2024

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)

2023

Alexander, P.G., van Wyk, H.C. , Pennel, K.A.F., Hay, J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S.D. , Edwards, J. and Park, J.H. (2023) The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer. British Journal of Cancer, 128(4), pp. 556-567. (doi: 10.1038/s41416-022-02069-x) (PMID:36476660) (PMCID:PMC9938140)

2022

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Fuglestad, A. J., Meltzer, S., Ree, A. H., McMillan, D. C. , Park, J. H. and Kersten, C. (2022) The clinical value of C-reactive protein and its association with tumour location in patients undergoing curative surgery for colorectal cancer – a ScotScan collaborative study. Acta Oncologica, 61(10), pp. 1248-1255. (doi: 10.1080/0284186X.2022.2117572) (PMID:36068730)

Alexander, P. G. et al. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012) (PMID:35623467)

Patel, M. et al. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126(12), pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2) (PMID:35173303) (PMCID:PMC9174220)

Ross, F. A., Park, J. H. , Mansouri, D. , Combet, E. , Horgan, P. G. , McMillan, D. C. and Roxburgh, C. S.D. (2022) The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis. BMC Gastroenterology, 22, 176. (doi: 10.1186/s12876-022-02220-1) (PMID:35397505) (PMCID:PMC8994317)

Ross, F. A., Park, J. H. , Mansouri, D. , Little, C., Di Rollo, D. G., Combet, E. , Van Wyk, H. , Horgan, P. G. , McMillan, D. C. and Roxburgh, C. S. D. (2022) The role of faecal calprotectin in the identification of colorectal neoplasia in patients attending for screening colonoscopy. Colorectal Disease, 24(2), pp. 188-196. (doi: 10.1111/codi.15942) (PMID:34614299)

2021

Knight, K. A., Drami, I., McMillan, D. C. , Horgan, P. G. , Park, J. H. , Jenkins, J. T. and Roxburgh, C. S.D. (2021) Vascular calcification and response to neoadjuvant therapy in locally advanced rectal cancer: an exploratory study. Journal of Cancer Research and Clinical Oncology, 147(11), pp. 3409-3420. (doi: 10.1007/s00432-021-03570-1) (PMID:33710416) (PMCID:PMC8484095)

Johnstone, M. S., Lynch, G., Park, J. , McSorley, S. and Edwards, J. (2021) Novel methods of risk stratifying patients for metachronous, pre-malignant colorectal polyps: a systematic review. Critical Reviews in Oncology/Haematology, 164, 103421. (doi: 10.1016/j.critrevonc.2021.103421) (PMID:34246774)

Mansouri, D. , McSorley, S. T. , Park, J. H. , Orange, C., Horgan, P. G. , McMillan, D. C. and Edwards, J. (2021) The inflammatory microenvironment in screen-detected premaligant adenomatous polyps: early results from the integrated technologies for improved polyp surveillance (INCISE) project. European Journal of Gastroenterology and Hepatology, 33(7), pp. 983-989. (doi: 10.1097/MEG.0000000000002202) (PMID:34034277)

Matly, A., Quinn, J. A. , McMillan, D. C. , Park, J. H. and Edwards, J. (2021) The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 163, 103337. (doi: 10.1016/j.critrevonc.2021.103337) (PMID:33992802)

Knight, K. A., Hon Fei, C., Boland, K. F., Dolan, D. R., Golder, A. M. , McMillan, D. C. , Horgan, P. G. , Black, D. H., Park, J. H. and Roxburgh, C. S.D. (2021) Aortic calcification is associated with non-infective rather than infective postoperative complications following colorectal cancer resection: an observational cohort study. European Radiology, 31(6), pp. 4319-4329. (doi: 10.1007/s00330-020-07189-7) (PMID:33201280)

Al-Badran, S. S.F. et al. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7(2), pp. 121-134. (doi: 10.1002/cjp2.193) (PMID:33338327)

Alexander, P.G. et al. (2021) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x) (PMID:33223535)

Alexander, P. G., McMillan, D. C. and Park, J. H. (2021) A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy. Critical Reviews in Oncology/Hematology, 157, p. 103147. (doi: 10.1016/j.critrevonc.2020.103147) (PMID:33278675)

2020

Dolan, R. D. , Alwahid, M., McSorley, S. T. , Park, J. H. , Stevenson, R. P., Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2020) A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer. Scientific Reports, 10, 17965. (doi: 10.1038/s41598-020-73909-0) (PMID:33087753) (PMCID:PMC7578034)

Roseweir, A. K. et al. (2020) Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer. Journal of Pathology: Clinical Research, 6(4), pp. 283-296. (doi: 10.1002/cjp2.171) (PMID:32401426) (PMCID:PMC7578335)

Park, J. H. , Fuglestad, A. J., Køstner, A. H., Oliwa, A., Graham, J., Horgan, P. G. , Roxburgh, C. S.D. , Kersten, C. and McMillan, D. C. (2020) Systemic inflammation and outcome in 2295 patients with stage I-III colorectal cancer from Scotland and Norway: First results from the ScotScan Colorectal Cancer Group. Annals of Surgical Oncology, 27, pp. 2784-2794. (doi: 10.1245/s10434-020-08268-1) (PMID:32248375) (PMCID:PMC7334267)

