Funded Projects

The Wellcome ISSF awards (2011-2021) have allowed, and continue to support, a variety of funding options for researchers in the College of Medical, Veterinary and Life Sciences.  Interdisciplinary projects have been particularly welcomed, exploiting capabilities across the University of Glasgow to answer key biomedical questions.

Catalysts

The strategic purpose of the Catalyst Fund is to help to advance or kick-start early-stage omics research initiatives and to generate preliminary data that will enhance the quality and competitiveness of research proposals for external funding.  Catalyst grants have been split into two categories Innovation and Early-Career Researcher (ECR).  The Innovation Catalyst Fund focuses on the development of new tools and/or methods for omics and analysis capabilities with an emphasis on cross-disciplinary research.  The ECR call is for early-career researchers that have not held significant external funding, who are initiating new and exciting projects in an effort to launch their independent career.

Excellence and Innovation Catalysts 2018-2019

Project Title

Applicant/s

Harnessing envirnomental metabolomics to understand algal warfare

Dr Sofie Spatharis (MVLS, BAHCM)
Chromatin Conformation Capture - a snapshot of global chromatin interactions regulating cell differentiation Dr Eirini Kaiserli (MVLS, MCSB)
Simultaneuos characterisation of pathogen genomes and host DNA in questing ticks using a genome capture approach Dr Roman Biek (MVLS, BAHCM)
Single cell sequencing of aortic immune cells from angiotensin-II-induced hypertenive mice Dr Pasquale Maffia (MVLS, III)
Applying TurboID proximity labelling proteomics to study the regulation of immune responses Dr Ruaidhri Carmody (MVLS, III)

ECR Catalysts 2018-2019

Project Title

Applicant/s

Elucidating the highliy divergent mitochondrial translation machinery in apicomplexan parasites Dr Andrew Maclean (MVLS, III)
Proteome analysis of cysteine oxidation in hypertension: role of Nox5 Dr Livia de Lucca Camargo (MVLS, ICAMS)
Identification of metabolites invovled in wound and fibrosis healing Dr Virgina Llopis-Hernandez (MVLS, MCSB)
Discovering the therapeitic potential of RunX1 in a new model of myocarditis using RNAseq Dr Tamara Martin (MVLS. ICAMS)
A novel hepatitis deltavirus in vampire bats Dr Laura Bergner (MVLS, III)
Investigating a novel role for the short chain fatty acid receptor FFA2 in regulating dendritic cell biology and its impact on autoimmunity Dr Daniele Bolognini (MVLS, MCSB)
Growing up (and old) with the help of little friends: understanding the role of gut microbiota in the growth lifespan trade-off. Dr Pablo Salmon (MVLS, BAHCM)

Excellence and Innovation Catalysts 2017-2018

Project Title

Applicant/s

The ‘Moonlighting’ Role of T. brucei dUTPase 

Prof Jose Penades (MVLS, III)
Identification of cell specific gene expression profiling in the adult Drosophila intestine Dr Julia Cordero (MVLS, ICS)
Implementation of single cell sequencing methods to Rheumatoid Arthritis joints to understand the mechanisms of disease resolution Dr Thomas Otto (MVLS, III)
The Yeast Polyome: Producing a reference dataset for Omics Integration Dr Rónán Daly (MVLS, GP)
Sodium intake – subclinical hYperCortisolism Association and MetabOlic signatuRE (SYCAMORE study) Prof Christian Delles (MVLS, CAMS)
Nanopore sequencing to resolve the composition of subtelomeric immune evasion loci in the African trypanosome genome  Dr Richard McCulloch (MVLS, III, WCMP)

ECR Catalysts 2017-2018

Project Title

Applicant/s

A field deployable genomic surveillance platform to guide rabies elimination in East Africa  Dr Kirstyn Brunker (MVLS, BAHCM)
Defining drug resistance mechanisms in breast cancer  Dr Kirsten Campbell (MVLS, ICS)
Directing chondrogenic differentiation through  stimulation with a Nanovibrational Bioreactor  Dr Tom Hodgekinson (MVLS, MCSB)
Impact of deforestation on Schistosoma hybridization and links to low parasite clearance  Dr Christina Faust (MVLS, BAHCM)

Secondments

The Secondment Scheme facilitates ECR's visiting another laboratory, academic or industrial, allowing them to learn new techniques and to complete experiments where the equipment or facility is not available in Glasgow.  It is hoped that new collaborations are borne of these visits and lead to increased fellowship prospects for the awardees.

Secondments 2018-2019

Project Title

Applicant/s

Investigating the antiapoptotic BCL-2 family depencey profile of blast phase chronic myeloid leukaemia

Miss Narissa Parry (MVLS, ICS)
 Analysing peer friendship networks and online-mediated netwroks with Exponsntial Randon Graph Models for understanding behavioral changes in public health Dr Chiara Brocatelli (MVLS, IHW)
 Screening asinine sarcoid tumors and flies for virus-like particles Miss Sarah Jones (BAHCM, MVLS)

Secondments 2017-2018

Project Title

Applicant

Tracking of lip movements during speech comprehension. Dr Anne Keitel (Supervisor: Prof Joachim Gross, MVLS, INP)
In the mind’s eye: Pupil size indicates hidden neural dynamics during focused spatial attention. Dr Christian Keitel (Supervisors: Prof Joachim Gross, MVLS, INP and Prof Gregor Thut, MVLS, INP)
IGF-1 measurement in non-model organisms. Dr Pablo Salmon (Supervisor: Prof Pat Monaghan, MVLS, BAHCM)
The influence of culture on scene and object perception. Sumita Chatterjee (Supervisor: Prof Jonathon Evans, MVLS, IHW)
Learn the novel semi-intact ex-vivo somatosensory preparation for the investigation of spinal cord pain and itch processing Dr Allen Dicke (Supervisor: Prof Andrew Todd, MVLS, INP)
Regulation of airway smooth muscle relaxation by the free fatty acid 4 (FFA4) receptor. Dr Rudi Prihandoko (Supervisor: Prof Andrew Tobin, MVLS, MCSB)
XC13MS and AssayR training Dr Isabel Vincent (Supervisor: Dr Karl Burgess, MVLS, GP)
Exploiting landscape genetic simulation to inform vector-borne disease control Mr Philipp Schwabl (Supervisor: Martin Llewellyn, MVLS, BAHCM)

