Dr William Stewart

  • Honorary Clinical Associate Professor, Honorary Clinical Senior Lecturer (School of Medicine)

Research interests

Dr Stewart is Consultant and Lead Neuropathologist at the Southern General Hospital, Glasgow, and holds honorary Associate Professor status at the University of Glasgow (School of Medicine) and the University of Pennsylvania (Department of Neurosurgery).

He has subspecialty diagnostic and research interests in forensic neuropathology, in particular traumatic brain injury, and neuro-oncology, with a focus on molecular sub-typing of adult high-grade gliomas. Recent studies in TBI describe the range of pathologies encountered in acute and long term survivors of head injury, with reference to pathologies linking TBI to neurodegenerative disease; work supported by major national and international grants from the US National Institutes of Health, the US Department of Defense and the Chief Scientist’s Office in Scotland.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • MICA - Assessing tau levels after traumatic Brain Injury (TBI) using [18F]T807 positron emission topography (PET)
    Medical Research Council
    2014 - 2016
     
  • Developing and testing novel therapies targeting the invasive behaviour of human glioblastoma
    NHS Greater Glasgow & Clyde
    2014 - 2017
     
  • Visualisation of activated microglia in traumatic brain injury: an in vitro autoradiography study in human post-mortem brain tissue
    NHS Greater Glasgow & Clyde, Endowment Funds Office
    2010 - 2011
     

Publications

List by: Type | Date

Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2004 | 2003 | 2002 | 1999 | 1991
Number of items: 33.

2014

Chaouch, A. et al. (2014) Two recurrent mutations are associated with GNE myopathy in the North of Britain. Journal of Neurology, Neurosurgery and Psychiatry, 85(12), pp. 1359-1365. (doi:10.1136/jnnp-2013-306314) (PMID:24695763)

Mouzon, B. C., Bachmeier, C., Ferro, A., Ojo, J.-O., Crynen, G., Acker, C. M., Davies, P., Mullan, M., Stewart, W., and Crawford, F. (2014) Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model. Annals of Neurology, 75(2), pp. 241-254. (doi:10.1002/ana.24064) (PMID:24243523)

Hong, Y.T. et al. (2014) Amyloid imaging with carbon 11–labeled pittsburgh compound b for traumatic brain injury. JAMA Neurology, 71(1), pp. 23-31. (doi:10.1001/jamaneurol.2013.4847)

2013

Mouzon, B., Chaytow, H., Crynen, G., Bachmeier, C., Stewart, J., Mullan, M., Stewart, W., and Crawford, F. (2013) Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes. Journal of Neurotrauma, 29(18), pp. 2761-2773. (doi:10.1089/neu.2012.2498)

Johnson, V.E., Stewart, W., and Smith, D.H. (2013) Axonal pathology in traumatic brain injury. Experimental Neurology, 246, pp. 35-43. (doi:10.1016/j.expneurol.2012.01.013)

Henderson, M. et al. (2013) Recessive desmin-null muscular dystrophy with central nuclei and mitochondrial abnormalities. Acta Neuropathologica, 125(6), pp. 917-919. (doi:10.1007/s00401-013-1113-x)

Smith, D.H., Johnson, V.E., and Stewart, W. (2013) Chronic neuropathologies of single and repetitive TBI: substrates of dementia? Nature Reviews Neurology, 9(4), pp. 211-221. (doi:10.1038/nrneurol.2013.29)

2012

Teo, M.K., Mathieson, C., Carruthers, R., Stewart, W., and Alakandy, L. (2012) Cauda equina lymphoma – a rare presentation of primary central nervous system lymphoma: case report and literature review. British Journal of Neurosurgery, 26(6), pp. 868-871. (doi:10.3109/02688697.2012.697225)

Johnson, V.E., Stewart, W., and Smith, D.H. (2012) Widespread tau and amyloid-beta pathology many years after a single traumatic brain injury in humans. Brain Pathology, 22(2), pp. 142-149. (doi:10.1111/j.1750-3639.2011.00513.x)

