Professor Clare Knottenbelt

  • Professor of Small Animal Medicine and Oncology (Small Animal Clinical Sciences)
  • Associate Academic (Institute of Biodiversity Animal Health and Comparative Medicine)

telephone: 01413305801
email: Clare.Knottenbelt@glasgow.ac.uk

Research interests

My major areas of interest are the prevention and treatment of cancer in domestic pets and the use of evidence based medicine to support management decisions. I have an interest in the role of non-steroidal anti-inflammatory drugs (COX inhibitors) in the management of cancer both as palliative care and as part of treatment protocols. In 1999 we demonstrated that the COX inhibitor piroxicam could be used in the management of rectal polyps (JSAP 2000; 41 393-397) which have been shown to express COX 2 (JSAP 2006; 47, 196-200), and have subsequently shown that non-steroidals inhibit the growth of canine cancer cell lines (JSAP 2006; 47, 14-20).

My recent research study involves assessment of hair nicotine in dogs exposed to second hand smoke. The link between disease and exposure to tobacco smoke has proved difficult to elucidate and further work is underway to establish better method of

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Nicotine hair concentration in cats exposed to environmental tobacco smoke or with gastronintestinal pathology on abdominal ultrasound examination
    Petsavers
    2015 - 2016
     
  • Nicotine concentrations in the hair of dogs and cats exposed to Environmental Tobacco Smoke
    Petsavers
    2010 - 2011
     
  • Quasispecies evolution in the progression of FIV infection
    Wellcome Trust
    2009 - 2015
     
  • Study into the synergistic effects of non-steroidal anti-inflammatory drugs on telomerase activity in canine transitional cell carcinoma
    The Pet Plan Charitable Trust
    2007 - 2007
     
  • Rehoming Centre
    The Dogs Trust
    2006 - 2012
     

Additional information

Invited International Presentations

  • 2011: Istanbul, Turkey - FECAVA Conference

Prizes, Awards and Distinctions

  • 2000: Petsavers - Best research paper in JSAP

Professional Learned Society

  • 2009 - 1970: VET Trust - Director

Publications

List by: Type | Date

Jump to: 2013 | 2012 | 2010 | 2009 | 2008 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000
Number of items: 26.

2013

Knottenbelt, C.M., Bawazeer, S., Hammond, J., Mellor, D., and Watson, D.G. (2013) Nicotine hair concentrations in dogs exposed to environmental tobacco smoke: a pilot study. Journal of Small Animal Practice, 53(11), pp. 623-626. (doi:10.1111/j.1748-5827.2012.01284.x)

2012

Bawazeer, S., Watson, D.G., and Knottenbelt, C. (2012) Determination of nicotine exposure in dogs subjected to passive smoking using methanol extraction of hair followed by hydrophilic interaction chromatography with Fourier transform mass spectrometry. Talanta, 88, pp. 408-411. (doi:10.1016/j.talanta.2011.11.008)

2010

Arteaga, A., Dhand, N.K., McCann, T., Knottenbelt, C.M., Tebb, A.J., Evans, H., Eckersall, P.D., and Ramsey, I.K. (2010) Monitoring the response of canine hyperadrenocorticism to trilostane treatment by assessment of acute phase protein concentrations. Journal of Small Animal Practice, 51(4), pp. 204-209. (doi:10.1111/j.1748-5827.2009.00863.x)

Helm, J.R., and Knottenbelt, C. (2010) Blood transfusions in dogs and cats 1. Indications. In Practice, 32(5), pp. 184-189. (doi:10.1136/inp.c2226)

Helm, J.R., and Knottenbelt, C. (2010) Blood transfusions in dogs and cats 2. Practicalities of blood collection and administration. In Practice, 32(6), pp. 231-237. (doi:10.1136/inpract.32.6.231)

McLauchlan, G., Knottenbelt, C., Augusto, M., Helm, J., McGrotty, Y., and Ramsey, I. (2010) Retrospective evaluation of the effect of trilostane on insulin requirement and fructosamine concentration in eight diabetic dogs with hyperadrenocorticism. Journal of Small Animal Practice, 51(12), pp. 642-648. (doi:10.1111/j.1748-5827.2010.01005.x)