Alexander, P. G., McMillan, D. C. and Park, J. H. (2020) The local inflammatory response in colorectal cancer – type, location or density? A systematic review and meta-analysis. Cancer Treatment Reviews, 83, 101949. (doi: 10.1016/j.ctrv.2019.101949) (PMID:31869737)

Knight, K.A., Horgan, P.G. , McMillan, D.C. , Roxburgh, C.S.D. and Park, J.H. (2020) The relationship between aortic calcification and anastomotic leak following gastrointestinal resection: a systematic review. International Journal of Surgery, 73, pp. 42-49. (doi: 10.1016/j.ijsu.2019.11.023) (PMID:31765846)

2019

Park, J. H. , van Wyk, H. , McMillan, D. C. , Edwards, J. , Orange, C., Horgan, P. G. and Roxburgh, C. S.D. (2019) Pre-operative, biopsy-based assessment of the tumour microenvironment in patients with primary operable colorectal cancer. Journal of Pathology: Clinical Research, 6(1), pp. 30-39. (doi: 10.1002/cjp2.143) (PMID:31486287) (PMCID:PMC6966701)

Park, J. H. , Woodley, N., McMillan, D. C. and Glen, P. (2019) Palliative stenting for oesophagogastric cancer: tumour and host factors and prognosis. BMJ Supportive and Palliative Care, 9, pp. 332-339. (doi: 10.1136/bmjspcare-2017-001490) (PMID:29574423)

Roseweir, A. K. , Clark, J., McSorley, S. T. , vanWyk, H. C. , Quinn, J. A. , Horgan, P. G. , McMillan, D. C. , Park, J. H. and Edwards, J. (2019) The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer. International Journal of Cancer, 144(9), pp. 2320-2329. (doi: 10.1002/ijc.32045) (PMID:30521130)

Roseweir, A. K. , Powell, A. G.M.T., Horstman, S. L., Inthagard, J., Park, J. A. , McMillan, D. C. , Horgan, P. G. and Edwards, J. (2019) Src family kinases, HCK and FGR, associate with local inflammation and tumour progression in colorectal cancer. Cellular Signalling, 56, pp. 15-22. (doi: 10.1016/j.cellsig.2019.01.007) (PMID:30684564)

Pennel, K. A.F., Park, J. H. , McMillan, D. C. , Roseweir, A. K. and Edwards, J. (2019) Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: implications for treatment. Cellular Signalling, 54, pp. 81-90. (doi: 10.1016/j.cellsig.2018.11.013) (PMID:30453014)

Roseweir, A.K. et al. (2019) A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with stage II/III colorectal cancer. International Journal of Cancer, 144(1), pp. 150-159. (doi: 10.1002/ijc.31739) (PMID:29992570)

Van Wyk, H. , Roseweir, A. , Alexander, P. , Park, J. H. , Horgan, P. , McMillan, D. and Edwards, J. (2019) The relationship between tumour budding, tumour microenvironment and survival in patients with primary operable colorectal cancer. Annals of Surgical Oncology, 26, pp. 4397-4404. (doi: 10.1245/s10434-019-07931-6) (PMID:31605345) (PMCID:PMC6863941)

2018

Park, J. H. et al. (2018) Staging the tumor and staging the host: A two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer. American Journal of Surgery, 216(3), pp. 458-464. (doi: 10.1016/j.amjsurg.2017.08.044) (PMID:28967380)

Dolan, R. D. , McSorley, S. T. , Park, J. H. , Watt, D. G. , Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2018) The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores. British Journal of Cancer, 119(1), pp. 40-51. (doi: 10.1038/s41416-018-0095-9) (PMID:29789606)

Morris, H. T. , Fort, L., Spence, H. J., Patel, R., Vincent, D. F., Park, J. H. , Snapper, S. B., Carey, F. A., Sansom, O. J. and Machesky, L. M. (2018) Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. Journal of Pathology, 245(3), pp. 337-348. (doi: 10.1002/path.5086) (PMID:29672847) (PMCID:PMC6033012)

Park, J.H. , Horgan, P.G. and McMillan, D.C. (2018) In reply to: “Meyer CP, et al. The association of hypoalbuminemia with early perioperative outcomes – A comprehensive assessment across 16 major procedures”. American Journal of Surgery, 216(1), pp. 174-175. (doi: 10.1016/j.amjsurg.2016.12.023) (PMID:28082008)

Park, J.H. and McMillan, D.C. (2018) Outcome in colorectal cancer – tumour, stroma and so much more. Annals of Oncology, 29(3), pp. 534-535. (doi: 10.1093/annonc/mdy007) (PMID:29324981)

Patel, M., McSorley, S. T. , Park, J. H. , Roxburgh, C. S.D. , Edwards, J. , Horgan, P. G. and McMillan, D. C. (2018) The relationship between right-sided tumour location, tumour microenvironment, systemic inflammation, adjuvant therapy and survival in patients undergoing surgery for colon and rectal cancer. British Journal of Cancer, 118(5), pp. 705-712. (doi: 10.1038/bjc.2017.441) (PMID:29337962) (PMCID:PMC5846060)

