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Leica Biosystems, the University of Glasgow and NHS Greater Glasgow & Clyde jointly have set-up a collaboration to optimise pre-analytic factors and standardise patient tissue sample preparation processes as well as technologies, improving the outcome of cutting-edge molecular diagnostic methods, specifically Next Generation Sequencing (NGS), for use in a clinical diagnostic pathology setting. Access to prospectively collected tissue offers a unique opportunity for the successful execution of an extensive study to revolutionise tissue processing and introduce validated and automated procedures based on clinical evidence. This collaboration is bringing together academic expertise in genomics and molecular pathology with the product development power of a market leader, aiming to set a new pre-analytic standard, creating a baseline for the future optimisation of companion diagnostic testing and sequencing, and opening the field for stratified medicine.