2009

McLauchlan, G., Augusto, M., McGrotty, Y., Knottenbelt, C.M., Helm, J.R., and Ramsay, I.K. (2009) Retrospective evaluation of trilostanes effect on insulin requirement and fructosamine in eight hyperadrenocorticoid diabetic dogs. In: 52nd British Small Animal Veterinary Association (BSAVA) Congress 2009, Birmingham UK, 2-5 April 2009,

2008

Helm, J.R., Nicholson, I., Nasir, L., and Knottenbelt, C.M. (2008) A study into the effects of meloxicam and piroxicam on telomerase activity in canine transitional cell carcinoma. In: 1st WorldVetCancer Joint ESVONC & VCS Meeting, Fredericksberg, Denmark, 28 Feb 1 Mar 2008, p. 49.

Helm, J.R., Nicholson, I., Nasir, L., Morris, J., and Knottenbelt, C. M. (2008) A preliminary study into the effects of meloxicam and piroxicam on telomerase activity in canine malignant melanoma. In: 51st British Small Animal Veterinary Association (BSAVA) Congress 2008, Birmingham UK, 3-6 April 2008, p. 496.

2006

Knottenbelt, C., Chambers, G., Gault, E., and Argyle, D. (2006) The in vitro effects of piroxicam and meloxicam on canine cell lines. Journal of Small Animal Practice, 47, pp. 14-20.

Knottenbelt, C., Mellor, D., Nixon, C., Thompson, H., and Argyle, D. (2006) Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours. Journal of Small Animal Practice, 47, pp. 196-200.

2005

Bell, R., Mellor, D., Ramsey, I., and Knottenbelt, C. (2005) Decreased sodium : potassium ratios in cats: 49 cases. Veterinary Clinical Pathology, 34, pp. 110-114.

McGrotty, Y., Arteaga, A., Knottenbelt, C., Ramsey, I., and Eckersall, P. (2005) Haptoglobin concentrations in dogs undergoing trilostane treatment for hyperadrenocorticism. Veterinary Clinical Pathology, 34, pp. 255-258.

2004

Nunn, F., Cave, I.A., Knottenbelt, C., and Poxton, I.R. (2004) Association between Key-Gaskell syndrome and infection by Clostridium botulinum type C/D. Veterinary Record, 155(4), pp. 111-115.

Kostis, J.B. et al. (2004) Collaborative meta-analysis of prospective studies of plasma fibrinogen and cardiovascular disease. European Journal of Cardiovascular Prevention and Rehabilitation, 11(1), pp. 9-17.

McGrotty, Y.L., Knottenbelt, C.M., Ramsey, I.K., Reid, S.W.J., and Eckersall, P.D. (2004) Evaluation of a rapid assay for canine C-reactive protein. Veterinary Record, 154(6), pp. 175-176. (doi:10.1136/vr.154.6.175)

2003

Cave, T.A., Knottenbelt, C., Mellor, D.J., Nunn, F., Nart, P., and Reid, S.W.J. (2003) Outbreak of dysautonomia (Key-Gaskell syndrome) in a closed colony of pet cats. Veterinary Record, 153(13), pp. 387-392. (doi:10.1136/vr.153.13.387)

McGrotty, Y.L., Knottenbelt, C.M., Ramsey, I.K., Reid, S.W.J., and Eckersall, P.D. (2003) Haptoglobin concentrations in a canine hospital population. Veterinary Record, 152(18), pp. 562-564. (doi:10.1136/vr.152.18.562)

Long, S., Michieletto, A., Anderson, T., Williams, A., and Knottenbelt, C. (2003) Suspected pituitary apoplexy in a German shorthaired pointer - Abstract. Journal of Small Animal Practice, 44, pp. 497-502.

McGrotty, Y., Knottenbelt, C., Doust, R., Ramsey, I., and Sullivan, M. (2003) Complications of open peritoneal drainage in nine dogs with gastrointestinal leakage. Irish Veterinary Journal, 56, pp. 354-360.

McGrotty, Y., Ramsey, I., and Knottenbelt, C. (2003) Diagnosis and management of hepatic copper accumulation in a Skye terrier. Journal of Small Animal Practice, 44, pp. 85-89.