Dolan, R. , McSorley, S. T. , Park, J. H. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2018) The Prognostic Value of Systemic Inflammation in Patients Undergoing Surgery for Rectal Cancer: Comparison of Composite Ratios and Cumulative Scores. Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 18-20 Jan 2018. (doi: 10.1200/JCO.2018.36.4_suppl.579)

Dolan, R. , Tilling, E., Kong, C. Y. , MacLeod, N. J., McSorley, S. T. , Park, J. H. , Glen, P., Horgan, P. G. , Laird, B. and McMillan, D. C. (2018) Evaluation of Systemic Inflammation Based Prognostic Scores in Patients with Advanced Oesophageal Cancer Receiving Palliative Radiotherapy. Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 18-20 Jan 2018.

2017

Watt, D. G. , Ramanathan, M. L., McSorley, S. T. , Walley, K., Park, J. H. , Horgan, P. G. and McMillan, D. C. (2017) Clinicopathological determinants of an elevated systemic inflammatory response following elective potentially curative resection for colorectal cancer. Annals of Surgical Oncology, 24(9), pp. 2588-2594. (doi: 10.1245/s10434-017-5987-z) (PMID:28695389) (PMCID:PMC5539269)

Park, J. H. , Roxburgh, C. S.D. , Edwards, J. , Horgan, P. G. and McMillan, D. C. (2017) In reply to "Hynes S.O. et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study". Histopathology, 71(2), pp. 326-327. (doi: 10.1111/his.13195) (PMID:28226191)

Park, J.H. , Van Wyk, H. , Roxburgh, C.S.D. , Horgan, P.G. , Edwards, J. and McMillan, D.C. (2017) Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer. British Journal of Cancer, 116, pp. 1444-1450. (doi: 10.1038/bjc.2017.108)

Park, J. H. , Van Wyk, H. C., McMillan, D. C. , Quinn, J. A. , Clark, J., Roxburgh, C. , Horgan, P. G. and Edwards, J. (2017) Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host. Clinical Cancer Research, 23(7), pp. 1698-1709. (doi: 10.1158/1078-0432.CCR-16-1416) (PMID:27678454)

Watt, D., Mcsorley, S. T. , Park, J. H. , Horgan, P. G. and McMillan, D. C. (2017) A postoperative systemic inflammation score predicts short- and long-term outcomes in patients undergoing surgery for colorectal cancer. Annals of Surgical Oncology, 24(4), pp. 1100-1109. (doi: 10.1245/s10434-016-5659-4) (PMID:27822634)

2016

Roseweir, A. K. , Powell, A. G.M.T., Bennett, L., Van Wyk, H. C. , Park, J. , McMillan, D. C. , Horgan, P. G. and Edwards, J. (2016) Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer. Oncotarget, 7(43), pp. 70601-70612. (doi: 10.18632/oncotarget.12134) (PMID:27661110)

van Wyk, H. C. , Park, J. H. , Edwards, J. , Horgan, P. G. , McMillan, D. C. and Going, J. J. (2016) The relationship between tumour budding, the tumour microenvironment and survival in patients with primary operable colorectal cancer. British Journal of Cancer, 115(2), pp. 156-163. (doi: 10.1038/bjc.2016.173) (PMID:27299960)

Mansouri, D. , Powell, A., Park, J. H. , McMillan, D. C. and Horgan, P. G. (2016) Long-term follow-up of patients undergoing resection of tnm stage i colorectal cancer: an analysis of tumour and host determinants of outcome. World Journal of Surgery, 40(6), pp. 1485-1491. (doi: 10.1007/s00268-016-3443-z) (PMID:26920405)

Park, J. H. , McMillan, D. C. , Edwards, J. , Horgan, P. G. and Roxburgh, C. S.D. (2016) Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer. OncoImmunology, 5(3), e1098801. (doi: 10.1080/2162402X.2015.1098801)

Park, J. H. , Watt, D. G., Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2016) Colorectal cancer, systemic inflammation, and outcome: staging the tumor and staging the host. Annals of Surgery, 263(2), pp. 326-336. (doi: 10.1097/SLA.0000000000001122) (PMID:25575264)

Park, J. H. , Powell, A. G., Roxburgh, C. S.D. , Horgan, P. G. , McMillan, D. c. and Edwards, J. (2016) Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment. British Journal of Cancer, 114, pp. 562-570. (doi: 10.1038/bjc.2016.17) (PMID:26859693)

2015

Watt, D. G., Martin, J. C., Park, J. H. , Horgan, P. G. and McMillan, D. C. (2015) Neutrophil count is the most important prognostic component of the differential white cell count in patients undergoing elective surgery for colorectal cancer. American Journal of Surgery, 210(1), pp. 24-30. (doi: 10.1016/j.amjsurg.2014.12.031) (PMID:25842358)

