and Comparative Medicine. In addition, many of the group are members of the Wellcome Trust Centre for Molecular Parasitology. The resources available provide the opportunity for excellent and cutting edge training in many different areas. These include molecular biology, biochemistry, ecology, epidemiology, mathematical modelling, bioinformatics, genetics, cell biology (including advanced in vitro and in vivo imaging), immunology and polyomics (genomics, transcriptomics, proteomics, metabolomics etc). Many projects are laboratory-based in up-to-date facilities with excellent research resources. Interdisciplinary research is a key aspect of our approach and we have many collaborators both within the university and externally. Some projects involve considerable amounts of fieldwork in the UK or overseas.

Specific areas of interest include:

  • molecular basis of sexual development in Plasmodium (Waters)
  • metabolism of P. falciparum (Müller)
  • genetics and biology of the interactions between P. falciparum and the mosquito vector (Ranford-Cartwright)
  • ecology and behaviour of malaria vectors (Ferguson)
  • cellular remodelling of trypanosomes and Leishmania during their life cycles (Mottram)
  • cell division in trypanosomes (Hammarton)
  • homologous recombination, DNA repair pathways and antigenic variation in T. brucei (McCulloch)
  • african trypanosomes and their interactions with their hosts (MacLeod)
  • neuropathology of African trypanosomiasis (Rodgers, Kennedy)
  • invasion of the host cell by T. gondii (Meissner)
  • biogenesis of the mitochondrion and apicoplast in T. gondii (Sheiner)
  • control of host cell division and parasite differentiation in Theileria (Shiels)
  • immune regulation in vivo in relation to parasitic infection (Brewer, Garside)
  • fitness costs of the immune response and wild immunology (Babayan)
  • imaging the immune response to parasites in vivo (Brewer)
  • mathematical modelling of host-parasite systems (Matthews, Stear)
  • epidemiology of zoonotic pathogens in Africa (MacLeod)
  • mechanisms of drug resistance (protozoan, nematode, ectoparasites) (Barrett, de Koning, Devaney, Jonsson)
  • the role of membrane transporters in parasite virulence and drug susceptibility (de Koning)
  • development of new lead compounds and vaccines for parasitic diseases (protozoan and nematode) (Shiels, Barrett, Page, Devaney, Britton)
  • use of C. elegans as a model for understanding gene function in parasitic nematodes (Britton, Devaney, Page)
  • microRNAs and their functions in parasitic nematodes (Britton, Devaney)

Entry requirements

Awarded or expected First-class or high Upper Second-class BSc degree (or equivalent).

English Language requirements for applicants whose first language is not English.

Fees and funding

Fees

2019/20

  • £4,320 UK/EU (to be confirmed by UKRI)
  • £21,020 outside EU

Prices are based on the annual fee for full-time study. Fees for part-time study are half the full-time fee.

Additional fees for all students:

  • Re-submission by a research student £500
  • Submission for a higher degree by published work £1,250
  • Submission of thesis after deadline lapsed £320
  • Submission by staff in receipt of staff scholarship £730
  • Research students registered as non-supervised Thesis Pending students (50% refund will be granted if the student completes thesis within the first six months of the period) £300

Depending on the nature of the research project, some students will be expected to pay a bench fee (also known as research support costs) to cover additional costs. The exact amount will be provided in the offer letter.

Alumni discount

A 10% discount is available to University of Glasgow alumni. This includes graduates and those who have completed a Junior Year Abroad, Exchange programme or International Summer School at the University of Glasgow. The discount is applied at registration for students who are not in receipt of another discount or scholarship funded by the University. No additional application is required.

2018/19 fees

  • £4,260 UK/EU
  • £20,150 outside EU

Prices are based on the annual fee for full-time study. Fees for part-time study are half the full-time fee.

Additional fees for all students:

  • Submission by a research student £480
  • Submission for a higher degree by published work £1,200
  • Submission of thesis after deadline lapsed £300
  • Submission by staff in receipt of staff scholarship £680
  • Research students registered as non-supervised Thesis Pending students (50% refund will be granted if the student completes thesis within the first six months of the period) £270

Depending on the nature of the research project, some students will be expected to pay a bench fee to cover additional costs. The exact amount will be provided in the offer letter.

Funding

Support

The College of Medical, Veterinary and Life Sciences Graduate School provides a vibrant, supportive and stimulating environment for all our postgraduate students. We aim to provide excellent support for our postgraduates through dedicated postgraduate convenors, highly trained supervisors and pastoral support for each student. Through their research interests in drug development, vaccines and diagnostics, many of our project supervisors have strong links with industry.
 
Our overarching aim is to provide a research training environment that includes:

  • provision of excellent facilities and cutting edge techniques
  • training in essential research and generic skills
  • excellence in supervision and mentoring
  • interactive discussion groups and seminars
  • an atmosphere that fosters critical cultural policy and research analysis
  • synergy between research groups and areas
  • extensive multidisciplinary and collaborative research
  • extensive external collaborations both within and beyond the UK 
  • a robust generic skills programme including opportunities in social and commercial training

Research environment

If you study with us, you will join a large community of  postgraduate taught and research students. Our institute brings together world-leading basic, applied, clinical and translational researchers to study infection with a focus on the viral, parasitic and bacterial pathogens of both humans and animals, and immunology and inflammation with a focus on chronic inflammatory diseases.

