Francois, A. K. et al. (2024) Single-genome analysis reveals heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts. mBio, (doi: 10.1128/mbio.03278-23) (PMID:32753500) (PMCID:PMC7407090) (Early Online Publication)
Pinto, R. M. et al. (2023) BTN3A3 evasion promotes the zoonotic potential of influenza A viruses. Nature, 619(7969), pp. 338-347. (doi: 10.1038/s41586-023-06261-8) (PMID:37380775)
Sims, A. et al. (2023) Superinfection exclusion creates spatially distinct influenza virus populations. PLoS Biology, 21(2), e3001941. (doi: 10.1371/journal.pbio.3001941) (PMID:36757937) (PMCID:PMC9910727)
Mai, J., Stubbe, M., Hofmann, S., Masser, S., Dobner, T., Boutell, C. , Groitl, P. and Schreiner, S. (2022) PML alternative splice products differentially regulate HAdV productive infection. Microbiology Spectrum, 10(4), e0078522. (doi: 10.1128/spectrum.00785-22) (PMID:35699431) (PMCID:PMC9431499)
Herder, V. et al. (2021) Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defences. PLoS Biology, 19(12), e3001065. (doi: 10.1371/journal.pbio.3001065) (PMID:34932557) (PMCID:PMC8765667)
Charman, M. et al. (2021) Constitutive TRIM22 expression in the respiratory tract confers a pre-existing defence against influenza A virus infection. Frontiers in Cellular and Infection Microbiology, 11, 689707. (doi: 10.3389/fcimb.2021.689707) (PMID:34621686) (PMCID:PMC8490869)
Suzich, J. B., Cuddy, S. R., Baidas, H., Dochnal, S., Ke, E., Schinlever, A. R., Babnis, A., Boutell, C. and Cliffe, A. R. (2021) PML-NB-dependent type I interferon memory results in a restricted form of HSV latency. EMBO Reports, 22(9), e52547. (doi: 10.15252/embr.202152547) (PMID:34197022)
Kim, E. T., Dybas, J. M., Kulej, K., Reyes, E. D., Price, A. M., Akhtar, L. N., Orr, A., Garcia, B. A., Boutell, C. and Weitzman, M. D. (2021) Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription. Nature Microbiology, 6, pp. 234-245. (doi: 10.1038/s41564-020-00826-3) (PMID:33432153) (PMCID:PMC7856100)
Cuddy, S. R. et al. (2020) Neuronal hyperexcitability is a DLK-dependent trigger of Herpes Simplex Virus reactivation that can be induced by IL-1. eLife, 9, e58037. (doi: 10.7554/eLife.58037) (PMID:33350386) (PMCID:PMC7773336)
Stokes, S., Almire, F., Tatham, M. H., McFarlane, S., Mertens, P., Pondeville, E. and Boutell, C. (2020) The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. PLoS Pathogens, 16(12), e1009134. (doi: 10.1371/journal.ppat.1009134) (PMID:33351855) (PMCID:PMC7802965)
Collados Rodríguez, M. , Dybas, J. M., Hughes, J. , Weitzman, M. D. and Boutell, C. (2020) The HSV-1 ubiquitin ligase ICP0: modifying the cellular proteome to promote infection. Virus Research, 285, 198015. (doi: 10.1016/j.virusres.2020.198015) (PMID:32416261)
McFarlane, S. et al. (2019) The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection. PLoS Pathogens, 15(3), e1007667. (doi: 10.1371/journal.ppat.1007667) (PMID:30901352) (PMCID:PMC6472835)
Alandijany, T., Roberts, A. P.E., Conn, K. L., Loney, C. , McFarlane, S., Orr, A. and Boutell, C. (2018) Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection. PLoS Pathogens, 14(1), e1006769. (doi: 10.1371/journal.ppat.1006769) (PMID:29309427) (PMCID:PMC5757968)
Brown, J. R., Conn, K. L., Wasson, P., Charman, M., Tong, L., Grant, K., McFarlane, S. and Boutell, C. (2016) The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1). Journal of Virology, 90, 13. (doi: 10.1128/JVI.00426-16) (PMID:27099310) (PMCID:PMC4907222)
Conn, K. L., Wasson, P., McFarlane, S., Tong, L., Brown, J. R., Grant, K. G., Domingues, P. and Boutell, C. (2016) A novel role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the restriction of herpes simplex virus 1 (HSV-1) by the cellular intrinsic antiviral immune response. Journal of Virology, 90(9), pp. 4807-4826. (doi: 10.1128/JVI.03055-15) (PMID:26937035)
Boutell, C. and Davido, D. J. (2015) A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro. Methods, 90, pp. 3-7. (doi: 10.1016/j.ymeth.2015.04.004) (PMID:25862948) (PMCID:PMC4655872)
