EPSRC Programme Grant

EPSRC Programme Grant

This a major research programme grant funded by the Engineering and Physical Sciences Research Council (EPSRC) and led by the University of Glasgow, with partners at the Imperial College London (Steven’s lab) and the University of Nottingham (Rose, Scammell). This project started in January 2017 and looks to develop safer and more effective methods for the use of growth factor molecules in regenerative medicine.

Growth factors are molecules within our body that participate in many physiological process that are key during development as they control stem cell function. These molecules thus have the potential to drive the regeneration of tissues in a broad range of medical conditions, including in musculoskeletal (bone repair), haematological (bone marrow transplantation) and cardiovascular (infarction, heart attack) diseases. Growth factors are currently produced commercially and are used regularly in clinical applications; however, these are very powerful molecules and therefore dose is critical as balance between effect and safety has to be considered. While their help in regeneration is undoubted, collateral side effects can be catastrophic e.g. tumour formation. This programme is about the safe use of growth factors in clinical applications. Our work intends not only to reduce risks for patients who currently receive growth factor treatments but will open up therapies that can include co-transplantation with stem cells to a wider range of patients.