Watt, D. G., McSorley, S. T. , Park, J. H. , Horgan, P. G. and McMillan, D. C. (2015) 879 The validation of C-reactive protein and albumin as predictors of post-operative infective complications and their clinical utility in patients with colorectal cancer. Gastroenterology, 148(4), S-1125. (doi: 10.1016/S0016-5085(15)33834-8)

Watt, D. G., Park, J. H. , Ramanathan, M. L., Horgan, P. G. and McMillan, D. C. (2015) Tu1760 neutrophil count, but not other components of a white cell count, reflects the impact of the systemic inflammatory response and long term survival in patients following elective surgery for colorectal cancer. Gastroenterology, 148(4), S-1175. (doi: 10.1016/S0016-5085(15)34008-7)

Park, J. H. , McMillan, D. C. , Powell, A. G., Richards, C. H., Horgan, P. G. , Edwards, J. and Roxburgh, C. S.D. (2015) Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer. Clinical Cancer Research, 21(4), pp. 882-888. (doi: 10.1158/1078-0432.CCR-14-1686) (PMID:25473000)

van Wyk, H.C. , Park, J. , Roxburgh, C. , Horgan, P. , Foulis, A. and McMillan, D. C. (2015) The role of tumour budding in predicting survival in patients with primary operable colorectal cancer: a systematic review. Cancer Treatment Reviews, 41(2), pp. 151-159. (doi: 10.1016/j.ctrv.2014.12.007) (PMID:25549950)

Grivennikov, S., Watt, D. G., Proctor, M. J., Park, J. H. , Horgan, P. G. and McMillan, D. C. (2015) The Neutrophil-Platelet Score (NPS) predicts survival in primary operable colorectal cancer and a variety of common cancers. PLoS ONE, 10(11), e0142159. (doi: 10.1371/journal.pone.0142159) (PMID:26544968) (PMCID:PMC4636235)

Mansouri, D. , Park, J.H. , Orange, C., Crighton, E.M., Horgan, P.G. and McMillan, D.C. (2015) Changes in the Inflammatory Microenvironment in Premalignant Colonic Adenomatous Polyps: Evidence for Immunosurveillance? Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 535. (doi: 10.1200/jco.2015.33.3_suppl.535)

Park, J.H. , Mansouri, D. , Orange, C., Horgan, P.G. and McMillan, D.C. (2015) Assessment of the Tumor Inflammatory Cell Infiltrate in Preoperative Colonoscopic Biopsies of Patients with Primary Operable Colorectal Cancer. Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 637. (doi: 10.1200/jco.2015.33.3_suppl.637)

Park, J.H. , McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S.D. (2015) The Clinical Utility of a Tumour Microenvironment-based Histopathological Score in Patients with Primary Operable Colorectal Cancer. Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 664. (doi: 10.1200/jco.2015.33.3_suppl.664)

Watt, D.G., Park, J.H. , Horgan, P.G. and McMillan, D.C. (2015) The Relationship Between Red Cell Distribution Width (RDW), Markers of Systemic Inflammation and Survival in Patients Undergoing Curative Surgery for Colorectal Cancer. Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 589. (doi: 10.1200/jco.2015.33.3_suppl.589)

Watt, D.G., Park, J.H. , Ramanathan, M.L., Horgan, P.G. and McMillan, D.C. (2015) Pre-and Postoperative Inflammatory Response to Predict Survival in Patients Undergoing Potentially Curative Resection for Colorectal Cancer. Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 609. (doi: 10.1200/jco.2015.33.3_suppl.609)

2014

Park, J.H. , Roxburgh, C.S.D. and McMillan, D.C. (2014) Comment on ‘Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis’. British Journal of Cancer, 111(12), p. 2372. (doi: 10.1038/bjc.2014.296)

Park, J.H. , Moyes, L. and STARSurg Collaborative, (2014) Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery. British Journal of Surgery, 101(11), pp. 1413-1423. (doi: 10.1002/bjs.9614) (PMID:25091299)

Park, J.H. , McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S. (2014) The impact of anti-inflammatory agents on the outcome of patients with colorectal cancer. Cancer Treatment Reviews, 40(1), pp. 68-77. (doi: 10.1016/j.ctrv.2013.05.006)

Park, J.H. , Richards, C.H., McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S.D. (2014) The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer. Annals of Oncology, 25(3), pp. 644-651. (doi: 10.1093/annonc/mdt593)

2013

Park, J.H. , Ruiz, M.C., Shields, D. and Orr, D.J. (2013) Socioeconomic deprivation does not affect prescribing of secondary prevention in patients with peripheral arterial disease. International Angiology, 32(6), pp. 593-598.

