Dr Janet Gardner-Medwin

Clinical Senior Lecturer (Medicine)

telephone: 0141 451 5882 internal 85882
email: Janet.Gardner-Medwin@glasgow.ac.uk

School of Medicine, Dentistry & Nursing, Child Health, Office CO2, Zone 1, Ground Floor, Office Block, Queen Elizabeth University Hospital, Glasgow, G51 4TF

Import to contacts

Research interests

Her research interests are the epidemiology of childhood rheumatological conditions, and the impact of chronic inflammatory conditions on normal childhood, adolescent development and beyond into adulthood.

Publications

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Number of items: 60.

2023

Charras, A. et al. (2023) Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE. Rheumatology, 62(SI2), SI210-SI225. (doi: 10.1093/rheumatology/keac275) (PMID:35532072) (PMCID:PMC9949710)

2022

Smith, E. M.D. et al. (2022) Attainment of low disease activity and remission targets reduces the risk of severe flare and new damage in childhood lupus. Rheumatology, 61(8), pp. 3378-3389. (doi: 10.1093/rheumatology/keab915) (PMID:34894234)

Smith, E. M. D. et al. (2022) Real world treatment of juvenile-onset systemic lupus erythematosus: Data from the UK JSLE cohort study. Clinical Immunology, 239, 109028. (doi: 10.1016/j.clim.2022.109028) (PMID:35513304)

2021

Smith, E. M.D. et al. (2021) Limited sensitivity and specificity of the ACR/EULAR-2019 classification criteria for SLE in JSLE?—observations from the UK JSLE Cohort Study. Rheumatology, 60(11), pp. 5271-5281. (doi: 10.1093/rheumatology/keab210) (PMID:33690793) (PMCID:PMC8566265)

2017

Dworski, S. et al. (2017) Acid ceramidase deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1863(2), pp. 386-394. (doi: 10.1016/j.bbadis.2016.11.031) (PMID:27915031)

2016

Biskou, O., Gardner-Medwin, J., Mackinder, M., Bertz, M., Clark, C., Svolos, V., Russell, R. K., Edwards, C. A. , McGrogan, P. and Gerasimidis, K. (2016) Faecal calprotectin in treated and untreated children with coeliac disease and juvenile idiopathic arthritis. Journal of Pediatric Gastroenterology and Nutrition, 63(5), e112-e115. (doi: 10.1097/MPG.0000000000001384) (PMID:27540707)

2014

Chiewchengchol, D. et al. (2014) Mucocutaneous manifestations in a UK national cohort of juvenile-onset systemic lupus erythematosus patients. Rheumatology, 53(8), pp. 1504-1512. (doi: 10.1093/rheumatology/keu137)

Hendry, G.J., Turner, D.E., Gardner-Medwin, J., Lorgelly, P.K. and Woodburn, J. (2014) An exploration of parents’ preferences for foot care in juvenile idiopathic arthritis: a possible role for the discrete choice experiment. Journal of Foot and Ankle Research, 7(10), (doi: 10.1186/1757-1146-7-10)

2013

Hendry, G.J., Rafferty, D., Barn, R., Gardner-Medwin, J., Turner, D.E. and Woodburn, J. (2013) Foot function is well preserved in children and adolescents with juvenile idiopathic arthritis who are optimally managed. Gait and Posture, 38(1), pp. 30-36. (doi: 10.1016/j.gaitpost.2012.10.009)

Mcerlane, F. et al. (2013) Validity of a three-variable juvenile arthritis disease activity score in children with new-onset juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, 72(12), pp. 1983-1988. (doi: 10.1136/annrheumdis-2012-202031)

2012

Martin, N., Krol, P., Smith, S., Beard, L., Pilkington, C. A., Davidson, J., Wedderburn, L. R. and Gardner-Medwin, J. (2012) Comparison of children with onset of juvenile dermatomyositis symptoms before or after their fifth birthday in a UK and Ireland juvenile dermatomyositis cohort study. Arthritis Care and Research, 64(11), pp. 1665-1672. (doi: 10.1002/acr.21753)

Watson, L. et al. (2012) Disease activity, severity, and damage in the UK juvenile-onset systemic lupus erythematosus cohort. Arthritis and Rheumatism, 64(7), pp. 2356-2365. (doi: 10.1002/art.34410)

Watson, L. et al. (2012) Juvenile-onset SLE; disease activity, severity and damage - the UK JSLE Cohort Study. Arthritis and Rheumatism, 64(7), pp. 2356-2365. (doi: 10.1002/art.34410)

