School of Medicine

Dr Nigel Jamieson

  • Clinical Lecturer in General Surgery (Surgery)

email: Nigel.Jamieson@glasgow.ac.uk


My clinical interests include upper GI surgery, with research interest strongly focused on pancreaticobiliary disease.  In my PhD thesis, funded by the Chief Scientist Office, I investigated novel pancreatic cancer prognostic markers identified by genomic profiling. Pancreatic ductal adenocarcinoma is the 5th commonest cancer and 4th commonest cause of cancer deaths in Europe. Current therapies are essentially ineffective in advanced, inoperable disease, and the 5-year overall survival less than 5%. Despite the poor outcome associated with pancreatic cancer a spectrum of outcomes exists.

Our first research aim is the improvement of outcome stratification for patients undergoing surgical resection. Translational clinical pancreatic cancer research is our next focus. We have constructed tissue microarrays (TMAs) that cover a broad range of pancreaticobiliary malignancies allowing high throughput validation of protein biomarkers, identified as part of gene expression microarray analysis.  To increase our tissue resource, we are involved in collecting a focused pancreatic biobank, including samples from pancreatic conditions at a pre- and post-operative stage.

A further thread of research involves microRNAs, small RNAs that play a critical role in post-transcriptional gene regulation. We have previously investigated microRNA expression profile of pancreatic cancer using microarray technology, with a proportion of these significantly associated with disease outcome. We aim to explore the mechanistic role of these microRNAs in various models of pancreatic disease and investigate their role in enhancing pre-operative diagnosis.

Finally, we previously identified that an elevated systemic inflammatory response is associated with poor outcome in pancreatic cancer. We are now profiling the complex tumour microenvironment and local inflammatory response associated with pancreatic cancer to better understand complex inter-relationship between the immune system, tumour and patient survival.

We currently have several active collaborations including Owen Sansom (Glasgow), Jim Norman (Glasgow), Professor Peter Adams (Glasgow), and Professor Nigel Pyne (Strathclyde).

As part of my role as clinical lecturer I will be involved in the running of SSCs focused on pancreatic disease, as well as the supervising of BMed Sci and MD students.

Jump to: 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2006 | 2005 | 2004 | 2003
Number of items: 25.

2013

Chang, D.K. et al. (2013) Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater. Journal of Clinical Oncology, 31 (10). pp. 1348-1356. ISSN 0732-183X (doi:10.1200/JCO.2012.46.8868)

Steele, C.W., Jamieson, N.B., Evans, T.R.J., McKay, C.J., Sansom, O.J., Morton, J., and Carter, C.R. (2013) Exploiting inflammation for therapeutic gain in pancreatic cancer. British Journal of Cancer, 108 (5). pp. 997-1003. ISSN 0007-0920 (doi:10.1038/bjc.2013.24)

Jamieson, N.B., Chan, N.I.J, Foulis, A.K., Dickson, E.J., McKay, C.J., and Carter, C.R. (2013) The prognostic influence of resection margin clearance following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. Journal of Gastrointestinal Surgery . ISSN 1091-255X (doi:10.1007/s11605-012-2131-z)

2012

Jamieson, N.B., Mohamed, M., Oien, K.A., Foulis, A.K., Dickson, E.J., Imrie, C.W., Carter, C.R., McKay, C.J., and McMillan, D.C. (2012) The relationship between tumor inflammatory cell infiltrate and outcome in patients with pancreatic ductal adenocarcinoma. Annals of Surgical Oncology, 19 (11). pp. 3581-3590. ISSN 1068-9265 (doi:10.1245/s10434-012-2370-y)

Dozynkiewicz, M.A. et al. (2012) Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Developmental Cell, 22 (1). pp. 131-145. ISSN 1534-5807 (doi:10.1016/j.devcel.2011.11.008)

Jamieson, N.B., Morran, D.C., Morton, J.P., Ali, A., Dickson, E.J., Carter, C.R., Sansom, O.J., Evans, T.R., McKay, C.J., and Oien, K.A. (2012) MicroRNA Molecular Profiles Associated with Diagnosis, Clinicopathologic Criteria, and Overall Survival in Patients with Resectable Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research, 18 (2). pp. 534-545. ISSN 1078-0432 (doi:10.1158/1078-0432.CCR-11-0679)

2011

Steele, C.W., Oien, K.A., McKay, C.J., and Jamieson, N.B. (2011) Clinical potential of microRNAs in pancreatic ductal adenocarcinoma. Pancreas, 40 (8). pp. 1165-1171. ISSN 0885-3177 (doi:10.1097/MPA.0b013e3182218ffb)

Kennedy, A.l. et al. (2011) Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis. Molecular Cell, 42 (1). pp. 36-49. ISSN 1097-2765 (doi:10.1016/j.molcel.2011.02.020)

Jamieson, N.B., Foulis, A.K., Oien, K.A., Dickson, E.J., Imrie, C.W., Carter, R., and McKay, C.J. (2011) Peripancreatic Fat Invasion Is an Independent Predictor of Poor Outcome Following Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma. Journal of Gastrointestinal Surgery, 15 (3). pp. 512-524. ISSN 1091-255X (doi:10.1007/s11605-010-1395-4)

