Alisha Aman

 

349 BHF-Glasgow Cardiovascular and Medical Sciences

University of Glasgow

G12 8TA

Email: a.aman.1@research.gla.ac.uk

Research title: Phenomic and pharmacogenomic dissection of blood pressure GW

Research Summary

Project title: Phenomic and pharmacogenomic dissection of blood pressure GWAS loci to prioritise pathways for translation.

The known genetic architecture of blood pressure includes around 30 rare mutations resulting in inherited forms of hypertension or hypotension and over 1400 common single nucleotide polymorphisms (SNPs). The majority of the GWAS-identified BP SNPs show pleiotropic associations and unravelling these signals and their underpinning biological pathways will enhance understanding of molecular mechanisms that regulate BP leading to new treatment and ultimately improve the categorisation of subtypes of hypertension. Our pilot studies show that over 100 blood pressure GWAS loci contain drugs that are either licensed for hypertension treatment or influence blood pressure levels. The primary objective of this PhD is to develop an integrated analysis of pleiotropy and pharmacogenomics in the dissection of BP GWAS loci. This will be achieved through a systematic analysis of pleiotropic associations, mendelian randomisation studies and phenome-wide association studies using UK Biobank. The primary outcome of this project will be the generation of compelling data on a set of GWAS loci that will lead on to new drug development or drug repurposing studies.

Publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2017
Number of items: 8.

2020

McCallum, L., Brooksbank, K., McConnachie, A. , Aman, A., Lip, S., Dawson, J. , MacIntyre, I.M., MacDonald, T.M., Webb, D.J. and Padmanabhan, S. (2020) Rationale and design of the genotype-blinded trial of torasemide for the treatment of hypertension (BHF UMOD). American Journal of Hypertension, (doi: 10.1093/ajh/hpaa166) (PMID:33084880) (Early Online Publication)

Ford, T. J. et al. (2020) Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction. European Heart Journal, 41(34), pp. 3239-3252. (doi: 10.1093/eurheartj/ehz915) (PMID:31972008) (PMCID:PMC7557475)

2019

Menni, C. et al. (2019) Metabolomic profiling identifies novel associations with electrolyte and acid-base homeostatic patterns. Scientific Reports, 9, 15088. (doi: 10.1038/s41598-019-51492-3) (PMID:31636301) (PMCID:PMC6803625)

Jones, F. E. et al. (2019) 4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease. Human Molecular Genetics, 28(4), pp. 628-638. (doi: 10.1093/hmg/ddy369) (PMID:30351356) (PMCID:PMC6360271)

Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genetics of hypertension and heart failure. In: Dorobantu, M., Mancia, G., Grassi, G. and Voicu, V. (eds.) Hypertension and Heart Failure. Series: Updates in hypertension and cardiovascular protection. Springer International Publishing, pp. 15-29. ISBN 9783319933191

Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genomics of hypertension. In: Touyz, R.M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer, pp. 171-181. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_16)

2018

Graham, L. A., Aman, A., Campbell, D. D. , Augley, J., Graham, D. , McBride, M. W. , Fraser, N. J., Ferreri, N. R., Dominiczak, A. F. and Padmanabhan, S. (2018) Salt stress in the renal tubules is linked to TAL specific expression of uromodulin and an upregulation of heat shock genes. Physiological Genomics, 50(11), pp. 964-972. (doi: 10.1152/physiolgenomics.00057.2018) (PMID:30216136) (PMCID:PMC6293113)

2017

Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2017) Genomics of hypertension. Pharmacological Research, 121, pp. 219-229. (doi: 10.1016/j.phrs.2017.04.031) (PMID:28495658)

This list was generated on Sat Apr 10 22:28:16 2021 BST.
Number of items: 8.

Articles

McCallum, L., Brooksbank, K., McConnachie, A. , Aman, A., Lip, S., Dawson, J. , MacIntyre, I.M., MacDonald, T.M., Webb, D.J. and Padmanabhan, S. (2020) Rationale and design of the genotype-blinded trial of torasemide for the treatment of hypertension (BHF UMOD). American Journal of Hypertension, (doi: 10.1093/ajh/hpaa166) (PMID:33084880) (Early Online Publication)

Ford, T. J. et al. (2020) Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction. European Heart Journal, 41(34), pp. 3239-3252. (doi: 10.1093/eurheartj/ehz915) (PMID:31972008) (PMCID:PMC7557475)

Menni, C. et al. (2019) Metabolomic profiling identifies novel associations with electrolyte and acid-base homeostatic patterns. Scientific Reports, 9, 15088. (doi: 10.1038/s41598-019-51492-3) (PMID:31636301) (PMCID:PMC6803625)

Jones, F. E. et al. (2019) 4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease. Human Molecular Genetics, 28(4), pp. 628-638. (doi: 10.1093/hmg/ddy369) (PMID:30351356) (PMCID:PMC6360271)

Graham, L. A., Aman, A., Campbell, D. D. , Augley, J., Graham, D. , McBride, M. W. , Fraser, N. J., Ferreri, N. R., Dominiczak, A. F. and Padmanabhan, S. (2018) Salt stress in the renal tubules is linked to TAL specific expression of uromodulin and an upregulation of heat shock genes. Physiological Genomics, 50(11), pp. 964-972. (doi: 10.1152/physiolgenomics.00057.2018) (PMID:30216136) (PMCID:PMC6293113)

Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2017) Genomics of hypertension. Pharmacological Research, 121, pp. 219-229. (doi: 10.1016/j.phrs.2017.04.031) (PMID:28495658)

Book Sections

Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genetics of hypertension and heart failure. In: Dorobantu, M., Mancia, G., Grassi, G. and Voicu, V. (eds.) Hypertension and Heart Failure. Series: Updates in hypertension and cardiovascular protection. Springer International Publishing, pp. 15-29. ISBN 9783319933191

Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genomics of hypertension. In: Touyz, R.M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer, pp. 171-181. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_16)

This list was generated on Sat Apr 10 22:28:16 2021 BST.

Conference

 

  1. Canadian Vascular Network Summer School, Montreal, Canada (August 2019)
  2. Brainstorm meeting for the Global Challenge Research Fund application at New Delhi (March 2018) and Sri Lanka (December 2017) in collaboration with University of Glasgow MVLS and Business School, Bangladesh, Indonesia, India, Nepal, and Malaysia.
  3. Oral presentation - European Society of Hypertension (ESH) annual meeting, Milan (June 2017)
  4. Poster Presentation -Indian Genetics Congress, Chennai (February 2015)