Hendry, G.J., Gardner-Medwin, J., Steultjens, M.P., Woodburn, J., Sturrock, R. and Turner, D.D. (2012) Frequent disconrdance between clinical and musculoskeletal ultrasound examinations of foot disease in juvenile idiopathic arthritis. Arthritis Care and Research, 64(3), pp. 441-447. (doi: 10.1002/acr.20655)

Cordingley, L., Vracas, T., Baildam, E., Chieng, A., Davidson, J., Foster, H.E., Gardner-Medwin, J., Wedderburn, L.R., Thomson, W. and Hyrich, K.L. (2012) Juvenile-onset inflammatory arthritis: a study of adolescents' beliefs about underlying cause. Rheumatology, 51(12), pp. 2239-2245. (doi: 10.1093/rheumatology/kes216)

Hendry, G.J., Gardner-Medwin, J., Steultjens, M.P.M., Woodburn, J., Sturrock, R.D. and Turner, D.D. (2012) Frequent discordance between clinical and musculoskeletal ultrasound examinations of foot disease in juvenile idiopathic arthritis. Arthritis Care and Research, 64(3), pp. 441-447. (doi: 10.1002/acr.20655)

Hinks, A. et al. (2012) Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap. Annals of the Rheumatic Diseases, 71(7), pp. 1117-1121. (doi: 10.1136/annrheumdis-2011-200814)

Omoyinmi, E. et al. (2012) Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA). PLoS ONE, 7(10), e47673. (doi: 10.1371/journal.pone.0047673) (PMID:23094074) (PMCID:PMC3475696)

2011

Hendry, G. J., Gardner-Medwin, J., Watt, G. F., Woodburn, J., McColl, J. H. and Sturrock, R. D. (2011) Foot related impairments and disability in juvenile idiopathic arthritis persist despite modern day treatment paradigms. Journal of Foot and Ankle Research, 4(S1), p. 24. (doi: 10.1186/1757-1146-4-S1-P24) (PMCID:PMC3102999)

Lal, S.D. et al. (2011) Agreement between proxy and adolescent assessment of disability, pain, and well-being in juvenile idiopathic arthritis. Journal of Pediatrics, 158,(2), pp. 307-312. (doi: 10.1016/j.jpeds.2010.08.003)

Martin, N., Krol, P., Smith, S., Murray, K., Pilkington, C.A., Davidson, J.E., Wedderburn, L.R. and Gardner-Medwin, J. [J. R. G.] (2011) A national registry for juvenile dermatomyositis and other paediatric idiopathic inflammatory myopathies: 10 years' experience; the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies. Rheumatology, 50(1), pp. 137-145. (doi: 10.1093/rheumatology/keq261)

2010

Hinks, A., Eyre, S., Ke, X., Barton, A., Martin, P., Flynn, E., Packham, J., Worthington, J., Thomson, W. and Gardner-Medwin, J. [C. a. B. s. g.] (2010) Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. Genes and Immunity, 11(2), pp. 194-198. (doi: 10.1038/gene.2009.105)

Mandall, N.A. et al. (2010) Juvenile idiopathic arthritis (JIA): a screening study to measure class II skeletal pattern, TMJ PDS and use of systemic corticosteroids. Journal of Orthodontics, 37(1), pp. 6-15. (doi: 10.1179/14653121042831)

Hinks, A., Martin, P., Flynn, E., Eyre, S., Packham, J., Barton, A., Worthington, J., Thomson, W. and Gardner-Medwin, J. [C. a. B. S. G.] (2010) Association of the CCR5 gene with juvenile idiopathic arthritis. Genes and Immunity, 11, pp. 584-589. (doi: 10.1038/gene.2010.25)

Hyrich, K.L. et al. (2010) Disease activity and disability in children with juvenile idiopathic arthritis one year following presentation to paediatric rheumatology. Results from the Childhood Arthritis Prospective Study. Rheumatology, 49(1), pp. 116-122. (doi: 10.1093/rheumatology/kep352)

2009

Gunawardena, H. et al. (2009) Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis. Arthritis and Rheumatism, 60(6), pp. 1807-1814. (doi: 10.1002/art.24547)

Gardner-Medwin, J. M. M., Irwin, G. and Johnson, K. (2009) MRI in juvenile idiopathic arthritis and juvenile dermatomyositis. Annals of the New York Academy of Sciences, 1154, pp. 52-83. (doi: 0.1111/j.1749-6632.2009.04498.x)

2008

van der Hilst, J.C., Bodar, E.J., Barron, K.S., Frenkel, J., Drenth, J.P., van der Meer, J.W., Simon, A. and Gardner-Medwin, J. [I. H. S. G.] (2008) Long-term follow-up, clinical features, and quality of life in a series of 103 patients with hyperimmunoglobulinemia D syndrome. Medicine, 87(6), pp. 301-310. (doi: 10.1097/MD.0b013e318190cfb7)