Bell, S.L., Hanzely, Z., Alakandy, L.M., Jackson, R., and Stewart, W. (2012) Primary meningeal histiocytic sarcoma: a report of two unusual cases. Neuropathology and Applied Neurobiology, 38(1), pp. 111-114. (doi:10.1111/j.1365-2990.2011.01205.x)

Bell, S.L., Suttner, N.J., and Stewart, W. (2012) An unusual intraventricular tumor. Neuropathology, 32(3), pp. 311-313. (doi:10.1111/j.1440-1789.2011.01247.x)

Goodfellow, J. A., Dani, K., Stewart, W., Santosh, C., McLean, J., Mulhern, S., and Razvi, S. (2012) Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes: an important cause of stroke in young people. Postgraduate Medical Journal, (doi:10.1136/postgradmedj-2011-130326)

2011

Behbahani, M., St. George, E.J., Dunn, L.T., Hadley, D.M., and Stewart, W. (2011) Atypical adult medulloblastoma. Acta Neurochirurgica, 153(7), pp. 1511-1517. (doi:10.1007/s00701-011-1040-3)

McEwan, K., McAdam, J., and Stewart, W. (2011) Regional neuropathology referral practice before and after new organ retention legislation. Forensic Science International, 211(1-3), e9-e11. (doi:10.1016/j.forsciint.2011.04.026)

2010

Behbahani, M., Ahmad, F.U., Siddiqui, M.A., Stewart, W., and Alakandy, L.M. (2010) Transjugular extension of meningioma into the mediastinum—a case report. Acta Neurochirurgica, 152(1), pp. 151-154. (doi:10.1007/s00701-009-0359-5)

Johnson, V.E., Stewart, W., and Smith, D.H. (2010) Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease? Nature Reviews Neuroscience, 11, pp. 361-370. (doi:10.1038/nrn2808)

Sav, A., Scheithauer, B.W., Taylor, W.A.S., Miller, G., and Stewart, W. (2010) Intraosseous soft tissue perineurioma: report of a vertebral example. Clinical Neuropathology, 29(2), pp. 94-99. (doi:10.5414/NPP29094)

2009

French, P.J., Barlow, A., Barlow, P., Jampana, R.V., and Stewart, W. (2009) A case of pilomyxoid astrocytoma presenting with CSF rhinorrhoea in a 15-year-old. British Journal of Neurosurgery, 23(5), pp. 545-547. (doi:10.1080/02688690902814733)

Johnson, V., Stewart, W., Graham, D., Stewart, J., Praestgaard, A., and Smith, D. (2009) A Neprilysin Polymorphism and Amyloid-beta Plaques after Traumatic Brain Injury. Journal of Neurotrauma, 26(8), pp. 1197-1202.

Mathieson, C.S., St George, E.J., Stewart, W., Sastry, J., and Jamal, S. (2009) Primary intracranial leiomyosarcoma: a case report and review of the literature. Child's Nervous System, 25(8), pp. 1013-1017. (doi:10.1007/s00381-009-0845-3)

Schulz, U.G., Thomas, S.R., and Stewart, W. (2009) A difficult case solved at autopsy: memory loss, behavioural change and seizures. Practical Neurology, 9(2), pp. 90-95. (doi:10.1136/jnnp.2008.166165)

2008

Barlow, A., Robertson, M., Doig, A., Stewart, W., and Drummond, M.W. (2008) Isolated central nervous system lymphoid blast crisis in chronic myeloid leukaemia in major molecular remission. British Journal of Haematology, 142(3), p. 327. (doi:10.1111/j.1365-2141.2008.07136.x)

Stewart, W., and Maxwell, D.J. (2008) Morphological evidence for selective modulation by serotonin of a subpopulation of dorsal horn cells which possess the neurokinin-1 receptor. European Journal of Neuroscience, 12(12), pp. 4583-4588. (doi:10.1111/j.1460-9568.2000.01350.x)

2007

Balsitis, M., Cooke, A., Griffiths, S., Onen, N.F., Shah, A.A., Stewart, W., Traynor, J.P., Upadhyaya, M., and Tobias, E. S. (2007) Gastric carcinoid: germline and somatic mutation of the neurofibromatosis type 1 gene. Familial Cancer, 6(1), pp. 147-152. (doi:10.1007/s10689-006-9002-2)

Barlow, A., and Stewart, W. (2007) The pathology of raised intracranial pressure. Advances in Clinical Neuroscience and Rehabilitation, 7(5), pp. 25-27.