Park, J.H. , Velu, L., Dayal, S.P. and Mukherjee, A. (2013) Sacral osteomyelitis following restorative rectal cancer resection: a delayed presentation of dormant pelvic sepsis. Scottish Medical Journal, 58(1), e20-e23. (doi: 10.1177/0036933012474608) (PMID:23596034)

2010

Park, J.H. , Balmain, S., Berry, C. , Morton, J.J. and McMurray, J.J.V. (2010) Potentially detrimental cardiovascular effects of oxygen in patients with chronic left ventricular systolic dysfunction. Heart, 96(7), pp. 533-538. (doi: 10.1136/hrt.2009.175257) (PMID:20350990)

Articles

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)

Alexander, P.G., van Wyk, H.C. , Pennel, K.A.F., Hay, J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S.D. , Edwards, J. and Park, J.H. (2023) The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer. British Journal of Cancer, 128(4), pp. 556-567. (doi: 10.1038/s41416-022-02069-x) (PMID:36476660) (PMCID:PMC9938140)

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Fuglestad, A. J., Meltzer, S., Ree, A. H., McMillan, D. C. , Park, J. H. and Kersten, C. (2022) The clinical value of C-reactive protein and its association with tumour location in patients undergoing curative surgery for colorectal cancer – a ScotScan collaborative study. Acta Oncologica, 61(10), pp. 1248-1255. (doi: 10.1080/0284186X.2022.2117572) (PMID:36068730)

Alexander, P. G. et al. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012) (PMID:35623467)

Patel, M. et al. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126(12), pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2) (PMID:35173303) (PMCID:PMC9174220)

Ross, F. A., Park, J. H. , Mansouri, D. , Combet, E. , Horgan, P. G. , McMillan, D. C. and Roxburgh, C. S.D. (2022) The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis. BMC Gastroenterology, 22, 176. (doi: 10.1186/s12876-022-02220-1) (PMID:35397505) (PMCID:PMC8994317)

Ross, F. A., Park, J. H. , Mansouri, D. , Little, C., Di Rollo, D. G., Combet, E. , Van Wyk, H. , Horgan, P. G. , McMillan, D. C. and Roxburgh, C. S. D. (2022) The role of faecal calprotectin in the identification of colorectal neoplasia in patients attending for screening colonoscopy. Colorectal Disease, 24(2), pp. 188-196. (doi: 10.1111/codi.15942) (PMID:34614299)

Knight, K. A., Drami, I., McMillan, D. C. , Horgan, P. G. , Park, J. H. , Jenkins, J. T. and Roxburgh, C. S.D. (2021) Vascular calcification and response to neoadjuvant therapy in locally advanced rectal cancer: an exploratory study. Journal of Cancer Research and Clinical Oncology, 147(11), pp. 3409-3420. (doi: 10.1007/s00432-021-03570-1) (PMID:33710416) (PMCID:PMC8484095)

Johnstone, M. S., Lynch, G., Park, J. , McSorley, S. and Edwards, J. (2021) Novel methods of risk stratifying patients for metachronous, pre-malignant colorectal polyps: a systematic review. Critical Reviews in Oncology/Haematology, 164, 103421. (doi: 10.1016/j.critrevonc.2021.103421) (PMID:34246774)

Mansouri, D. , McSorley, S. T. , Park, J. H. , Orange, C., Horgan, P. G. , McMillan, D. C. and Edwards, J. (2021) The inflammatory microenvironment in screen-detected premaligant adenomatous polyps: early results from the integrated technologies for improved polyp surveillance (INCISE) project. European Journal of Gastroenterology and Hepatology, 33(7), pp. 983-989. (doi: 10.1097/MEG.0000000000002202) (PMID:34034277)

Matly, A., Quinn, J. A. , McMillan, D. C. , Park, J. H. and Edwards, J. (2021) The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 163, 103337. (doi: 10.1016/j.critrevonc.2021.103337) (PMID:33992802)

Knight, K. A., Hon Fei, C., Boland, K. F., Dolan, D. R., Golder, A. M. , McMillan, D. C. , Horgan, P. G. , Black, D. H., Park, J. H. and Roxburgh, C. S.D. (2021) Aortic calcification is associated with non-infective rather than infective postoperative complications following colorectal cancer resection: an observational cohort study. European Radiology, 31(6), pp. 4319-4329. (doi: 10.1007/s00330-020-07189-7) (PMID:33201280)

Al-Badran, S. S.F. et al. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7(2), pp. 121-134. (doi: 10.1002/cjp2.193) (PMID:33338327)

Alexander, P.G. et al. (2021) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x) (PMID:33223535)

Alexander, P. G., McMillan, D. C. and Park, J. H. (2021) A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy. Critical Reviews in Oncology/Hematology, 157, p. 103147. (doi: 10.1016/j.critrevonc.2020.103147) (PMID:33278675)

Dolan, R. D. , Alwahid, M., McSorley, S. T. , Park, J. H. , Stevenson, R. P., Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2020) A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer. Scientific Reports, 10, 17965. (doi: 10.1038/s41598-020-73909-0) (PMID:33087753) (PMCID:PMC7578034)

Roseweir, A. K. et al. (2020) Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer. Journal of Pathology: Clinical Research, 6(4), pp. 283-296. (doi: 10.1002/cjp2.171) (PMID:32401426) (PMCID:PMC7578335)

Park, J. H. , Fuglestad, A. J., Køstner, A. H., Oliwa, A., Graham, J., Horgan, P. G. , Roxburgh, C. S.D. , Kersten, C. and McMillan, D. C. (2020) Systemic inflammation and outcome in 2295 patients with stage I-III colorectal cancer from Scotland and Norway: First results from the ScotScan Colorectal Cancer Group. Annals of Surgical Oncology, 27, pp. 2784-2794. (doi: 10.1245/s10434-020-08268-1) (PMID:32248375) (PMCID:PMC7334267)

