Psoriasis

Clinical and Molecular Genetics of Psoriasis

Funded by:

• Wellcome Trust
• National Psoriasis Foundation (USA)

Collaborators:

Glasgow
Dr AD Burden, Consultant Dermatologist, North Glasgow University NHS Trust
Dr MB Hodgins, Reader in Dermatology, University of Glasgow
London
Professor JNWN Barker, St John's Institute of Dermatology, St Thomas's Hospital, London
Leicester
Professor R Trembath, Department of Medical Genetics, University of Leicester
Overseas
International Psoriasis Genetics Consortium

Identification of psoriasis susceptibility loci by genome scanning in extended pedigrees and sib pair analysis and fine mapping of the PSORS 1 locus on chromosome 6 p.

The Role of the Transcription Factors NFkB and AP-1 in Psoriasis

Funded by:

• The Psoriasis Association

Collaborators:

Glasgow
Dr AD Burden, Consultant Dermatologist, North Glasgow University NHS Trust
Dr R Plevin, Senior Lecturer, Department of Physiology & Pharmacology, University of Strathclyde
Edinburgh
Dr R McKenzie, Senior Lecturer, Department of Dermatology, University of Edinburgh

 

Melanoma

The role of BRAF Mutations in Melanoma

Collaborators :

Glasgow
Dr K Blessing, Consultant Pathologist, North Glasgow University NHS Trust
Dr R Herd, Consultant Dermatologist, North Glasgow University NHS Trust
Dr AD Burden, Consultant Dermatologist, North Glasgow University NHS Trust

The study of BRAF gene mutations in the pathogenesis, prognosis and molecular detection of early recurrence of malignant melanoma.

Capon F, Helms C, Veal CD, Tillman D, Burden AD, Barker JN, Bowcock AM, Trembath RC.
Genetic analysis of PSORS2 markers in a UK dataset supports the association between RAPTOR SNPs and familial psoriasis.
J Med Genet. 2004 Jun;41(6):459-460.

The International Psoriasis Genetics Consortium.
The International Psoriasis Genetics Study: Assessing Linkage to 14
Candidate Susceptibility Loci in a Cohort of 942 Affected Sib Pairs.
Am. J. Hum. Genet. 73:430–437, 2003
No Abstract available.

Capon F, Toal IK, Evans JC, Allen MH, Patel S, Tillman D, Burden D, Barker JN, Trembath RC.
Haplotype analysis of distantly related populations implicates corneodesmosin in psoriasis susceptibility.
J Med Genet. 2003 Jun;40(6):447-52.
Abstract

Van de Kerkoff P.C.M, Green C, Hamberg K.J, Huthinson P.E, Jensen J.K, Kidson P, Kragballe K, Larsen F.G, Munro C.S, Tillman, D.M.
Safety and efficacy of combined high dose treatment with Calcipotriol ointment and solution in patients with Psoriasis. Dermatology 2002; 204;211-221
Abstract

Veal CD, Capon F, Allen MH, Heath EK, Evans JC, Jones A, Patel S, Burden AD, Tillman DM, Barker JNWN, Trembath RC.
Family based analysis using a dense single-nucleotide polymorphism based map defines genetic variation at PSORS 1, the major psoriasis susceptibility locus. Am J Hum Genetics 2002; 71:554-564
Abstract

Asumalahti K, Veal C, Laitinen T, et al,
Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS 1 locus. Hum Mol Genetics 2002; 11: 589-597.
Abstract

Veal CD, Clough RL, Barber RC, Mason S, Tillman DM,
Identification of a novel psoriasis susceptibility locus at 1p and evidence of epistasis between PSORS 1 and candidate loci. J Med Genet 2001; 38: 7-13.
Abstract

Gupta G, Long J, Tillman DM
The efficacy of narrowband ultraviolet B phototherapy in psoriasis using objective and subjective outcome measures. Br J Dermatol 1999; 140: 887-90. Abstract

Burden AD, Javed S, Bailey M, Hodgins M, Connor JM, Tillman DM.
Genetics of psoriasis: paternal inheritance and a locus on chromosome 6p.
J Invest Dermatol 1998; 110: 958-60.
Abstract

Burden AD, Tillman DM, Foley P, Holme E
IgA class anticardiolipin antibodies in cutaneous leucocytoclastic vasculitis. J Am Acad Dermatol 1996; 35: 411-415.
Abstract

Burden AD, Gibson IW, Rodger RS, Tillman DM
IgA anticardiolipin antibodies associated with Henoch-Schonlein purpura. J Am Acad Dermatol 1994; 31: 857-860.
Abstract

Burden AD, Tillman DM, Richardson MD
Human Trychophyton equinum infection treated with terbinafine. Clin Exper Dermatol 1994; 19: 359-360.
Abstract

Tillman DM.
Gene rearrangement studies in cutaneous lymphoma. Skin cancer 1993; 8: 285-293.

Williams REA, Tillman DM, White SI, Barnett EI, MacKie RM.
Re-examining crude coal tar treatment for psoriasis. Br J Dermatol 1992; 126: 608-610.
Abstract

Tillman DM, Aitchison T, Watt DC, MacKie RM.
Stage II melanoma in the west of Scotland 1976-1985: prognostic factors for survival. Eur J Cancer 1991; 27: 870-76.
Abstract

Tel: +44 (0)141 330 4013

Fax: +44 (0)141 330 4008

Email - d.tillman@northglasgow.scot.nhs.uk