Professor William Martin

Prof William  Martin
  • Professor of Cardiovascular Pharmacology (Life Sciences Human Biology)
  • Senate Assessor (Senate Office)

telephone: 01413304489
email: William.Martin@glasgow.ac.uk

R507B Level 5
School of Life Sciences
West Medical Building
Glasgow G12 8QQ


Professor William Martin (Professor of Cardiovascular Pharmacology, Adviser of Studies). My research interests lie in the role played by the endothelium in controlling vascular tone, particularly through release of the vasodilators, nitric oxide and endothelium-derived hyperpolarising factor (EDHF). They also extend into the functions of nitric oxide released as a neurotransmitter from certain peripheral autonomic (nitrergic) nerves.

List all by: Type | Date

Jump to: 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 22.

2012

Craig, J., and Martin, W. (2012) Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery. British Journal of Pharmacology, 167 (3). pp. 527-536. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2012.02006.x)

2011

AL-Zobaidy, M.J., Craig, J., Brown, K., Pettifor, G., and Martin, W. (2011) Stimulus-specific blockade of nitric oxide-mediated dilatation by asymmetric dimethylarginine (ADMA) and monomethylarginine (L-NMMA) in rat aorta and carotid artery. European Journal of Pharmacology, 673 (1-3). pp. 78-84. ISSN 0014-2999 (doi:10.1016/j.ejphar.2011.10.024)

2010

AL-Zobaidy, M.J., Craig, J., and Martin, W. (2010) Differential sensitivity of basal and acetylcholine-induced activity of nitric oxide to blockade by asymmetric dimethylarginine (ADMA) in the rat aorta. British Journal of Pharmacology, 160 (6). pp. 1476-1483. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2010.00802.x)

Higgins, C. A., Martin, W., Anderson, L., Blanks, A. M., Norman, J.E., McConnachie, A., and Nelson, S.M. (2010) Maternal Obesity and its Relationship With Spontaneous and Oxytocin-Induced Contractility of Human Myometrium In Vitro. Reproductive Sciences, 17 (2). pp. 177-185. ISSN 1933-7191 (doi:10.1177/1933719109349780)

2009

Anderson, L., Martin, W., Higgins, C., Nelson, S., and Norman, J.E. (2009) The effect of progesterone on myometrial contractility, potassium channels, and tocolytic efficacy. Reproductive Sciences, 16 (11). pp. 1052-1061. ISSN 1933-7191 (doi:10.1177/1933719109340926)

Nelli, S., Craig, J., and Martin, W. (2009) Oxidation by trace Cu2+ ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery. European Journal of Pharmacology, 614 (1-3). pp. 84-90. ISSN 0014-2999 (doi:10.1016/j.ejphar.2009.04.033)

Martin, W. (2009) Nitroxyl anion - the universal signalling partner of endogenously produced nitric oxide? British Journal of Pharmacology, 157 (4). pp. 537-539. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2009.00153.x)

Martin, W. (2009) Robert F. Furchgott, Nobel laureate (1916-2009) - a personal reflection. British Journal of Pharmacology, 158 (3). pp. 633-637. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2009.00418.x)

2008

Stirrat, A., Nelli, S., Dowell, F.J., and Martin, W. (2008) Flow-induced enhancement of vasoconstriction and blockade of endothelium-derived hyperpolarizing factor (EDHF) by ascorbate in the rat mesentery. British Journal of Pharmacology, 153 (6). pp. 1162-1168. ISSN 0007-1188 (doi:10.1038/sj.bjp.0707499)

2007

Stirrat, A., Nelli, S., Dowell, F.J., and Martin, W. (2007) Flow-induced enhancement of vasoconstriction and blockade of endothelium-derived hyperpolarizing factor (EDHF) by ascorbate in the rat mesentery. British Journal of Pharmacology, 153 (6). pp. 1162-1168. ISSN 0007-1188 (doi:10.1038/sj.bjp.0707499)

Overend, J., and Martin, W. (2007) Differential effects of nitric oxide synthase inhibitors on endothelium-dependent and nitrergic nerve-mediated vasodilatation in the bovine ciliary artery. British Journal of Pharmacology, 150 (4). pp. 488-493. ISSN 1476-5381

