Living Biointerfaces

Living Biointerfaces

Cells interact with the extracellular environment through a highly dynamic process that comprises different spatiotemporal stimuli at different stages. Cells cultured in vitro are often a very poor representation of in vivo behaviours because of the static nature of the culture systems used in the lab. To address this issue, we have devised a new approach where we utilise genetically modified non-pathogenic bacteria as a functional and dynamic interface between biomaterials and stem cells. These living interfaces consist of engineered bacteria that dynamically express functional fragments, such as fragments of extracellular matrix proteins or growth factors, on their membrane and promote cell adhesion, signalling and differentiation.