- Honorary Senior Research Fellow (School of Medicine)
Alan Crozier, formerly Professor of Plant Biochemistry, is currently an Honorary Senior Research Fellow in the School of Medicine. He has previously carried out research on plant hormones and as well as continuing research on purine alkaloids in coffees and teas, but the focus of his research is now dietary flavonoids and phenolic compounds and their potential to protect against non-communicable diseases, such as cardiovascular disease and cancer. He has published extensively in this area, and has edited four recent books on the topic. Alan is one of seven University of Glasgow Thomson Reuters “highly cited researcher 2014” with only 19 academics in this category in Scotland (http://highlycited.com/). His current Google Scholar h-index index is 67.
The Crozier research group has identified a number of common food products, especially berries, teas, coffee, wines and fruit juices, that are unusually rich sources of phenolic components, and have identified the specific compounds involved, such as ellagitannins and anthocyanins in pomegranates and raspberries, dihydrochalcones in apples, flavanones in oranges and other citrus fruits, caffeoylquinic acids in coffee and several fruits and a diversity of flavan-3-ol-derived structures in teas and cocoa-based products. Linking laboratory and clinical research his group has developed novel HPLC-MS methodology to monitor the metabolic fate of these compounds in the human body following the ingestion of fruit juices, vegetables, cocoa, coffee and teas by healthy human subjects and by volunteers with an ileostomy. Detailed information has been obtained on their digestion and complex metabolism within the gastrointestinal tract prior to absorption of metabolites from the small intestine into the blood stream where they may have in vivo biological effects. Current research concerns (poly)phenolic compounds which pass intact from the small to the large intestine where they can i) impact on colonic health, ii) modify the colonic microflora as well as iii) being broken down to potential protective compounds, such as valerolactones, urolithins and phenolic acids, which enter the circulatory system.
Grants and Awards listed are those received whilst working with the University of Glasgow.
- The feasibility of a randomised controlled trial of dieting interventions for men at high risk of prostate cancer.
Cancer Research UK
2011 - 2012
- Inter-individual variations in the colonic metabolism of flavonols
2010 - 2012
- Bioavailability, metabolism and impact of anthocyanins and ellagitannins on colonic health after consumption of raspberries.
Washington Red Rasberry Commission AG
2009 - 2011
- Reducing false-postives in the HVA assay for the diagnosis of catecholamine-secreting tumours: Possible dietary interference
Scottish Executive Health Department
2008 - 2009
- Absorption and metabolism of flavenoids and hydroxycinnmates - interactions with other dietary components
2004 - 2007
- Influence of lipids on nN-nitrosative chemistry arising from dietary nitrate at the gastro-oesophagal junction
World Cancer Research Fund
2004 - 2007
- Absorption and metabolism of green tea phenolics using human volunteers with an ileostomy
The World Green Tea Association
2004 - 2006
- Identification and Assessment of Nutritional Relevance of Antioxidant Compounds From Soft Fruit Species
Scottish Office Agriculture, Environment & Fisheries Dept.
1999 - 2005
- 2013 - ongoing: Biofactors
- 2012 - ongoing: Nutrition and Aging
- 2012 - ongoing: International Journal of Food Sciences and Nutrition
- 2006 - ongoing: University of Mauritius Research Journal
- 2005 - ongoing: Phytochemistry
- 2003 - ongoing: Molecular Nutrition Food Research
Grant Advisory Board
- 2011 - ongoing: European Commission Framework 7 - Reviewer in the Food-Health-Well-being Programme
- 2011 - ongoing: European Research Council - Panel Member Starting Grant Evaluation Committee
- 2006 - 2012: French National Institute of Health and Medical Research - International reviewer for research programmes in nutrition and health
Invited International Presentations
- 2014: Kyoto, Japan - "[2-14C](-)-Epicatechin metabonomics: absorption and metabolism in the small intestine and colon". Society for Free Radical Biology and Medicine
- 2014: Nagoya, Japan - "Natural medicine and kampo", XXVIIth International Conference on Polyphenols
- 2013: New Orleans, Louisiana, USA - "Bioavaliability and bioactivity of dietary flavonoids and related compounds", American Chemical Society Symposium 'Natural Products for Health and Pharmaceuticals'
- 2013: Charlotte, North Carolina, USA - "Bioavailability of berry phenolics and potential protective effects", Fifth International Berry Health Benefits Symposium organized by the Linus Pauling Institute, the Oregon Raspberry and Blackberry Commission and the Californian Strawberry Commission
- 2013: Buenos Aires, Argentina - "Absorption, metabolism and excretion of [14C]epicatechin in humans", Fifth International Conference on Polyphenols and Health
- 2013: Valencia, Spain - "Catabolism of dietary polyphenols by colonic microbiota". European Network for Gastrointestinal Health Research Symposium
- 2012: Araraquara, Sao Paulo, Brazil - "Bioavailability and potential protective effects on health of dietary polyphenols". IX Brazilian Meeting on Chemistry of Food and Beverages
- 2012: Washington, DC, USA - "Recent research on the bioavailability of tea flavan-3-ols", Fifth International Scientific Symposium on Tea and Human Health
- 2012: Spetses, Greece - "Bioavailability of dietary flavonoids", Society for Free Radical Research Summer School
- 2012: Adelaide, Australia - "An up-date on the bioavailability of dietary phenolics", Heath Benefits of Polyphenol-Rich Foods and Beverages, International Life Sciences Institute
- 2012: Brisbane, Australia - "Bioavailability of Dietary Phenolics", CSIRO Division of Food and Nutritional Sciences
- 2012: Adelaide, Australia - "Bioavailability of Dietary Phenolics", CSIRO Division of Food and Nutritional Sciences
- 2012: New York City, New York, USA - "Dietary polyphenols: absorption, metabolism and bioactivity", International Congress for Natural Products Research 2012
- 2012: San Diego, California, USA - "New methods for the identification of flavonoid metabolites in human biological samples", Federation of American Societies for Experimental Biology Annual Meeting, PhenHIRG Symposium, 'The Human Microbiome and Formation of Bioactive Flavonoid Metabolites'
- 2012: Adelaide, Australia - "Wine polyphenolics", Australian Wine Research Institute
- 2011: Wagga Wagga, Australia - "Dietary phenolics, bioavailability and impact on health", Charles Sturt University
- 2011: Montpellier, France - "Flavan-3-ols, bioavailability and impact on health", University of Montpellier II
- 2011: Wirrebee, Victoria, Australia - "The role of the colon in the bioavailability of dietary phenolics", CSIRO Division of Food and Nutritional Sciences
- 2011: Avignon, France - "Bioavailability of green tea flavan-3-ols". INRA - Universite d'Avignon
- 2010: Shizuoka, Japan - "Bioavailability of green tea flavan-3-ols". International Conference on Tea Culture and Science
- 2010: Basel, Switzerland - "Apple polyphenols, bioavailability and potential protective effects", DSM Nutritional Products Ltd.