2006

Ferguson, M., Stewart, W., Cowie, F., and White, J. (2006) Late-onset meningeal metastases in liposarcoma: A case report and review of the literature. Sarcoma, 2006(23039), pp. 1-3. (doi:10.1155/SRCM/2006/23039)

2004

Robinson, S., and Stewart, W. (2004) Inflammatory diseases of the CNS II: Meningitis and cerebral abscess. Advances in Clinical Neuroscience and Rehabilitation, 4(4), pp. 38-40.

Stewart, W., Black, M., Kalimo, H., and Graham, D.I. (2004) Non-traumatic forensic neuropathology. Forensic Science International, 146(2-3), pp. 125-147. (doi:10.1016/j.forsciint.2004.06.025)

2003

Sivaji, N., Basavaraj, S., Stewart, W., and Dempster, J. (2003) Adenoid cystic carcinoma of the nasal septum. Rhinology, 41(4), pp. 253-254.

Stewart, W., and Maxwell, D.J. (2003) Distribution of and organisation of dorsal horn neuronal cell bodies that possess the muscarinic m2 acetylcholine receptor. Neuroscience, 119(1), pp. 121-135. (doi:10.1016/S0306-4522(03)00116-7)

2002

Spike, R.C., Puskar, Z., Sakamoto, H., Stewart, W., Watt, C., and Todd, A.J. (2002) MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli. European Journal of Neuroscience, 15(8), pp. 1306-1316. (doi:10.1046/j.1460-9568.2002.01969.x)

1999

Welton, J., Stewart, W., Kerr, R., and Maxwell, D.J. (1999) Differential expression of the muscarinic m2 acetylcholine receptor by small and large motoneurons of the rat spinal cord. Brain Research, 817(1-2), pp. 215-219. (doi:10.1016/S0006-8993(98)01208-6)

1991

McKie, A.T., Stewart, W., and Lucas, M.L. (1991) The effect of sodium deoxycholate and other surfactants on the mucosal surface pH in proximal jejunum or rat. Naunyn-Schmiedeberg's Archives of Pharmacology, 343(6), pp. 659-664. (doi:10.1007/BF00184299)

This list was generated on Tue Jul 7 22:59:15 2015 BST.
Jump to: Articles
Number of items: 33.

Articles

Chaouch, A. et al. (2014) Two recurrent mutations are associated with GNE myopathy in the North of Britain. Journal of Neurology, Neurosurgery and Psychiatry, 85(12), pp. 1359-1365. (doi:10.1136/jnnp-2013-306314) (PMID:24695763)

Mouzon, B. C., Bachmeier, C., Ferro, A., Ojo, J.-O., Crynen, G., Acker, C. M., Davies, P., Mullan, M., Stewart, W., and Crawford, F. (2014) Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model. Annals of Neurology, 75(2), pp. 241-254. (doi:10.1002/ana.24064) (PMID:24243523)

Hong, Y.T. et al. (2014) Amyloid imaging with carbon 11–labeled pittsburgh compound b for traumatic brain injury. JAMA Neurology, 71(1), pp. 23-31. (doi:10.1001/jamaneurol.2013.4847)

Mouzon, B., Chaytow, H., Crynen, G., Bachmeier, C., Stewart, J., Mullan, M., Stewart, W., and Crawford, F. (2013) Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes. Journal of Neurotrauma, 29(18), pp. 2761-2773. (doi:10.1089/neu.2012.2498)