2006

Stirrat, A., Nelli, S., McGuckin, A., Ho, V., Wilson, W., and Martin, W. (2006) Ascorbate elevates perfusion pressure in the bovine extraocular long posterior ciliary artery: Role of endothelium-derived hyperpolarizing factor (EDHF). European Journal of Pharmacology, 534 . pp. 152-158. (doi:10.1016/j.ejphar.2006.01.029)

2005

Overend, J., Wilson, W., and Martin, W. (2005) Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery: involvement of nitric oxide and an additional unidentified neurotransmitter. British Journal of Pharmacology, 145 . pp. 1001-1008. (doi:10.1038/sj.bjp.0706264)

2004

Nelli, S., Dowell, F., Wilson, W., Stirrat, A., and Martin, W. (2004) Requirement for flow in the blockade of endothelium-derived hyperpolarizing factor (EDHF) by ascorbate in the bovine ciliary artery. British Journal of Pharmacology, 142 . pp. 1081-1090. (doi:10.1038/sj.bjp.0705816)

2003

Cleland, J., Gemmell, I., Khand, A., Martin, W., Rankin, A., and Taylor, J. (2003) Carvedilol alone or in combination with digoxin for the management of atrial fibrillation in patients with heart failure? Journal of the American College of Cardiology, 42 (11). pp. 1944-1951.

McNeish, A., Nelli, S., Wilson, W., Dowell, F., and Martin, W. (2003) Differential effects of ascorbate on endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation in the bovine ciliary vascular bed and coronary artery. British Journal of Pharmacology, 138 . pp. 1172-1180. (doi:10.1038/sj.bjp.705143)

Nelli, S., Wilson, W., Laidlaw, H., Llano, A., Middleton, S., Price, A., and Martin, W. (2003) Evaluation of potassium ion as the endothelium-derived hyperpolarizing factor (EDHF) in the bovine coronary artery. British Journal of Pharmacology, 139 . pp. 982-988. (doi:10.1038/sj.bjp.0705329)

2002

McNeish, A., Wilson, W., and Martin, W. (2002) Ascorbate blocks endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation in the bovine ciliary vascular bed and rat mesentery. British Journal of Pharmacology, 135 . pp. 1801-1809.

Shahidullah, M., Duncan, A., Strachan, P., Rafique, K., Ball, S., McPate, M., Nelli, S., and Martin, W. (2002) Role of catalase in the smooth muscle relaxant actions of sodium azide and cyanamide. European Journal of Pharmacology, 435 . pp. 93-101.

2001

Buyukafsar, K., Nelli, S., and Martin, W. (2001) Formation of nitric oxide from nitroxyl anion: role of quinones and ferricytochrome c. British Journal of Pharmacology, 132 . pp. 165-172.

McNeish, A., Wilson, W., and Martin, W. (2001) Dominant role of an endothelium-derived hyperpolarizing factor (EDHF)-like vasodilator in the ciliary vascular bed of the bovine isolated perfused eye. British Journal of Pharmacology, 134 . pp. 912-920.

Nelli, S., McIntosh, L., and Martin, W. (2001) Role of copper ions and cytochrome P450 in the vasodilator actions of the nitroxyl anion generator, Angeli's salt, on rat aorta. European Journal of Pharmacology, 412 . pp. 281-289.

This list was generated on Mon Sep 1 13:08:16 2014 BST.
Jump to: Article
Number of items: 22.

Article

Craig, J., and Martin, W. (2012) Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery. British Journal of Pharmacology, 167 (3). pp. 527-536. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2012.02006.x)

AL-Zobaidy, M.J., Craig, J., Brown, K., Pettifor, G., and Martin, W. (2011) Stimulus-specific blockade of nitric oxide-mediated dilatation by asymmetric dimethylarginine (ADMA) and monomethylarginine (L-NMMA) in rat aorta and carotid artery. European Journal of Pharmacology, 673 (1-3). pp. 78-84. ISSN 0014-2999 (doi:10.1016/j.ejphar.2011.10.024)