- 2010: Geneva, Switzerland - "Phytochemicals, antioxidants and evidence of the protective effects of fruit juice consumption", World Juice Conference 2010
- 2010: Padova, Italy - "Flavonoids and related compounds in wines and their potential protective effects". Wine Health 2010. University of Padova
- 2009: Buenos Aires, Argentina - "Bioavailability of chlorogenic acids in coffee". Oxidative Stress and Antioxidants, meeting at the University of Buenos Aires
- 2009: Harrowgate, England, UK - "Bioavailability of flavonoids in a polyphenol-rich drink", Coca-Cola Lecture, Fourth International Conference on Polyphenols and Health
- 2009: Langkawi. Malaysia - "Recent research on the bioavailability of dietary phenolics", Chemoprevention and Translational Research, 7th COSTAM/Society for Free Radical Research International Workshop
- 2009: Santiago, Chile - "Novel insights into the bioavailability of dietary flavonoids and phenolics", Free Radicals and Antioxidants. Meeting of the Society for Free Radical Biology and Medicine
- 2009: Parma, Italy - "Functional plant products in the food chain", European Project FEED-SEG Symposium
- 2009: Monterey, California, USA - "Bioavailability of potentially protective compounds in berries", Third International Berry Health Benefits Symposium organized by the Linus Pauling Institute, the Oregon Raspberry and Blackberry Commission and the Californian Strawberry Commission
- 2009: Harrowgate, England, UK - "Pharmacokinetic metabolite profiling of hydroxycinnamate derivatives in plasma and urine following the ingestion of coffee by humans: identification of biomarkers of coffee consumption", Nestle Lecture, Fourth International Conference on Polyphenols and Health
- 2008: Port Louis, Mauritius - "Bioavailability and protective effects of dietary phenolics", 7th Society for Free Radical Research-Africa Conference and 28th African Health Science Congress
- 2008: Santa Barbara, California, USA - "Flavonoids and neurofunction", Oxygen Club of California 2008 World Congress - Oxidants and Antioxidants in Biology
- 2007: Vienna, Austria - "The absorption, metabolism and in vivo bioactivity of dietary phenolics". Department of Pharmacognosy, University of Vienna
- 2007: Bordeaux, France - "Red wine procyanidins and vascular health", Third International Congress on Wine and Health
- 2007: Athens, Greece - "Polyphenol-rich fruit juices", Greek National Congress of Nutrition & Dietetics
- 2007: Sao Carlos, Sao Paulo, Brazil - "Dietary plant secondary metabolites", First Brazilian Conference on Natural Products
- 2007: Hong Kong, China - "Development of a phenolic-rich fruit juice", Coca-Cola Company Symposium
- 2007: Corvallis, Oregon, USA - "Raspberry phenolics and their in vivo protective effects". 2nd International Berry Health Benefits Symposium organized by Oregon State University, the Linus Pauling Institute and the Oregon Raspberry and Blackberry Commission
- 2007: Canandaigua, New York, USA - "Polyphenol-rich fruit juices: potential protective effects", New York Wine and Grape Foundation 'Healthy Harvest' Symposium
- 2007: Washington, DC, USA - "Metabolism of tea flavonoids", Fourth International Scientific Symposium on Tea and Human Health
- 2007: Hangzhou, China - "Bioavailability of green tea flavan-3-ols", TEA Symposium
- 2007: Kyoto, Japan - "Animal and human studies on the bioavailability and metabolism of dietary phenolics", Third International Conference on Polyphenols and Health
Prizes, Awards and Distinctions
- 2009: Mars Prize for "The development of novel procedures aimed at improving analyses of flavonoids in plants, food sources and especially biological samples". Fourth International Conference on Polyphenols and Health, Harrowgate, UK
- 2002: Japanese Ministry of Education, Science, Culture, Sports and Technology Visiting Professor, Ochanomizu University, Tokyo.
- 1999: Visiting Professor, Frontier Research Program, RIKEN (Institute of Chemical and Physical Research), Japan. Invited for three month period as part of the RIKEN Visiting Eminent Scientist Program
- 1999: Eminent Scientist of RIKEN (Institute of Physical and Chemical Research, Japan).