Domingues, P., Bamford, C. G.G., Boutell, C. and McLauchlan, J. (2015) Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase. Journal of General Virology, 96(11), pp. 3236-3242. (doi: 10.1099/jgv.0.000283) (PMID:26361997) (PMCID:PMC4806579)
Brennan, B. et al. (2015) In memoriam – Richard M. Elliott (1954–2015). Journal of General Virology, 96(8), pp. 1975-1978. (doi: 10.1099/jgv.0.000241) (PMID:26315040)
Busnadiego, I. et al. (2014) Host and viral determinants of Mx2 antiretroviral activity. Journal of Virology, 88(14), pp. 7738-7752. (doi: 10.1128/JVI.00214-14) (PMID:24760893) (PMCID:PMC4097781)
Everett, R.D., Boutell, C. , Pheasant, K., Cuchet-Lourenco, D. and Orr, A. (2014) Sequences related to SUMO interaction motifs in herpes simplex virus 1 protein ICP0 act cooperatively to stimulate virus infection. Journal of Virology, 88(5), pp. 2763-2774. (doi: 10.1128/JVI.03417-13) (PMID:24352468) (PMCID:PMC3958091)
Everett, R.D., Boutell, C. and Hale, B.G. (2013) Interplay between viruses and host sumoylation pathways. Nature Reviews Microbiology, 11(6), pp. 400-411. (doi: 10.1038/nrmicro3015) (PMID:23624814)
Boutell, C. and Everett, R. (2013) Regulation of alphaherpesvirus infections by the ICP0 family of proteins. Journal of General Virology, 94(3), pp. 465-481. (doi: 10.1099/vir.0.048900-0) (PMID:23239572)
Griffiths, S.J. et al. (2013) A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication. PLoS Pathogens, 9(8), e1003514. (doi: 10.1371/journal.ppat.1003514) (PMID:23950709) (PMCID:PMC3738494)
Chaurushiya, M.S. et al. (2012) Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain. Molecular Cell, 46(1), pp. 79-90. (doi: 10.1016/j.molcel.2012.02.004) (PMID:22405594) (PMCID:PMC3648639)
Grant, K., Grant, L., Tong, L. and Boutell, C. (2012) Depletion of intracellular zinc inhibits the ubiquitin ligase activity of viral regulatory protein ICP0 and restricts herpes simplex virus 1 replication in cell culture. Journal of Virology, 86(7), pp. 4029-4033. (doi: 10.1128/jvi.06962-11) (PMID:22278229) (PMCID:PMC3302540)
Vanni, E., Gatherer, D., Tong, L., Everett, R.D. and Boutell, C. (2012) Functional characterization of residues required for the herpes simplex virus 1 E3 ubiquitin ligase ICP0 to interact with the cellular E2 ubiquitin-conjugating enzyme UBE2D1 (UbcH5a). Journal of Virology, 86(11), pp. 6323-6333. (doi: 10.1128/jvi.07210-11) (PMID:22438555) (PMCID:PMC3372195)
Boutell, C. , Cuchet, D., Vanni, E., Orr, A., Glass, M., McFarlane, S. and Everett, R.D. (2011) A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence. PLoS Pathogens, 7(9), e1002245. (doi: 10.1371/journal.ppat.1002245) (PMID:21949651) (PMCID:PMC3174244)
Cuchet-Lourenço, D., Boutell, C. , Lukashchuk, V., Grant, K., Sykes, A. , Murray, J., Orr, A. and Everett, R.D. (2011) SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes. PLoS Pathogens, 7(7), e1002123. (doi: 10.1371/journal.ppat.1002123) (PMID:21779164) (PMCID:PMC3136452)
Lilley, C.E., Chaurushiya, M.S., Boutell, C. , Everett, R.D. and Weitzman, M.D. (2011) The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0. PLoS Pathogens, 7(6), e1002084. (doi: 10.1371/journal.ppat.1002084) (PMID:20075863) (PMCID:PMC2837166)
Smith, M.C., Boutell, C. and Davido, D.J. (2011) HSV-1 ICP0: paving the way for viral replication. Future Virology, 6(4), pp. 421-429. (doi: 10.2217/FVL.11.24) (PMID:21765858) (PMCID:PMC313393)
Everett, R.D., Boutell, C., McNair, C., Grant, L. and Orr, A. (2010) Comparison of the biological and biochemical activities of several members of the alphaherpesvirus ICP0 family of proteins. Journal of Virology, 84(7), pp. 3476-3487. (doi: 10.1128/JVI.02544-09) (PMID:20106921) (PMCID:PMC2838103)
Lilley, C.E., Chaurushiya, M.S., Boutell, C. , Landry, S., Suh, J., Panier, S., Everett, R.D., Stewart, G.S., Durocher, D. and Weitzman, M.D. (2010) A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. EMBO Journal, 29(5), pp. 943-955. (doi: 10.1038/emboj.2009.400) (PMID:22405594) (PMCID:PMC3648639)