Jamieson, N.B., Carter, C.R., McKay, C.J., and Oien, K.O. (2011) Tissue Biomarkers for Prognosis in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis. Clinical Cancer Research, 17 (10). pp. 3316-3331. ISSN 1078-0432 (doi:10.1158/1078-0432.CCR-10-3284)

Jamieson, N.B., Denley, S.M., Logue, J., MacKenzie, D.J., Foulis, A.K., Dickson, E.J., Imrie, C.W., Carter, R., McKay, C.J., and McMillan, D.J. (2011) A prospective comparison of the prognostic value of tumor- and patient-related factors in patients undergoing potentially curative surgery for pancreatic ductal adenocarcinoma. Annals of Surgical Oncology, 18 (8). pp. 2318-2328. ISSN 1068-9265 (doi:10.1245/s10434-011-1560-3)

2010

Morton, J.P. et al. (2010) Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 107 (1). pp. 246-251. ISSN 0027-8424 (doi:10.1073/pnas.0908428107)

Jamieson, N. B., Foulis, A. K., Oien, K. A., Going, J. J., Glen, P., Dickson, E. J., Imrie, C. W., McKay, C. J., and Carter, R. (2010) Positive Mobilization Margins Alone Do Not Influence Survival Following Pancreatico-Duodenectomy for Pancreatic Ductal Adenocarcinoma. Annals of Surgery, 251 (6). pp. 1003-1010. ISSN 0003-4932 (doi:10.1097/SLA.0b013e3181d77369)

Lafferty-Whyte, K. et al. (2010) Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma. BMC Genomics, 11 (1). p. 532. ISSN 1471-2164 (doi:10.1186/1471-2164-11-532)

Morton, J. et al. (2010) LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology, 139 (2). pp. 586-597. ISSN 0016-5085 (doi:10.1053/j.gastro.2010.04.055)

Morton, JP et al. (2010) Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma. Gastroenterology, 139 (1). pp. 292-303. ISSN 0016-5085 (doi:10.1053/j.gastro.2010.03.034)

Nitsche, C. J., Jamieson, N., Lerch, M. M., and Mayerle, J. V. (2010) Drug induced pancreatitis. Best Practice and Research: Clinical Gastroenterology, 24 (2). pp. 143-155. ISSN 1521-6918 (doi:10.1016/j.bpg.2010.02.002)

2009

Lafferty-Whyte, K., Cairney, C.J., Jamieson, N., Oien, K.A., and Keith, W.N. (2009) Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1792 (4). pp. 341-352. ISSN 0925-4439 (doi:10.1016/j.bbadis.2009.02.003 )

2008

Robertson, E, Austin, D, Jamieson, N, and Hogg, KJ (2008) Balsalazide-induced myocarditis. International Journal of Cardiology, 130 (3). E121-E122.

2006

Glen, P., Jamieson, N.B., McMillan, D.C., Carter, R., Imrie, C.W., and Mckay, C.J. (2006) Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer. Pancreatology, 6 (5). pp. 450-453. ISSN 1424-3903 (doi:10.1159/000094562)

2005

Jamieson, N.B., Glen, P., McMillan, D.C., McKay, C.J., Foulis, A.K., Carter, R., and Imrie, C.W. (2005) Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas. British Journal of Cancer, 92 (1). pp. 21-23. ISSN 0007-0920 (doi:10.1038/sj.bjc.6602305)

Singhal, A., Jamieson, N.B., Fewtrell, M., Deanfield, J., Lucas, A., and Sattar, N. (2005) Adiponectin predicts insulin resistance but not endothelial function in young, healthy adolescents. Journal of Clinical Endocrinology and Metabolism, 90 (8). pp. 4615-4621. ISSN 0021-972X (doi:10.1210/jc.2005-0131)

2004

Jamieson, N.B., Brown, D.J.F., Wallace, A.M., and McMillan, D.C. (2004) Adiponectin and the systemic inflammatory response in weight-losing patients with non-small cell lung cancer. Cytokine, 27 (2-3). pp. 90-92. ISSN 1043-4666 (doi:10.1016/j.cyto.2004.03.017)

2003

Jamieson, N.B., McMillan, D.C., Brown, D.J.F., and Wallace, A.M. (2003) Comparison of simple acid-ethanol precipitation with gel exclusion chromatography for measuring leptin binding in serum of normal subjects and cancer patients. Annals of Clinical Biochemistry, 40 (2). pp. 185-187. ISSN 0004-5632 (doi:10.1258/000456303763046157)

Ramsay, J.E., Jamieson, N.B., Greer, I.A., and Sattar, N. (2003) Paradoxical elevation in adiponectin concentrations in women with preeclampsia. Hypertension, 42 (5). pp. 891-894. ISSN 0194-911X (doi:10.1161/01.HYP.0000095981.92542.F6)

This list was generated on Sat May 25 07:31:49 2013 BST.