2002

Knottenbelt, C. (2002) The feline AB blood group system and its importance in transfusion medicine. Journal of Feline Medicine and Surgery, 4(2), pp. 69-76. (doi:10.1053/jfms.2001.0162)

Knottenbelt, C., and Herrtage, M. (2002) Use of proligestone in the management of three German shepherd dogs with pituitary dwarfism. Journal of Small Animal Practice, 43, pp. 164-170.

McGrotty, Y., and Knottenbelt, C. (2002) Oesophageal stricture in a cat due to oral administration of tetracyclines. Journal of Small Animal Practice, 43, pp. 221-223.

2001

Knottenbelt, C. (2001) Investigation of anaemia in dogs. In Practice, 23, p. 306.

2000

Knottenbelt, C.M., Simpson, J.W., Tasker, S., Ridyard, A.E., Chandler, M.L., Jamieson, P.M., and Welsh, E.M. (2000) Preliminary clinical observations on the use of piroxicam in the management of rectal tubulopapillary polyps. Journal of Small Animal Practice, 41(9), pp. 393-397. (doi:10.1111/j.1748-5827.2000.tb03230.x) (PMID:11023124)

This list was generated on Thu Jul 28 20:58:14 2016 BST.
Number of items: 26.

Articles

Knottenbelt, C.M., Bawazeer, S., Hammond, J., Mellor, D., and Watson, D.G. (2013) Nicotine hair concentrations in dogs exposed to environmental tobacco smoke: a pilot study. Journal of Small Animal Practice, 53(11), pp. 623-626. (doi:10.1111/j.1748-5827.2012.01284.x)

Bawazeer, S., Watson, D.G., and Knottenbelt, C. (2012) Determination of nicotine exposure in dogs subjected to passive smoking using methanol extraction of hair followed by hydrophilic interaction chromatography with Fourier transform mass spectrometry. Talanta, 88, pp. 408-411. (doi:10.1016/j.talanta.2011.11.008)

Arteaga, A., Dhand, N.K., McCann, T., Knottenbelt, C.M., Tebb, A.J., Evans, H., Eckersall, P.D., and Ramsey, I.K. (2010) Monitoring the response of canine hyperadrenocorticism to trilostane treatment by assessment of acute phase protein concentrations. Journal of Small Animal Practice, 51(4), pp. 204-209. (doi:10.1111/j.1748-5827.2009.00863.x)

Helm, J.R., and Knottenbelt, C. (2010) Blood transfusions in dogs and cats 1. Indications. In Practice, 32(5), pp. 184-189. (doi:10.1136/inp.c2226)

Helm, J.R., and Knottenbelt, C. (2010) Blood transfusions in dogs and cats 2. Practicalities of blood collection and administration. In Practice, 32(6), pp. 231-237. (doi:10.1136/inpract.32.6.231)

McLauchlan, G., Knottenbelt, C., Augusto, M., Helm, J., McGrotty, Y., and Ramsey, I. (2010) Retrospective evaluation of the effect of trilostane on insulin requirement and fructosamine concentration in eight diabetic dogs with hyperadrenocorticism. Journal of Small Animal Practice, 51(12), pp. 642-648. (doi:10.1111/j.1748-5827.2010.01005.x)

Knottenbelt, C., Chambers, G., Gault, E., and Argyle, D. (2006) The in vitro effects of piroxicam and meloxicam on canine cell lines. Journal of Small Animal Practice, 47, pp. 14-20.

Knottenbelt, C., Mellor, D., Nixon, C., Thompson, H., and Argyle, D. (2006) Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours. Journal of Small Animal Practice, 47, pp. 196-200.

Bell, R., Mellor, D., Ramsey, I., and Knottenbelt, C. (2005) Decreased sodium : potassium ratios in cats: 49 cases. Veterinary Clinical Pathology, 34, pp. 110-114.

McGrotty, Y., Arteaga, A., Knottenbelt, C., Ramsey, I., and Eckersall, P. (2005) Haptoglobin concentrations in dogs undergoing trilostane treatment for hyperadrenocorticism. Veterinary Clinical Pathology, 34, pp. 255-258.

Nunn, F., Cave, I.A., Knottenbelt, C., and Poxton, I.R. (2004) Association between Key-Gaskell syndrome and infection by Clostridium botulinum type C/D. Veterinary Record, 155(4), pp. 111-115.