Alexander, P. G., McMillan, D. C. and Park, J. H. (2020) The local inflammatory response in colorectal cancer – type, location or density? A systematic review and meta-analysis. Cancer Treatment Reviews, 83, 101949. (doi: 10.1016/j.ctrv.2019.101949) (PMID:31869737)

Knight, K.A., Horgan, P.G. , McMillan, D.C. , Roxburgh, C.S.D. and Park, J.H. (2020) The relationship between aortic calcification and anastomotic leak following gastrointestinal resection: a systematic review. International Journal of Surgery, 73, pp. 42-49. (doi: 10.1016/j.ijsu.2019.11.023) (PMID:31765846)

Park, J. H. , van Wyk, H. , McMillan, D. C. , Edwards, J. , Orange, C., Horgan, P. G. and Roxburgh, C. S.D. (2019) Pre-operative, biopsy-based assessment of the tumour microenvironment in patients with primary operable colorectal cancer. Journal of Pathology: Clinical Research, 6(1), pp. 30-39. (doi: 10.1002/cjp2.143) (PMID:31486287) (PMCID:PMC6966701)

Park, J. H. , Woodley, N., McMillan, D. C. and Glen, P. (2019) Palliative stenting for oesophagogastric cancer: tumour and host factors and prognosis. BMJ Supportive and Palliative Care, 9, pp. 332-339. (doi: 10.1136/bmjspcare-2017-001490) (PMID:29574423)

Roseweir, A. K. , Clark, J., McSorley, S. T. , vanWyk, H. C. , Quinn, J. A. , Horgan, P. G. , McMillan, D. C. , Park, J. H. and Edwards, J. (2019) The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer. International Journal of Cancer, 144(9), pp. 2320-2329. (doi: 10.1002/ijc.32045) (PMID:30521130)

Roseweir, A. K. , Powell, A. G.M.T., Horstman, S. L., Inthagard, J., Park, J. A. , McMillan, D. C. , Horgan, P. G. and Edwards, J. (2019) Src family kinases, HCK and FGR, associate with local inflammation and tumour progression in colorectal cancer. Cellular Signalling, 56, pp. 15-22. (doi: 10.1016/j.cellsig.2019.01.007) (PMID:30684564)

Pennel, K. A.F., Park, J. H. , McMillan, D. C. , Roseweir, A. K. and Edwards, J. (2019) Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: implications for treatment. Cellular Signalling, 54, pp. 81-90. (doi: 10.1016/j.cellsig.2018.11.013) (PMID:30453014)

Roseweir, A.K. et al. (2019) A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with stage II/III colorectal cancer. International Journal of Cancer, 144(1), pp. 150-159. (doi: 10.1002/ijc.31739) (PMID:29992570)

Van Wyk, H. , Roseweir, A. , Alexander, P. , Park, J. H. , Horgan, P. , McMillan, D. and Edwards, J. (2019) The relationship between tumour budding, tumour microenvironment and survival in patients with primary operable colorectal cancer. Annals of Surgical Oncology, 26, pp. 4397-4404. (doi: 10.1245/s10434-019-07931-6) (PMID:31605345) (PMCID:PMC6863941)

Park, J. H. et al. (2018) Staging the tumor and staging the host: A two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer. American Journal of Surgery, 216(3), pp. 458-464. (doi: 10.1016/j.amjsurg.2017.08.044) (PMID:28967380)

Dolan, R. D. , McSorley, S. T. , Park, J. H. , Watt, D. G. , Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2018) The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores. British Journal of Cancer, 119(1), pp. 40-51. (doi: 10.1038/s41416-018-0095-9) (PMID:29789606)

Morris, H. T. , Fort, L., Spence, H. J., Patel, R., Vincent, D. F., Park, J. H. , Snapper, S. B., Carey, F. A., Sansom, O. J. and Machesky, L. M. (2018) Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. Journal of Pathology, 245(3), pp. 337-348. (doi: 10.1002/path.5086) (PMID:29672847) (PMCID:PMC6033012)

Park, J.H. , Horgan, P.G. and McMillan, D.C. (2018) In reply to: “Meyer CP, et al. The association of hypoalbuminemia with early perioperative outcomes – A comprehensive assessment across 16 major procedures”. American Journal of Surgery, 216(1), pp. 174-175. (doi: 10.1016/j.amjsurg.2016.12.023) (PMID:28082008)

Park, J.H. and McMillan, D.C. (2018) Outcome in colorectal cancer – tumour, stroma and so much more. Annals of Oncology, 29(3), pp. 534-535. (doi: 10.1093/annonc/mdy007) (PMID:29324981)

Patel, M., McSorley, S. T. , Park, J. H. , Roxburgh, C. S.D. , Edwards, J. , Horgan, P. G. and McMillan, D. C. (2018) The relationship between right-sided tumour location, tumour microenvironment, systemic inflammation, adjuvant therapy and survival in patients undergoing surgery for colon and rectal cancer. British Journal of Cancer, 118(5), pp. 705-712. (doi: 10.1038/bjc.2017.441) (PMID:29337962) (PMCID:PMC5846060)

