Scientists identify why some kidney transplants don’t work

Issued: Fri, 14 Sep 2018 11:27:00 BST

Research led by researchers from the Institute of Cancer Sciences can now explain why some kidney transplants do not work as well as expected. The study, published in Aging Cell, and in collaboration with NHS GGC and GlaxoSmithKline, explains why “wear and tear” of kidneys develops at a molecular and cellular level, and how it affects physiological function and the role of age-related organ capability.

Professor Paul Sheils, Professor of Geroscience, Institute of Cancer Sciences commented: “We now have strong evidence that an organ’s biological age in combination with physiological stress, plays a major role in Delayed Graft Function which is when the organ fails to work after transplant. These findings suggest that these effects are driven by donor characteristics, which may be more of a factor than the transplant itself”.