Wong, S.C. , Macrae, V.E., Gracie, J.A., McInnes, I.B. , Galea, P., Gardner-Medwin, J. and Ahmed, S.F. (2008) Inflammatory cytokines in juvenile idiopathic arthritis: Effects on physical growth and the insulin-like-growth factor axis. Growth Hormone and IGF Research, 18(5), pp. 369-378. (doi: 10.1016/j.ghir.2008.01.006) (PMID:18378173)

Thornton, J. et al. (2008) Costing juvenile idiopathic arthritis: examining patient-based costs during the first year after diagnosis. Rheumatology, 47(7), pp. 985-990. (doi: 10.1093/rheumatology/ken039)

Adib, N., Hyrich, K., Thornton, J., Lunt, M., Davidson, J., Gardner-Medwin, J., Foster, H., Baildam, E., Wedderburn, L. and Thomson, W. (2008) Disease activity and disability in children with juvenile idiopathic arthritis one year following presentation to paediatric rheumatology. Results from the Childhood Arthritis Prospective Study. Rheumatology, 47(7), pp. 991-995.

Adib, N., Hyrich, K., Thornton, J., Lunt, M., Davidson, J., Gardner-Medwin, J.M., Foster, H., Baildam, E., Wedderburn, L. and Thomson, W. (2008) Association between duration of symptoms and severity of disease at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study. Rheumatology, 47(7), pp. 991-995. (doi: 10.1093/rheumatology/ken085)

Hendry, G., Gardner-Medwin, J., Watt, G.F. and Woodburn, J. (2008) A survey of foot problems in juvenile idiopathic arthritis. Musculoskeletal Care, 6(4), pp. 221-232. (doi: 10.1002/msc.134)

2007

Macrae, V.E., Wong, S.C. , Smith, W., Gracie, A., McInnes, I., Galea, P., Gardner-Medwin, J., Farquharson, C. and Ahmed, S.F. (2007) Cytokine profiling and in vitro studies of murine bone growth using biological fluids from children with juvenile idiopathic arthritis. Clinical Endocrinology, 67(3), pp. 442-448. (doi: 10.1111/j.1365-2265.2007.02908.x) (PMID:17555514)

Piper, M. et al. (2007) Impaired endothelial function in systemic lupus erythematosus. Lupus, 16, pp. 84-88. (doi: 10.1177/0961203306074842)

2006

Gardner-Medwin, J. (2006) Rheumatoid factor polyarthritis. In: Szer, I.S., Kimura, P., Malleson, P. and Southwood, T. (eds.) Arthritis in Children and Adolescents: Juvenile Idiopathic Arthritis. Series: Oxford medical publications. Oxford University Press: Oxford, UK. ISBN 9780192632920

Gardner-Medwin, J., Killeen, O., Ryder, C., Bradshaw, K. and Johnson, K. (2006) Magnetic resonance imaging identifies features in clinically unaffected knees predicting extension of arthritis in children with monoarthritis. Journal of Rheumatology, 33, pp. 2337-2343.

Killeen, O. and Gardner-Medwin, J. (2006) In juvenile idiopathic arthritis, is folate supplementation effective against methotrexate toxicity at the expense of methotrexate's efficacy? Archives of Disease in Childhood, 91(6), pp. 537-538.

2005

Gardner-Medwin, J., Galea, P. and Duncan, R. (2005) Muculoskeletal and connective tissue disorders. In: Beattie, J. and Carachi, R. (eds.) Practical Paediatric Problems: A textbook for MRCPCH. Hodder Arnold: London, UK. ISBN 9780340809327

2004

Neven, B. et al. (2004) Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU. Blood, 103, pp. 2809-2815. (doi: 10.1182/blood-2003-07-2531)

2003

Black, A., Bhayani, H., Ryder, C., Pugh, M., Gardner-Medwin, J. and Southwood, T. (2003) An association between the acute phase response and patterns of antigen induced T cell proliferation in juvenile idiopathic arthritis. Arthritis Research and Therapy, 5, R277-R284. (doi: 10.1186/ar791)

Filer, A., Gardner-Medwin, J., Thambyrajah, J., Raza, K., Carruthers, D., Stevens, R., Liu, L., Lowe, S., Townend, J. and Bacon, P. (2003) Diffuse endothelial dysfunction is common to ANCA associated systemic vasculitis and polyarteritis nodosa. Annals of the Rheumatic Diseases, 62, pp. 162-167.

