Previous Tenovus Symposia
The University of Glasgow has hosted Symposia supported by Tenovus Scotland since 1974.
14th TENOVUS-SCOTLAND Symposium, June 2012: Molecular Mechanisms of Disease - Celebrating 30 years of Tenovus Symposia
See end of page for more about this Symposium
Stephen Bell (Oxford), Wendy Bickmore (MRC Edinburgh), Neil Brockdorff (Oxford), Phillip Cohen (Dundee), Tom Curran (Children's Hospital of Philadephia), Margaret Frame (Edinburgh), Roger Everett (MRC Glasgow), Tony Kouzarides (Cambridge), Darren Monckton (Glasgow), Tom Owen-Hughes (Dundee), Neil Perkins (Newcastle), Stefan Roberts (Bristol), Kevin Ryan (Beatson Inst Glasgow), Karen Vousden (Beatson Inst, Glasgow)
13th TENOVUS-SCOTLAND Symposium, April 2009: Gene Expression in Development and Disease
Prof Neil Perkins, Prof Adrian Bird, Prof Amanda Fisher, Dr Veronica Van Heyningen, Dr Peter Adams, Prof Dennis McCance, Prof Louis Mahadevan, Prof Colin Coding, Dr Eric Miska, Dr Andrew Hamilton, Dr Gyorgy Hutvagner, Dr John Rossi, Dr Javier Caceres, Prof Stuart Wilson, Dr David Elliott, Dr Georg Stoecklin
12th TENOVUS-SCOTLAND Symposium, April 2006: Stability and Regulation of Genes and Genomes
Dr. Stephen D. Bell, Dr. John Diffley, Dr. Frank Uhlmann, Dr. Patrick Varga-Weisz, Dr. Joan Boyes, Dr. Aidan Doherty, Dr. Kevin Hiom, Dr. Alain Verreault, Dr. Gary Felsenfeld, Prof. Wendy Bickmore, Dr. Anne Ferguson-Smith, Dr. Peter Fraser, Dr. Richard Meehan, Dr. Jane Mellor, Dr. Wolf Reik, Prof. Bob White.
11th TENOVUS-SCOTLAND Symposium, April 2003: Molecular Regulation of Genes and Genomes
Dr Darren Monckton, Dr Ilan Davis, Professor David Gillespie, Professor Wendy Bickmore, Professor Julian Blow, Dr Stefan Roberts, Professor Dale Wigley, Professor David Baulcombe, Professor Karen Vousden, Professor Tom Owen-Hughes, Professor Bill Earnshaw, Professor Robin Allshire, Professor Iain Hagan, Professor Ron Hay, Professor Jeff Errington, Professor Adrian Bird
10th TENOVUS-SCOTLAND Symposium, April 2000: Gene Expression and Disease
Rabbitts (Cambridge), Gellert (Yale), Lane (Dundee), Arnheim (UCLA), Petes (UNC), Lamond (Dundee), Tollervey (Edinburgh), Tighlman (Princeton), Tapscott (Seattle), Brockdorf (London), Hastie (Edinburgh), Higgs (Oxford), Kaelin (Boston), Van Heyningen (Edinburgh), White (Glasgow), Wilkinson (Atlanta), Dejean (Paris), Everett (Glasgow), Wagstaff (Harvard), Porteous (Edinburgh), Paraskeva (Bristol), McGuffin (London), Wolf (Dundee), Staskawicz (Berkeley), Davies (Oxford), Southern (Oxford), Willard (Case Western)
2014 Tenovus-Scotland Medal Lecture and Mini Symposium
Cardiovascular Inflammation: To the Heart of the Problem
Monday 15th September 2014
University of Glasgow, UK
A report by Helen Cambrook, Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Tenovus Scotland is a charity that provides funding to support innovative medical research projects within Scotland. Often there are ‘pilot projects’. Their high success rate enables researchers to gather data to attract substantial grants from large funding bodies. Another major activity of Tenovus Scotland is to support high profile lectures and symposia organised at the University of Glasgow in fields related to biomedical science. The Tenovus Medal has been awarded to world-class scientists since 1992. The recipients are usually Scottish or have studied or worked in Scotland.