Antrobus, R., Grant, K., Gangadharan, B., Chittenden, D., Everett, R.D., Zitzmann, N. and Boutell, C. (2009) Proteomic analysis of cells in the early stages of herpes simplex virus type-1 infection reveals widespread changes in the host cell proteome. Proteomics, 9(15), pp. 3913-3927. (doi: 10.1002/pmic.200900207) (PMID:19670248)
Morris, J. R. et al. (2009) The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Nature, 462(7275), pp. 886-890. (doi: 10.1038/nature08593) (PMID:20016594)
Antrobus, R. and Boutell, C. (2008) Identification of a novel higher molecular weight isoform of USP7/HAUSP that interacts with the Herpes simplex virus type-1 immediate early protein ICP0. Virus Research, 137(1), pp. 64-71. (doi: 10.1016/j.virusres.2008.05.017)
Boutell, C., Everett, R.D., Hilliard, J., Schaffer, P., Orr, A. and Davido, D. (2008) Herpes simplex virus type 1 ICP0 phosphorylation mutants impair the E3 ubiquitin ligase activity of ICP0 in a cell type-dependent manner. Journal of Virology, 82(21), pp. 10647-10656. (doi: 10.1128/JVI.01063-08)
Kummer, M., Turza, N.M., Muhl-Zurbes, P., Lechmann, M., Boutell, C. , Coffin, R.S., Everett, R.D., Steinkasserer, A. and Prechtel, A.T. (2007) Herpes simplex virus type 1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome. Journal of Virology, 81(12), pp. 6326-6338. (doi: 10.1128/jvi.02327-06)
Morris, J.R., Pangon, L., Boutell, C. , Katagiri, T., Keep, N.H. and Solomon, E. (2006) Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility. Human Molecular Genetics, 15(4), pp. 599-606. (doi: 10.1093/hmg/ddi476)
Boutell, C. , Canning, M., Orr, A. and Everett, R.D. (2005) Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7. Journal of Virology, 79(19), pp. 12342-12354. (doi: 10.1128/jvi.79.19.12342-12354.2005)
Meulmeester, E., Maurice, M., Boutell, C. , Teunisse, A., Ovaa, H., Abraham, T., Dirks, R. and Jochemsen, A. (2005) Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2. Molecular Cell, 18(5), pp. 565-576. (doi: 10.1016/j.molcel.2005.04.024)
Boutell, C. and Everett, R.D. (2004) Herpes simplex virus type 1 infection induces the stabilization of p53 in a USP7- and ATM-independent manner. Journal of Virology, 78(15), pp. 8068-8077. (doi: 10.1128/jvi.78.15.8068-8077.2004)
Everett, R.D., Boutell, C. and Orr, A. (2004) Phenotype of a herpes simplex virus type 1 mutant that fails to express immediate-early regulatory protein ICP0. Journal of Virology, 78(4), pp. 1763-1774. (doi: 10.1128/jvi.78.4.1763-1774.2004)
Canning, M., Boutell, C.J. , Parkinson, J. and Everett, R.D. (2004) A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7. Journal of Biological Chemistry, 279(37), pp. 38160-38168. (doi: 10.1074/jbc.M402885200)
Boutell, C. and Everett, R.D. (2003) The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and ubiquitinates p53. Journal of Biological Chemistry, 278(38), pp. 36596-36602. (doi: 10.1074/jbc.M300776200)
Boutell, C.J. , Orr, A. and Everett, R.D. (2003) PML residue lysine 160 is required for the degradation of PML induced by herpes simplex virus type 1 regulatory protein ICP0. Journal of Virology, 77(16), pp. 8686-8694. (doi: 10.1128/jvi.77.16.8686-8694.2003)
Engelhardt, O.G., Boutell, C.J. , Orr, A., Ullrich, E., Haller, O. and Everett, R.D. (2003) The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML. Experimental Cell Research, 283(1), pp. 36-50. (doi: 10.1016/s0014-4827(02)00025-3)
Boutell, C. , Sadis, S. and Everett, R.D. (2002) Herpes simplex virus type 1 immediate-early protein ICP0 and its isolated RING finger domain act as ubiquitin E3 ligases In vitro. Journal of Virology, 76(2), pp. 841-850. (doi: 10.1128/jvi.76.2.841-850.2002)
Kirkitadze, M.D., Barlow, P.N., Price, N.C., Kelly, S.M. , Boutell, C.J. , Rixon, F.J. and McClelland, D.A. (1998) The herpes simplex virus triplex protein, VP23, exists as a molten globule. Journal of Virology, 72(12), pp. 10066-10072.
Kazushige, I., Clark, J.C., Shaw-White, J.R., Stahlman, M.T., Boutell, C.J. and Whitsett, J.A. (1995) Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells. Journal of Biological Chemistry, 270(14), pp. 8108-8114. (doi: 10.1074/jbc.270.14.8108)