Johnson, K., Haigh, S., Ehtisham, S., Ryder, C. and Gardner-medwin, J. (2003) Childhood idiopathic chondrolysis of the hip: MRI features. Pediatric Radiology, 33(3), pp. 194-199.

Wilkinson, N., Jackson, G. and Gardner-Medwin, J. (2003) Biologic therapies for juvenile arthritis. Archives of Disease in Childhood, 88, pp. 186-191.

2002

Black, A., Bhayani, H., Ryder, C., Gardner-Medwin, J. and Southwood, T. (2002) T-cell activation without proliferation in juvenile idiopathic arthritis. Arthritis Research, 4, pp. 177-183.

Gardner-Medwin, J., Dolezalova, P., Cummins, C. and Southwood, T. (2002) Incidence of Henoch-Schonlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins. Lancet, 360, pp. 1197-1202.

Johnson, K. and Gardner-Medwin, J. (2002) Childhood arthritis: Classification and radiology. Clinical Radiology, 57, pp. 47-58. (doi: 10.1053/crad.2001.0732)

Johnson, K., Wittkop, B., Haigh, F., Ryder, C. and Gardner-Medwin, J. (2002) The early magnetic resonance imaging features of the knee in juvenile idiopathic arthritis. Clinical Radiology, 57(6), pp. 466-471.

2001

Gardner-Medwin, J., Macdonald, I., Taylor, J., Riley, P. and Powell, R. (2001) Seasonal differences in finger skin temperature and microvascular blood flow in healthy men and women are exaggerated in women with primary Raynaud's phenomenon. British Journal of Clinical Pharmacology, 52, pp. 17-23.

2000

Njeh, C.F., Shaw, N., Gardner-Medwin, J.M., Boivin, C.M. and Southwood, T.R. (2000) Use of quantitative ultrasound to assess bone status in children with juvenile idiopathic arthritis. Journal of Clinical Densitometry, 3(3), pp. 251-260. (doi: 10.1385/JCD:3:3:251)

1997

Cockcroft, J.R., Noon, J.P., Gardner-Medwin, J. and Bennett, T. (1997) Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels. British Journal of Clinical Pharmacology, 44(1), pp. 57-60. (doi: 10.1046/j.1365-2125.1997.00622.x)

Gardner-Medwin, J.M., Taylor, J.Y., Macdonald, I.A. and Powell, R.J. (1997) An investigation into variability in microvascular skin blood flow and the responses to transdermal delivery of acetylcholine at different sites in the forearm and hand. British Journal of Clinical Pharmacology, 43(4), pp. 391-397. (doi: 10.1046/j.1365-2125.1997.00558.x)

Pallis, M., Lim, K., Gardner-Medwin, J.M., Robins, R. and Powell, R. (1997) Correlation between CD29 density on CD8 + lymphocytes and serum IgG in systemic lupus erythematosus. Lupus, 6(4), pp. 379-384. (doi: 10.1177/096120339700600406)

1996

Gardner-Medwin, J.M. and Powell, R.J. (1996) One patient, two unusual conditions and three basic lessons. Annals of the Rheumatic Diseases, 55(6), pp. 350-352. (doi: 10.1136/ard.55.6.350)

1994

Gardner-Medwin, J.M., Smith, N.J. and Powell, R.J. (1994) Clinical experience with thalidomide in the management of severe oral and genital ulceration in conditions such as Behçet's disease: use of neurophysiological studies to detect thalidomide neuropathy. Annals of the Rheumatic Diseases, 53(12), pp. 828-832.

Powell, R.J. and Gardner-Medwin, J.M. (1994) Guideline for the clinical use and dispensing of thalidomide. Postgraduate Medical Journal, 70(830), pp. 901-904.

Gardner-Medwin, J.M., Lim, K.L. and Powell, R.J. (1994) Fever as an unusual presentation of a common condition. Annals of the Rheumatic Diseases, 53(11), pp. 711-713.

Gardner-Medwin, J.M. and Powell, R.J. (1994) Thalidomide--the way forward. Postgraduate Medical Journal, 70(830), pp. 860-862.

Hopkinson, N.P., Lim, K. and Gardner-Medwin, J.M. (1994) Antiphospholipid antibodies (aPL) in systemic lupus erythematosus. Are they specific tools for the diagnosis of aPL syndrome? Annals of the Rheumatic Diseases, 53(9), pp. 619-620.

1989

Gardner-Medwin, J.M., Sayer, J., Mahida, Y.R. and Spiller, R.C. (1989) Spontaneous rupture of spleen following streptokinase therapy. Lancet, 334(8676), p. 1398. (doi: 10.1016/S0140-6736(89)92009-6)

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