Mathematical approaches for studying form and function of vascular tumours

Prof Helen Byrne (University of Oxford)

Thursday 17th March, 2022 14:00-15:00 Room 110/ZOOM (ID: 967 1396 5355)

Abstract

Over the past twenty-five years we have witnessed an unparalleled increase in understanding of cancer. This transformation is exemplified by Hanahan and Weinberg's decision in 2011 to expand their original Hallmarks of Cancer from six traits to ten and, very recently, to fourteen! At the same time, mathematical modelling has emerged as a natural tool for unravelling the complex processes that contribute to the initiation and progression of tumours, for testing hypotheses about experimental and clinical observations, and assisting with the development of new approaches for improving its treatment. 

Following Hanahan and Weinberg's lead, in this talk I will reflect on how increased access to experimental data is stimulating the application of new theoretical approaches for studying tumour growth. I will focus on three case studies which illustrate how mathematical approaches can be used to characterise and quantify tumour vascular networks, to understand how microstructural features of these networks affect tumour blood flow, and to study the impact of unsteady blood flow on tumour growth. 

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