Johnson, V.E., Stewart, W., and Smith, D.H. (2013) Axonal pathology in traumatic brain injury. Experimental Neurology, 246, pp. 35-43. (doi:10.1016/j.expneurol.2012.01.013)

Henderson, M. et al. (2013) Recessive desmin-null muscular dystrophy with central nuclei and mitochondrial abnormalities. Acta Neuropathologica, 125(6), pp. 917-919. (doi:10.1007/s00401-013-1113-x)

Smith, D.H., Johnson, V.E., and Stewart, W. (2013) Chronic neuropathologies of single and repetitive TBI: substrates of dementia? Nature Reviews Neurology, 9(4), pp. 211-221. (doi:10.1038/nrneurol.2013.29)

Teo, M.K., Mathieson, C., Carruthers, R., Stewart, W., and Alakandy, L. (2012) Cauda equina lymphoma – a rare presentation of primary central nervous system lymphoma: case report and literature review. British Journal of Neurosurgery, 26(6), pp. 868-871. (doi:10.3109/02688697.2012.697225)

Johnson, V.E., Stewart, W., and Smith, D.H. (2012) Widespread tau and amyloid-beta pathology many years after a single traumatic brain injury in humans. Brain Pathology, 22(2), pp. 142-149. (doi:10.1111/j.1750-3639.2011.00513.x)

Bell, S.L., Hanzely, Z., Alakandy, L.M., Jackson, R., and Stewart, W. (2012) Primary meningeal histiocytic sarcoma: a report of two unusual cases. Neuropathology and Applied Neurobiology, 38(1), pp. 111-114. (doi:10.1111/j.1365-2990.2011.01205.x)

Bell, S.L., Suttner, N.J., and Stewart, W. (2012) An unusual intraventricular tumor. Neuropathology, 32(3), pp. 311-313. (doi:10.1111/j.1440-1789.2011.01247.x)

Goodfellow, J. A., Dani, K., Stewart, W., Santosh, C., McLean, J., Mulhern, S., and Razvi, S. (2012) Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes: an important cause of stroke in young people. Postgraduate Medical Journal, (doi:10.1136/postgradmedj-2011-130326)

Behbahani, M., St. George, E.J., Dunn, L.T., Hadley, D.M., and Stewart, W. (2011) Atypical adult medulloblastoma. Acta Neurochirurgica, 153(7), pp. 1511-1517. (doi:10.1007/s00701-011-1040-3)

McEwan, K., McAdam, J., and Stewart, W. (2011) Regional neuropathology referral practice before and after new organ retention legislation. Forensic Science International, 211(1-3), e9-e11. (doi:10.1016/j.forsciint.2011.04.026)

Behbahani, M., Ahmad, F.U., Siddiqui, M.A., Stewart, W., and Alakandy, L.M. (2010) Transjugular extension of meningioma into the mediastinum—a case report. Acta Neurochirurgica, 152(1), pp. 151-154. (doi:10.1007/s00701-009-0359-5)

Johnson, V.E., Stewart, W., and Smith, D.H. (2010) Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease? Nature Reviews Neuroscience, 11, pp. 361-370. (doi:10.1038/nrn2808)

Sav, A., Scheithauer, B.W., Taylor, W.A.S., Miller, G., and Stewart, W. (2010) Intraosseous soft tissue perineurioma: report of a vertebral example. Clinical Neuropathology, 29(2), pp. 94-99. (doi:10.5414/NPP29094)

French, P.J., Barlow, A., Barlow, P., Jampana, R.V., and Stewart, W. (2009) A case of pilomyxoid astrocytoma presenting with CSF rhinorrhoea in a 15-year-old. British Journal of Neurosurgery, 23(5), pp. 545-547. (doi:10.1080/02688690902814733)

Johnson, V., Stewart, W., Graham, D., Stewart, J., Praestgaard, A., and Smith, D. (2009) A Neprilysin Polymorphism and Amyloid-beta Plaques after Traumatic Brain Injury. Journal of Neurotrauma, 26(8), pp. 1197-1202.