Despite the continual development of new therapies, antibiotics and vaccines, chronic inflammatory and infectious diseases still pose persistent health threats. We aim to:

  • understand the basic science of the immune systems and how the immune system can inturn affect disease outcome understand the biology of parasites, viruse and bacteria and the interactions with their hosts, that in turn leads to high levels of infectious diseases worldwide
  • develop therapies (drugs and vaccines) targeted on these processes
  • explore new treatments and strategies in clinical and translational medicine

Research centres

Resources

Our excellent facilities underpin a bench to bedside approach that will equip you with training complementary to a range of career options, and you can tailor your study pathway to the precise aspects of infection and immunology that suit your objectives. Facilities include:

  • core facilities in fluorescence activated cell sorting analysis
  • histology and state-of-the-art imaging.
  • IVIS imaging system
  • high content screening microscopy
  • mass spectrometry
  • an X-ray capable FX Pro bioluminescence imaging system
  • a protein purification service
  • a wide range of molecular, immunological and biochemical analysis tools 

How to apply

Step 1: identify potential supervisors

Identify potential supervisors

All Postgraduate Research Students are allocated a supervisor who will act as the main source of academic support and research mentoring. You may want to identify a potential supervisor and contact them to discuss your research proposal before you apply. Please note, even if you have spoken to an academic staff member about your proposal you still need to submit an online application form.

You can find relevant academic staff members with our staff research interests search.


Step 2: gather your documents

Before applying please make sure you gather the following supporting documentation:

  1. Final or current degree transcripts including grades (and an official translation, if needed) – scanned copy in colour of the original document
  2. Degree certificates (and an official translation, if needed): scanned copy in colour of the original document
  3. Two references on headed paper (academic and/or professional).
  4. Research proposal, CV, samples of written work as per requirements for each subject area.

Submitting References

To complete your application we will need two references (one must be academic the other can be academic or professional).

There are two options for you to submit references as part of your application.  You can upload a document as part of your application or you can enter in your referee’s contact details and we will contact them to request a reference.

Option 1 – Uploading as part of the application form

Your references should be on official headed paper. These should also be signed by the referee. You can then upload these via theOnline Application form with the rest your documents to complete the application process.

Please be aware that documents must not exceed 5MB in size and therefore you may have to upload your documents separately. The online system allow you to upload supporting documents only in PDF format. For a free PDF writer go to www.pdfforge.org.

Option 2 - Entering contact details as part of the application form

If you enter your referees contact details including email on the application form we will email them requesting they submit a reference once you have submitted the application form.  When the referee responds and sends a reference you will be sent an email to confirm the university has received this.

After submitting your application form

Use our Applicant Self Service uploading documents function to submit a new reference. We can also accept confidential references direct to rio-researchadmissions@glasgow.ac.uk, from the referee’s university or business email account.  


Step 3: apply online

Once you have all your supporting documentation you can apply through our Online Application System


I've applied. What next?

If you have any other trouble accessing Applicant Self-Service, please see Application Troubleshooting/FAQs.

If you are requested to upload further documents

Log into the Applicant Self Service and scroll down to the Admissions Section. The screenshot below indicates the section on the page, and the specific area you should go to, highlighted in red:

Applicant self service

Documents must be uploaded in .jpg, .jpeg or .pdf format and must not exceed 5MB in size.  There is a maximum 10MB upload size for all documents with the application.

Decisions

Once a decision has been made regarding your application the Research Admissions Office will contact you by email.

If you are made an unconditional offer

You can accept your offer through the Applicant-Self-Service by clicking on the ‘Accept/Decline link’ for your chosen programme under the ‘Admissions Section’ at the bottom of the Applicant Self Service screen.  You can access the Applicant Self Service by using the link, username and password you used to apply and selecting the “Self Service” button below your application.

Please make sure you accept your unconditional offer within 4 weeks of receiving your offer. If you are an international student your CAS will not be issued until you have accepted an unconditional offer.

If you are made a conditional offer

If you accept a conditional offer then the offer status on Applicant-Self-Service will change to ‘incomplete’ to indicate that the application is incomplete until such time as all the conditions are met.

Your offer letter will list all the conditions that apply to your offer and you can upload the required document(s) through Applicant Self Service. If you have met the conditions satisfactorily, you will automatically be sent an unconditional offer.

If your application is unsuccessful

If your application is unsuccessful then we will send you an email to inform you of this which will outline the reason why we have been unable to offer you a place on this particular programme. Please note that your application status will be updated to 'Cancelled' on Applicant Self Service if the offer is rejected.

Deferring your offer

If you want to defer your start date, please contact us directly at rio-researchadmissions@glasgow.ac.uk. We need authorisation from your supervisor before we confirm your request to defer. Once we have this we will contact you by email to confirm.

How to register

After you have accepted an unconditional offer you will receive an email nearer to the start of your studies to tell you how to register online using the University's MyCampus website, the University’s student information system. That email will provide you with your personal login details and the website address. Please ensure that your email address is kept up to date as all correspondence is sent via email. You can update your email address through the Applicant Self Service Portal under the Personal Information section.


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