The 2014 University of Glasgow Tenovus-Scotland Symposium was held in the Wolfson Medical School on 15th September. This year’s symposium was a joint initiative between the Institutes of Cardiovascular & Medical Sciences and Infection, Immunity & Inflammation to promote collaborative interactions in the cardiovascular inflammation area. The meeting was attended by over 100 delegates, with presentations from internationally renowned basic and clinician scientists from Glasgow and other UK centres of excellence in cardiovascular research. These included the host Institutes’ Directors Professors Rhian Touyz and Iain McInnes, Dr Gillian Gray (Edinburgh), Dr Jason Johnson (Bristol) and Professor Ziad Mallat (Cambridge). Subjects ranged from a discussion of clinical links between rheumatoid arthritis and vascular dysfunction through to elegant studies of the molecular basis of inflammation in several models of cardiovascular disease. The multidisciplinary nature of the symposium made for a successful event and an extremely engaging day of science.
The 2014 Tenovus Medal was awarded to Dr Joseph Boyle for his achievements in the field of cardiovascular medicine. Dr Boyle is a British Heart Foundation Senior Clinical Research Fellow at Imperial College, London. He carried out both his Pharmacology and Medical degrees at the University of Glasgow in the late 1980s before achieving great success as an independent clinician scientist. A very deserving winner of the Tenovus Medal, Dr Boyle’s seminar discussed how our understanding of cardiovascular diseases has changed over time. Specifically, he gave a stimulating presentation on his work examining how macrophages can trigger vascular dysfunction, and how these mechanisms could potentially be exploited to improve anti-inflammatory therapeutics for cardiovascular diseases.
From left to right: Prof Sheila Graham (Tenovus Symposium Committee Chair), Dr Pasquale Maffia (Symposium Organiser), Dr Stuart Nicklin (Symposium Organiser), Dr Joseph Boyle (Tenovus Medal winner), Dr Ian Salt (Symposium Organiser), Dr Ashley Miller (Symposium Organiser) and Dr Tim Palmer (Symposium Organiser)
From left to right: Dr Alastair Beattie (Tenovus), Prof Andrew Calder (Tenovus Chair), Dr Joseph Boyle (Tenovus Medal winner) and Mr Iain McFadzean (Tenovus)
Symposium speakers and organisers
Prof Iain McInnes (University of Glasgow) started the day with a thought provoking talk linking systemic inflammatory conditions such as Rheumatoid Arthritis to the increasing burden of cardiovascular diseases seen in the clinic. These diseases share many systemic biomarkers such as cholesterol levels. As a consequence, patients with RA are 50% more likely to die from a cardiovascular event, a factor which is often over looked. Treatment regimes which modulate immune functions such as TNF blockade, IL-6R inhibition and inhibition of JAK signalling, have shown success in treating classical Rheumatoid Arthritis symptoms as well as affecting cardiovascular parameters.
This was followed by Dr Gillian Gray (University of Edinburgh) who showed some fantastic images of the intact mouse heart after myocardial infarction (MI). Using this imaging as a read out of heart function, her group is working to develop enzymatic inhibitors that aim to limit fibroblast responses that occur with inflammation after MI. These responses cause scar formations and thus limit the heart tissues' ability to return to normal function.
Prof Ziad Mallat (University of Cambridge) discussed the deregulation of immune cells in atherosclerosis, and how experimental models are elucidating the key players in this balance. In particular, he presented data on the role of plasmacytoid dendritic cells. This work has shown how specific genetic knockouts can be used not only to remove individual cell populations, but also to deplete them of their antigen presentation capabilities.
After a lunch break to allow time for catching up with colleagues, Prof Rhian Touyz (University of Glasgow) discussed ways to reverse the effects of hypertension on the vascular wall. Aberrant reactive oxygen species production can be controlled by targeting NOX enzymes and this has been shown to be effective in decreasing cellular modifications and reducing blood pressure.
This was followed by Dr Jason Johnson (University of Bristol) who discussed how macrophage phenotype is linked to unstable plaques in atherosclerosis. Efforts to modulate matrix metalloproteinase expression using miRNAs has been successful in altering macrophages towards a more M2/plaque-stabilising phenotype. This talk expertly led us into the topics discussed in the Tenovus Medal Lecture (Dr Joseph Boyle, see above).