Watt, D. G. , Ramanathan, M. L., McSorley, S. T. , Walley, K., Park, J. H. , Horgan, P. G. and McMillan, D. C. (2017) Clinicopathological determinants of an elevated systemic inflammatory response following elective potentially curative resection for colorectal cancer. Annals of Surgical Oncology, 24(9), pp. 2588-2594. (doi: 10.1245/s10434-017-5987-z) (PMID:28695389) (PMCID:PMC5539269)

Park, J. H. , Roxburgh, C. S.D. , Edwards, J. , Horgan, P. G. and McMillan, D. C. (2017) In reply to "Hynes S.O. et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study". Histopathology, 71(2), pp. 326-327. (doi: 10.1111/his.13195) (PMID:28226191)

Park, J.H. , Van Wyk, H. , Roxburgh, C.S.D. , Horgan, P.G. , Edwards, J. and McMillan, D.C. (2017) Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer. British Journal of Cancer, 116, pp. 1444-1450. (doi: 10.1038/bjc.2017.108)

Park, J. H. , Van Wyk, H. C., McMillan, D. C. , Quinn, J. A. , Clark, J., Roxburgh, C. , Horgan, P. G. and Edwards, J. (2017) Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host. Clinical Cancer Research, 23(7), pp. 1698-1709. (doi: 10.1158/1078-0432.CCR-16-1416) (PMID:27678454)

Watt, D., Mcsorley, S. T. , Park, J. H. , Horgan, P. G. and McMillan, D. C. (2017) A postoperative systemic inflammation score predicts short- and long-term outcomes in patients undergoing surgery for colorectal cancer. Annals of Surgical Oncology, 24(4), pp. 1100-1109. (doi: 10.1245/s10434-016-5659-4) (PMID:27822634)

Roseweir, A. K. , Powell, A. G.M.T., Bennett, L., Van Wyk, H. C. , Park, J. , McMillan, D. C. , Horgan, P. G. and Edwards, J. (2016) Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer. Oncotarget, 7(43), pp. 70601-70612. (doi: 10.18632/oncotarget.12134) (PMID:27661110)

van Wyk, H. C. , Park, J. H. , Edwards, J. , Horgan, P. G. , McMillan, D. C. and Going, J. J. (2016) The relationship between tumour budding, the tumour microenvironment and survival in patients with primary operable colorectal cancer. British Journal of Cancer, 115(2), pp. 156-163. (doi: 10.1038/bjc.2016.173) (PMID:27299960)

Mansouri, D. , Powell, A., Park, J. H. , McMillan, D. C. and Horgan, P. G. (2016) Long-term follow-up of patients undergoing resection of tnm stage i colorectal cancer: an analysis of tumour and host determinants of outcome. World Journal of Surgery, 40(6), pp. 1485-1491. (doi: 10.1007/s00268-016-3443-z) (PMID:26920405)

Park, J. H. , McMillan, D. C. , Edwards, J. , Horgan, P. G. and Roxburgh, C. S.D. (2016) Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer. OncoImmunology, 5(3), e1098801. (doi: 10.1080/2162402X.2015.1098801)

Park, J. H. , Watt, D. G., Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2016) Colorectal cancer, systemic inflammation, and outcome: staging the tumor and staging the host. Annals of Surgery, 263(2), pp. 326-336. (doi: 10.1097/SLA.0000000000001122) (PMID:25575264)

Park, J. H. , Powell, A. G., Roxburgh, C. S.D. , Horgan, P. G. , McMillan, D. c. and Edwards, J. (2016) Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment. British Journal of Cancer, 114, pp. 562-570. (doi: 10.1038/bjc.2016.17) (PMID:26859693)

Watt, D. G., Martin, J. C., Park, J. H. , Horgan, P. G. and McMillan, D. C. (2015) Neutrophil count is the most important prognostic component of the differential white cell count in patients undergoing elective surgery for colorectal cancer. American Journal of Surgery, 210(1), pp. 24-30. (doi: 10.1016/j.amjsurg.2014.12.031) (PMID:25842358)

Watt, D. G., McSorley, S. T. , Park, J. H. , Horgan, P. G. and McMillan, D. C. (2015) 879 The validation of C-reactive protein and albumin as predictors of post-operative infective complications and their clinical utility in patients with colorectal cancer. Gastroenterology, 148(4), S-1125. (doi: 10.1016/S0016-5085(15)33834-8)

Watt, D. G., Park, J. H. , Ramanathan, M. L., Horgan, P. G. and McMillan, D. C. (2015) Tu1760 neutrophil count, but not other components of a white cell count, reflects the impact of the systemic inflammatory response and long term survival in patients following elective surgery for colorectal cancer. Gastroenterology, 148(4), S-1175. (doi: 10.1016/S0016-5085(15)34008-7)