Mathieson, C.S., St George, E.J., Stewart, W., Sastry, J., and Jamal, S. (2009) Primary intracranial leiomyosarcoma: a case report and review of the literature. Child's Nervous System, 25(8), pp. 1013-1017. (doi:10.1007/s00381-009-0845-3)

Schulz, U.G., Thomas, S.R., and Stewart, W. (2009) A difficult case solved at autopsy: memory loss, behavioural change and seizures. Practical Neurology, 9(2), pp. 90-95. (doi:10.1136/jnnp.2008.166165)

Barlow, A., Robertson, M., Doig, A., Stewart, W., and Drummond, M.W. (2008) Isolated central nervous system lymphoid blast crisis in chronic myeloid leukaemia in major molecular remission. British Journal of Haematology, 142(3), p. 327. (doi:10.1111/j.1365-2141.2008.07136.x)

Stewart, W., and Maxwell, D.J. (2008) Morphological evidence for selective modulation by serotonin of a subpopulation of dorsal horn cells which possess the neurokinin-1 receptor. European Journal of Neuroscience, 12(12), pp. 4583-4588. (doi:10.1111/j.1460-9568.2000.01350.x)

Balsitis, M., Cooke, A., Griffiths, S., Onen, N.F., Shah, A.A., Stewart, W., Traynor, J.P., Upadhyaya, M., and Tobias, E. S. (2007) Gastric carcinoid: germline and somatic mutation of the neurofibromatosis type 1 gene. Familial Cancer, 6(1), pp. 147-152. (doi:10.1007/s10689-006-9002-2)

Barlow, A., and Stewart, W. (2007) The pathology of raised intracranial pressure. Advances in Clinical Neuroscience and Rehabilitation, 7(5), pp. 25-27.

Ferguson, M., Stewart, W., Cowie, F., and White, J. (2006) Late-onset meningeal metastases in liposarcoma: A case report and review of the literature. Sarcoma, 2006(23039), pp. 1-3. (doi:10.1155/SRCM/2006/23039)

Robinson, S., and Stewart, W. (2004) Inflammatory diseases of the CNS II: Meningitis and cerebral abscess. Advances in Clinical Neuroscience and Rehabilitation, 4(4), pp. 38-40.

Stewart, W., Black, M., Kalimo, H., and Graham, D.I. (2004) Non-traumatic forensic neuropathology. Forensic Science International, 146(2-3), pp. 125-147. (doi:10.1016/j.forsciint.2004.06.025)

Sivaji, N., Basavaraj, S., Stewart, W., and Dempster, J. (2003) Adenoid cystic carcinoma of the nasal septum. Rhinology, 41(4), pp. 253-254.

Stewart, W., and Maxwell, D.J. (2003) Distribution of and organisation of dorsal horn neuronal cell bodies that possess the muscarinic m2 acetylcholine receptor. Neuroscience, 119(1), pp. 121-135. (doi:10.1016/S0306-4522(03)00116-7)

Spike, R.C., Puskar, Z., Sakamoto, H., Stewart, W., Watt, C., and Todd, A.J. (2002) MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli. European Journal of Neuroscience, 15(8), pp. 1306-1316. (doi:10.1046/j.1460-9568.2002.01969.x)

Welton, J., Stewart, W., Kerr, R., and Maxwell, D.J. (1999) Differential expression of the muscarinic m2 acetylcholine receptor by small and large motoneurons of the rat spinal cord. Brain Research, 817(1-2), pp. 215-219. (doi:10.1016/S0006-8993(98)01208-6)

McKie, A.T., Stewart, W., and Lucas, M.L. (1991) The effect of sodium deoxycholate and other surfactants on the mucosal surface pH in proximal jejunum or rat. Naunyn-Schmiedeberg's Archives of Pharmacology, 343(6), pp. 659-664. (doi:10.1007/BF00184299)

This list was generated on Tue Jul 7 22:59:15 2015 BST.