AL-Zobaidy, M.J., Craig, J., and Martin, W. (2010) Differential sensitivity of basal and acetylcholine-induced activity of nitric oxide to blockade by asymmetric dimethylarginine (ADMA) in the rat aorta. British Journal of Pharmacology, 160 (6). pp. 1476-1483. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2010.00802.x)

Higgins, C. A., Martin, W., Anderson, L., Blanks, A. M., Norman, J.E., McConnachie, A., and Nelson, S.M. (2010) Maternal Obesity and its Relationship With Spontaneous and Oxytocin-Induced Contractility of Human Myometrium In Vitro. Reproductive Sciences, 17 (2). pp. 177-185. ISSN 1933-7191 (doi:10.1177/1933719109349780)

Anderson, L., Martin, W., Higgins, C., Nelson, S., and Norman, J.E. (2009) The effect of progesterone on myometrial contractility, potassium channels, and tocolytic efficacy. Reproductive Sciences, 16 (11). pp. 1052-1061. ISSN 1933-7191 (doi:10.1177/1933719109340926)

Nelli, S., Craig, J., and Martin, W. (2009) Oxidation by trace Cu2+ ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery. European Journal of Pharmacology, 614 (1-3). pp. 84-90. ISSN 0014-2999 (doi:10.1016/j.ejphar.2009.04.033)

Martin, W. (2009) Nitroxyl anion - the universal signalling partner of endogenously produced nitric oxide? British Journal of Pharmacology, 157 (4). pp. 537-539. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2009.00153.x)

Martin, W. (2009) Robert F. Furchgott, Nobel laureate (1916-2009) - a personal reflection. British Journal of Pharmacology, 158 (3). pp. 633-637. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2009.00418.x)

Stirrat, A., Nelli, S., Dowell, F.J., and Martin, W. (2008) Flow-induced enhancement of vasoconstriction and blockade of endothelium-derived hyperpolarizing factor (EDHF) by ascorbate in the rat mesentery. British Journal of Pharmacology, 153 (6). pp. 1162-1168. ISSN 0007-1188 (doi:10.1038/sj.bjp.0707499)

Stirrat, A., Nelli, S., Dowell, F.J., and Martin, W. (2007) Flow-induced enhancement of vasoconstriction and blockade of endothelium-derived hyperpolarizing factor (EDHF) by ascorbate in the rat mesentery. British Journal of Pharmacology, 153 (6). pp. 1162-1168. ISSN 0007-1188 (doi:10.1038/sj.bjp.0707499)

Overend, J., and Martin, W. (2007) Differential effects of nitric oxide synthase inhibitors on endothelium-dependent and nitrergic nerve-mediated vasodilatation in the bovine ciliary artery. British Journal of Pharmacology, 150 (4). pp. 488-493. ISSN 1476-5381

Stirrat, A., Nelli, S., McGuckin, A., Ho, V., Wilson, W., and Martin, W. (2006) Ascorbate elevates perfusion pressure in the bovine extraocular long posterior ciliary artery: Role of endothelium-derived hyperpolarizing factor (EDHF). European Journal of Pharmacology, 534 . pp. 152-158. (doi:10.1016/j.ejphar.2006.01.029)

Overend, J., Wilson, W., and Martin, W. (2005) Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery: involvement of nitric oxide and an additional unidentified neurotransmitter. British Journal of Pharmacology, 145 . pp. 1001-1008. (doi:10.1038/sj.bjp.0706264)

Nelli, S., Dowell, F., Wilson, W., Stirrat, A., and Martin, W. (2004) Requirement for flow in the blockade of endothelium-derived hyperpolarizing factor (EDHF) by ascorbate in the bovine ciliary artery. British Journal of Pharmacology, 142 . pp. 1081-1090. (doi:10.1038/sj.bjp.0705816)

Cleland, J., Gemmell, I., Khand, A., Martin, W., Rankin, A., and Taylor, J. (2003) Carvedilol alone or in combination with digoxin for the management of atrial fibrillation in patients with heart failure? Journal of the American College of Cardiology, 42 (11). pp. 1944-1951.

