My research interest is to develop a better understanding of the mechanism of hot flushing. It is the commonest symptom experienced by menopausal women and it can have a significant impact on quality of life. It is also a common side effect of treatment in women with breast cancer and men with prostate cancer. Indeed many women with breast cancer discontinue their endocrine therapy as a result of flushing, and this has an impact on breast cancer recurrence and mortality.
HRT is an effective treatment for flushing, but is not suitable for all women, and there are many who are now reluctant to take it; an understanding of the mechanism is essential in developing alternative therapies. We have used Laser Doppler Imaging with iontophoresis as a biomarker for hot flushing in healthy postmenopausal women and have conducted further studies to investigate potential treatments in healthy postmenopausal women.
We are currently aiming to develop projects investigating the mechanism and treatment of hot flushing in those with breast cancer.