Kostis, J.B. et al. (2004) Collaborative meta-analysis of prospective studies of plasma fibrinogen and cardiovascular disease. European Journal of Cardiovascular Prevention and Rehabilitation, 11(1), pp. 9-17.

McGrotty, Y.L., Knottenbelt, C.M., Ramsey, I.K., Reid, S.W.J., and Eckersall, P.D. (2004) Evaluation of a rapid assay for canine C-reactive protein. Veterinary Record, 154(6), pp. 175-176. (doi:10.1136/vr.154.6.175)

Cave, T.A., Knottenbelt, C., Mellor, D.J., Nunn, F., Nart, P., and Reid, S.W.J. (2003) Outbreak of dysautonomia (Key-Gaskell syndrome) in a closed colony of pet cats. Veterinary Record, 153(13), pp. 387-392. (doi:10.1136/vr.153.13.387)

McGrotty, Y.L., Knottenbelt, C.M., Ramsey, I.K., Reid, S.W.J., and Eckersall, P.D. (2003) Haptoglobin concentrations in a canine hospital population. Veterinary Record, 152(18), pp. 562-564. (doi:10.1136/vr.152.18.562)

Long, S., Michieletto, A., Anderson, T., Williams, A., and Knottenbelt, C. (2003) Suspected pituitary apoplexy in a German shorthaired pointer - Abstract. Journal of Small Animal Practice, 44, pp. 497-502.

McGrotty, Y., Knottenbelt, C., Doust, R., Ramsey, I., and Sullivan, M. (2003) Complications of open peritoneal drainage in nine dogs with gastrointestinal leakage. Irish Veterinary Journal, 56, pp. 354-360.

McGrotty, Y., Ramsey, I., and Knottenbelt, C. (2003) Diagnosis and management of hepatic copper accumulation in a Skye terrier. Journal of Small Animal Practice, 44, pp. 85-89.

Knottenbelt, C. (2002) The feline AB blood group system and its importance in transfusion medicine. Journal of Feline Medicine and Surgery, 4(2), pp. 69-76. (doi:10.1053/jfms.2001.0162)

Knottenbelt, C., and Herrtage, M. (2002) Use of proligestone in the management of three German shepherd dogs with pituitary dwarfism. Journal of Small Animal Practice, 43, pp. 164-170.

McGrotty, Y., and Knottenbelt, C. (2002) Oesophageal stricture in a cat due to oral administration of tetracyclines. Journal of Small Animal Practice, 43, pp. 221-223.

Knottenbelt, C. (2001) Investigation of anaemia in dogs. In Practice, 23, p. 306.

Knottenbelt, C.M., Simpson, J.W., Tasker, S., Ridyard, A.E., Chandler, M.L., Jamieson, P.M., and Welsh, E.M. (2000) Preliminary clinical observations on the use of piroxicam in the management of rectal tubulopapillary polyps. Journal of Small Animal Practice, 41(9), pp. 393-397. (doi:10.1111/j.1748-5827.2000.tb03230.x) (PMID:11023124)

Conference Proceedings

McLauchlan, G., Augusto, M., McGrotty, Y., Knottenbelt, C.M., Helm, J.R., and Ramsay, I.K. (2009) Retrospective evaluation of trilostanes effect on insulin requirement and fructosamine in eight hyperadrenocorticoid diabetic dogs. In: 52nd British Small Animal Veterinary Association (BSAVA) Congress 2009, Birmingham UK, 2-5 April 2009,

Helm, J.R., Nicholson, I., Nasir, L., and Knottenbelt, C.M. (2008) A study into the effects of meloxicam and piroxicam on telomerase activity in canine transitional cell carcinoma. In: 1st WorldVetCancer Joint ESVONC & VCS Meeting, Fredericksberg, Denmark, 28 Feb 1 Mar 2008, p. 49.

Helm, J.R., Nicholson, I., Nasir, L., Morris, J., and Knottenbelt, C. M. (2008) A preliminary study into the effects of meloxicam and piroxicam on telomerase activity in canine malignant melanoma. In: 51st British Small Animal Veterinary Association (BSAVA) Congress 2008, Birmingham UK, 3-6 April 2008, p. 496.

This list was generated on Thu Jul 28 20:58:14 2016 BST.