McNeish, A., Nelli, S., Wilson, W., Dowell, F., and Martin, W. (2003) Differential effects of ascorbate on endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation in the bovine ciliary vascular bed and coronary artery. British Journal of Pharmacology, 138 . pp. 1172-1180. (doi:10.1038/sj.bjp.705143)

Nelli, S., Wilson, W., Laidlaw, H., Llano, A., Middleton, S., Price, A., and Martin, W. (2003) Evaluation of potassium ion as the endothelium-derived hyperpolarizing factor (EDHF) in the bovine coronary artery. British Journal of Pharmacology, 139 . pp. 982-988. (doi:10.1038/sj.bjp.0705329)

McNeish, A., Wilson, W., and Martin, W. (2002) Ascorbate blocks endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation in the bovine ciliary vascular bed and rat mesentery. British Journal of Pharmacology, 135 . pp. 1801-1809.

Shahidullah, M., Duncan, A., Strachan, P., Rafique, K., Ball, S., McPate, M., Nelli, S., and Martin, W. (2002) Role of catalase in the smooth muscle relaxant actions of sodium azide and cyanamide. European Journal of Pharmacology, 435 . pp. 93-101.

Buyukafsar, K., Nelli, S., and Martin, W. (2001) Formation of nitric oxide from nitroxyl anion: role of quinones and ferricytochrome c. British Journal of Pharmacology, 132 . pp. 165-172.

McNeish, A., Wilson, W., and Martin, W. (2001) Dominant role of an endothelium-derived hyperpolarizing factor (EDHF)-like vasodilator in the ciliary vascular bed of the bovine isolated perfused eye. British Journal of Pharmacology, 134 . pp. 912-920.

Nelli, S., McIntosh, L., and Martin, W. (2001) Role of copper ions and cytochrome P450 in the vasodilator actions of the nitroxyl anion generator, Angeli's salt, on rat aorta. European Journal of Pharmacology, 412 . pp. 281-289.

This list was generated on Mon Sep 1 13:08:16 2014 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • The myometrial effects of prolonged in vivo treatment with progesterone in pregnancy
    Scottish Executive Health Department
    2006 - 2008
     
  • Flow and endothelium-derived hyperpolarising factor (EDHF)
    Wellcome Trust
    2004 - 2008
     
  • Nitrergic vasodilation in the ciliary and retinal circulations - Jill Overend
    British Heart Foundation
    2003 - 2006
     
  • Ascorbate & endothelium-derived hyperpolarizing factor (EDHF)
    British Heart Foundation
    2003 - 2006
     

I teach pharmacology and physiology to science and medical students. I am also Chair of the College of Medicine, Veterinary Medicine & Life Sciences Ethics Committee for Non-Clinical Research Involving Humans

Editorial Board

  • 1989 - 1996: British Journal of Pharmacology

Grant Advisory Board

  • 2008 - 2011: University of Malaysia, Kuala Lumpur - Pharmacology Staff Promotions Committee
  • 2005 - 2008: National University of Singapore - Scientific Advisory Board - Cardiovascular Programme
  • 2000 - 2001: HEFCE - RAE 2001 Panel Member, UoA 5-8 (Preclinical, Anatomy, Physiology, Pharmacology)

Invited International Presentations

  • 2002: Vaux de Cernay, France - 4th International Symposium on "Endothelium-derived hyperpolarising factor".
  • 2001: Boston, USA - 8th International Symposium on "Mechanisms of Vasodilatation" (Scientific Committee Member)
  • 2001: Gent, Belgium - Symposium on "Regulation of nitrergic neurotransmission."

Prizes, Awards and Distinctions

  • 2012: British Pharmacological Society - Elected Fellow
  • 2002: ISI Highly Cited Researcher Award for Pharmacology - Awarded to the 100 most highly cited Pharmacologists (isihighlycited.com)

Professional Learned Society

  • 2012 - ongoing: British Pharmacological Society - Election to a Fellowship of the British Pharmacological Society
  • 1999 - ongoing: British Atherosclerosis Society - Member
  • 1997 - ongoing: Scottish Cardiovascular Forum - Member
  • 1995 - ongoing: Research Defence Society - Member
  • 1986 - ongoing: British Pharmacological Society - Member, Animal Welfare Committee 2002-2006, Diploma in Advanced Pharmacology Steering Group Member 2006-2011