Park, J. H. , McMillan, D. C. , Powell, A. G., Richards, C. H., Horgan, P. G. , Edwards, J. and Roxburgh, C. S.D. (2015) Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer. Clinical Cancer Research, 21(4), pp. 882-888. (doi: 10.1158/1078-0432.CCR-14-1686) (PMID:25473000)

van Wyk, H.C. , Park, J. , Roxburgh, C. , Horgan, P. , Foulis, A. and McMillan, D. C. (2015) The role of tumour budding in predicting survival in patients with primary operable colorectal cancer: a systematic review. Cancer Treatment Reviews, 41(2), pp. 151-159. (doi: 10.1016/j.ctrv.2014.12.007) (PMID:25549950)

Grivennikov, S., Watt, D. G., Proctor, M. J., Park, J. H. , Horgan, P. G. and McMillan, D. C. (2015) The Neutrophil-Platelet Score (NPS) predicts survival in primary operable colorectal cancer and a variety of common cancers. PLoS ONE, 10(11), e0142159. (doi: 10.1371/journal.pone.0142159) (PMID:26544968) (PMCID:PMC4636235)

Park, J.H. , Roxburgh, C.S.D. and McMillan, D.C. (2014) Comment on ‘Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis’. British Journal of Cancer, 111(12), p. 2372. (doi: 10.1038/bjc.2014.296)

Park, J.H. , Moyes, L. and STARSurg Collaborative, (2014) Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery. British Journal of Surgery, 101(11), pp. 1413-1423. (doi: 10.1002/bjs.9614) (PMID:25091299)

Park, J.H. , McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S. (2014) The impact of anti-inflammatory agents on the outcome of patients with colorectal cancer. Cancer Treatment Reviews, 40(1), pp. 68-77. (doi: 10.1016/j.ctrv.2013.05.006)

Park, J.H. , Richards, C.H., McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S.D. (2014) The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer. Annals of Oncology, 25(3), pp. 644-651. (doi: 10.1093/annonc/mdt593)

Park, J.H. , Ruiz, M.C., Shields, D. and Orr, D.J. (2013) Socioeconomic deprivation does not affect prescribing of secondary prevention in patients with peripheral arterial disease. International Angiology, 32(6), pp. 593-598.

Park, J.H. , Velu, L., Dayal, S.P. and Mukherjee, A. (2013) Sacral osteomyelitis following restorative rectal cancer resection: a delayed presentation of dormant pelvic sepsis. Scottish Medical Journal, 58(1), e20-e23. (doi: 10.1177/0036933012474608) (PMID:23596034)

Park, J.H. , Balmain, S., Berry, C. , Morton, J.J. and McMurray, J.J.V. (2010) Potentially detrimental cardiovascular effects of oxygen in patients with chronic left ventricular systolic dysfunction. Heart, 96(7), pp. 533-538. (doi: 10.1136/hrt.2009.175257) (PMID:20350990)

Conference or Workshop Item

Dolan, R. , McSorley, S. T. , Park, J. H. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2018) The Prognostic Value of Systemic Inflammation in Patients Undergoing Surgery for Rectal Cancer: Comparison of Composite Ratios and Cumulative Scores. Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 18-20 Jan 2018. (doi: 10.1200/JCO.2018.36.4_suppl.579)

Dolan, R. , Tilling, E., Kong, C. Y. , MacLeod, N. J., McSorley, S. T. , Park, J. H. , Glen, P., Horgan, P. G. , Laird, B. and McMillan, D. C. (2018) Evaluation of Systemic Inflammation Based Prognostic Scores in Patients with Advanced Oesophageal Cancer Receiving Palliative Radiotherapy. Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 18-20 Jan 2018.

Mansouri, D. , Park, J.H. , Orange, C., Crighton, E.M., Horgan, P.G. and McMillan, D.C. (2015) Changes in the Inflammatory Microenvironment in Premalignant Colonic Adenomatous Polyps: Evidence for Immunosurveillance? Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 535. (doi: 10.1200/jco.2015.33.3_suppl.535)

Park, J.H. , Mansouri, D. , Orange, C., Horgan, P.G. and McMillan, D.C. (2015) Assessment of the Tumor Inflammatory Cell Infiltrate in Preoperative Colonoscopic Biopsies of Patients with Primary Operable Colorectal Cancer. Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 637. (doi: 10.1200/jco.2015.33.3_suppl.637)

Park, J.H. , McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S.D. (2015) The Clinical Utility of a Tumour Microenvironment-based Histopathological Score in Patients with Primary Operable Colorectal Cancer. Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 664. (doi: 10.1200/jco.2015.33.3_suppl.664)

Watt, D.G., Park, J.H. , Horgan, P.G. and McMillan, D.C. (2015) The Relationship Between Red Cell Distribution Width (RDW), Markers of Systemic Inflammation and Survival in Patients Undergoing Curative Surgery for Colorectal Cancer. Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 589. (doi: 10.1200/jco.2015.33.3_suppl.589)

Watt, D.G., Park, J.H. , Ramanathan, M.L., Horgan, P.G. and McMillan, D.C. (2015) Pre-and Postoperative Inflammatory Response to Predict Survival in Patients Undergoing Potentially Curative Resection for Colorectal Cancer. Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 609. (doi: 10.1200/jco.2015.33.3_suppl.609)