Feasibility

The aim of the ISSF Feasibility Funding scheme is to support the collection of omics data for a novel and interesting project, the data should also support an upcoming grant application therefore high-risk projects are not encouraged.  These are small pots of money (£5K) which can be used for the collection and processing of omics samples/data.

Feasibility 2018-2019

Project Title

Applicant

Comparative single cell sequencing analysis of melanoblast populations from different anatomics regions of the developing mouse embryo Dr Karthic Swaminathan (MVLS, ICS)
Characterising the viral diversity and distribution in wild rodents in Uganda Dr Christina Faust (MVLS, BAHCM)
Singel cell transcriptomics analysis of differentiating Trypanosoma brucei Dr Emma Briggs (MVLS, III)
Identification of the replication form proteome in Leishmania Dr Jeziel Dener Damasceno (MVLS, III)
Genome wide Locus Sequence Typing (GLST) of eukaryotic pathogens Mr Philipp Schwabl (MVLS, BAHCM)
Cardiovascular Sciences PhD Ms Sonia Frazier (MVLS, CAMS)
Developing LOPIT-DC for spatial proteomic analysis of Leishmania-infected macrophages Dr Richard Murchmore (MVLS, III)
Forward genetics approach to identify modifiers for collagen type IV-related disorders in the nematode C. elegans Ms Anna Gatseva (MVLS, CAMS)
Targetting osteoporosis with micro RNAs - a metabolomic study Dr Catherine Berry (MVLS, MCSB)
Establishing scRNA-Seq in Leishmania Prof Richard McCulloch (MVLS, III)
SLAMdunk analysis of host-parasite interaction using the effect of Plasmodium falciparum histones on primary human brain endothelia cells Dr Dagmara McGuinness (MVLS, III)
Molecular detection of Toxoplasma gondii in rats trapped from Gaza Strip, Palestine Dr Lilach Sheiner (MVLS, III)
Engineering hydrogels for rheumatology research Dr Miguel Pineda (MVLS, III)

Feasibility 2017-2018

Project Title

Applicant

Accumulation of potential protein degraders in bacteria. Dr David France (CoSE, Chemistry), Prof Andew Roe (MVLS, III)
Developing methods for the detection of drugs of abuse in ancient hair. Dr Isabel Vincent (MVLS, GP)
How does T. gondii manipulate the immune system to survive? Dr Lilach Sheiner (MVLS, III)
Do host microRNAs contribute to hyper-proliferation of Theileria annulata infected cells? Dr Victoria Gillan (MVLS, BAHCM)
Support vector machine learning to explain inter-patient variability in a clinical metabolomic study. Dr Richard Burchmore (MVLS, III)
Characterisation of gene expression in defined E. coli mutants. Dr James Connolly (MVLS, III)
A metabolomics approach to identify metabolomic signatures for therapeutic intervention in neuroblastoma. Dr Donna Nile (MVLS, ICS)
ScaRob: Rebuilding the metabolomics pipeline for Scalability and Robustness. Dr Karl Burgess (MVLS, III)
Metabolite identification and targetting between normal and cancerous cells on titantium nansurfaces Dr Penelope Tsimbouri (MVLS, MCSB)
Identify candidate genes associated with disruption of T cell / Dendritic cell communication as a result of malaria infection Dr Thomas Otto (MVLS, III)
Proteomic analysis of amyloid β plaque in traumatic brain injury Miss Hannah Morgan (MVLS, INP)
GC-MS method development: short chain fatty acid analysis  Dr Emily Dickie (MVLS, III)
Elucidating dynamics of SNARE interactions during pathogenesis Dr Rucha Karnik (MVLS, MCSB)
Skeletal muscle transcriptomic responses to resistance exercise in South Asians Dr Stuart Gray (MVLS, III)

Diversity and Inclusion

The latest ISSF award form Wellcome includes funds to support and improve gender equality throughout the College.

Network and Event 2017-2018

Project Title

Applicant

Women in Research Network (WIRN). Dr Jennifer Logue (MVLS, CAMS)
A Learning Community to Support Progression and Scholarship in the 'Early Career Development Programme'. Dr Sharon Sneddon (MVLS,SoMDN) and Dr Genevieve Stapleton (MVLS,SoMDN)
Network for Early career Researcher Development (NERD) – ‘sandpit’ event series. Dr Vicky Morrison (MVLS,CAMS), Dr Lilach Sheiner (MVLS,III) and Dr Angela Bradshaw (MVLS,CAMS)
"Out of sight, out of mind?" - Invisible disability event Jane Goodfellow (MVLS, IHW)

Academic Returners 2018-2019

Applicant

Dr Swetha Vijayakrishnan (MVLS, III)
Dr Catherine Berry (MVLS, MCSB)

Academic Returners 2017-2018

Applicant

Dr Katarina Oravcova (MVLS, BAHCM)
Dr Kathryn Elmer (MVLS, BAHCM)
Dr Elisa Alvarez-Curto (MVLS, MCSB)
Alix McBrearty (MVLS, SoVM)
Dr Vicky Morrison (MVLS, III)
Prof Emily Cross (MVLS, INP)